1. Focused Role of Nanoparticles Against COVID-19: Diagnosis and Treatment
- Author
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Hawraa Ali Khaleel, Mohammed Ali Dheyab, Ammar A. Oglat, Azlan Abdul Aziz, Baharak Mehrdel, Mahmood S. Jameel, and Pegah Moradi Khaniabadi
- Subjects
AuNP-ab, Gold-Antibody Nanoparticle ,BAL, Bronchoalveolar Lavage ,diagnosis ,viruses ,GQD, Graphene Quantum Dot ,Disease ,Review ,IC, Inhibitory Concentration ,medicine.disease_cause ,CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats ,030207 dermatology & venereal diseases ,SPION, Superparamagnetic Iron Oxide Nanoparticles ,0302 clinical medicine ,MERS-CoV, Middle East Respiratory Syndrome Coronavirus ,Medicine ,FDA, Food And Drug Administration ,Pharmacology (medical) ,PCR, Polymerase Chain Reaction ,PS, Photosensitizer ,GSH, Glutathione ,Viral etiology ,ERGIC, Endoplasmic Reticulum-Golgi Intermediate Compartment ,Coronavirus ,UV, Ultraviolet ,0303 health sciences ,Photosensitizing Agents ,IgG, Immunoglobulin G ,RdRP, RNA-Dependent RNA Polymerase ,virus diseases ,ARDS, Acute Respiratory Distress Syndrome ,LAMP, Loop-Mediated Isothermal Amplification ,CT, Computed Tomography ,AMT, 4'-Aminomethyl-Trioxsalene ,TPPS2a, Tetraphenyl Porphyrin Disulphonate ,nanomedicine ,HBV, Hepatitis B Virus ,PDT, Photodynamic Therapy ,Oncology ,2019-nCoV, Severe Acute Respiratory Syndrome Coronavirus 2 ,PTAF, Photocatalytic Titanium Apatite Filter ,G-CSF, (Granulocyte Colony-Stimulating Facto) ,cDNA, Complementary DNA ,HIV, Human Immunodeficiency Virus ,EUA, Emergency Use Authorization ,China ,medicine.medical_specialty ,PDI, Photodynamic Inactivation ,Coronavirus disease 2019 (COVID-19) ,Middle East respiratory syndrome coronavirus ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MB, Methylene Blue ,030303 biophysics ,treatment protocols ,Biophysics ,IP10, 10 Kda Interferon Gamma-Induced Protein ,MCP1, Monocyte Chemoattractant Protein-1 ,Dermatology ,WHO, World Health Organization ,Ag-MES, Silver Nanoparticle Capped With Mercaptoethane Sulfonate ,NagC, Nano-Silver Colloids ,03 medical and health sciences ,MHV-A59, Mouse Coronavirus ,TNFα, Tumor Necrosis Factor Alpha ,IgM, Immunoglobulin M ,Humans ,In patient ,SARS-CoV, Severe Acute Respiratory Syndrome Coronavirus ,Th2, T-Helper-2 ,Intensive care medicine ,ELISA, Enzyme-Linked Immunosorbent Assay ,ComputingMethodologies_COMPUTERGRAPHICS ,RPA, Recombinase Polymerase Amplification ,MagLev, Magnetic Levitation ,IFN-γ, Interferon Gamma ,SARS-CoV-2 ,business.industry ,COVID-19 ,RNA, Ribonucleic Acid ,RCA, Rolling Circle Amplification ,COVID-19, Coronavirus Disease ,EHEC, Enterohemorrhagic Escherichia Coli ,MWCNTs, Multi-Walled Carbon Nanotubes ,medicine.disease ,USFDA, United States Food And Drug Administration ,FISH, Fluorescent In Situ Hybridization ,ICU, Intensive Care Units ,RT-PCR, Reverse Transcription Polymerase Chain Reaction ,Pneumonia ,PICALM, Phosphatidylinositol Binding Clathrin Assembly Protein ,Photochemotherapy ,HCV, Hepatitis C Virus ,HSV-1, Herpes Simplex Type-1 Virus ,nanoparticles ,business ,ROS, Reactive Oxygen Species - Abstract
Graphical abstract, The 2019 novel coronavirus (2019-nCoV; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) has witnessed a rapid and global proliferation since its early identification in patients with severe pneumonia in Wuhan, China. As of 27th May 2020, 2019-nCoV cases have risen to >5 million, with confirmed deaths of 350,000. However, Coronavirus disease (COVID-19) diagnostic and treatment measures are yet to be fully unraveled, given the novelty of this particular coronavirus. Hence, no drug or vaccine has been adapted for treatment, and the accuracy of the current diagnostic tests is debatable. Therefore, existing antiviral agents used for severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) were repurposed for COVID-19, taking their biological features into consideration. This study provides a concise review of the current and emerging detection and supervision technologies for SARS-CoV-2, which is the viral etiology of COVID19, and their performance characteristics, with emphasis on the novel Nano-based diagnostic tests (protein corona sensor array and magnetic levitation) and treatment measures (treatment protocols based on nano-silver colloids) for COVID-19.
- Published
- 2021