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Electromagnetic Calorimeter (ECal), a subdetector of Multipurpose Detector (MPD), is designed to identify electrons, photons, and neutral hadrons produced in high-energy heavy-ion collisions at nuclotron-based ion collider facility (NICA) and measure their energies and positions. A Shashlyk-type sampling calorimeter composed of lead plates as absorbers and plastic scintillators arranged alternately was selected for ECal. Chinese MPD consortium is responsible for the development of 768 ECal modules which is of the whole ECal detector. In this report, the mass production process of ECal modules and a performance test system designed for the mass production will be presented. The uniformity of the ECal modules achieved based on cosmic ray test will be discussed. Preliminary results demonstrate the produced ECal modules met the design requirements, indicating the quality control in mass production is effective. These modules were delivered to the Joint Institute for Nuclear Research (JINR) at Dubna in March 2023, and will soon be installed on MPD detector for further commissioning. [ABSTRACT FROM AUTHOR]

Primary Muscle Tension Dysphonia (MTD) occurs in the absence of structural or neurologic etiologies. Patients with MTD are frequently encountered in clinics and are evaluated using multiple measures of voice evaluation. Studies reporting on the correlation of multiple measures of voice evaluation among individuals with MTD are minimal, which led to this study. This single-group correlational study involved 48 participants diagnosed with primary MTD at a tertiary care institute. Multidimensional measures of voice (acoustic, aerodynamic, auditory-perceptual, and self-rating) were obtained from the participants. GRBAS scale, Acoustic Voice Quality Index, Acoustic Breathiness Index, Maximum Phonation Duration, S/Z ratio, Voice Handicap Index, and Vocal Fatigue Index were the variables considered. These measures were correlated using Spearman's correlation (ρ) within and between different measures of voice evaluation. Several statistically significant (P < 0.05) correlations were found within and across different measures of voice evaluation. Moderate to very high correlations (ρ between 0.48 and 0.87) were found between auditory-perceptual measures and multiparametric acoustic measures. Weak to moderate correlations (ρ between 0.31 and 0.62) were observed between the VHI and its subsections, with GRBAS, AVQI, and ABI. No statistically significant correlations were observed between aerodynamic measures and other measures of voice evaluation. Results from this study suggest that compared to across measures, the correlation between different variables was stronger within each measure of voice evaluation. These findings highlight the need for a multidimensional voice evaluation in patients with MTD. [ABSTRACT FROM AUTHOR]

The strange baryon production in Bi + Bi collisions at s N N = 9.0 GeV is studied using the PHSD transport model. Hyperon and anti-hyperon yields, transverse momentum spectra, and rapidity spectra are calculated, and their centrality dependence and the effect of rapidity and transverse momentum cuts are studied. The rapidity distributions for Λ ¯ , Ξ , Ξ ¯ baryons are found to be systematically narrower than for Λ s. The p T slope parameters for anti-hyperons vary more with centrality than those for hyperons. Restricting the accepted rapidity range to | y | < 1 increases the slope parameters by 13–30 MeV, depending on the centrality class and the hyperon mass. Hydrodynamic velocity and vorticity fields are calculated, and the formation of two oppositely rotating vortex rings moving in opposite directions along the collision axis is found. The hyperon spin polarization induced by the medium vorticity within the thermodynamic approach is calculated, and the dependence of the polarization on the transverse momentum and rapidity cuts and on the centrality selection is analyzed. The cuts have stronger effect on the polarization of Λ and Ξ hyperons than on the corresponding anti-hyperons. The polarization signal is maximal for the centrality class, 60–70%. We show that, for the considered hyperon polarization mechanism, the structure of the vorticity field makes an imprint on the polarization signal as a function of the azimuthal angle in the transverse momentum plane, ϕ H , cos ϕ H = p x / p T . For particles with positive longitudinal momentum, p z > 0 , the polarization increases with cos ϕ H , while for particles with p z < 0 it decreases. [ABSTRACT FROM AUTHOR]

Excess molar volume, excess isentropic compressibility, deviation in viscosity, and excess Gibbs free energy of activation of viscous flow for binary mixtures of Hexylene glycol (2-methyl-pentanediol-2,4 or MPD) with aliphatic ketones (4-hydroxy-4-methyl-pentan-2-one (J1), 4-methyl-pentan-2-one (J2), and pentan-2-one (J3)) components selected compositions were determined from the measured values of densities (ρ), viscosities (η), and speeds of sound (u) of pure components and their mixtures from 303.15 K to 313.15 K. The results were analysed in terms of intermolecular interactions or hydrogen bonding or hetero-association interactions in the binary mixtures. Finally, the Prigogine-Flory-Patterson (PFP) theory is applied to identify the most predominant molecular interaction. The results of the Jouyban-Acree model are discussed in terms of mean relative deviation (MRDs) and individual relative deviation (IRD) between calculated and experimental densities, speeds of sound, and viscosities as an accuracy criterion. [ABSTRACT FROM AUTHOR]

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Excess molar volume, excess isentropic compressibility, deviation in viscosity and excess Gibbs free energy of activation of viscous flow for binary mixtures of Hexylene glycol (2-methyl-2,4-pentanediol- or MPD) with 1-butanol (J1), 2-butanol (J2) and 2-methyl-2-propanol (J3) components selected compositions were determined from the measured values of densities (ρ), viscosities ($\eta $ η), and speeds of sound (u) of pure components and their mixtures from 303.15 K to 313.15 K. The results are analysed in terms of intermolecular interactions or hydrogen bonding or hetero-association interactions in the binary mixtures. Finally, the Prigogine-Flory-Patterson (PFP) Theory is applied to identify the most predominant molecular interaction. Using Jouyban–Acree model, results are discussed in terms of mean relative deviation (MRDs) and individual relative deviation (IRD) between calculated and experimental densities, speeds of sound and viscosities as an accuracy criterion. [ABSTRACT FROM AUTHOR]

Excess molar volume, excess isentropic compressibility, deviation in viscosity and excess Gibbs free energy for the activation of viscous flow for binary mixtures of 2-methyl-2,4-pentanediol (MPD) with 1,2-dichlorobenzene (1,2-DCB), 1,3-dichlorobenzene (1,3-DCB) and 1,2,4-trichlorobenzene (1,2,4-TCB) components selected compositions are determined from the measured values of densities (ρ), speeds of sound (u) and viscosities (η) of pure components and their mixtures from 303.15 K to 313.15 K. The results are analysed in terms of intermolecular interactions or hydrogen bonding or hetero-association interactions in the binary mixtures. The Prigogine–Flory–Patterson (PFP) theory is applied to identify the predominant molecular interaction. The results of Jouyban–Acree model are discussed in terms of mean relative deviation (MRD) and individual relative deviation (IRD) between the calculated and experimental densities, speeds of sound and viscosities as accuracy criteria. [ABSTRACT FROM AUTHOR]

The urgent need to find mitigating pathways for limiting world CO2 emissions to net zero by 2050 has led to intense research on CO2 sequestration in deep saline reservoirs. This paper reviews key advancements in lab- and simulation-scale research on petrophysical, geochemical, and mineralogical changes during CO2–brine–rock interactions performed in the last 25 years. It delves into CO2 MPD (mineralization, precipitation, and dissolution) and explores alterations in petrophysical properties during core flooding and in static batch reactors. These properties include changes in wettability, CO2 and brine interfacial tension, diffusion, dispersion, CO2 storage capacity, and CO2 leakage in caprock and sedimentary rocks under reservoir conditions. The injection of supercritical CO2 into deep saline aquifers can lead to unforeseen geochemical and mineralogical changes, possibly jeopardizing the CCS (carbon capture and storage) process. There is a general lack of understanding of the reservoir's interaction with the CO2 phase at the pore/grain scale. This research addresses the gap in predicting the long-term changes of the CO2–brine–rock interaction using various geochemical reactive transport simulators. Péclet and Damköhler numbers can contribute to a better understanding of geochemical interactions and reactive transport processes. Additionally, the dielectric constant requires further investigation, particularly for pre- and post-CO2–brine–rock interactions. For comprehensive modeling of CO2 storage over various timescales, the geochemical modeling software called the Geochemist's Workbench was found to outperform others. Wettability alteration is another crucial aspect affecting CO2–brine–rock interactions under varying temperature, pressure, and salinity conditions, which is essential for ensuring long-term CO2 storage security and monitoring. Moreover, dual-energy CT scanning can provide deeper insights into geochemical interactions and their complexities. [ABSTRACT FROM AUTHOR]

Densities (ρ), speeds of sound (u) and viscosities (η) for three binary mixtures of hexylene glycol (2-methyl-2,4-pentanediol or MPD) with 1-octanol (D1), 1-nonanol (D2) and 1-decanol (D3) are calculated at temperatures ranging from 303.15 to 313.15 K and atmospheric pressure over the entire composition range. Experimental measurements are used to calculate the excess molar volume, excess isentropic compressibility, deviation in viscosity and excess Gibbs-free energy of activation of viscous flow. Partial molar properties and infinite dilution molar partial properties are also calculated for each binary system. The results obtained can be discussed in terms of weaker interactions and dispersion forces with the absence of specific intermolecular interactions in binary mixtures. Finally, the Prigogine-Flory-Patterson (PFP) theory is applied to identify the most predominant molecular interaction. Jouyban-Acree model results are discussed in terms of mean relative deviation (MRDs) and individual relative deviation (IRD) between calculated and experimental densities, speeds of sound and viscosities as an accuracy criterion. [ABSTRACT FROM AUTHOR]

Abstract We report the first case of pancreatic stent (PS) migration placed early into the main pancreatic duct (MPD) during endoscopic retrograde cholangiopancreatography (ERCP) due to subsequent endoscopic papillary balloon dilation. A 74‐year‐old woman who complained of fever and abdominal pain was diagnosed with acute calculous cholangitis. On ERCP, a needle‐knife precut papillotomy was performed from the orifice because of difficult cannulation. Because of unintentional guidewire insertion into the MPD from the orifice, a PS with bilateral flaps was promptly placed to prevent post‐ERCP pancreatitis. After successful biliary cannulation from the orifice alongside the PS, endoscopic papillary balloon dialtion was performed, leading to PS migration into the MPD during the dilation. Two days after the first ERCP, the migrated PS was successfully removed on the second ERCP. The strategy of early PS placement in the ERCP session appears theoretically promising for preventing post‐ERCP pancreatitis. However, early PS placement during the ERCP session should be noted to pose the risk of migration into the MPD, especially when pushing the device into the bile duct.

Pavement surface texture is an essential factor in influencing the sound emission of vehicles, and reducing noise pollution would be a big issue for all humans. According to the Economic Commission for Europe (ECE) R-117 requirement, all the vehicle tires vending in Europe should pass noise accreditation after September 2009, and the pavement surface of the test track should follow ISO 10844. The Mean Profile Depth (MPD) is adopted to be the texture parameter of the test track surface in ISO 10844. the MPD of the Test track should be controlled at specific intervals, and the material design should be a big challenge of pavement Engineering. This study aims to establish an MPD prediction function with material properties for pavement Engineers. In material, there were two fine aggregates, three gradation curves, three air voids of the specimen, and 18 mixture designs adopted in this study. There were three specimens in each mixture design; the total specimen number was 54 for MPD measurement. Fifty-four laboratory test specimens were compacted using a Superpave gyratory compactor (SGC). A High-Definition Pavement Texture Machine (HDPTM) measured the specimen surface MPD. The parameters in this study included fineness module (FM), fine aggregate angularity (FAA), air void (AV) of the specimen, and Gyration number (G) of SGC. Gene Expression Programming (GEP) was adopted to build a prediction model between MPD and various parameters. Based on the results of this study, the best MPD forecasting model using FAA, FM, and AV, the R2 of is 0.74, meaning the best MPD forecasting model could be a very nice tool to help pavement engineers to do MPD quality control on the test track for ISO 10844. In addition, GEP was an excellent method to discover the nonlinear relationship between MPD and various parameters of asphalt concrete, and it was worthy of further study.

ABSTRACTCandidiasis caused by Candida albicans infection has long been a serious human health problem. The pathogenicity of C. albicans is mainly due to its virulence factors, which are novel targets of antifungal drugs for low risk of resistance development. In this study, we identified a maleimide compound [1-(4-methoxyphenyl)-1hydro-pyrrole-2,5-dione, MPD] that exerts effective anti-virulence activity. It could inhibit the process of adhesion, filamentation, and biofilm formation in C. albicans. In addition, it exhibited low cytotoxicity, hemolytic activity, and drug resistance development. Moreover, in Galleria mellonella-C. albicans (in vivo) infection model, the survival time of infected larvae was significantly prolonged under the treatment of MPD. Further, mechanism research revealed that MPD increased farnesol secretion by upregulating the expression of Dpp3. The increased farnesol inhibited the activity of Cdc35, which then decreased the intracellular cAMP content resulting in the inhibition of virulence factors via the Ras1-cAMP-Efg1 pathway. In all, this study evaluated the inhibitory effect of MPD on various virulence factors of C. albicans and identified the underlying mechanisms. This suggests a potential application of MPD to overcome fungal infections in clinics.

The NICA (Nuclotron-based Ion Collider fAcility) project at the Joint Institute for Nuclear Research (JINR, Dubna, Russia) is aimed at the construction of a new accelerator complex for heavy ions and polarized particles. Heavy-ion collisions at NICA are planned to be studied in the region of the highest net-baryon density, which favors the formation of bound nuclear systems with strangeness hypernuclei. The multipurpose detector (MPD) at NICA is designed to reconstruct interactions of relativistic nuclei in a high-multiplicity environment. In this paper, we report the feasibility study results for the reconstruction of Λ3H, Λ4H and Λ4He in Bi+Bi collisions at the nucleon-nucleon center-of-mass energy, sNN= 9.2 GeV.

The production of nuclei and hypernuclei is of interest for experimental and theoretical studies: it is a big question how such weakly bound objects survive in a hot, dense environment and which new insights on the heavy-ion collisions dynamics they can bring us. We present the results on the hypernuclei feasibility study for the flagship Nuclotron-based Ion Collider fAcility (NICA)/Multi-Purpose Detector (MPD) experiment at the Joint Institute for Nuclear Research (JINR) in Dubna using the Parton-Hadron-Quantum-Molecular Dynamics (PHQMD) transport approach and a realistic reconstruction chain.

Managed pressure drilling (MPD) is the most effective means to ensure drilling safety, and MPD is able to avoid further deterioration of complex working conditions through precise control of the wellhead back pressure. The key to the success of MPD is the well control strategy, which currently relies heavily on manual experience, hindering the automation and intelligence process of well control. In response to this issue, an MPD knowledge graph is constructed in this paper that extracts knowledge from published papers and drilling reports to guide well control. In order to improve the performance of entity extraction in the knowledge graph, a few-shot Chinese entity recognition model CEntLM-KL is extended from the EntLM model, in which the KL entropy is built to improve the accuracy of entity recognition. Through experiments on benchmark datasets, it has been shown that the proposed model has a significant improvement compared to the state-of-the-art methods. On the few-shot drilling datasets, the F-1 score of entity recognition reaches 33%. Finally, the knowledge graph is stored in Neo4J and applied for knowledge inference. [ABSTRACT FROM AUTHOR]

Massive-Multiple Inputs and Multiple Outputs (M-MIMO) is considered as one of the standard techniques in improving the performance of Fifth Generation (5G) radio. 5G signal detection with low propagation delay and high throughput with minimum computational intricacy are some of the serious concerns in the deployment of 5G. The evaluation of 5G promises a high quality of service (QoS), a high data rate, low latency, and spectral efficiency, ensuring several applications that will improve the services in every sector. The existing detection techniques cannot be utilised in 5G and beyond 5G due to the high complexity issues in their implementation. In the proposed article, the Approximation Message Passing (AMP) is implemented and compared with the existing Minimum Mean Square Error (MMSE) and Message Passing Detector (MPD) algorithms. The outcomes of the work show that the performance of Bit Error Rate (BER) is improved with minimal complexity. [ABSTRACT FROM AUTHOR]

During the COVID-19 pandemic, mobile phone dependence (MPD) became a common addictive behavior among adolescents because of social isolation. To understand the underlying mechanisms of the impact of social isolation on MPD, this study examined the mediating role of loneliness and the moderating role of parent–child communication patterns on social isolation and MPD. Six hundred and eighty-three adolescents from a middle school in Huang'gang city, China, were recruited to complete a self-report questionnaire. Data analysis comprised latent profile analysis and structural equation modelling. The results showed that social isolation had a significant and positive indirect effect on MPD via loneliness. In addition, three types of parent–child communication patterns were observed: complex, adaptive, and maladaptive. For adolescents with complex parent–child communication, the indirect relation of social isolation to MPD via loneliness is weaker than that of adolescents with maladaptive parent–child communication. These findings suggested that the indirect effect of social isolation on MPD via loneliness was moderated by parent-child communication patterns. Psychological intervention for MPD should emphasize relieving adolescents' loneliness and improving the quality of their communication with parents during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Massive-Multiple Inputs and Multiple Outputs (M-MIMO) is considered as one of the standard techniques in improving the performance of Fifth Generation (5G) radio. 5G signal detection with low propagation delay and high throughput with minimum computational intricacy are some of the serious concerns in the deployment of 5G. The evaluation of 5G promises a high quality of service (QoS), a high data rate, low latency, and spectral efficiency, ensuring several applications that will improve the services in every sector. The existing detection techniques cannot be utilised in 5G and beyond 5G due to the high complexity issues in their implementation. In the proposed article, the Approximation Message Passing (AMP) is implemented and compared with the existing Minimum Mean Square Error (MMSE) and Message Passing Detector (MPD) algorithms. The outcomes of the work show that the performance of Bit Error Rate (BER) is improved with minimal complexity. [ABSTRACT FROM AUTHOR]

The NICA (Nuclotron-based Ion Collider fAcility) project at the Joint Institute for Nuclear Research (JINR, Dubna, Russia) is aimed at the construction of a new accelerator complex for heavy ions and polarized particles. Heavy-ion collisions at NICA are planned to be studied in the region of the highest net-baryon density, which favors the formation of bound nuclear systems with strangeness hypernuclei. The multipurpose detector (MPD) at NICA is designed to reconstruct interactions of relativistic nuclei in a high-multiplicity environment. In this paper, we report the feasibility study results for the reconstruction of Λ 3 H, Λ 4 H and Λ 4 He in Bi+Bi collisions at the nucleon-nucleon center-of-mass energy, s N N = 9.2 GeV. [ABSTRACT FROM AUTHOR]

The production of nuclei and hypernuclei is of interest for experimental and theoretical studies: it is a big question how such weakly bound objects survive in a hot, dense environment and which new insights on the heavy-ion collisions dynamics they can bring us. We present the results on the hypernuclei feasibility study for the flagship Nuclotron-based Ion Collider fAcility (NICA)/Multi-Purpose Detector (MPD) experiment at the Joint Institute for Nuclear Research (JINR) in Dubna using the Parton-Hadron-Quantum-Molecular Dynamics (PHQMD) transport approach and a realistic reconstruction chain. [ABSTRACT FROM AUTHOR]

Enrico Brambilla,1 Tanner J Ferguson,2 Nathan Chu,1 David Ammar,3 Paul Yoo1 1Equinox Ophthalmic, Inc., Newport Beach, CA, USA; 2Vance Thompson Vision, Sioux Falls, SD, USA; 3Lions Eye Institute for Transplant & Research, Tampa, FL, USACorrespondence: Tanner J Ferguson, Vance Thompson Vision, 3101 W. 57th St, Sioux Falls, SD, USA, Email tannerferg@gmail.comPurpose: This is a 2-part study to investigate the agreement between pneumatonometry and direct pressure transducer intraocular pressure (IOP) measurements in a perfusion organ culture (POC) model where (1) the perfusion fluid column is open to atmospheric pressure, holding IOP constant to permit evaluation of the impact of negative pressure (NP) on IOP measurements, and (2) the perfusion fluid column is a closed system, allowing IOP to vary with NP application.Methods: The first part incorporated a fluid column open to atmospheric pressure, maintaining IOP constant to permit evaluation of the effect of applied NP on IOP measurement accuracy. In the second part, the POC column was closed, allowing IOP to vary with NP application and permit evaluation of agreement between pneumatonometry and pressure transducer measurements. In each part, four perfused tissues were used in thirteen paired pre-set IOP (10, 20, 25, 30 mmHg) and NP (0, 5, 10, 15, 20 mmHg) combinations, resulting in a total of 1040 paired measurements (520 per study). The difference in IOP measurements (Δ IOP = Excursion tonometry – pressure transducer) was calculated at each paired configuration.Results: During the first part, the mean Δ IOP was − 0.7 ± 1.6 mmHg across all measurements. During the second part, the mean Δ IOP across all measurements was +0.7 ± 1.4 mmHg. At NP settings of − 5, − 10, − 15, and − 20 mmHg, across all pre-set IOPs, the mean IOP reduction via Excursion tonometry was 3.1 ± 0.3, 5.6 ± 1.3, 8.5 ± 1.7 and 11.2 ± 1.8 mmHg, respectively.Conclusion: Measurement of IOP via Excursion tonometry yields results within the accuracy range of the pneumatonometry device (per manufacturer) and is minimally impacted by NP application. The IOP-lowering results are consistent with previous studies and further support the effectiveness of the Multi-Pressure Dial in lowering IOP relative to atmospheric pressure.Keywords: tonometry, intraocular pressure, IOP, multi-pressure dial, MPD, ophthalmic techniques, diagnostics

MPDRoot is an off-line software framework for simulation, reconstruction, and physical analyses of the simulated or experimental data for MPD experiment at NICA collider. The experiment is projected to run for a few decades and to obtain ~ 108 events of heavy ion collisions for physics analysis. Hence, provided software must be sufficiently flexible, resilient, robust to be used, developed, and maintainable for the full lifetime of the experiment and the analysis of its data. In this paper, we describe the effective and efficient implementation of build automatization, configuration, and installation of the software (DevOps) for the development and use of the MPDRoot, playing crucial role for the success of the whole MPD project in the future. Compared to previously existing state, the major improvement requirements were to reduce the complexity and to increase the universality of these deployment related actions for various system and hardware configurations. We show how this was achieved by the use of containers to deploy unified development and user environment with CernVM-FS service to dynamically load built modularized software from CernVM-FS server located in existing JINR infrastructure. Typical MPDRoot DevOps operations, being before heavy, cumbersome, and time-consuming, are now scaled down to running few commands accompanied by short deployment guide, significantly reducing possibility of errors on end-user and developer side. Above all, the main benefit of the current implementation is its wide compatibility and full modularization, making it easy to maintain, upgrade, and to identify the source of potential issues in the future.

The short-lived hadronic resonances are used to study the properties of the hot and dense medium produced in the relativistic heavy-ion collisions. The resonance masses and widths, yields and mean transverse momenta measured in the hadronic decay channels probe different stages of the nuclear collisions and are most sensitive to strangeness production, collective flow and hadronization mechanisms as well as to lifetime and density of the hadronic phase. In this contribution, we discuss line shape modifications for short-lived resonances and their consequences for the yields and shapes of the production spectra measured in heavy-ion collisions at intermediate collision energies, s NN ∼ 1 0 GeV. Capabilities of the MPD facility at NICA to reconstruct resonances in Bi+Bi collisions at s NN = 9. 2 GeV are presented and discussed. [ABSTRACT FROM AUTHOR]

The road surface texture is responsible for controlling several quality/safety road indicators, such as friction, noise, and fuel consumption. Road texture can be classified into different wavelengths, and it is dependent on the material used in the paving solution. With the aim of evaluating and characterizing the surface texture of a microsurfacing road pavement, six microsurfacing samples were made in the laboratory with both traditional materials (basaltic aggregates and bituminous emulsion) and with innovative materials from recycling procedures (crumb rubber (CR) and artificial engineered aggregate (AEA)). The characterization was performed through the use of a conoscopic holography profilometer with high precision and post-processing of the profiles detected through consolidated algorithms (ISO standards). We found that the aggregate type plays a very important role in the pavement texture. The binder agent seems to be highly important, but more studies regarding this are necessary. The use of crumb rubber as an aggregate proved to be feasible, and the texture parameters that were obtained were in accordance with the benchmark ones. In addition, the study shows that the use of artificial engineered aggregates does not impair the surface texture. Finally, the use of the texture parameters defined by the ISO standards, together with a statistical analysis, could be useful for defining the surface texture characteristics of microsurfacing. [ABSTRACT FROM AUTHOR]

At present, the casing program design of Managed pressure drilling (MPD) relies on artificial experience to determine the optimal pressure control parameters and wellbore Equivalent cycle density (ECD) in open hole section, which leads to heavy workload, lack of scientific basis for design and accuracy of results. By analyzing the feasibility of artificial bee colony (ABC) algorithm to solve the optimization problem of pressure control parameters, a casing program design method for MPD based on ABC algorithm is proposed. This method can intelligently and efficiently analyze ECD profile in the wellbore samples under different pressure control parameters, and accurately optimize ECD profile in the wellbore and its pressure control parameters according to the safe drilling fluid density window in the open hole section, so as to obtain the accurate maximum safe running depth of each layer casing. The example analysis shows that the ABC algorithm can optimize the maximum running depth of the second layer casing and its pressure control parameters in 370 steps, which not only reduces the workload of manual calculation, but also improves the scientificity of the design process and the accuracy of the design results. [ABSTRACT FROM AUTHOR]

Managed pressure drilling (MPD) is defined as "an adaptive drilling process used to precisely control the annular pressure profile throughout the wellbore" in API RP 92M. The MPD technology became known in the early 2000s and is now getting common practices for drilling a well with a narrow drilling window, such as high-pressure/high-temperature (HPHT) and deepwater wells, and provides a function of early kick detection by reading accurate mud return rate at Coriolis flow meter. In 2021, JX Nippon Oil & Gas Exploration drilled a HPHT exploration well by utilizing MPD services provided by Weatherford in Malaysia. This paper introduces essential points in MPD planning and actual MPD experience while drilling operations including MPD related challenges during the HPHT exploration well drilling. [ABSTRACT FROM AUTHOR]

The article is devoted to the interaction of the police and the elected bodies of Greater London-its Administration and municipal districts (boroughs) - in ensuring law and order. Both the history of the issue and its current state are touched upon. The foreign experience of interaction of the authorities in the maintenance of public security is of interest to the Russian Federation, which continues to search for effective forms of regional and municipal government, its place in the implementation of state functions. The experience of the United Kingdom is of particular interest in this regard, since in this country, the municipal and regional (self) government has historically developed significantly. The article mainly uses political and legal documents as sources of information. The author concludes that historically municipalities and local social forces played a crucial role in ensuring public security. It was typically for a «small state» with a tiny bureaucratic apparatus. Then government bodies played this role. Changes in the organization of the police were associated with the transition from the traditional rural society to modern urbanized. This required the creation of a professional centrally managed police force. The reform lasted for several decades. It’s important stage – Home office secretary R. Peel′s activity. Currently, efforts are being made to entrust the elected regional and municipal authorities with a new mission in ensuring public security – the exercise of democratic control over the activities of the police. In London this control is carried out by the mayor and the city council – Assembly. Municipal districts coordinate the activities of public services, civil, non-profit organization, business and individual citizens to ensure security in their territory.

Despite technical advances in recent decades and a decrease in hospital mortality (<5%), pancreaticoduodenectomy (PD) is still associated with major postoperative complications, even in high-volume centers. The present study aimed to assess the effect of a modified reconstruction technique on postoperative morbidity and mortality. A cohort study of all patients (n=218) undergoing PD between January 2010 and December 2019 was performed at Attikon University Hospital (Athens, Greece). Several variables were studied, including demographic data, past medical history, perioperative parameters, tumor markers and pathology, duration of hospitalization, postoperative complications, 30-day-survival, postoperative mortality and overall survival using multivariate logistic regression and survival analysis techniques. In this cohort, 123 patients [modified PD (mPD) group] underwent a modified reconstruction after a pylorus-preserving pancreaticoduodenectomy, which consisted of gastrojejunostomy and pancreaticojejunostomy on the same loop and an isolated hepaticojejunostomy on another loop. In the standard PD (StPD) group, 95 patients underwent standard reconstruction. The median age was 67 years, ranging from 25 to 89 years. Compared with in the StPD group, the mPD group had significantly lower rates of grade B and C pancreatic fistula (4.9% vs. 28.4%), delayed gastric emptying (7.3% vs. 42.1%), postoperative hemorrhage (3.3% vs. 20%), intensive care unit admission (8.1% vs. 18.9%), overall morbidity (Clavien-Dindo grade III-V: 14.7% vs. 42.0%), perioperative mortality (4.1% vs. 14.7%), and shorter hospitalization stay (11 days vs. 20 days). However, no difference was noted regarding median survival (35 months vs. 30 months). In this single-center series, a modified reconstruction after PD appears to be associated with improved postoperative outcomes. However, further evaluation in larger multi-center trials is required. [ABSTRACT FROM AUTHOR]

Two approaches related to the centrality determination in heavy-ion Multi-Purpose Detector (MPD) experiments, using charge-particles multiplicity in Time Projection Chamber (TPC) and the energy deposition in Forward Hadron Calorimeter (FHCal) are discussed. The main features of the FHCal are the fine transverse segmentation and the beam holes in the center of the calorimeters. Leaking the heavy non-interacting fragments (spectators) leads to ambiguity in the dependence of energy deposition in the FHCal on the collision centrality. However, the calorimeter transverse segmentation allows one to measure the energy distributions in each of the FHCal modules and to construct combined observables to resolve the problems associated with the beam hole. The comparison of these approaches in the collision centrality measurements is discussed.

This project was a continuation of a previous study that focused on the effects of pavement macrotexture on bicycle ride quality using input from bicycle club members and their bicycles on state highways, and considered changes to Caltrans chip seal specifications that resulted in seals with larger maximum size stones being typically used. This second project included a wider range of bicycle riders and bicycle types, considered pavement roughness and distresses in addition to macrotexture, and included measurements on urban preservation treatments and city streets as well as on treatments on state highways and county roads. This study also examined preservation treatment aggregate gradations and the mechanistic responses of bicycles to pavement macrotexture and roughness. The results of both projects were used to prepare recommended guidelines for the selection of preservation treatments that are best suited to bicycle routes on California’s state highways and local streets. Macrotexture, roughness, and pavement distresses were measured for different preservation treatments on 67 road sections distributed in five northern California and Nevada cities (Davis, Richmond, Sacramento, Reno, and Chico) and on a number of Caltrans highway sections and county roads. Bicycle ride quality surveys were conducted with a total of 155 participants. Correlations of pavement texture, bicycle vibration, and bicycle ride quality were developed. Correlations between pavement roughness and distresses, correlations between bicycle ride quality and roughness, and correlations between pavement texture and treatment specifications were preliminarily explored. Models for bicycle ride quality and physical rolling resistance were also developed. Long-term monitoring of pavement macrotexture for larger stone seals on LA-2, SLO-1, and Mon-198 was completed to determine how much texture is reduced by traffic. Major conclusions drawn from the results and analyses include the following: 1) changes in Caltrans chip seal gradation specifications have resulted in higher macrotexture values, as seen on example sections on LA-2, SLO-1, and Mon-198; 2) preliminary (first study on highways plus second study on streets) results show that 80 percent of riders rate pavements with mean profile depth (MPD) values of 1.8 mm or less as acceptable and 50 percent rate pavements with MPD values of 2.3 mm or less as acceptable; 3) most slurry seals on city streets produce high acceptability across all cities; 4) a clear relationship was found between the critical aggregates sizes (#4 and #8 [4.26 and 1.18 mm]) and MPD; 5) pavement texture generally tends to decrease over time due to traffic; 6) both IRI and MPD are important parameters for determining whether riders find a particular pavement section acceptable; 7) there is considerable variability among people and among sections that influences what bicyclists’ perceive as acceptable pavement condition; and 8) the presence of distresses, particularly cracking, lowers the ratings that riders give to pavements.

The study of hadronic resonance production is an essential part of the physical programs of many heavy-ion experiments. Detailed measurement of the resonance properties is also foreseen in the future Multi-Purpose Detector (MPD) experiment at the NICA collider. In this report, we focus on the experimental challenges for the reconstruction of resonances in heavy-ion experiments and examine the MPD capabilities for the reconstruction of ρ(770)0, K*(892)0,±, φ(1020), Λ(1520), Σ(1385)± and Ξ(1530)0.

Simple Summary: Mammary Paget's disease of the breast is an uncommon and often misdiagnosed breast malignancy. The review discusses the diagnosis, work-up, treatment, and prognosis of mammary Paget's disease. Mammary Paget's Disease is a non-invasive cutaneous malignancy of the breast involving the nipple-areolar complex that is commonly mistaken for benign breast conditions, leading to delay in diagnosis. This review article discusses Paget's disease etiology, clinical presentation, differential diagnosis, diagnostic work-up, natural history and prognosis. This article also discusses evolving strategies for the surgical and non-surgical management of Paget's disease. [ABSTRACT FROM AUTHOR]

Introduction: To investigate the effect of applying negative pressure (vacuum) to the periocular space on intraocular pressure (IOP) and retrobulbar pressure (RBP) by use of the Multi-Pressure Dial (MPD) system (Equinox Ophthalmic, Inc.). Methods: Two eyes of two full body cadavers were studied. In each subject, the retrobulbar space, posterior segment and intra-goggle space were cannulated to provide direct IOP, RBP and intra-goggle pressure measurements via a pressure transducer data acquisition system. The goggles of the MPD system were placed over the eyes of each subject, and multiple test runs were performed, with negative pressure settings programmed to 5, 10 and 20 mmHg. IOP and RBP measurements were continuously obtained during each run and plotted against time for analysis. Results: For both subjects, the mean reduction (± standard deviation) in IOP was 1.6 ± 0.9 (10%), 3.5 ± 1.8 (23%) and 5.6 ± 2.0 (37%) mmHg at programmed negative pressure levels of − 5, − 10 and − 20 mmHg, respectively. The overall mean change in RBP (mmHg) during negative pressure application was 0.02 ± 0.14 at − 5 mmHg, 0.03 ± 0.19 at − 10 mmHg and − 0.01 ± 0.18 at − 20 mmHg. In both subjects, the magnitude of RBP change during application of negative pressure fell below the uncertainty of the measurement system. Conclusions: The application of negative pressure to the periocular space with the MPD decreases IOP but does not affect RBP. [ABSTRACT FROM AUTHOR]

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The aim of the present study was to evaluate the acute effects of combined use of marijuana and Methylphenidate (MPD) on cognition performance of male rats. Rats received marijuana, MPD and co-administration of effective & ineffective doses of both. Spatial learning and memory were evaluated by Morris Water Maze (MWM) apparatus. MPD revealed significant beneficial effects on learning process while marijuana caused a significant impairment in learning. MPD administration did not attenuate the marijuana induced memory impairment. Co-administration of MPD and marijuana was associated with significant impairment in learning, without any significant effect on memory. [ABSTRACT FROM AUTHOR]

The Inner Tracker System (ITS) of the Multi-Purpose Detector (MPD) at Nuclotron-based Ion Collider fAcility (NICA) is responsible for detecting charmed particles with average decay lengths (λ) of several hundred micrometers. Monolithic active pixel sensors are adopted in the inner tracker. A high speed serializer presented in this paper is used to convert the parallel data from the front end of the pixel sensor chip into serial data and transmit the serial data off chip. A test chip of the serializer has been manufactured in a 180 nm process and the preliminary tests have been done. During the tests, 10-channel parallel data with a data rate of 425 Mbps is injected into the chip. The test results show that the output data rate is 4.25 Gbps. The measured power consumption is about 55.8 mW under the power supply of 1.8 V including the receiver and current-mode-logic driver. The power consumption of the core circuitry is estimated to be about 31.5 mW. The measured total jitter is about 49.37 ps at a bit error rate (BER) of <1 × 1 0 − 12 , and the output differential peak-to-peak value is up to 600 mV. • A high speed serializer is designed for MAPS. • The output data rate of the serializer is 4.25 Gbps. • The measured total jitter is 49.37 ps at a bit error rate (BER) of less than 10−12. • The output differential peak-to-peak value is up to 600 mV. [ABSTRACT FROM AUTHOR]

Managed Pressure Drilling (MPD) is a technology that allows for precise wellbore pressure control, especially in formations with uncertain geomechanics. The Rotating Control Device (RCD) is a crucial part of the MPD equipment but is prone to failure. Therefore, a new condition monitoring system was developed to improve the reliability of RCDs and eliminate their catastrophic failures during MPD jobs. Non-intrusive sensors were selected during the design of this condition monitoring system. Sensors measure: vibrations, acoustic emissions, rotation, pipe movement, temperatures, and contamination level in the coolant fluid. The system can display the measurements in real-time to the operator, giving early warnings to prevent the RCD's catastrophic failures during the job. Additionally, the data is recorded to allow further processing and analysis using ML and AI techniques. [ABSTRACT FROM AUTHOR]

This memorandum summarizes the results of measurements of macrotexture on a set of Caltrans and local government pavement surface treatments, and the results of bicycle vibration measurements and a survey of bicycle ride quality on most of those sections. The work was performed to address concerns raised by local bicyclists regarding ride quality after a modified-binder seal coat (chip seal) was placed on State Route 1 in San Luis Obispo County (SLO-1). The test sections that were used for the bicycle vibration and ride quality measurements included various surface treatments on existing chip seals on State Route 198 in Monterey County (Mon-198), several locations on SLO-1, and on other state highway and county road sections in Yolo, Butte, El Dorado, Placer, Sonoma, Marin, and San Mateo counties. Macrotexture was measured in terms of mean profile depth (MPD). Three different test methods were used to measure MPD: the sand patch method and the laser texture scanner (LTS), which provide measurements on a small area at a single location (about 12 square inches [100 square cm]); and the inertial profiler (IP), which is mounted on a vehicle and provides a continuous measurement in the longitudinal direction. Also presented are statistical correlations between macrotexture, roughness (in terms of International Roughness Index [IRI]), bicycle vibration, and bicycle ride quality for the initial set of treatment sections surveyed, and modeling of the relationships between macrotexture, roughness, vibration, and perceived ride quality for bicyclists. Conclusions are presented regarding the MPD values measured on various road sections, including those built with two 3/8" aggregate gradation chip seal specifications (one coarser than the other), and the variability of MPD found between sections built using the coarser 3/8" aggregate grading. Conclusions are also presented regarding the three MPD measurement methods. Findings are presented regarding the MPD values from other types of treatments, including possible treatments to be placed on SLO-1 to address a bicycle ride quality issue. Results are also presented regarding the effects of trafficking on MPD values. Correlations between bicycle vibration and MPD are shown, and between MPD, IRI, bicycle vibration, and bicyclists’ perception of ride quality and pavement acceptability for use by bicycles. Recommendations are made regarding a range of MPD values that might be used to select chip seal specifications based on “acceptability” where bicycle ride quality is an issue, selection of remedial treatments for SLO-1 based on the Mon-198 test sections, naming conventions for chip seals, and the use of additional rolling to reduce the texture of chip seals built using the coarser 3/8" aggregate grading.

The objectives of the four-year quieter concrete pavement research study presented in this report were to measure noise from tire/pavement interaction, pavement smoothness, and drainability characteristics of concrete pavement surface textures currently used on the California state highway network. This study also was undertaken to develop recommendations for safe, durable, and cost-effective concrete pavement surface textures that minimize noise from tire/pavement interaction. The fourth and final year of this research study included testing on 60 test sections grouped by texture type as follows: 27 diamond ground (DG), 12 diamond grooved (Gr), 19 longitudinally tined (LT), 1 burlap drag (BD), and 1 longitudinally broomed (LB). Five of the 60 test sections were continuously reinforced concrete pavement (CRCP) and the rest were jointed plain concrete pavement (JPCP). This report presents the results of measurements of tire/pavement interaction noise and of the pavement smoothness and surface drainability characteristics of concrete pavement textures commonly used for new construction finishes or pavement preservation and rehabilitation strategies. Tire/pavement interaction noise was measured using the on-board sound intensity (OBSI) method; smoothness was measured in terms of the International Roughness Index (IRI) using a wide-spot (RoLineTM) laser; pavement surface drainability was measured using outflow meter measurements as well as in terms of Mean Profile Depth (MPD) and Mean Texture Depth (MTD). The results indicate that the OBSI levels for the concrete pavement sections evaluated in this study ranged from 100 dBA to 112 dBA, which is the same as the range of OBSI levels for concrete pavement textures measured in other similar studies. The average OBSI levels for the three commonly used texture types in California (DG, Gr, and LT) where the textures were not worn out ranged from 104 to 107 dBA, with DG and Gr sections typically being quieter than LT sections of similar age and texture condition. For comparison, the OBSI levels for the experimental grind-and-groove sections averaged 101 dBA. The average IRI values for the DG, Gr, and LT sections across all three texture conditions (new, aged, or worn out) were 68, 81, and 96 inches/mile, respectively. The results for the outflow meter times and the MPD values indicate that diamond-grooved sections had a greater capacity for allowing water to move out from under the tire. This suggests that diamond-grooved concrete pavements would generally be more effective in reducing the risk of hydroplaning than diamond-ground or longitudinally tined concrete pavements.

The PICALM (CALM) gene, whose product is involved in clathrin-mediated endocytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT10 (AF10). We developed a mouse model of CALM-AF10(+) leukemia to examine the hypothesis that disruption of endocytosis contributes to leukemogenesis. Exclusion of the C-terminal portion of CALM from the fusion protein, which is required for optimal binding to clathrin, resulted in the development of a myeloproliferative disease, whereas inclusion of this domain led to the development of acute myeloid leukemia and changes in gene expression of several cancer-related genes, notably Pim1 and Crebbp. Nonetheless, the development of leukemia could not be attributed directly to interference with endocytosis or consequential changes in proliferation and signaling. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin. Using fluorescence resonance energy transfer analysis, we show that CALM-AF10 has a propensity to homo-oligomerize, raising the possibility that the function of endocytic proteins involved in chimeric fusions may be to provide dimerization properties, a recognized mechanism for unleashing oncogenic properties of chimeric transcription factors, rather than disrupting the internalization of growth factor receptors.

The hand is an organ of our body that fulfills a lot of different functions. Through efficiently functioning upper limbs, we experience and learn, communicate with the world, and gain independence. In the cerebral palsy, the role of the therapist is to properly plan the hand therapy process, it requires him to have a good knowledge of what MPD is, which is associated with movement symptoms and coexisting disorders that affect the child's abnormal development. The physiotherapist must properly assess the child's functional level, anticipate and plan therapy so that the child reaches its maximum development potential. This is not an easy task because virtually every child with cerebral palsy is different, other are its movement limitations, accompanying symptoms and the environment in which he is brought up.

Questions: Phylogenetic analyses provide important insights in the study of biological invasions. Previous studies have shown contrasting effects of alien species on the phylogenetic structure of recipient communities. In this study, we focus on two riparian plant communities with contrasting natural disturbance regimes: riparian forests and river bar communities. We ask whether these communities differ in alpha diversity and degree of plant invasion. Further, are the phylogenetic diversity (PD) and structure of these habitats related to the level of plant invasion? Location: Northern Spain. Methods: We determined level of plant invasion in forest and river bar vegetation plots, and calculated PD using mean pairwise distance (MPD) and mean nearest taxon distance (MNTD). We applied null models to analyse the phylogenetic structure of plots, and we tested whether inclusion of alien plant species was associated with differences in observed phylogenetic structure. Results: River bar plots experienced more invasion than forest plots, but the level of invasion was only related to the PD of native species in forests. Most plots had random phylogenetic structure, with a minority of plots tending to phylogenetic overdispersion in forests and to phylogenetic clustering in river bars. MPD increased with the inclusion of alien plant species in forest plots, suggesting phylogenetic overdispersion, while no such pattern was detected with MNTD. MPD increased slightly with increasing invasion in river bar plots, suggesting reduced clustering, while MNTD values decreased with increasing invasion, suggesting the opposite trend. Conclusions: Invasion by alien plants is differentially associated with phylogenetic structure in riparian habitats with different disturbance levels. Our results contrast with those of previous studies of plant invasion of riparian communities, which suggests geographic and ecological variation in the relationship between invasion and phylogenetic community structure in riparian systems. Research is needed to identify the causal factors underlying this variation. [ABSTRACT FROM AUTHOR]