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151 results on '"MOSCATO, TIZIANA"'

1. Effectiveness of biosimilar pegfilgrastim in patients with multiple myeloma after high-dose melphalan and autologous stem cell transplantation

Author

Martino, Massimo, Gori, Mercedes, Porto, Gaetana, Pellicano, Maria, Santoro, Ludovica, Verduci, Chiara, Canale, Filippo Antonio, Loteta, Barbara, Moscato, Tiziana, Alati, Caterina, Ieracitano, Maria Consuelo, Cuzzocrea, Amelia, Altomonte, Maria, Florenzano, Maria Teresa, Morabito, Antonella, Irrera, Giuseppe, Naso, Virginia, Pugliese, Marta, Console, Giuseppe, Ferreri, Anna, Imbalzano, Lucrezia, Tripepi, Giovanni, and Pitino, Annalisa

Published
2023
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2. Correction to: Effectiveness of biosimilar pegfilgrastim in patients with multiple myeloma after high‑dose melphalan and autologous stem cell transplantation

Author

Martino, Massimo, Gori, Mercedes, Porto, Gaetana, Pellicano, Maria, Santoro, Ludovica, Verduci, Chiara, Canale, Filippo Antonio, Loteta, Barbara, Moscato, Tiziana, Alati, Caterina, Ieracitano, Maria Consuelo, Cuzzocrea, Amelia, Altomonte, Maria, Florenzano, Maria Teresa, Morabito, Antonella, Irrera, Giuseppe, Naso, Virginia, Pugliese, Marta, Console, Giuseppe, Ferreri, Anna, Imbalzano, Lucrezia, Tripepi, Giovanni, and Pitino, Annalisa

Published
2023
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4. Netupitant/palonosetron without dexamethasone for preventing nausea and vomiting in patients with multiple myeloma receiving high-dose melphalan for autologous stem cell transplantation: a single-center experience

Author

Loteta, Barbara, Paviglianiti, Annalisa, Naso, Virginia, Ferreri, Anna, Moscato, Tiziana, Console, Giuseppe, Canale, Filippo Antonio, Irrera, Giuseppe, Pugliese, Marta, Di Costanzo, Antonella, Provenzano, Pasquale Fabio, Loddo, Viviana, Porto, Gaetana, Cusumano, Giuseppa, Russo, Letteria, Meliambro, Nicola, Romeo, Valentina, Porcino, Domenico, Gallo, Salvatore, Gangemi, Tiziana, Rossetti, Antonio Maria, and Martino, Massimo

Published
2022
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5. Granisetron transdermal system and dexamethasone for the prevention of nausea and vomiting in multiple myeloma patients receiving chemo-mobilization: An observational real-world study of effectiveness and safety

Author

Martino, Massimo, Naso, Virginia, Porto, Gaetana, Paviglianiti, Annalisa, Ferreri, Anna, Loteta, Barbara, Moscato, Tiziana, Console, Giuseppe, Gentile, Massimo, Rossi, Marco, Provenzano, Pasquale Fabio, Gori, Mercedes, Pitino, Anna Lisa, Morabito, Antonella, and Tripepi, Giovanni

Published
2020
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6. Effectiveness of CAR-T treatment toward the potential risk of second malignancies.

Author

Martino, Massimo, Porto, Gaetana, Policastro, Giorgia, Alati, Caterina, Loteta, Barbara, Micó, Maria Caterina, Argiro', Clizia, Altomonte, Maria, Moscato, Tiziana, Labate, Demetrio, Dattola, Vincenzo, Rao, Carmelo Massimiliano, Cogliandro, Francesca, Canale, Filippo Antonio, Naso, Virginia, Filippelli, Gianfranco, Iaria, Antonino, and Pitea, Martina

Subjects
TREATMENT effectiveness, TUMOR lysis syndrome, SKIN cancer, HEMATOPOIETIC stem cell transplantation
Abstract

This document provides a list of references to studies and articles related to CAR-T cell therapy for various types of lymphoma and multiple myeloma. The studies mentioned discuss the outcomes, safety, and efficacy of CAR-T cell therapies such as lisocabtagene maraleucel, axicabtagene ciloleucel, brexucabtagene autoleucel, ciltacabtagene autoleucel, and idecabtagene vicleucel. The document also includes references to studies that discuss the potential risk of secondary malignancies and other long-term effects associated with CAR-T cell therapy. [Extracted from the article]

Published
2024
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7. A comparative effectiveness study of lipegfilgrastim in multiple myeloma patients after high dose melphalan and autologous stem cell transplant

Author

Martino, Massimo, Gori, Mercedes, Tripepi, Giovanni, Recchia, Anna Grazia, Cimminiello, Michele, Provenzano, Pasquale Fabio, Naso, Virginia, Ferreri, Anna, Moscato, Tiziana, Console, Giuseppe, Loteta, Barbara, Gallo, Giuseppe Alberto, Gentile, Massimo, Innao, Vanessa, Rossi, Marco, Morabito, Antonella, Vincelli, Iolanda Donatella, Mannina, Donato, and Pitino, Annalisa

Published
2020
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8. Challenge to Predict Mobilized Peripheral Blood Stem Cells on the Fourth Day of Granulocyte Colony-Stimulating Factor Treatment in Healthy Donors: Predictive Value of Basal CD34+ Cell and Platelet Counts

Author

Martino, Massimo, Gori, Mercedes, Moscato, Tiziana, Naso, Virginia, Ferreri, Anna, Provenzano, Fabio, Loteta, Barbara, Sanguedolce, Maria Cristina, Console, Giuseppe, Dattola, Antonia, Pucci, Giulia, Gentile, Massimo, Morabito, Antonella, Recchia, Anna Grazia, Tripepi, Giovanni, and Pitino, Annalisa

Published
2019
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10. Basal CD34+ Cell Count Predicts Peripheral Blood Stem Cell Mobilization in Healthy Donors after Administration of Granulocyte Colony–Stimulating Factor: A Longitudinal, Prospective, Observational, Single-Center, Cohort Study

Author

Martino, Massimo, Gori, Mercedes, Pitino, Annalisa, Gentile, Massimo, Dattola, Antonia, Pontari, Antonella, Vigna, Ernesto, Moscato, Tiziana, Recchia, Anna Grazia, Barilla', Santina, Tripepi, Giovanni, and Morabito, Fortunato

Published
2017
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12. Predicting failure of hematopoietic stem cell mobilization before it starts: the predicted poor mobilizer (pPM) score

Author

Olivieri, Jacopo, Attolico, Immacolata, Nuccorini, Roberta, Pascale, Sara Pasquina, Chiarucci, Martina, Poiani, Monica, Corradini, Paolo, Farina, Lucia, Gaidano, Gianluca, Nassi, Luca, Sica, Simona, Piccirillo, Nicola, Pioltelli, Pietro Enrico, Martino, Massimo, Moscato, Tiziana, Pini, Massimo, Zallio, Francesco, Ciceri, Fabio, Marktel, Sarah, Mengarelli, Andrea, Musto, Pellegrino, Capria, Saveria, Merli, Francesco, Codeluppi, Katia, Mele, Giuseppe, Lanza, Francesco, Specchia, Giorgina, Pastore, Domenico, Milone, Giuseppe, Saraceni, Francesco, Di Nardo, Elvira, Perseghin, Paolo, and Olivieri, Attilio

Published
2018
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13. Efficacy of biosimilar granulocyte colony-stimulating factor versus originator granulocyte colony-stimulating factor in peripheral blood stem cell mobilization in de novo multiple myeloma patients

Author

Martino, Massimo, Recchia, Anna Grazia, Moscato, Tiziana, Fedele, Roberta, Neri, Santo, Gentile, Massimo, Alati, Caterina, Vincelli, Iolanda Donatella, Piro, Eugenio, Penna, Giuseppa, Musolino, Caterina, Ronco, Francesca, Molica, Stefano, and Morabito, Fortunato

Published
2015
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15. Tolerability and Efficacy of Busulfan and Fludarabine As Allogeneic Pretransplant Conditioning Therapy in Acute Myeloid Leukemia: Comparison With Busulfan and Cyclophosphamide Regimen

Author

Fedele, Roberta, Messina, Giuseppe, Martinello, Tiziana, Gallo, Giuseppe Alberto, Pontari, Antonella, Moscato, Tiziana, Console, Giuseppe, Dattola, Antonia, Princi, Domenica, Cuzzola, Maria, Alati, Caterina, Ronco, Francesca, Molica, Stefano, Irrera, Giuseppe, and Martino, Massimo

Published
2014
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16. Long-Term Results in Multiple Myeloma After High-Dose Melphalan and Autologous Transplantation According to Response Categories in the Era of Old Drugs

Author

Martino, Massimo, Postorino, Maurizio, Gallo, Giuseppe Alberto, Messina, Giuseppe, Neri, Santo, Piro, Eugenio, Gentile, Massimo, Moscato, Tiziana, Monteleone, Renza, Fedele, Roberta, Mazzone, Carla, Console, Giuseppe, Penna, Giuseppa, Alati, Caterina, Vincelli, Iolanda Donatella, Irrera, Giuseppe, Musolino, Caterina, Ronco, Francesca, Molica, Stefano, and Morabito, Fortunato

Published
2014
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17. Improved outcome of patients with relapsed/refractory Hodgkin lymphoma with a new fotemustine-based high-dose chemotherapy regimen

Author

Musso, Maurizio, Messina, Giuseppe, Di Renzo, Nicola, Di Carlo, Paolo, Vitolo, Umberto, Scalone, Renato, Marcacci, Gianpaolo, Scalzulli, Potito R., Moscato, Tiziana, Matera, Rossella, Crescimanno, Alessandra, Santarone, Stella, Orciuolo, Enrico, Merenda, Anxur, Pavone, Vincenzo, Pastore, Domenico, Donnarumma, Daniela, Carella, Angelo M., Ciochetto, Chiara, Cascavilla, Nicola, Mele, Anna, Lanza, Francesco, Di Nicola, Massimo, Bonizzoni, Erminio, and Pinto, Antonello

Published
2016
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18. Identifying and Managing CAR T-Cell–Mediated Toxicities: on behalf of an Italian CAR-T Multidisciplinary Team

Author

Martino, Massimo, primary, Macheda, Sebastiano, additional, Aguglia, Umberto, additional, Arcudi, Luciano, additional, Pucci, Giulia, additional, Martino, Bruno, additional, Altomonte, Maria, additional, Rossetti, Antonio Maria, additional, Cusumano, Giuseppa, additional, Russo, Letteria, additional, Imbalzano, Lucrezia, additional, Stelitano, Caterina, additional, Alati, Caterina, additional, Germano’, Jessyca, additional, Labate, Demetrio, additional, Amalfi, Vincenzo, additional, Florenzano, Maria Teresa, additional, Morabito, Antonella, additional, Borzumati, Vittoria, additional, Dattola, Vincenzo, additional, Gattuso, Caterina, additional, Moschella, Antonio, additional, Quattrone, Domenico, additional, Curmaci, Francesco, additional, Franzutti, Claudio, additional, Scappatura, Giuseppe, additional, Rao, Carmelo Massimiliano, additional, Loddo, Viviana, additional, Pontari, Antonella, additional, Pellicano’, Maria, additional, Surace, Rosangela, additional, Sanguedolce, Cristina, additional, Naso, Virginia, additional, Ferreri, Anna, additional, Irrera, Giuseppe, additional, Console, Giuseppe, additional, Moscato, Tiziana, additional, Loteta, Barbara, additional, Canale, Filippo Antonio, additional, Trimarchi, Alfonso, additional, Monteleone, Renza, additional, Said, Al Sayyad, additional, Cirrone, Frank, additional, and Bruno, Benedetto, additional

Published
2021
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19. Netupitant/palonosetron without dexamethasone for preventing nausea and vomiting in patients with multiple myeloma receiving high-dose melphalan for autologous stem cell transplantation: a single-center experience

Author

Loteta, Barbara, primary, Paviglianiti, Annalisa, additional, Naso, Virginia, additional, Ferreri, Anna, additional, Moscato, Tiziana, additional, Console, Giuseppe, additional, Canale, Filippo Antonio, additional, Irrera, Giuseppe, additional, Pugliese, Marta, additional, Di Costanzo, Antonella, additional, Provenzano, Pasquale Fabio, additional, Loddo, Viviana, additional, Porto, Gaetana, additional, Cusumano, Giuseppa, additional, Russo, Letteria, additional, Meliambro, Nicola, additional, Romeo, Valentina, additional, Porcino, Domenico, additional, Gallo, Salvatore, additional, Gangemi, Tiziana, additional, Rossetti, Antonio Maria, additional, and Martino, Massimo, additional

Published
2021
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21. CART-Cell Therapy: Recent Advances and New Evidence in Multiple Myeloma

Author

Martino, Massimo, primary, Canale, Filippo Antonio, additional, Alati, Caterina, additional, Vincelli, Iolanda Donatella, additional, Moscato, Tiziana, additional, Porto, Gaetana, additional, Loteta, Barbara, additional, Naso, Virginia, additional, Mazza, Massimiliano, additional, Nicolini, Fabio, additional, Ghelli Luserna di Rorà, Andrea, additional, Simonetti, Giorgia, additional, Ronconi, Sonia, additional, Ceccolini, Michela, additional, Musuraca, Gerardo, additional, Martinelli, Giovanni, additional, and Cerchione, Claudio, additional

Published
2021
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23. A comparative effectiveness study of lipegfilgrastim in multiple myeloma patients after high dose melphalan and autologous stem cell transplant

Author

Martino, Massimo, primary, Gori, Mercedes, additional, Tripepi, Giovanni, additional, Recchia, Anna Grazia, additional, Cimminiello, Michele, additional, Provenzano, Pasquale Fabio, additional, Naso, Virginia, additional, Ferreri, Anna, additional, Moscato, Tiziana, additional, Console, Giuseppe, additional, Loteta, Barbara, additional, Gallo, Giuseppe Alberto, additional, Gentile, Massimo, additional, Innao, Vanessa, additional, Rossi, Marco, additional, Morabito, Antonella, additional, Vincelli, Iolanda Donatella, additional, Mannina, Donato, additional, and Pitino, Annalisa, additional

Published
2019
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24. UTILITY OF THE CLINICAL PRACTICE OF ADMNISTERING THROMBOPHILIC SCREENING AND ANTITHROMBOTIC PROPHYLAXIS WITH LOW-MOLECULAR-WEIGHT HEPARIN TO HEALTHY DONORS TREATED WITH G-CSF FOR MOBILIZATION OF PERIPHERAL BLOOD STEM CELLS

Author

Martino, Massimo, Luise, Francesca, Oriana, Vincenzo, Console, Giuseppe, Moscato, Tiziana, Mammì, Corrado, Messina, Giuseppe, Massara, Elisabetta, Irrera, Giuseppe, Piromalli, Angela, Lombardo, Vincenzo Trapani, Laganà, Carmelo, and Iacopino, Pasquale

Published
2007
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25. A Comparative Assessment of Quality of Life in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation Through an Outpatient and Inpatient Model

Author

Martino, Massimo, Ciavarella, Sabino, De Summa, Simona, Russo, Letteria, Meliambro, Nicola, Imbalzano, Lucrezia, Gallo, Giuseppe Alberto, Moscato, Tiziana, Messina, Giuseppe, Ferreri, Anna, Cuzzola, Maria, Irrera, Giuseppe, Naso, Virginia, Cimminiello, Michele, Console, Giuseppe, Loseto, Giacomo, Tommasi, Stefania, and Guarini, Attilio

Published
2018
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26. Identifying and managing CAR T-cell–mediated toxicities: on behalf of an Italian CAR-T multidisciplinary team

Author

Martino, Massimo, Macheda, Sebastiano, Aguglia, Umberto, Arcudi, Luciano, Pucci, Giulia, Martino, Bruno, Altomonte, Maria, Rossetti, Antonio Maria, Cusumano, Giuseppa, Russo, Letteria, Imbalzano, Lucrezia, Stelitano, Caterina, Alati, Caterina, Germano’, Jessyca, Labate, Demetrio, Amalfi, Vincenzo, Florenzano, Maria Teresa, Morabito, Antonella, Borzumati, Vittoria, Dattola, Vincenzo, Gattuso, Caterina, Moschella, Antonio, Quattrone, Domenico, Curmaci, Francesco, Franzutti, Claudio, Scappatura, Giuseppe, Rao, Carmelo Massimiliano, Loddo, Viviana, Pontari, Antonella, Pellicano’, Maria, Surace, Rosangela, Sanguedolce, Cristina, Naso, Virginia, Ferreri, Anna, Irrera, Giuseppe, Console, Giuseppe, Moscato, Tiziana, Loteta, Barbara, Canale, Filippo Antonio, Trimarchi, Alfonso, Monteleone, Renza, Al Sayyad, Said, Cirrone, Frank, and Bruno, Benedetto

Abstract

ABSTRACTIntroductionChimeric antigen receptor (CAR)-T-cell therapy is a new treatment for patients with hematologic malignancies in which other therapies have failed.Areas coveredThe review provides an overview for recognizing and managing the most acute toxicities related to CAR-T cells.Expert opinionThe development of immune-mediated toxicities is a common challenge of CAR-T therapy. The mechanism that determines this toxicity is still unclear, although an unfavorable tumor microenvironment and a pro-inflammatory state put patients at risk. The monitoring, diagnosis, and treatment of post-CAR-T toxicities must be determined and based on international guidelines and internal clinical practice. It is urgent to identify biomarkers that can identify patients at greater risk of developing complications. The adoption of consistent grading criteria is necessary to improve toxicity management strategies continually. The first-line therapy consists of supportive care and treatment with tocilizumab or corticosteroids. An early start of cytokine blockade therapies could mitigate toxicity. The plan will include cytokine release prophylaxis, a risk-adapted treatment, prevention of on-target/off-tumor effect, and a switch on/off CAR-T approach.

Published
2022
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27. Quality of life outcomes in multiple myeloma patients: a summary of recent clinical trials

Author

Martino, Massimo, primary, Rossi, Marco, additional, Ferreri, Anna, additional, Loteta, Barbara, additional, Morabito, Antonella, additional, Moscato, Tiziana, additional, Console, Giuseppe, additional, Innao, Vanessa, additional, Naso, Virginia, additional, Provenzano, Pasquale Fabio, additional, Recchia, Anna Grazia, additional, and Gentile, Massimo, additional

Published
2019
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28. The use of ibrutinib before and after allogeneic stem cell transplantation

Author

Martino, Massimo, primary, Ferreri, Anna, additional, Naso, Virginia, additional, Moscato, Tiziana, additional, Loteta, Barbara, additional, Gentile, Massimo, additional, Morabito, Antonella, additional, Provenzano, Fabio, additional, Cimminiello, Michele, additional, Carella, Angelo Michele, additional, Console, Giuseppe, additional, and Recchia, Anna Grazia, additional

Published
2019
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29. Can we improve the conditioning regimen before autologous stem cell transplantation in multiple myeloma?

Author

Martino, Massimo, primary, Recchia, Anna Grazia, additional, Console, Giuseppe, additional, Gentile, Massimo, additional, Cimminiello, Michele, additional, Gallo, Giuseppe Alberto, additional, Ferreri, Anna, additional, Naso, Virginia, additional, Irrera, Giuseppe, additional, Messina, Giuseppe, additional, Moscato, Tiziana, additional, Vigna, Ernesto, additional, Vincelli, Iolanda Donatella, additional, and Morabito, Fortunato, additional

Published
2017
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30. Basal CD34 + Cell Count Predicts Peripheral Blood Stem Cell Mobilization in Healthy Donors after Administration of Granulocyte Colony–Stimulating Factor: A Longitudinal, Prospective, Observational, Single-Center, Cohort Study

Author

Martino, Massimo, primary, Gori, Mercedes, additional, Pitino, Annalisa, additional, Gentile, Massimo, additional, Dattola, Antonia, additional, Pontari, Antonella, additional, Vigna, Ernesto, additional, Moscato, Tiziana, additional, Recchia, Anna Grazia, additional, Barilla', Santina, additional, Tripepi, Giovanni, additional, and Morabito, Fortunato, additional

Published
2017
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31. Basal CD34+ Cell Count Predicts Peripheral Blood Hematopoietic Progenitor Cells Mobilization in Healthy Donors after Administration of G-CSF

Author

Martino, Massimo, primary, Gori, Mercedes, additional, Pitino, Annalisa, additional, Dattola, Antonella, additional, Fedele, Roberta, additional, Gallo, Giuseppe Alberto, additional, Barillà, Santina, additional, Pontari, Antonella, additional, Irrera, Giuseppe, additional, Messina, Giuseppe, additional, Moscato, Tiziana, additional, Console, Giuseppe, additional, Morabito, Fortunato, additional, and Tripepi, Giovanni, additional

Published
2016
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33. Improved outcome of patients with relapsed/refractory Hodgkin lymphoma with a new fotemustine‐based high‐dose chemotherapy regimen

Author

Musso, Maurizio, primary, Messina, Giuseppe, additional, Di Renzo, Nicola, additional, Di Carlo, Paolo, additional, Vitolo, Umberto, additional, Scalone, Renato, additional, Marcacci, Gianpaolo, additional, Scalzulli, Potito R., additional, Moscato, Tiziana, additional, Matera, Rossella, additional, Crescimanno, Alessandra, additional, Santarone, Stella, additional, Orciuolo, Enrico, additional, Merenda, Anxur, additional, Pavone, Vincenzo, additional, Pastore, Domenico, additional, Donnarumma, Daniela, additional, Carella, Angelo M., additional, Ciochetto, Chiara, additional, Cascavilla, Nicola, additional, Mele, Anna, additional, Lanza, Francesco, additional, Di Nicola, Massimo, additional, Bonizzoni, Erminio, additional, and Pinto, Antonello, additional

Published
2015
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36. Biosimilar Compared with Originator Filgrastim for Autologous Stems CELL Mobilisation: A Prospective-Historical Control Study in Multiple Myeloma REAL-Life Setting

Author

Martino, Massimo, primary, Moscato, Tiziana, additional, Vincelli, Iolanda Donatella, additional, Ronco, Francesca, additional, Fedele, Roberta, additional, Irrera, Giuseppe, additional, Console, Giuseppe, additional, Messina, Giuseppe, additional, Piro, Eugenio, additional, Molica, Stefano, additional, and Morabito, Fortunato, additional

Published
2014
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39. A home-care, early discharge model after autografting in multiple myeloma: results of a three-arm prospective, non-randomized study

Author

Martino, Massimo, primary, Russo, Letteria, additional, Martinello, Tiziana, additional, Gallo, Giuseppe Alberto, additional, Fedele, Roberta, additional, Moscato, Tiziana, additional, Console, Giuseppe, additional, Vincelli, Donatella Iolanda, additional, Ronco, Francesca, additional, Postorino, Maurizio, additional, Irrera, Giuseppe, additional, and Messina, Giuseppe, additional

Published
2014
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42. Addressing the questions of tomorrow: melphalan and new combinations as conditioning regimens before autologous hematopoietic progenitor cell transplantation in multiple myeloma

Author

Martino, Massimo, primary, Olivieri, Attilio, additional, Offidani, Massimo, additional, Vigna, Ernesto, additional, Moscato, Tiziana, additional, Fedele, Roberta, additional, Montanari, Mauro, additional, Console, Giuseppe, additional, Gentile, Massimo, additional, Messina, Giuseppe, additional, Irrera, Giuseppe, additional, and Morabito, Fortunato, additional

Published
2013
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43. Autologous hematopoietic progenitor cell transplantation for multiple myeloma through an outpatient program

Author

Martino, Massimo, primary, Montanari, Mauro, additional, Bruno, Benedetto, additional, Console, Giuseppe, additional, Irrera, Giuseppe, additional, Messina, Giuseppe, additional, Offidani, Massimo, additional, Scortechini, Ilaria, additional, Moscato, Tiziana, additional, Fedele, Roberta, additional, Milone, Giuseppe, additional, Castagna, Luca, additional, and Olivieri, Attilio, additional

Published
2012
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46. At-Home Management of Aplastic Phase Following High-Dose Melphalan and Autologous Haematopoietic Stem Cell Transplantation for Multiple Myeloma Patients: A Pilot Study

Author

Martino, Massimo, primary, Pellicano’, Grazia, additional, Moscato, Tiziana, additional, Massara, Elisabetta, additional, Fedele, Roberta, additional, Console, Giuseppe, additional, Russo, Letteria, additional, Messina, Giuseppe, additional, Di Filippo Scali, Rosalba, additional, and Irrera, Giuseppe, additional

Published
2011
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47. A home-care, early discharge model after autografting in multiple myeloma: results of a three-arm prospective, non-randomized study.

Author

Martino, Massimo, Russo, Letteria, Martinello, Tiziana, Gallo, Giuseppe Alberto, Fedele, Roberta, Moscato, Tiziana, Console, Giuseppe, Vincelli, Donatella Iolanda, Ronco, Francesca, Postorino, Maurizio, Irrera, Giuseppe, and Messina, Giuseppe

Subjects
MULTIPLE myeloma treatment, MELPHALAN, HEMATOPOIETIC agents
Abstract

A letter to the editor is presented which discusses a three-arm prospective and non-randomized study of clinical efficiency of an early discharge model (EDM) and home-care (HC) treatment for multiple myeloma (MM) being treated with high dose melphalan (HDM) with hematopoietic progenitor cell (HPC).

Published
2015
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48. Erythropoiesis-stimulating agents in allogeneic and autologous hematopoietic stem cell transplantation

Author

Martino, Massimo, Lanza, Francesco, Demirer, Taner, Moscato, Tiziana, Secondino, Simona, and Pedrazzoli, Paolo

Abstract

Introduction:Erythropoiesis-stimulating agents (ESAs) are used in treating cancer- and chemotherapy-induced anemia with the aim of accelerating the recovery of red blood cells (RBCs), reduce the risks associated with RBC transfusions and improve quality of life.Areas covered:A systematic review has been conducted to examine the current evidence for the efficacy and safety of using ESAs in hematopoietic stem cell transplants (HSCTs).Expert opinion:Despite the international recommendations for the use of ESAs in treating different malignancies, there is a lack of guidelines for their use in patients undergoing HSCT. An evaluation of published clinical trials shows that there are no available powerful studies concerning the use of ESAs in this setting, with only heterogeneous and small numbers of patients reported so far. Nevertheless, the more robust and intriguing of these data suggest that the ESA’s administration at an appropriate time after the infusion of stem cells may be effective both in autologous and allogeneic HSCTs. New guidelines are required, overseen by an expert in the in the field of stem cell transplantation.

Published
2015
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49. Surrogate Thresholds for Iron Chelation in Patients with Hematological Malignancies

Author

Oliva, Esther Natalie, Zappavigna, Sabrina, Santacaterina, Irene, Moscato, Tiziana, Arcadi, Nicola, Cufari, Patrizia, Alati, Caterina, and Maggio, Aurelio

Abstract

Background:The reference standard for evaluating the magnitude of body iron overload is measurement of the liver iron concentration (LIC). Until recently, the conventional clinical method for measuring LIC was through analysis of biopsy specimens considered the “gold standard” of LIC measurement. To counter the shortcomings of liver biopsy, several noninvasive techniques have been applied to estimate LIC. The spin-density projection-assisted (SDPA) R2-MRI (FerriScan) technique has been recently validated to estimate LIC. There are reports in the literature that ferritin levels in patients with hematological malignancies (HM) may not correlate sufficiently with LIC. We conducted R2-MRI Ferriscan sequencing in consecutive patients with HM followed in our center to better evaluate the diagnostic value of ferritin levels and packed red blood cell (pRBC) transfusions for iron overload.

Published
2017
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50. Predicting failure of hematopoietic stem cell mobilization before it starts: the Predicted Poor Mobilizer (pPM) score

Author

Nicola Piccirillo, Paolo Corradini, Domenico Pastore, Roberta Nuccorini, Giorgina Specchia, Francesco Saraceni, Massimo Martino, Massimo Pini, Sarah Marktel, Andrea Mengarelli, Pietro Pioltelli, Giuseppe Milone, Francesco Zallio, Monica Poiani, Elvira Di Nardo, Saveria Capria, Sara Pasquina Pascale, Tiziana Moscato, Gianluca Gaidano, Immacolata Attolico, Pellegrino Musto, Paolo Perseghin, Francesco Merli, Lucia Farina, Luca Nassi, Martina Chiarucci, Simona Sica, Giuseppe Mele, Jacopo Olivieri, Francesco Lanza, Attilio Olivieri, Fabio Ciceri, Katia Codeluppi, Olivieri, Jacopo, Attolico, Immacolata, Nuccorini, Roberta, Pascale, Sara Pasquina, Chiarucci, Martina, Poiani, Monica, Corradini, Paolo, Farina, Lucia, Gaidano, Gianluca, Nassi, Luca, Sica, Simona, Piccirillo, Nicola, Pioltelli, Pietro Enrico, Martino, Massimo, Moscato, Tiziana, Pini, Massimo, Zallio, Francesco, Ciceri, Fabio, Marktel, Sarah, Mengarelli, Andrea, Musto, Pellegrino, Capria, Saveria, Merli, Francesco, Codeluppi, Katia, Mele, Giuseppe, Lanza, Francesco, Specchia, Giorgina, Pastore, Domenico, Milone, Giuseppe, Saraceni, Francesco, Di Nardo, Elvira, Perseghin, Paolo, and Olivieri, Attilio

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Multivariate analysis, Adolescent, lymphoma, Filgrastim, Likelihood ratios in diagnostic testing, NO, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Child, Hematopoietic Stem Cell Mobilization, Aged, Retrospective Studies, Transplantation, Mobilization, Receiver operating characteristic, business.industry, Plerixafor, Patient Selection, Area under the curve, poor mobiliser, Hematology, Middle Aged, stem cell mobilization, lymphoma, myeloma, poor mobiliser, oredicting clinical score, stem cell mobilization, Settore MED/15 - MALATTIE DEL SANGUE, myeloma, oredicting clinical score, 030220 oncology & carcinogenesis, Area Under Curve, Child, Preschool, Female, business, Multiple Myeloma, 030215 immunology, medicine.drug
Abstract

Predicting mobilization failure before it starts may enable patient-tailored strategies. Although consensus criteria for predicted PM (pPM) are available, their predictive performance has never been measured on real data. We retrospectively collected and analyzed 1318 mobilization procedures performed for MM and lymphoma patients in the plerixafor era. In our sample, 180/1318 (13.7%) were PM. The score resulting from published pPM criteria had sufficient performance for predicting PM, as measured by AUC (0.67, 95%CI: 0.63–0.72). We developed a new prediction model from multivariate analysis whose score (pPM-score) resulted in better AUC (0.80, 95%CI: 0.76–0.84, p < 0001). pPM-score included as risk factors: increasing age, diagnosis of NHL, positive bone marrow biopsy or cytopenias before mobilization, previous mobilization failure, priming strategy with G-CSF alone, or without upfront plerixafor. A simplified version of pPM-score was categorized using a cut-off to maximize positive likelihood ratio (15.7, 95%CI: 9.9–24.8); specificity was 98% (95%CI: 97–98.7%), sensitivity 31.7% (95%CI: 24.9–39%); positive predictive value in our sample was 71.3% (95%CI: 60–80.8%). Simplified pPM-score can “rule in” patients at very high risk for PM before starting mobilization, allowing changes in clinical management, such as choice of alternative priming strategies, to avoid highly likely mobilization failure.

Published
2018

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