1. Maternal residence near municipal waste incinerators and the risk of urinary tract birth defects
- Author
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Christine Monfort, Mireille Chiron, Elisabeth Robert-Gnansia, Sylvaine Cordier, Cécile Chevrier, Martine Hours, Lucie Anzivino-Viricel, Anne Lehébel, Emmanuelle Amar, Forgeron, Christine, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre des Malformations Rhône-Alpes, REMERA, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche sur les Transports et leur Sécurité (INRETS), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes ( GERHM ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -IFR140-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement ( UMRESTTE ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Recherche sur les Transports et leur Sécurité ( INRETS ) -Institut de Veille Sanitaire (INVS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)
- Subjects
Hazardous Waste ,Municipal solid waste ,MESH : Prenatal Exposure Delayed Effects ,[ SDV.TOX ] Life Sciences [q-bio]/Toxicology ,Incineration ,010501 environmental sciences ,01 natural sciences ,0302 clinical medicine ,MESH: Pregnancy ,Pregnancy ,Surveys and Questionnaires ,Epidemiology ,MESH: Urinary Tract ,MESH: Incineration ,MESH : Female ,030212 general & internal medicine ,Urinary Tract ,MESH : Incineration ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,2. Zero hunger ,education.field_of_study ,MESH : Pregnancy Outcome ,MESH: Dioxins ,MESH: Infant, Newborn ,Pregnancy Outcome ,MESH : Questionnaires ,MESH : Urinary Tract ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Congenital Abnormalities ,MESH : Adult ,MESH: Case-Control Studies ,[SDV.TOX] Life Sciences [q-bio]/Toxicology ,Prenatal Exposure Delayed Effects ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,Female ,MESH: Hazardous Waste ,France ,Adult ,medicine.medical_specialty ,MESH : Case-Control Studies ,MESH: Air Pollution ,Population ,Dioxins ,MESH : Infant, Newborn ,Congenital Abnormalities ,MESH: Prenatal Exposure Delayed Effects ,03 medical and health sciences ,MESH : Dioxins ,Environmental health ,Air Pollution ,[SDV.BDD] Life Sciences [q-bio]/Development Biology ,medicine ,Humans ,[ SDV.BDD ] Life Sciences [q-bio]/Development Biology ,MESH : Hazardous Waste ,education ,MESH : France ,0105 earth and related environmental sciences ,MESH: Humans ,business.industry ,MESH: Questionnaires ,MESH : Humans ,Public Health, Environmental and Occupational Health ,Infant, Newborn ,Ecological study ,MESH: Adult ,MESH : Congenital Abnormalities ,medicine.disease ,MESH: Pregnancy Outcome ,MESH: France ,MESH : Pregnancy ,13. Climate action ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Case-Control Studies ,MESH : Air Pollution ,Residence ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,MESH: Female ,Waste disposal - Abstract
International audience; OBJECTIVES: Waste incineration releases a mixture of chemicals with high embryotoxic potential, including heavy metals and dioxins/furans, into the atmosphere. In a previous ecological study we found an association between the risk of urinary tract birth defects and residence in the vicinity of municipal solid waste incinerators (MSWIs). The objective of the present study was to specifically test this association. METHODS: A population-based case-control study compared 304 infants with urinary tract birth defects diagnosed in the Rhône-Alpes region (2001-2003) with a random sample of 226 population controls frequency-matched for infant sex and year and district of birth. Exposure to dioxins in early pregnancy at the place of residence, used as a tracer of the mixture released by 21 active waste incinerators, was predicted with second-generation Gaussian modelling (ADMS3 software). Other industrial emissions of dioxins, population density and neighbourhood deprivation were also assessed. Individual risk factors including consumption of local food were obtained by interviews with 62% of the case and all control families. RESULTS: Risk was increased for mothers exposed to dioxins above the median at the beginning of pregnancy (OR 2.95, 95% CI 1.47 to 5.92 for dioxin deposits). When only interviewed cases were considered, risk estimates decreased mainly because the non-interviewed cases were more likely to live in exposed residential environments (OR 2.05, 95% CI 0.92 to 4.57). The results suggest that consumption of local food modifies this risk. CONCLUSIONS: This study confirms our previous observation of a link between the risk of urinary tract birth defects and exposure to MSWI emissions in early pregnancy and illustrates the effect of participation bias on risk estimates of environmental health impacts.
- Published
- 2010