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2 results on '"MESH : Dihydropteroate Synthase"'

1. High Prevalence and Fixation of Plasmodium vivax dhfr/dhps Mutations Related to Sulfadoxine/Pyrimethamine Resistance in French Guiana

Author

Stéphane Picot, Thierry Fusai, Magali Tichit, Lise Musset, Eric Legrand, Sébastien Briolant, Christiane Bouchier, Didier Menard, Céline Barnadas, Christophe Rogier, Radicaux Libres, Substrats Énergétiques et Physiopathologie Cérébrale, Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon, Laboratoire de parasitologie-mycologie EA 209 - Transports membranaires et chimiorésistances, Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ), Laboratoire de parasitologie - CNR Paludisme, Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ), Génomique (Plate-Forme), Institut Pasteur [Paris], Unité de Recherche en Biologie et Epidémiologie Parasitaires, Institut de Médecine Tropicale du Service de Santé des Armées-Centre National de la Recherche Scientifique ( CNRS ), Institut Pasteur de Madagascar, Institut Pasteur de Madagascar-Réseau International des Instituts Pasteur ( RIIP ), Université Claude Bernard Lyon 1 (UCBL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Génomique (Plate-Forme) - Genomics Platform, Institut de Médecine Tropicale du Service de Santé des Armées-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Laboratoire de Parasitologie [Cayenne, Guyane française], Institut Pasteur [Paris] (IP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5), and CNR Paludisme - Laboratoire associé pour la Région Antilles-Guyane

Subjects
medicine.medical_treatment, MESH : Tetrahydrofolate Dehydrogenase, Plasmodium vivax, Drug Resistance, DHPS, MESH: Tetrahydrofolate Dehydrogenase, Drug resistance, 0302 clinical medicine, [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Animals, MESH: Dihydropteroate Synthase, 0303 health sciences, education.field_of_study, MESH: Polymorphism, Single Nucleotide, MESH : Polymorphism, Single Nucleotide, MESH: Plasmodium vivax, 3. Good health, Drug Combinations, Pyrimethamine, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH : Drug Combinations, Infectious Diseases, MESH : Plasmodium vivax, MESH: Drug Resistance, MESH : Mutation, MESH : Dihydropteroate Synthase, medicine.drug, MESH: Mutation, MESH: Pyrimethamine, Sulfadoxine, 030231 tropical medicine, Population, Biology, Polymorphism, Single Nucleotide, MESH : Sulfadoxine, Antimalarials, 03 medical and health sciences, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Virology, parasitic diseases, medicine, Animals, MESH : Pyrimethamine, education, MESH: Drug Combinations, Dihydropteroate Synthase, MESH : Drug Resistance, 030306 microbiology, biology.organism_classification, MESH: Antimalarials, Sulfadoxine/pyrimethamine, Tetrahydrofolate Dehydrogenase, Mutation, MESH : Antimalarials, Parasitology, MESH : Animals, Dihydropteroate synthase, MESH: Sulfadoxine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Plasmodium vivax isolates from French Guiana were studied for the presence of mutations associated with sulfadoxine/pyrimethamine (SP) drug resistance. Ninety-six blood samples were collected from 2000 to 2005 from symptomatic malaria patients. SP drug resistance was predicted by determining point mutations in the dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) genes. All samples showed mutant genotypes in both genes with a prevalence > 90% for the 58R, 117N, 382C, and 383G. A new mutation (116G) in pvdhfr was found at a frequency of 3.3%. Six different pvdhfr/dhps multilocus genotypes were observed with the predominance of the quintuple mutant-type 58R/117N/173L-382C/383G (59.3%). No significant differences were observed between the prevalence of haplotypes and the year of collection. Our results indicate that, in this area, the fixation of SP drug-resistant parasites in the P. vivax population is stable.

Published
2009
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2. Pneumocystosis: a network survey in the Paris area 2003-2008

Author

P. Roux, Marie-Elisabeth Bougnoux, M. Cornet, C. Sarfati, Françoise Botterel, Claire Bouges-Michel, Patrice Bourée, Hélène Yera, G. Galeazzi, D. Magne, C. Chochillon, Adela Angoulvant, Eric Dannaoui, Arnaud Fekkar, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Tenon [AP-HP], Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Necker - Enfants Malades [AP-HP], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Thérapeutique Recombinante Expérimentale (TIMC-IMAG-TheREx), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CHU Pitié-Salpêtrière [AP-HP], Hôpital Louis Mourier - AP-HP [Colombes], Hôpital Cochin [AP-HP], Hôpital St Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Information – Technologies – Analyse Environnementale – Procédés Agricoles (UMR ITAP), Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Hôpital Bichat-Claude Bernard, Hôpital Hôtel Dieu, Hôpital Européen Georges Pompidou, Hôpital St Antoine, Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ), Parasitogie-Mycologie, CHU Saint-Antoine [APHP], CHU Tenon [APHP], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Hôpital avicenne, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne-Université Paris 13 ( UP13 ), CHU Pitié-Salpêtrière [APHP], Hopital Louis Mourier - AP-HP [Colombes], CHU Cochin [AP-HP], Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Thérapeutique Recombinante Expérimentale ( TIMC-IMAG-THEREX ), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] ( TIMC-IMAG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Information – Technologies – Analyse Environnementale – Procédés Agricoles ( UMR ITAP ), Institut national d’études supérieures agronomiques de Montpellier ( Montpellier SupAgro ) -Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris 13 (UP13)-Hôpital Avicenne, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)

Subjects
Male, Antifungal Agents, MESH: CD4 Lymphocyte Count, MESH : Genotype, DHPS, HIV Infections, MESH: Comorbidity, Drug resistance, Comorbidity, Pneumocystis carinii, MESH: Genotype, 0302 clinical medicine, Adrenal Cortex Hormones, Neoplasms, Epidemiology, Pneumocystosis, MESH: Immunocompromised Host, MESH : Female, MESH: Neoplasms, MESH : Sulfanilamides, 030212 general & internal medicine, MESH: Dihydropteroate Synthase, [ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, MESH : Pneumocystis jirovecii, 0303 health sciences, MESH: Middle Aged, Mortality rate, Pneumonia, Pneumocystis, MESH: Paris, MESH : Pneumonia, Pneumocystis, MESH : Paris, Life Sciences, MESH : Immunocompromised Host, General Medicine, MESH: HIV Infections, MESH: Transplantation, Middle Aged, MESH: Hospitals, Hospitals, 3. Good health, MESH : Hospitals, MESH : Antineoplastic Agents, Infectious Diseases, MESH : Comorbidity, Female, MESH : Dihydropteroate Synthase, Microbiology (medical), medicine.medical_specialty, Paris, Genotype, MESH : Male, MESH : Antifungal Agents, Antineoplastic Agents, MESH: Drug Resistance, Fungal, MESH : Adrenal Cortex Hormones, MESH: Adrenal Cortex Hormones, 03 medical and health sciences, Immunocompromised Host, MESH: Sulfanilamides, MESH: Pneumocystis jirovecii, Drug Resistance, Fungal, Internal medicine, Sulfanilamides, MESH : CD4 Lymphocyte Count, MESH : HIV Infections, medicine, Humans, MESH : Middle Aged, Mycosis, Dihydropteroate Synthase, Transplantation, MESH: Humans, 030306 microbiology, business.industry, MESH : Humans, MESH : Drug Resistance, Fungal, medicine.disease, MESH: Antifungal Agents, MESH : Neoplasms, MESH: Male, Surgery, CD4 Lymphocyte Count, MESH : Transplantation, MESH: Antineoplastic Agents, business, MESH: Female, MESH: Pneumonia, Pneumocystis
Abstract

International audience; The aims of this network group were to collect epidemiological data of PcP cases in 14 hospitals in the Paris area and to determine the Di-Hydro Pteroate Synthase (DHPS) genotypes, genetic markers for possible sulfamide resistance. From January 1, 2003 to December 31, 2008, 993 (mean 166/year) PcP cases have been reported. Sixty-five percent of patients were HIV-positive. The median count of CD4 lymphocytes was 32/mm(3) (30 in HIV-positive patients, 152 in HIV-negative patients). In HIV-positive patients, PcP revealed the HIV infection in 39%. Among 304 PcP occurring in HIV known infected patients, no prophylaxis was prescribed for 64%; cotrimoxazole prophylaxis had been prescribed to 47 patients but only one of them had the right compliance. In HIV-negative patients (264), corticosteroids were prescribed in 59% and cytotoxic chemotherapies in 34%; 78% did not receive prophylaxis. One hundred sixty nine tumoral pathologies and 116 transplantations were notified. The mortality rate was 16% at day 14 (13% in HIV-positive patients, 26% in HIV-negative patients). Mutations in DHPS genes were detected in 18.5% of samples; 12.5% of patients were infected with several strains. The total annual number of cases has been stable for five years but the proportion of HIV-negative patients increased from 25% to 43%.

Published
2011
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