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8 results on '"MESH: Xanthones"'

1. Eumitrins C-E: Structurally diverse xanthone dimers from the vietnamese lichen Usnea baileyi

Author

Pierre Le Pogam, Grégory Genta-Jouve, Solenn Ferron, Joël Boustie, Mehdi A. Beniddir, Van-Kieu Nguyen, Philippe Grellier, Warinthorn Chavasiri, Jean-François Gallard, Elisabeth Mouray, Thuc-Huy Duong, Chulalongkorn University [Bangkok], Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens (LEEISA), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS), Hétérocycles et Peptides (UMR 8638), Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale (COMETE - UMR 8638), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Vietnam National University - Ho Chi Minh City (VNU-HCM), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Molécules de Communication et Adaptation des Micro-organismes (MCAM), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Equipe C-TAC (UMR 8638), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine, Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Graduate School, University of Texas, Austin, Chulalongkorn University, Université Paris-Sud - Paris 11 (UP11)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Rennes-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)

Subjects
Circular dichroism, Magnetic Resonance Spectroscopy, Antiparasitic, medicine.drug_class, Stereochemistry, Xanthones, MESH: Molecular Structure, MESH: Plant Extracts, MESH: Usnea, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 01 natural sciences, MESH: Circular Dichroism, chemistry.chemical_compound, Drug Discovery, Xanthone, medicine, [CHIM]Chemical Sciences, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Pharmacology, Molecular Structure, Plant Extracts, 010405 organic chemistry, Depsidone, MESH: Magnetic Resonance Spectroscopy, Circular Dichroism, MESH: Xanthones, Absolute configuration, General Medicine, Nuclear magnetic resonance spectroscopy, 0104 chemical sciences, Thallus, 010404 medicinal & biomolecular chemistry, Usnea, Vietnam, chemistry, MESH: Vietnam, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

International audience; Three new xanthone dimers, eumitrins C - E (1-3), along with a new depsidone, 3'-O-demethylcryptostictinolide (4) were isolated from the acetone extract of the whole thallus of the lichen Usnea baileyi collected in Vietnam. Their structures were unambiguously established by spectroscopic analyses (HRESIMS, 1D and 2D NMR), as well as comparison to literature data. The absolute configurations of 1-3 were elucidated through electronic circular dichroism (ECD) analyses. The absolute configuration of 2 was validated by comparison between experimental and TDDFT-calculated ECD spectra while that of 3 was based on DFT-NMR calculations and subsequent DP4 probability score. The antiparasitic activities against Plasmodium falciparum as well as the cytotoxic activity against seven cell lines were determined for the new compounds 1-3, and led from null to mild bioactivities.

Published
2020
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2. Allanxanthone B, a polyisoprenylated xanthone from the stem bark of Allanblackia monticola Staner L.C

Author

Augustin Ephraim Nkengfack, Michele Meyer, Bernard Bodo, Anatole Guy Blaise Azebaze, Laboratoire de chimie et biochimie des substances naturelles, and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Magnetic Resonance Spectroscopy, Stereochemistry, Xanthones, MESH: Molecular Structure, MESH: Plant Extracts, Allanblackia, Plant Science, Horticulture, Biochemistry, chemistry.chemical_compound, Triterpene, Clusiaceae, MESH: Anti-Bacterial Agents, Xanthone, Molecular Biology, Lupeol, chemistry.chemical_classification, Stem bark, Stigmasterol, Molecular Structure, biology, Traditional medicine, Plant Extracts, MESH: Magnetic Resonance Spectroscopy, Phytosterol, MESH: Xanthones, General Medicine, Antimicrobial, biology.organism_classification, Terpenoid, Anti-Bacterial Agents, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], MESH: Clusiaceae, chemistry, visual_art, visual_art.visual_art_medium, Bark
Abstract

International audience; In addition to five known compounds including three xanthones, tovophyllin A, rubraxanthone and garciniafuran, one pentacyclic triterpene, lupeol and one phytosterol, stigmasterol, a polyisoprenylated xanthone named allanxanthone B was isolated from the stem bark of Allanblackia monticola. The structure of the new compound was assigned as 2-geranyl-1,3,6-trihydroxy-2',2'-dimethyl[5',6':7,8]xanthone by means of spectroscopic analysis. The antimicrobial activities of some of these compounds against a range of micro-organisms are also reported.

Published
2004
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3. Isolation of C-glycosyl xanthones from Coffea pseudozanguebariae and their location

Author

Jean-Luc Poëssel, Pascale Talamond, Jean-Luc Verdeil, Geneviève Conejero, Diversité, adaptation, développement des plantes (UMR DIADE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro), Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche Génétique et amélioration des fruits et légumes (GALF), Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Génétique et Amélioration des Fruits et Légumes (GAFL), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)

Subjects
0106 biological sciences, Spectroscopie RMN, Rubiaceae, Coffea, Plant Science, 01 natural sciences, Plante sauvage, chemistry.chemical_compound, Drug Discovery, Xanthone, isomangiferin, Mangiferin, ComputingMilieux_MISCELLANEOUS, biology, MESH: Xanthones, Feuille, food and beverages, Composition chimique, General Medicine, MESH: Plant Leaves, Caféine, fluorescence, Two-dimensional nuclear magnetic resonance spectroscopy, Stereochemistry, F60 - Physiologie et biochimie végétale, Xanthones, Spectrométrie de masse, Coffea canephora, mangiferin, Coffea pseudozanguebariae Bridson, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Glycosyl, Q04 - Composition des produits alimentaires, Pharmacology, Chromatography, Epidermis (botany), MESH: Coffea, 010405 organic chemistry, biology.organism_classification, 0104 chemical sciences, Plant Leaves, Complementary and alternative medicine, chemistry, Composé phénolique, Polyphenol, U30 - Méthodes de recherche, 010606 plant biology & botany
Abstract

The biochemical composition of leaves from Coffea pseudozanguebariae, a wild caffeine-free coffee species, was determined. Two phenolic compounds were extracted from leaves, separated and characterized. Their structures were elucidated by mass spectrometry, and 1D and 2D NMR spectroscopy and were shown to be mangiferin (1) and isomangiferin (2), which were the main polyphenol products. Multiphoton fluorescence imaging was performed to visualize polyphenol distribution in leaf cross sections. Consistent biochemical analysis cell imaging techniques on leaves revealed yellow fluorescence in the epidermis and parenchyma cells corresponding to xanthone compounds.

Published
2012
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4. UA62784 Is a cytotoxic inhibitor of microtubules, not CENP-E

Author

Sébastien Deshayes, Gilles Divita, Sergey Tcherniuk, Vasiliki Sarli, Ariane Abrieu, Centre de recherche en Biologie Cellulaire (CRBM), and Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)

Subjects
Chromosomal Proteins, Non-Histone, Clinical Biochemistry, Apoptosis, MESH: Tubulin, Biochemistry, Microtubules, Microtubule polymerization, chemistry.chemical_compound, 0302 clinical medicine, Tubulin, Drug Discovery, Oxazoles, 0303 health sciences, MESH: Microtubules, Nocodazole, MESH: Xanthones, MESH: Oxazoles, General Medicine, Tubulin Modulators, 3. Good health, Vinblastine, Cell biology, 030220 oncology & carcinogenesis, Molecular Medicine, Dimerization, medicine.drug, Xanthones, MESH: Vinblastine, Mitosis, Spindle Apparatus, Biology, MESH: Nocodazole, 03 medical and health sciences, Microtubule, MESH: Chromosomal Proteins, Non-Histone, MESH: Tubulin Modulators, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Molecular Biology, 030304 developmental biology, Pharmacology, MESH: Mitotic Spindle Apparatus, Binding Sites, MESH: Humans, MESH: Apoptosis, MESH: Mitosis, Molecular biology, Spindle apparatus, MESH: Hela Cells, MESH: Colchicine, chemistry, MESH: Binding Sites, MESH: Dimerization, biology.protein, Colchicine, HeLa Cells
Abstract

International audience; A recent screen for compounds that selectively targeted pancreatic cancer cells isolated UA62784. We found that UA62784 inhibits microtubule polymerization in vitro. UA62784 interacts with tubulin dimers ten times more potently than colchicine, vinblastine, or nocodazole. Competition experiments revealed that UA62784 interacts with tubulin at or near the colchicine-binding site. Nanomolar doses of UA62784 promote the accumulation of mammalian cells in mitosis, due to aberrant mitotic spindles, as shown by immunofluorescence and live cell imaging. Treatment of cancerous cell lines with UA62784 is lethal, following activation of apoptosis signaling. By monitoring mitotic spindle perturbations and apoptosis, we found that the effects of UA62784 and of some known microtubule-depolymerizing drugs are additive. Finally, high content screening of H2B-GFP HeLa cells revealed that low doses of UA62784 and vinblastine potentiate each other to inhibit proliferation.

Published
2011
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5. Labeling of oxidizable proteins with a photoactivatable analog of the antitumor agent DMXAA: evidence for redox signaling in its mode of action

Author

Brian D. Palmer, Liang-Chuan S. Wang, See-Tarn Woon, David J. A. Bridewell, Stefanie N. Vogel, Dieter Malinger, Romy Brauer, Lai-Ming Ching, Sofian M. Tijono, Kimiora Henare, Claudine Kieda, Frapart, Isabelle, Auckland Cancer Society Research Centre (ACSRC), University of Auckland [Auckland], Centre de biophysique moléculaire (CBM), and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
MESH: Oxidation-Reduction, MESH: Signal Transduction, Cancer Research, Small interfering RNA, MESH: Spleen, medicine.medical_treatment, MESH: Rabbits, MESH: Photoaffinity Labels, MESH: Dogs, 0302 clinical medicine, MESH: RNA, Small Interfering, MESH: Animals, MESH: Endothelial Cells, MESH: Proteins, MESH: Haplorhini, chemistry.chemical_classification, 0303 health sciences, MESH: Xanthones, Transfection, MESH: Blood Pressure, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, MESH: Staining and Labeling, Cytokine, Biochemistry, 030220 oncology & carcinogenesis, Tumor necrosis factor alpha, Signal transduction, MESH: Acetanilides, MESH: Cats, MESH: Photochemistry, MESH: Cells, Cultured, MESH: Rats, Biology, lcsh:RC254-282, 03 medical and health sciences, MESH: Mice, Inbred C57BL, medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Viability assay, MESH: Mice, 030304 developmental biology, Reactive oxygen species, MESH: Electrophoresis, Gel, Two-Dimensional, MESH: Male, Cytosol, MESH: Lethal Dose 50, chemistry, MESH: Tumor Markers, Biological, MESH: Antineoplastic Agents, MESH: Trimecaine, MESH: Neovascularization, Pathologic
Abstract

International audience; The signaling pathway(s) and molecular target(s) for 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a tumor vascular disrupting agent in late stages of clinical development, are still undefined. As an approach toward identifying potential targets for DMXAA, a tritiated azido-analog of DMXAA was used to probe for cellular binding proteins. More than 20 cytosolic proteins from murine splenocytes, RAW 264.7 cells, and the HECPP immortalized endothelial cells were photoaffinity-labeled. Although no protein domain, fold, or binding site for a specific ligand was found to be shared by all the candidate proteins, essentially all were noted to be oxidizable proteins, implicating a role for redox signaling in the action of DMXAA. Consistent with this hypothesis, DMXAA caused an increase in concentrations of reactive oxygen species (ROS) in RAW264.7 cells during the first 2 hours. This increase in ROS was suppressed in the presence of the antioxidant, N-acetyl-L-cysteine, which also suppressed DMXAA-induced cytokine production in the RAW 264.7 cells with no effects on cell viability. Short interfering RNA (siRNA)-mediated knockdown of one of the photoaffinity-labeled proteins, superoxide dismutase 1, an ROS scavenger, resulted in an increase in tumor necrosis factor-alpha production by RAW 264.7 cells in response to DMXAA compared with negative or positive controls transfected with nontargeting or lamin A/C-targeting siRNA molecules, respectively. The results from these lines of study all suggest that redox signaling plays a central role in cytokine induction by DMXAA.

Published
2010

6. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer

Author

Mark Rosenthal, JJ Lafitte, Martin Reck, Elisabeth Quoix, Monika Serke, Mark J. McKeage, Richard Sullivan, David Gibbs, J. von Pawel, P. N. Mainwaring, Lutz Freitag, Michael B. Jameson, Christos Chouaid, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), MJ McKeage, Von Pawel J, MA Rosenthal, R Sullivan, Gibbs D, PN Mainwaring, M Serke, JJ Lafitte, C Chouaid, Freitag L, E Quoix ., M Reck, and MB Jameson

Subjects
Male, Oncology, Cancer Research, Lung Neoplasms, medicine.medical_treatment, Phases of clinical research, Carboplatin, tumour-VDA, chemistry.chemical_compound, 0302 clinical medicine, MESH: Carboplatin, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Clinical Studies, MESH: Treatment Outcome, ASA404, 0303 health sciences, MESH: Middle Aged, Hazard ratio, MESH: Xanthones, MESH: Neoplasm Staging, Middle Aged, 3. Good health, Survival Rate, MESH: Antineoplastic Combined Chemotherapy Protocols, Treatment Outcome, Paclitaxel, 030220 oncology & carcinogenesis, DMXAA, Disease Progression, Female, MESH: Disease Progression, medicine.medical_specialty, MESH: Survival Rate, Xanthones, AS1404, VDA, 03 medical and health sciences, Vadimezan, Internal medicine, medicine, Humans, MESH: Paclitaxel, Lung cancer, Survival rate, non-small cell lung cancer, Neoplasm Staging, 030304 developmental biology, Chemotherapy, MESH: Humans, business.industry, medicine.disease, MESH: Male, Surgery, MESH: Lung Neoplasms, chemistry, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, MESH: Carcinoma, Non-Small-Cell Lung
Abstract

ASA404 (5,6-dimethylxanthenone-4-acetic acid or DMXAA) is a small-molecule tumour-vascular disrupting agent (Tumour-VDA). This randomised phase II study evaluated ASA404 plus standard therapy of carboplatin and paclitaxel in patients with histologically confirmed stage IIIb or IV non-small cell lung cancer (NSCLC) not previously treated with chemotherapy. Patients were randomised to receive/=6 cycles of carboplatin area under the plasma concentration-time curve 6 mg ml(-1) min and paclitaxel 175 mg m(-2) (CP, n=36) or standard therapy plus ASA404 1200 mg m(-2) (ASA404-CP, n=37). There was little change in the systemic exposure of either total or free carboplatin or paclitaxel on addition of ASA404. Safety profiles were similar and manageable in both groups, with most adverse effects attributed to standard therapy. Tumour response rate (31 vs 22%), median time to tumour progression (5.4 vs 4.4 months) and median survival (14.0 vs 8.8 months, hazard ratio 0.73, 95% CI 0.39, 1.38) were improved in the ASA404 combination group compared with the standard therapy group. In conclusion, this study establishes the feasibility of combining ASA404 with carboplatin and paclitaxel in patients with previously untreated, advanced NSCLC, demonstrating a manageable safety profile and lack of adverse pharmacokinetic interactions. The results indicate that there may be a benefit associated with ASA404, but this needs to be evaluated in a larger trial.

Published
2008
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7. Laurentixanthones A and B, Antimicrobial Xanthones from Vismia laurentii

Author

Bernard Bodo, Jean Robert Nguemeving, Victor Kuete, Alain Blond, Véronique Penlap Beng, Nono Nono Eric Carly, Anatole Guy Blaise Azebaze, Michele Meyer, Augustin Ephrem Nkengfack, Laboratoire de chimie et biochimie des substances naturelles, and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Magnetic Resonance Spectroscopy, Antimicrobial activities, Stereochemistry, Xanthones, MESH: Anti-Infective Agents, MESH: Molecular Structure, Friedelin, Diol, Anthraquinones, Plant Science, Horticulture, Gram-Positive Bacteria, Biochemistry, Vismia laurentii, MESH: Gram-Positive Bacteria, Xanthone Derivatives, chemistry.chemical_compound, Anti-Infective Agents, Clusiaceae, MESH: Gram-Negative Bacteria, Xanthone, Gram-Negative Bacteria, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Molecular Biology, Stigmasterol, Vismia, Molecular Structure, biology, MESH: Magnetic Resonance Spectroscopy, MESH: Xanthones, General Medicine, Antimicrobial, biology.organism_classification, Guttiferae, MESH: Clusiaceae, MESH: Xanthenes, Xanthenes, chemistry, Phytochemical, Kaempferol
Abstract

International audience; A phytochemical investigation of the constituents of the roots of Vismia laurentii has resulted in the isolation of two xanthone derivatives named laurentixanthone A (1) (6-hydroxy-3,3-dimethyl-11-(3-methylbut-2-enyl)pyrano[2,3-c]xanthen-7(3H)-one) and laurentixanthone B (2) (1-hydroxy-5,6,7,8-tetramethoxyxanthone), along with 11 known compounds: 1,7-dihydroxyxanthone, vismiaquinone, vismiaquinone B, bivismiaquinone, 3-geranyloxy-6-methyl-1,8-dihydroxyanthraquinone, O(1)-demethyl-3',4'-deoxypsorospermin-3',4'-diol, 6-deoxyisojacareubin, 1,8-dihydroxy-6-methoxy-3-methylanthraquinone, kaempferol, friedelin and stigmasterol. The structures of compounds were established by means of spectroscopic methods. Furthermore, the compounds were screened for antimicrobial activities in vitro.

Published
2006
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8. Antimicrobial and cytotoxic agents from Calophyllum inophyllum

Author

A. Michele Meyer, Marie C. Yimdjo, Augustin Ephraim Nkengfack, Bernard Bodo, Zacharias Tanee Fomum, Anatole Guy Blaise Azebaze, Laboratoire de chimie et biochimie des substances naturelles, and Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)

Subjects
Plant Science, Pharmacognosy, Biochemistry, KB Cells, Calophyllum inophyllum, chemistry.chemical_compound, Triterpene, Xanthone, Cytotoxicity, Antibacterial agent, chemistry.chemical_classification, biology, Molecular Structure, MESH: Xanthones, MESH: Carcinoma, Squamous Cell, Clusiaceae, General Medicine, Antimicrobial, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Anti-Bacterial Agents, visual_art, Seeds, visual_art.visual_art_medium, Carcinoma, Squamous Cell, Plant Bark, Bark, Antibacterial activity, MESH: Plant Bark, Stereochemistry, Xanthones, MESH: Antineoplastic Agents, Phytogenic, MESH: Molecular Structure, MESH: KB Cells, MESH: Plant Extracts, Horticulture, MESH: Anti-Bacterial Agents, Potency, Humans, Molecular Biology, MESH: Calophyllum, MESH: Humans, Bacteria, Plant Extracts, biology.organism_classification, Antineoplastic Agents, Phytogenic, MESH: Bacteria, MESH: Seeds, chemistry, Calophyllum, Derivative (chemistry)
Abstract

International audience; The study of the chemical constituents of the root bark and the nut of Calophyllum inophyllum has resulted in the isolation and characterization of a xanthone derivative, named inoxanthone, 3, together with 12 known compounds: caloxanthones A, 4 and B, 5, macluraxanthone, 6, 1,5-dihydroxyxanthone, 7, calophynic acid, 8, brasiliensic acid, 9 inophylloidic acid, 10, friedelan-3-one, 11, calaustralin, 12, calophyllolide, 13, inophyllums C, 14 and E, 15. Their structures were established on the basis of spectral evidence. Their in vitro cytotoxicity against the KB cell line and their antibacterial activity and potency against a wide range of micro organisms were evaluated.

Published
2004
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