1. Acute lower respiratory infections on lung sequelae in Cambodia, a neglected disease in highly tuberculosis-endemic country
- Author
-
Arnaud Tarantola, Patrich Lorn Try, Sophie Goyet, Sopheak Hem, Blandine Rammaert, Bertrand Guillard, Sokleaph Cheng, Charles Mayaud, Sirenda Vong, Laurence Borand, Sareth Rith, Philippe Buchy, Vantha Te, Institut Pasteur du Cambodge, Institut Pasteur du Cambodge-Réseau International des Instituts Pasteur ( RIIP ), Centre d'infectiologie Necker-Pasteur, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Donkeo Provincial Hospital, CHU Tenon [APHP], Rammaert B, Goyet S, Mayaud C, Buchy P, Borand L., Tarantola A, Hem S, Rith S, Cheng S, Te V, Try PL, Guillard B, Vong S, CHU Necker - Enfants Malades [AP-HP], Kampong Cham Provincial hospital, Kampong Cham Provincial hospital [Cambodia], Surveillance and Investigation of endemic situations in South-East Asia (SISEA) was funded by the French Agency for Development (Agence Française de Développement, AFD) and the US Department of Human and Health Services (US DHHS). Blandine Rammaert received a grant from the Fondation Pierre Ledoux Jeunesse Internationale and the Société de Pathologie Infectieuse de Langue Française., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Réseau International des Instituts Pasteur (RIIP), CHU Tenon [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Subjects
Male ,MESH : Prospective Studies ,MESH : Aged ,Haemophilus influenzae ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Prospective Studies ,MESH: Developing Countries ,Respiratory Tract Infections ,Aged, 80 and over ,MESH: Middle Aged ,MESH : Acute Disease ,Neglected Diseases ,MESH : Superinfection ,MESH : Diagnosis, Differential ,Countries ,3. Good health ,Bronchiectasis ,[ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,MESH: Young Adult ,Acute Disease ,MESH: Acute Disease ,MESH : Hospitalization ,MESH : Endemic Diseases ,MESH : Community-Acquired Infections ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Tuberculosis ,MESH : Young Adult ,[ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Article ,03 medical and health sciences ,MESH: Anti-Bacterial Agents ,MESH : Adolescent ,Humans ,MESH : Middle Aged ,MESH : Developing Countries ,Intensive care medicine ,MESH : Aged, 80 and over ,MESH: Age Distribution ,Developing Countries ,Tuberculosis, Pulmonary ,Aged ,MESH: Adolescent ,MESH: Tuberculosis, Pulmonary ,MESH: Humans ,MESH : Cambodia ,MESH : Humans ,MESH: Adult ,medicine.disease ,030228 respiratory system ,Superinfection ,Developing ,Chest radiograph ,MESH: Female ,MESH : Tuberculosis, Pulmonary ,Endemic Diseases ,MESH : Age Distribution ,MESH : Respiratory Tract Infections ,MESH: Hospitalization ,medicine.disease_cause ,MESH: Aged, 80 and over ,MESH : Female ,030212 general & internal medicine ,Respiratory system ,MESH : Anti-Bacterial Agents ,MESH: Aged ,medicine.diagnostic_test ,Airway remodeling ,MESH : Adult ,Middle Aged ,Anti-Bacterial Agents ,Community-Acquired Infections ,Hospitalization ,medicine.anatomical_structure ,MESH: Community-Acquired Infections ,MESH: Endemic Diseases ,Pseudomonas aeruginosa ,Female ,Abnormality ,Cambodia ,Adult ,Adolescent ,MESH : Male ,Diagnosis, Differential ,Young Adult ,Age Distribution ,MESH: Diagnosis, Differential ,Internal medicine ,Streptococcus pneumoniae ,medicine ,Lung ,business.industry ,MESH: Cambodia ,MESH: Male ,MESH: Prospective Studies ,MESH: Superinfection ,MESH: Respiratory Tract Infections ,MESH: Neglected Diseases ,business ,MESH : Neglected Diseases - Abstract
International audience; BACKGROUND: Little is known about post-infectious pulmonary sequelae in countries like Cambodia where tuberculosis is hyper-endemic and childhood pulmonary infections are highly frequent. We describe the characteristics of hospitalized Cambodian patients presenting with community-acquired acute lower respiratory infections (ALRI) on post-infectious pulmonary sequelae (ALRIPS). METHODS: Between 2007 and 2010, inpatients ≥15 years with ALRI were prospectively recruited. Clinical, biological, radiological and microbiological data were collected. Chest radiographs were re-interpreted by experts to compare patients with ALRIPS, on previously healthy lungs (ALRIHL) and active pulmonary tuberculosis (TB). Patients without chest radiograph abnormality or with abnormality suggestive as other chronic respiratory diseases were excluded from this analysis. RESULTS: Among the 2351 inpatients with community-acquired ALRI, 1800 were eligible: 426 (18%) ALRIPS, 878 (37%) ALRIHL and 496 (21%) TB. ALRIPS patients had less frequent fever than other ALRI (p
- Published
- 2013