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3 results on '"MESH : Influenza in Birds"'

1. Practices associated with Highly Pathogenic Avian Influenza spread in traditional poultry marketing chains: Social and economic perspectives

Author

Sirichai Wongnarkpet, François Roger, Weerapong Thanapongtharm, Pascal Bonnet, Christian Ducrot, Chaithep Poolkhet, Virginie Baritaux, Mathilde Paul, Institut National de la Recherche Agronomique ( INRA ), Ecole Nationale Vétérinaire de Toulouse, Animal et gestion intégrée des risques ( Agirs ), Centre de Coopération Internationale en Recherche Agronomique pour le Développement ( CIRAD ), Unité de recherche d'Épidémiologie Animale ( UEA ), Institut National de la Recherche Agronomique (INRA), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Animal et gestion intégrée des risques (Cirad-Bios-UPR 22 AGIRs), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Unité de recherche d'Épidémiologie Animale (UEA), Animal et gestion intégrée des risques (UPR AGIRs), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), and Unité de Recherche d'Épidémiologie Animale (UR EpiA)

Subjects
Epidemiology, Pauvreté, [SDV]Life Sciences [q-bio], Politique sanitaire, Disease perception, L73 - Maladies des animaux, medicine.disease_cause, 0403 veterinary science, 0302 clinical medicine, INFECTION, MESH : Socioeconomic Factors, MESH: Animals, Marketing, health care economics and organizations, 2. Zero hunger, Food security, Enquête, Santé animale, Environnement socioéconomique, MESH: Chickens, 1. No poverty, Contamination biologique, H5N1, 04 agricultural and veterinary sciences, Poultry farming, Thailand, MESH : Influenza in Birds, MESH : Marketing, Infectious Diseases, MESH : Chickens, Q03 - Contamination et toxicologie alimentaires, Circuit de commercialisation, Viande de volaille, VIETNAM, MESH: Socioeconomic Factors, MESH: Influenza A Virus, H5N1 Subtype, 040301 veterinary sciences, Veterinary (miscellaneous), Supply chain, E70 - Commerce, commercialisation et distribution, Small-scale farming, MESH : Influenza A Virus, H5N1 Subtype, 030231 tropical medicine, Petite exploitation agricole, 03 medical and health sciences, FARMS, MESH: Influenza in Birds, medicine, Animals, Humans, Influenzavirus aviaire, MESH: Marketing, Social determinants of health, MESH: Thailand, Value chain, Transmission des maladies, MESH: Humans, Influenza A Virus, H5N1 Subtype, [ SDV ] Life Sciences [q-bio], Poverty, business.industry, MESH : Humans, L70 - Sciences et hygiène vétérinaires - Considérations générales, Animal health policies, MESH : Thailand, Influenza A virus subtype H5N1, Socioeconomic Factors, Influenza in Birds, Insect Science, RISK-FACTORS, BACKYARD, Parasitology, MESH : Animals, Business, Élevage de volailles, Rural area, Chickens
Abstract

International audience; In developing countries, smallholder poultry production contributes to food security and poverty alleviation in rural areas. However, traditional poultry marketing chains have been threatened by the epidemics caused by the Highly Pathogenic Avian Influenza (H5N1) virus. The article presents a value chain analysis conducted on the traditional poultry marketing chain in the rural province of Phitsanulok, Thailand. The analysis is based on quantitative data collected on 470 backyard chicken farms, and on qualitative data collected on 28 poultry collectors, slaughterhouses and market retailers, using semi-structured interviews. The article examines the organization of poultry marketing chains in time and space, and shows how this may contribute to the spread of Highly Pathogenic Avian Influenza H5N1 in the small-scale poultry sector. The article also discusses the practices and strategies developed by value chain actors facing poultry mortality, with their economic and social determinants. More broadly, this study also illustrates how value chain analysis can contribute to a better understanding of the complex mechanisms associated with the spread of epidemics in rural communities.

Published
2013
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2. Variability of tropism and replicative capacity of two naturally occurring influenza A H9N2 viruses in cell cultures from different tissues

Author

Wafa Tombari, Imen Elbehi, F. Amouna, Abdeljelil Ghram, Laboratoire d’Epidémiologie et de Microbiologie Vétérinaire ( LR11IPT03 ), Institut Pasteur de Tunis, and Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP )

Subjects
low pathogenicity influenza virus, 0301 basic medicine, viruses, medicine.medical_treatment, Cell, Amino Acid Motifs, Hemagglutinin Glycoproteins, Influenza Virus, Chick Embryo, Virus Replication, Food Animals, MESH : Chick Embryo, Influenza A Virus, H9N2 Subtype, MESH : Female, MESH : Neuraminidase, MESH : Influenza A Virus, H9N2 Subtype, Cells, Cultured, virus diseases, Trypsin, MESH : Specific Pathogen-Free Organisms, MESH : Influenza in Birds, Specific Pathogen-Free Organisms, MESH : Virus Replication, Titer, medicine.anatomical_structure, virus host range, MESH : Chickens, Female, MESH : Mutation, medicine.drug, MESH : Amino Acid Motifs, Neuraminidase, Culture cells, Biology, [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Tropism, Virus, Microbiology, Birds, 03 medical and health sciences, MESH : Amino Acid Substitution, MESH : Cells, Cultured, medicine, Animals, MESH : Birds, Protease, cell tropism, [ SDV ] Life Sciences [q-bio], General Immunology and Microbiology, [ SDV.BC ] Life Sciences [q-bio]/Cellular Biology, MESH : Tropism, Virology, Reverse genetics, MESH : Hemagglutinin Glycoproteins, Influenza Virus, 030104 developmental biology, Viral replication, Amino Acid Substitution, Influenza in Birds, Mutation, Animal Science and Zoology, kinetic replication, MESH : Animals, Chickens
Abstract

International audience; Studies carried out on cell permissivity are of great interest to understand virus replication and pathogenicity. We described the results of a comparative analysis of replication efficiency of two naturally occurring influenza A H9N2 variants isolated from poultry and wild birds, differing by only two substitutions Q226L and T384N, in the receptor-binding site of haemagglutinin and the 380 loop region of NA proteins, respectively. Considering the overall growth of both viruses, lung cultures ensured the most efficient growth of TUN12L226N384 strain with titres up to 10(9) TCID50/ml whereas small intestine culture was highly susceptible to the TUN51Q226T384 virus reaching a titre of 10(6) TCID50/ml. The lowest replication was shown in liver cells. The addition of trypsin was essential for the replication of either virus in primary fibroblasts, but it had a marginal positive effect on virus replication in the four other culture types with maximum titres of 10(8) TCID50/ml. This means that in chicken, the proteolytic activation of the H9N2 viruses with the cleavage motif RSSR may be mediated by other endoproteases than trypsin. Further investigations should concentrate on the production of the appropriate set of viruses by a reverse genetics approach and the examination of cellular protease expression in chicken tissues. This would lead to a more complete understanding of the tropism of low-pathogenic Influenza A viruses.

Published
2016
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3. Delivery of mengovirus-derived RNA replicons into tumoural liver enhances the anti-tumour efficacy of a peripheral peptide-based vaccine

Author

Sylvie van der Werf, Mireille Viguier, Carmen Marchiol, Didier Fradelizi, Anne-Marie Crain, Jean-Pierre Couty, Sarah Boudaly, Marilyne Labasque, Marco Vignuzzi, Catherine Guettier, Nicolas Escriou, Sylvie Gerbaud, Institut Cochin (UMR_S567 / UMR 8104), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Université Paris Diderot - Paris 7 (UPD7), Génétique Moléculaire des Virus Respiratoires, Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Pathologie cellulaire : aspects moléculaires et viraux / Pathologie et Virologie Moléculaire, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Anatomie Pathologique, Hôpital Paul Brousse, Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut Cochin ( UMR_S567 / UMR 8104 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ), Université Paris Diderot - Paris 7 ( UPD7 ), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Immunologie Cellulaire et Immunopathologie de l'Ecole Pratique des Hautes Etudes, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, MESH : Prevalence, MESH: Immunotherapy, medicine.medical_treatment, MESH: Flow Cytometry, Epitope, MESH: Cancer Vaccines, Mice, 0302 clinical medicine, MESH: Liver Neoplasms, Cytotoxic T cell, MESH: Animals, Replicon, MESH : Influenza A Virus, H9N2 Subtype, MESH: Phylogeny, MESH: Treatment Outcome, 0303 health sciences, MESH : Peptides, MESH: Peptides, Liver Neoplasms, MESH : Reverse Transcriptase Polymerase Chain Reaction, Flow Cytometry, MESH : Influenza in Birds, 3. Good health, MESH : Influenza A virus, MESH : Immunotherapy, Oncology, MESH: RNA, Viral, MESH : Animal Migration, Immunotherapy, Carcinoma, Hepatocellular, T cell, Immunology, MESH: Replicon, 03 medical and health sciences, MESH: Species Specificity, MESH: Animals, Wild, MESH : Birds, MESH: Prevalence, Histocompatibility Antigens Class I, Mengovirus, RNA, MESH : Disease Models, Animal, Mice, Inbred C57BL, MESH: Disease Models, Animal, Peptides, MESH: Female, Cancer Research, MESH : Liver Neoplasms, MESH : Mengovirus, MESH: Histocompatibility Antigens Class I, MESH: Reverse Transcriptase Polymerase Chain Reaction, Immunology and Allergy, MESH : Female, MESH: Carcinoma, Hepatocellular, MESH : Animals, Wild, MESH : Cloaca, biology, MESH : Cancer Vaccines, MESH: Animal Migration, medicine.anatomical_structure, Treatment Outcome, MESH: Birds, MESH: Sentinel Surveillance, RNA, Viral, MESH : Histocompatibility Antigens Class I, MESH : Replicon, MESH : Carcinoma, Hepatocellular, MESH : Sentinel Surveillance, MESH : Flow Cytometry, MESH : Male, MESH: Influenza A virus, MESH : Mice, Inbred C57BL, MESH : Treatment Outcome, Cancer Vaccines, MESH: Influenza in Birds, MESH: Mice, Inbred C57BL, MESH : Mice, medicine, MESH : Species Specificity, MESH : RNA, Viral, Animals, MESH : France, MESH: Mice, 030304 developmental biology, MESH : Phylogeny, biology.organism_classification, MESH: Male, MESH: Cloaca, MESH: Influenza A Virus, H9N2 Subtype, MESH: France, Disease Models, Animal, MESH : Animals, CD8, MESH: Mengovirus, 030215 immunology
Abstract

International audience; Hepatocellular carcinoma is a deadly cancer with growing incidence for which immunotherapy is one of the most promising therapeutic approach. Peptide-based vaccines designed to induce strong, sustained CD8+ T cell responses are effective in animal models and cancer patients. We demonstrated the efficacy of curative peptide-based immunisation against a unique epitope of SV40 tumour antigen, through the induction of a strong CD8+ T cell-specific response, in our liver tumour model. However, as in human clinical trials, most tumour antigen epitopes did not induce a therapeutic effect, despite inducing strong CD8+ T cell responses. We therefore modified the tumour environment to enhance peptide-based vaccine efficacy by delivering mengovirus (MV)-derived RNA autoreplicating sequences (MV-RNA replicons) into the liver. The injection of replication-competent RNA replicons into the liver converted partial tumour regression into tumour eradication, whereas non-replicating RNA had no such effect. Replicating RNA replicon injection induced local recruitment of innate immunity effectors (NK and NKT) to the tumour and did not affect specific CD8+ T cell populations or other myelolymphoid subsets. The local delivery of such RNA replicons into tumour stroma is therefore a promising strategy complementary to the use of peripheral peptide-based vaccines for treating liver tumours.

Published
2008
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