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143,535 results on '"MICRORNAS"'

10. Comparative analysis of extracellular vesicles miRNAs (EV-miRNAs) and cell-free microRNAs (cf-miRNAs) reveals that EV-miRNAs are more promising as diagnostic and prognostic biomarkers for prostate cancer

Author

Nobrega, Monyse, Reis, Mariana Bisarro dos, Souza, Marilesia Ferreira de, Furini, Hector Hugo, Costa Brandão Berti, Fernanda, Souza, Ingrid Larissa Melo, Mingorance Carvalho, Tamyres, Zanata, Silvio M., Fuganti, Paulo Emilio, Malheiros, Danielle, Ribeiro, Enilze Maria de Souza Fonseca, and Cólus, Ilce Mara de Syllos

Published
2025
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36. Synergic Integration of the miRNome, Machine Learning and Bioinformatics for the Identification of Potential Disease-Modifying Agents in Obstructive Sleep Apnea

Author

Belmonte, Thalia, Benitez, Iván D., García-Hidalgo, María C., Molinero, Marta, Pinilla, Lucía, Mínguez, Olga, Vaca, Rafaela, Aguilà, Maria, Moncusí-Moix, Anna, Torres, Gerard, Mediano, Olga, Masa, Juan F., Masdeu, Maria J., Montero-San-Martín, Blanca, Ibarz, Mercè, Martinez-Camblor, Pablo, Gómez-Carballa, Alberto, Salas, Antonio, Martinón-Torres, Federico, Barbé, Ferran, Sánchez-de-la-Torre, Manuel, and de Gonzalo-Calvo, David

Published
2024
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47. Defining the activity of pro-reparative extracellular vesicles in wound healing based on miRNA payloads and cell type-specific lineage mapping

Author

Park, Dong Jun, Choi, Wooil, Sayeed, Sakeef, Dorschner, Robert A, Rainaldi, Joseph, Ho, Kayla, Kezios, Jenny, Nolan, John P, Mali, Prashant, Costantini, Todd, and Eliceiri, Brian P

Subjects
Biological Sciences, Genetics, Biotechnology, Wound Healing and Care, Diabetes, 5.2 Cellular and gene therapies, Animals, MicroRNAs, Extracellular Vesicles, Wound Healing, Mice, Macrophages, Adiponectin, Fibroblasts, Cell Lineage, Disease Models, Animal, Skin, Tetraspanin 29, Humans, Mice, Obese, Diabetes Mellitus, Experimental, adiponectin, diabetic wound closure, extracellular vesicles, macrophage, miR-425-5p, single-cell RNA sequence, Technology, Medical and Health Sciences, Clinical sciences, Medical biotechnology
Abstract

Small extracellular vesicles (EVs) are released by cells and deliver biologically active payloads to coordinate the response of multiple cell types in cutaneous wound healing. Here we used a cutaneous injury model as a donor of pro-reparative EVs to treat recipient diabetic obese mice, a model of impaired wound healing. We established a functional screen for microRNAs (miRNAs) that increased the pro-reparative activity of EVs and identified a down-regulation of miR-425-5p in EVs in vivo and in vitro associated with the regulation of adiponectin. We tested a cell type-specific reporter of a tetraspanin CD9 fusion with GFP to lineage map the release of EVs from macrophages in the wound bed, based on the expression of miR-425-5p in macrophage-derived EVs and the abundance of macrophages in EV donor sites. Analysis of different promoters demonstrated that EV release under the control of a macrophage-specific promoter was most abundant and that these EVs were internalized by dermal fibroblasts. These findings suggested that pro-reparative EVs deliver miRNAs, such as miR-425-5p, that stimulate the expression of adiponectin that has insulin-sensitizing properties. We propose that EVs promote intercellular signaling between cell layers in the skin to resolve inflammation, induce proliferation of basal keratinocytes, and accelerate wound closure.

Published
2024

48. MicroRNAs in Genitourinary Malignancies: An Exciting Frontier of Cancer Diagnostics and Therapeutics.

Author

Kathuria-Prakash, Nikhita, Dave, Pranali, Garcia, Lizette, Brown, Paige, and Drakaki, Alexandra

Subjects
MicroRNA, adrenocortical cancer, genitourinary cancers, kidney cancer, prostate cancer, testicular cancer, urothelial cancer, Humans, MicroRNAs, Urogenital Neoplasms, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Animals
Abstract

Genitourinary (GU) malignancies, including prostate, urothelial, kidney, testicular, penile, and adrenocortical cancers, comprise a significant burden of cancers worldwide. While many practice-changing advances have been made in the management of GU malignancies in the last decade, there is still significant room for improvement. MicroRNAs (miRNAs) are noncoding RNAs that regulate post-transcription gene expression and which have been implicated in multiple mechanisms of carcinogenesis. Therefore, they have the potential to revolutionize personalized cancer therapy, with several ongoing preclinical and clinical studies underway to investigate their efficacy. In this review, we describe the current landscape of miRNAs as diagnostics, therapeutics, and biomarkers of response for GU malignancies, reflecting a novel frontier in cancer treatment.

Published
2024

49. Epigenetic Control in Schizophrenia

Author

D’Addario, Claudio, Di Bartolomeo, Martina, Kundu, Tapas K., Series Editor, Harris, J. Robin, Advisory Editor, Holzenburg, Andreas, Advisory Editor, Korolchuk, Viktor, Advisory Editor, Bolanos-Garcia, Victor, Advisory Editor, Marles-Wright, Jon, Advisory Editor, van Zundert, Brigitte, editor, and Montecino, Martin, editor

Published
2025
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50. Circulating extracellular vesicular microRNA signatures in early gestation show an association with subsequent clinical features of pre-eclampsia.

Author

Ghosh, Shubhamoy, Thamotharan, Shanthie, Fong, Jeanette, Lei, Margarida, Janzen, Carla, and Devaskar, Sherin

Subjects
Humans, Pregnancy, Female, Pre-Eclampsia, Extracellular Vesicles, Adult, Circulating MicroRNA, Placenta, Prospective Studies, MicroRNAs, Biomarkers, Gestational Age
Abstract

In a prospective cohort of subjects who subsequently developed preeclampsia (PE, n = 14) versus remaining healthy (NORM, n = 12), early gestation circulating extracellular vesicles (EVs) containing a panel of microRNA signatures were characterized and their biological networks of targets deciphered. Multiple microRNAs of which some arose from the placenta (19MC and 14MC) demonstrated changes in association with advancing gestation, while others expressed were pathognomonic of the subsequent development of characteristic clinical features of PE which set in as a late-onset subtype. This panel of miRNAs demonstrated a predictability with an area under the curve of 0.96 using leave-one-out cross-validation training in a logistic regression model with elastic-net regularization and precautions against overfitting. In addition, this panel of miRNAs, some of which were previously detected in either placental tissue or as maternal cell-free non-coding transcripts, lent further validation to our EV studies and the observed association with PE. Further, the identified biological networks of targets of these detected miRNAs revealed biological functions related to vascular remodeling, cellular proliferation, growth, VEGF, EGF and the PIP3/Akt signaling pathways, all mediating key cellular functions. We conclude that we have demonstrated a proof-of-principle by detecting a panel of EV packaged miRNAs in the maternal circulation early in gestation with possibilities of biological function in the placenta and other maternal tissues, along with the probability of predicting the subsequent clinical appearance of PE, particularly the late-onset subtype.

Published
2024

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