1. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
- Author
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Sandra Nolte, Laura L Laslett, Anthony D. Woolf, Emma Smith, Theo Vos, Damian G Hoy, Ilana N. Ackerman, Marita Cross, Richard H. Osborne, Marlene Fransen, Flavia M. Cicuttini, Lisa Bridgett, Rachelle Buchbinder, Graeme Jones, Lyn March, Sean R.M. Williams, Francis Guillemin, Christopher Hill, Institute of Bone & Joint Research, Royal North Shore Hospital (RNSH)-The University of Sydney, School of Population Health, University of Queensland, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Institute of Public Health [Berlin, Germany], School of Health and Social Development [Deakin University], Deakin University [Burwood], The Royal Melbourne Hospital, Melbourne EpiCentre, Faculty of Health Sciences [University of Sydney], The University of Sydney, School of Medicine [Western Sydney University], Western Sydney University (UWS), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), The Queen Elizabeth Hospital, Adelaide, The Health Observatory [University of Adelaide], University of Adelaide, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, University of Tasmania (UTAS), Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia, Monash University [Clayton], Institute for Health Metrics and Evaluation [University of Washington], University of Washington [Seattle], Cabrini Institute, Monash University [Melbourne], Royal Cornwall Hospital, Royal North Shore Hospital ( RNSH ) -The University of Sydney [Sydney], Charite-Universitatsmedizin Berlin [Berlin], Hôpital universitaire de la Charité de Berlin, Melbourne Medical School-The Royal Melbourne Hospital, The University of Sydney [Sydney], Western Sydney University ( UWS ), Maladies chroniques, santé perçue, et processus d'adaptation. Approches épidémiologiques et psychologiques. ( APEMAC - EA 4360 ), Université de Lorraine ( UL ) -Université Paris Descartes - Paris 5 ( UPD5 ), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Western Sydney University, and University of Tasmania [Hobart, Australia] (UTAS)
- Subjects
Male ,MESH : Prevalence ,Epidemiology ,MESH : Age Distribution ,MESH : Aged ,MESH: Global Health ,Osteoarthritis ,MESH : Child, Preschool ,Global Health ,MESH: Regression Analysis ,Severity of Illness Index ,Osteoarthritis, Hip ,MESH: Aged, 80 and over ,MESH : Child ,Cost of Illness ,MESH : Regression Analysis ,MESH: Child ,MESH: Osteoarthritis, Knee ,Prevalence ,Immunology and Allergy ,MESH : Cost of Illness ,MESH : Female ,MESH: Incidence ,Young adult ,Child ,MESH : Sex Distribution ,MESH: Aged ,Aged, 80 and over ,education.field_of_study ,MESH: Middle Aged ,Incidence ,Incidence (epidemiology) ,MESH: Sex Distribution ,MESH : Infant ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH : Adult ,MESH: Cost of Illness ,Middle Aged ,Osteoarthritis, Knee ,MESH: Infant ,MESH : Incidence ,3. Good health ,MESH: Quality-Adjusted Life Years ,MESH: Young Adult ,Child, Preschool ,Regression Analysis ,MESH : Severity of Illness Index ,Female ,Quality-Adjusted Life Years ,MESH : Osteoarthritis, Hip ,Adult ,musculoskeletal diseases ,medicine.medical_specialty ,Adolescent ,MESH : Male ,Immunology ,Population ,MESH : Young Adult ,General Biochemistry, Genetics and Molecular Biology ,Knee Osteoarthritis ,Young Adult ,Age Distribution ,Rheumatology ,MESH : Adolescent ,MESH: Severity of Illness Index ,Severity of illness ,medicine ,Humans ,MESH : Middle Aged ,MESH : Osteoarthritis, Knee ,Sex Distribution ,MESH : Aged, 80 and over ,education ,MESH: Age Distribution ,MESH: Prevalence ,Aged ,MESH: Adolescent ,MESH: Humans ,business.industry ,MESH : Humans ,MESH: Child, Preschool ,Infant ,MESH: Adult ,MESH : Quality-Adjusted Life Years ,medicine.disease ,Obesity ,MESH: Male ,Quality-adjusted life year ,Physical therapy ,MESH : Global Health ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Osteoarthritis, Hip ,business ,MESH: Female - Abstract
International audience; OBJECTIVE:To estimate the global burden of hip and knee osteoarthritis (OA) as part of the Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA compares with other conditions.METHODS:Systematic reviews were conducted to source age-specific and sex-specific epidemiological data for hip and knee OA prevalence, incidence and mortality risk. The prevalence and incidence of symptomatic, radiographic and self-reported hip or knee OA were included. Three levels of severity were defined to derive disability weights (DWs) and severity distribution (proportion with mild, moderate and severe OA). The prevalence by country and region was multiplied by the severity distribution and the appropriate disability weight to calculate years of life lived with disability (YLDs). As there are no deaths directly attributed to OA, YLDs equate disability-adjusted life years (DALYs).RESULTS:Globally, of the 291 conditions, hip and knee OA was ranked as the 11th highest contributor to global disability and 38th highest in DALYs. The global age-standardised prevalence of knee OA was 3.8% (95% uncertainty interval (UI) 3.6% to 4.1%) and hip OA was 0.85% (95% UI 0.74% to 1.02%), with no discernible change from 1990 to 2010. Prevalence was higher in females than males. YLDs for hip and knee OA increased from 10.5 million in 1990 (0.42% of total DALYs) to 17.1 million in 2010 (0.69% of total DALYs).CONCLUSIONS:Hip and knee OA is one of the leading causes of global disability. Methodological issues within this study make it highly likely that the real burden of OA has been underestimated. With the aging and increasing obesity of the world's population, health professions need to prepare for a large increase in the demand for health services to treat hip and knee OA.
- Published
- 2014
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