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17 results on '"MXM-AXONIC"'

1. Evaluation of chronically implanted subdural boron doped diamond/CNT recording electrodes in miniature swine brain

Author

Christophe Gaude, Fabien Sauter-Starace, Jean-Louis Divoux, Thomas Costecalde, Jean-Paul Mazellier, Philippe Bergonzo, Pascal Mailley, Celine Cretallaz, Napoleon Torres-Martinez, Clément Hébert, Emmanuel Scorsone, David Ratel, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Clinatec - Centre de recherche biomédicale Edmond J.Safra (SCLIN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Département Microtechnologies pour la Biologie et la Santé (DTBS), Laboratoire Capteurs Diamant (LCD-LIST), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Thales Research and Technology [Palaiseau], THALES [France], MXM-AXONIC, European Project: 280433,EC:FP7:NMP,FP7-NMP-2011-SMALL-5,NEUROCARE(2012), CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and THALES

Subjects
Materials science, Biocompatibility, Swine, Biophysics, chemistry.chemical_element, Miniature swine, Biocompatible Materials, 02 engineering and technology, engineering.material, Electrochemistry, 01 natural sciences, Glial Fibrillary Acidic Protein, Surface roughness, Animals, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, Boron, 010401 analytical chemistry, Brain, Diamond, Electrochemical Techniques, General Medicine, 021001 nanoscience & nanotechnology, Electrodes, Implanted, Nanostructures, 0104 chemical sciences, Dielectric spectroscopy, chemistry, Dielectric Spectroscopy, Electrode, engineering, Swine, Miniature, 0210 nano-technology, Platinum, Biomedical engineering
Abstract

International audience; When implantable recording devices for brain or neural electrical activity are designed, the number of available materials for electrodes is quite limited. The material must be biocompatible with respect to ISO10993, its electrochemical properties must remain stable and the response of cells or tissues can be mitigated, especially on the glial scar. This involves electrode characterization pre- implantation and impedance spectroscopy during chronic implantation, in order to evaluate both electrode properties and performance. This study was aimed at a comparison of the long-term behavior of a nanostructured boron-doped diamond (BDD) with a nanostructured Platinum Iridium (PtIr) electrode. Firstly, a batch of cortical grids with bare and modified contacts (2 mm in diameter) was engineered for implantation. Secondly a miniature swine model was developed.This study highlighted the predominant role of electrode surface roughness on the quality of recordings. Rough PtIr contacts and BDD coated ones showed comparable behavior after three-month implantation with a slight increase of the modulus of the impedance and a tissue capsule. Nevertheless, immunohistochemistry analysis did not exhibit either a toxic or irritation reaction. With regard to biocompatibility, promising long term results are shown for both materials.

Published
2019

2. Selective neural electrical stimulation restores hand and forearm movements in individuals with complete tetraplegia

Author

Tigra, Wafa, Dali, Mélissa, William, Lucie, Fattal, Charles, Gélis, Anthony, Divoux, Jean-Louis, Coulet, Bertrand, Teissier, Jacques, Guiraud, David, Azevedo Coste, Christine, Contrôle Artificiel de Mouvements et de Neuroprothèses Intuitives (CAMIN), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre de Rééducation et de Réadaptation Fonctionnelles de La Chataigneraie [Menucourt] (CRRF), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, MXM-AXONIC, Hôpital Lapeyronie [Montpellier] (CHU), Clinique Médicale Beausoleil, and NEURINNOV

Subjects
Adult, Male, Tetraplegia, Movement, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Electric Stimulation Therapy, Quadriplegia, lcsh:RC321-571, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Young Adult, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Spinal Cord Injuries, Research, Middle Aged, Hand, Electrodes, Implanted, Median Nerve, Multicontact cuff electrode, body regions, Forearm, Grasping movement, Radial Nerve, Selective stimulation, Neural stimulation
Abstract

Background We hypothesized that a selective neural electrical stimulation of radial and median nerves enables the activation of functional movements in the paralyzed hand of individuals with tetraplegia. Compared to previous approaches for which up to 12 muscles were targeted through individual muscular stimulations, we focused on minimizing the number of implanted electrodes however providing almost all the needed and useful hand movements for subjects with complete tetraplegia. Methods We performed acute experiments during scheduled surgeries of the upper limb with eligible subjects. We scanned a set of multicontact neural stimulation cuff electrode configurations, pre-computed through modeling simulations. We reported the obtained isolated and functional movements that were considered useful for the subject (different grasping movements). Results In eight subjects, we demonstrated that selective stimulation based on multicontact cuff electrodes and optimized current spreading over the active contacts provided isolated, compound, functional and strong movements; most importantly 3 out of 4 had isolated fingers or thumb flexion, one patient performed a Key Grip, another one the Power and Hook Grips, and the 2 last all the 3 Grips. Several configurations were needed to target different areas within the nerve to obtain all the envisioned movements. We further confirmed that the upper limb nerves have muscle specific fascicles, which makes it possible to activate isolated movements. Conclusions The future goal is to provide patients with functional restoration of object grasping and releasing with a minimally invasive solution: only two cuff electrodes above the elbow. Ethics Committee / ANSM clearance prior to the beginning of the study (inclusion period 2016–2018): CPP Sud Méditerranée, #ID-RCB:2014-A01752–45, first acceptance 10th of February 2015, amended 12th of January 2016. Trial registration ( www.clinicaltrials.gov ): # NCT03721861 , Retrospectively registered on 26th of October 2018.

Published
2020

3. Six-months assessment of a hand prosthesis with intraneural tactile feedback

Author

Petrini, Francesco, Valle, Giacomo, Strauss, Ivo, Granata, Giuseppe, Di Iorio, Riccardo, d'Anna, Edoardo, Čvančara, Paul, Mueller, Matthias, Carpaneto, Jacopo, Clemente, Francesco, Controzzi, Marco, Bisoni, Lorenzo, Carboni, Caterina, Barbaro, Michael, Iodice, Francesco, Andreu, David, Hiairrassary, Arthur, Divoux, Jean-Louis, Cipriani, Christian, Guiraud, David, Raffo, Luigi, Fernandez, Eduardo, Stieglitz, Thomas, Raspopovic, Stanisa, Rossini, Paolo Maria, Micera, Silvestro, Fondation Bertarelli Chair inTranslational Neuroscience and Neuroengineering [Lausanne], Center for Neuroprosthetics and Institute of Bioengineering, EPFL.-Fondation Bertarelli, Università cattolica del Sacro Cuore [Roma] (Unicatt), Fondazione 'Policlinico Universitario A. Gemelli' [Rome], Bernstein Center Freiburg (BCF), Albert-Ludwigs-Universität Freiburg, Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Department of Electrical and Electronic Engineering [University of Cagliari] (DIEE), University of Cagliari, Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), MXM-AXONIC, University of Freiburg [Freiburg], Department of Health Sciences and Technology [ETH Zürich] (D-HEST), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), This work was supported by EU grant CP-FP-INFSO224012 (TIME project), the project NEMESIS (Neurocontrolled Mechatronic Hand Prosthesis) funded by the Italian Ministry of Health, EU grant FP7-611687 (NEBIAS, NEurocontrolled BIdirectional Artificial upperlimb and hand prosthesiS), EU grant FP7-HEALTH-1602547 (EPIONE, Natural Sensory Feedback for Phan-tom Limb Pain Modulation and Therapy), the SwissNational Science Foundation through the National Center of Competence in Research Robotics, and the Bertarelli Foundation., European Project: 602547,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,EPIONE(2013), European Project: 611687,EC:FP7:ICT,FP7-ICT-2013-10,NEBIAS(2013), Ecole Polytechnique Fédérale de Lausanne (EPFL)-Fondation Bertarelli, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
Neuroprosthetics, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Neural stimulation, Sensory feedback, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract

International audience; OBJECTIVE:Hand amputation is a highly disabling event, which significantly affects quality of life. An effective hand replacement can be achieved if the user, in addition to motor functions, is provided with the sensations that are naturally perceived while grasping and moving. Intraneural peripheral electrodes have shown promising results toward the restoration of the sense of touch. However, the long-term usability and clinical relevance of intraneural sensory feedback have not yet been clearly demonstrated.METHODS:To this aim, we performed a six months clinical study with three trans-radial amputees who received implants of transverse intrafascicular multichannel electrodes (TIMEs) in their median and ulnar nerves. After calibration, electrical stimulation was delivered through the TIMEs connected to artificial sensors in the digits of a prosthesis to generate sensory feedback, which was then used by the subjects while performing different grasping tasks.RESULTS:All the subjects, notwithstanding their important clinical differences, reported stimulation-induced sensations from the phantom hand for the whole duration of the trial. They also successfully integrated the sensory feedback into their motor control strategies while performing experimental tests simulating tasks of real life (with and without the support of vision). Finally, they reported a decrement of their phantom limb pain and a general improvement in mood state.INTERPRETATION:The promising results achieved with all subjects show the feasibility of the use of intraneural stimulation in clinical settings.

Published
2019

4. Support of Justification Elicitation: Two Industrial Reports

Author

Clément Duffau, Mireille Blay-Fornarino, Thomas Polacsek, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), MXM-AXONIC, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe MODALIS, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), ONERA - The French Aerospace Lab [Toulouse], and ONERA

Subjects
Soundness, Certification, Traceability, Requirements engineering, Computer science, 020206 networking & telecommunications, 020207 software engineering, 02 engineering and technology, Requirements elicitation, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], Justification, Documentation, Risk analysis (engineering), [INFO.INFO-IR]Computer Science [cs]/Information Retrieval [cs.IR], 0202 electrical engineering, electronic engineering, information engineering, PHYLOG, [INFO]Computer Science [cs], Product (category theory), Set (psychology), Quality requirements
Abstract

International audience; The result of productive processes is commonly accompanied by a set of justifications which can be, depending on the product, process-related qualities , traceability documents, product-related experiments, tests or expert reports, etc. In critical contexts, it is mandatory to substantiate that a product's development has been carried out appropriately which results in an inflation of the quantity of justification documents. This mass of document and information is difficult to manage and difficult to assess (in terms of soundness). In this paper, we report on the experience gained on two industrial case studies, in which we applied a justification elicitation approach based on justification diagrams and justification pattern diagrams in order to identify necessary and sufficient justification documentation.

Published
2018

5. Une sémantique pour les patrons de justification

Author

DUFFAU, Clément, Polacsek, Thomas, Blay-Fornarino, Mireille, Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), MXM-AXONIC, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe MODALIS, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), ONERA / DTIS, Université de Toulouse [Toulouse], and ONERA-PRES Université de Toulouse

Subjects
Certification, Ingénierie des exigences, Requirements engineering, Exigences de qualité, Ingénierie dirigée par les modèles, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], Model-driven engineering, Justification des transgressions, Quality requirements, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Justification
Abstract

International audience; The creation of a product, whether it is an object or a service, is accompanied by the production of justifications which may be, depending on the case, elements of conformity in the context of quality, traceability documents, experimental reports, expert reports, etc. In critical contexts, such as medical, railway or aeronautics, it is mandatory to convince a certifying authority that the development of a product has been carried out correctly. This obligation leads to an inflation of justification documents, which makes it difficult to read and to understand this set of justifications. To structure these justifications, it may be useful to use Justification Diagrams. However, these diagrams, while useful, are only an informal graphical notation. In this article, we define a formal semantics of the Justification Diagram and we give the first hints of what could be a software to support the design of such diagrams.; La création d'un produit, que cela soit un objet matériel ou un service, s'accompagne de la production de justifications qui peuvent être, suivant les cas, des éléments de conformité dans le cadre de la qualité, des documents de traçabilité, des rapports d'expérimentations, des rapports d'experts, etc. Dans des contextes critiques, comme le médical, le ferroviaire ou l'aéronautique, il est obligatoire de convaincre une autorité certificatrice, que le développe-ment d'un produit a été correctement réalisé. Cette obligation entraîne une inflation des documents justificatifs, inflation qui rend la lecture et la compréhension de cet ensemble de justifications difficile. Pour structurer ces justifications, il peut être utile d'utiliser des diagrammes de justification. Cependant, ces diagrammes, bien qu'utiles, ne sont qu'une notation graphique informelle. Dans cet article, nous définissons une sémantique formelle du diagramme de justification et nous donnons les premières pistes de ce que pourrait être un logiciel d'aide à la conception de tels diagrammes.

Published
2018

6. A novel EMG interface for individuals with tetraplegia to pilot robot hand grasping

Author

Christine Azevedo Coste, Andrea Cherubini, Benjamin Navarro, Charles Fattal, X. Gorron, Anthony Gelis, David Guiraud, Wafa Tigra, Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), MXM-AXONIC, Interactive Digital Humans (IDH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique (PRISME), Université d'Orléans (UO)-Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Euromov (EuroMov), Université de Montpellier (UM), Centre de Rééducation Fonctionnelle Divio [Dijon] (CRF COS Divio), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO)

Subjects
Adult, Male, Tetraplegia, 030506 rehabilitation, medicine.medical_specialty, Computer science, Interface (computing), Biomedical Engineering, Electromyography, Wrist, Quadriplegia, [SPI.AUTO]Engineering Sciences [physics]/Automatic, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, EMG, Robot hand, Control, Internal Medicine, medicine, Humans, [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], Patient Comfort, Assistive device, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Muscle, Skeletal, Set (psychology), Spinal Cord Injuries, Grip function, Modalities, Hand Strength, medicine.diagnostic_test, General Neuroscience, Rehabilitation, Robotics, Hand, Self-Help Devices, medicine.disease, body regions, medicine.anatomical_structure, Physical therapy, Feasibility Studies, 0305 other medical science, Algorithms, 030217 neurology & neurosurgery
Abstract

International audience; This article introduces a new human-machine interface for individuals with tetraplegia. We investigated the feasibility of piloting an assistive device by processing supra-lesional muscle responses online. The ability to voluntarily contract a set of selected muscles was assessed in five spinal cord-injured subjects through electromyographic (EMG) analysis. Two subjects were also asked to use the EMG interface to control palmar and lateral grasping of a robot hand. The use of different muscles and control modalities was also assessed. These preliminary results open the way to new interface solutions for high-level spinal cord-injured patients.

Published
2018

7. Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees

Author

Thomas Stieglitz, Riccardo Di Iorio, Paolo Maria Rossini, Jean-Louis Divoux, Ivo Strauss, Silvestro Micera, Stanisa Raspopovic, David Andreu, Francesco Iodice, Arthur Hiairrassary, Winnie Jensen, Giacomo Valle, Francesco Maria Petrini, David Guiraud, Roberto Romanello, Paul Čvančara, Loic Wauters, Giuseppe Granata, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Center for Neuroprosthetics [Geneva] (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Department of Microsystems Engineering [Freiburg] (IMTEK), University of Freiburg [Freiburg], Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), MXM-AXONIC, Center for Sensory-Motor Interaction (SMI), Aalborg University [Denmark] (AAU), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), European Project: 602547,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,EPIONE(2013), Università cattolica del Sacro Cuore [Roma] (Unicatt), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
Adult, Male, 0301 basic medicine, Nerve stimulation, Phantom hand, Electrical stimulator, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Stimulation, Somatosensory system, Amputation, Surgical, Imaging phantom, [SPI.AUTO]Engineering Sciences [physics]/Automatic, 03 medical and health sciences, 0302 clinical medicine, Amputees, Evoked Potentials, Somatosensory, Physiology (medical), Sensation, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Medicine, Somatosensory evoked potentials, Brain–computer interface, business.industry, Somatosensory Cortex, Middle Aged, Hand, Electric Stimulation, Sensory Systems, Somatosensory feedback, Robotic hand prosthesis, Settore MED/26 - NEUROLOGIA, 030104 developmental biology, Phantom Limb, Neurology, Somatosensory evoked potential, Neural interface, Neurology (clinical), Female, business, 030217 neurology & neurosurgery, Biomedical engineering
Abstract

International audience; ObjectiveThe aim of the paper is to objectively demonstrate that amputees implanted with intraneural interfaces are truly able to feel a sensation in the phantom hand by recording “phantom” somatosensory evoked potentials from the corresponding brain areas.MethodsWe implanted four transverse intrafascicular multichannel electrodes, available with percutaneous connections to a multichannel electrical stimulator, in the median and ulnar nerves of two left trans-radial amputees. Two channels of the implants that were able to elicit sensations during intraneural nerve stimulation were chosen, in both patients, for recording somatosensory evoked potentials.ResultsWe recorded reproducible evoked responses by stimulating the median and the ulnar nerves in both cases. Latencies were in accordance with the arrival of somatosensory information to the primary somatosensory cortex.ConclusionOur results provide evidence that sensations generated by intraneural stimulation are truly perceived by amputees and located in the phantom hand. Moreover, our results strongly suggest that sensations perceived in different parts of the phantom hand result in different evoked responses.SignificanceSomatosensory evoked potentials obtained by selective intraneural electrical stimulation in amputee patients are a useful tool to provide an objective demonstration of somatosensory feedback in new generation bidirectional prostheses.

Published
2018

8. Towards Embedded System Agile Development Challenging Verification, Validation and Accreditation: Application in a Healthcare Company

Author

Bartosz Grabiec, Mireille Blay-Fornarino, Clément Duffau, MXM-AXONIC, Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Subjects
justification, Engineering, agile development, business.industry, 010401 analytical chemistry, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], 02 engineering and technology, 01 natural sciences, 020202 computer hardware & architecture, 0104 chemical sciences, Continuous integration, continuous integration, 13. Climate action, Embedded system, Health care, 0202 electrical engineering, electronic engineering, information engineering, embedded systems, business, VV&A, Agile software development, Accreditation
Abstract

International audience; When Agile development meets critical embedded systems, verification, validation and accreditation activities are impacted. Challenges such as tests increase or accreditation documents production have to be managed in terms of time and resources. In this paper, we highlight these challenges and present a continuous integration ecosystem that aims to tackle these issues. We report on how this approach has been applied in a research and development healthcare company named AXONIC.

Published
2017

9. Vers l'argumentation automatique d'expérimentations : application à un portfolio de workflows

Author

DUFFAU, Clément, Camillieri, Cécile, Blay-Fornarino, Mireille, MXM-AXONIC, Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Subjects
[INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE]
Abstract

National audience; De nombreux systèmes sont construits aujourd'hui sur la base d'expérimentations à partir desquelles des connaissances sont apprises et construites. Ces connaissances évoluent en fonction des nouvelles expérimentations, de même que les systèmes qui les exploitent. Comment justifier la confiance dans ces systèmes non pas a posteriori mais au fur et à mesure de l'évolution de ces systèmes ? Au travers d'une étude de cas basée sur la mise au point d'un portfolio de Machine Learning nous présentons notre approche qui repose sur l'utilisation de graphes d'argumentation et leur construction automatique au fur et des évolutions de la base d'expérimentations et des connaissances acquises.

Published
2017

10. Effects of chronic abdominal vagal stimulation of small-diameter neurons on brain metabolism and food intake

Author

Chloé Picq, David Guiraud, Eric Bobillier, Charles-Henri Malbert, Jean-Louis Divoux, Christine Henry, US 1395 ANI-SCAN [INRA], Institut National de la Recherche Agronomique (INRA), MXM-AXONIC, Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), LivaNova France SAS, Projet PSPC INTENSE, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
Male, medicine.medical_specialty, Food intake, Vagal stimulation, Vagus Nerve Stimulation, Swine, Biophysics, PET imaging, 030209 endocrinology & metabolism, Stimulation, lcsh:RC321-571, [SPI.AUTO]Engineering Sciences [physics]/Automatic, 03 medical and health sciences, Eating, 0302 clinical medicine, Internal medicine, Medicine, Ingestion, Animals, Animal model, Evoked Potentials, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 2. Zero hunger, Neurons, Bariatric surgery, business.industry, General Neuroscience, digestive, oral, and skin physiology, Vagus Nerve, Metabolism, Pet imaging, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, pulson, Vagus nerve, Endocrinology, Anesthesia, Positron-Emission Tomography, Female, Neurology (clinical), Brainstem, business, 030217 neurology & neurosurgery, Brain Stem
Abstract

Supplementary data related to this article can be found at http://dx.doi.org/10.1016/j.brs.2017.04.126; International audience; Background :Abdominal bilateral vagal stimulation reduces food intake in animals. However, the classical square wave, mA range current generator is poorly effective to evoke action potentials on A∂ and C neurons that represent the majority of vagal neurons at the abdominal level.Objective/Hypothesis :(i) To ascertain the capability of very high-frequency stimulation schemes (pulsons) to trigger action potentials in abdominal vagal neurons in anaesthetized pigs. (ii) To compare these stimulation schemes with classical ones using PET imaging of brain metabolism and food intake behaviour in conscious pigs.Methods :The current thresholds for pulsons (S2 & S3) and millisecond pulses (S1) required to trigger action potentials were calculated in 5 anaesthetized pigs using single fibre recording. Similar stimulation protocols were compared chronically to sham stimulation in 24 pigs. After two weeks of chronic stimulation, food intake and brain metabolism were investigated. The electrical characteristics and histology of the vagus nerve were also studied.Results :S3 stimulation required a lower amount of charges to trigger an action potential. Chronically applied S2 & S3 activated the dorsal vagal complex and increased the metabolism of its afferent cortical structures. They also reduced energy intake together with a reduced ingestion of high fat and high sugar diets. All these effects were not observed for the S1 group. The vagal histology for the S1, S2 and S3 groups was not different from that of the sham.Conclusions :These findings demonstrate that pulsons applied bilaterally on the abdominal vagus reduced food intake as a consequence of the activation of the brainstem and higher-order brain areas.

Published
2017

11. Advanced 56 Channels Stimulation System to Drive Intrafascicular Electrodes

Author

Giuseppe Granata, Loic Wauters, David Guiraud, Arthur Hiairrassary, Thomas Guiho, David Andreu, Xavier Navarro, Jean-Louis Divoux, Thomas Stieglitz, Silvestro Micera, Winnie Jensen, Paul Čvančara, Victor Lopezalvarez, Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Universitat Autònoma de Barcelona (UAB), University of Freiburg [Freiburg], MXM-AXONIC, Università cattolica del Sacro Cuore [Roma] (Unicatt), Aalborg University [Denmark] (AAU), Ecole Polytechnique Fédérale de Lausanne (EPFL), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), and Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt)

Subjects
Software platform, Computer science, medicine.medical_treatment, Wearable computer, Stimulation, 03 medical and health sciences, 0302 clinical medicine, Software, experimental validation, Real-time Control System, Digital architecture, medicine, Neurostimulation, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, Electrical impedance, 030304 developmental biology, 0303 health sciences, business.industry, Pulse generator, MESH: methods, MESH: instrumentation, Electrode, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], business, 030217 neurology & neurosurgery, Biomedical engineering
Abstract

International audience; A wearable, 56-channel stimulator was developed and successfully tested to drive multichannel intrafascicular electrodes. It is able to safely elicit sensory afferent signals through the activation of 4 Time-4H intrafascicular electrodes. The STIMEP embeds not only the pulse generator but also a software that ensures: i) real time control by a hand-prosthesis, ii) embedded procedures for sensation mapping interfaced with a PC software, iii) impedance follow-up, iv) real-time safety management.

Published
2016

12. Du recueil d'expertises à la production de logiciels fiables Application aux systèmes de neurostimulation médicale

Author

DUFFAU, Clément, Blay-Fornarino, Mireille, MXM-AXONIC, Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Subjects
software product line, expert, génie logiciel, ligne de produits logiciels, connaissance, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], medical, ComputingMilieux_MISCELLANEOUS, software engineering, knowlegde
Abstract

National audience

Published
2016

13. Exploring selective neural electrical stimulation for upper limb function restoration

Author

B. Coulet, Chloé Picq, Jacques Teissier, Pawel Maciejasz, Anthony Gelis, David Guiraud, Wafa Tigra, Christine Azevedo Coste, Charles Fattal, Olivier Rossel, David Andreu, Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), MXM-AXONIC, Hôpital Lapeyronie [Montpellier] (CHU), Euromov (EuroMov), Université de Montpellier (UM), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Centre de Rééducation Fonctionnelle Divio [Dijon] (CRF COS Divio), Clinique Médicale Beausoleil, and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
0301 basic medicine, medicine.medical_specialty, Grasping function restoration, lcsh:Medicine, Stimulation, Wrist, lcsh:QM1-695, 03 medical and health sciences, Neural selectivity, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Orthopedics and Sports Medicine, Molecular Biology, Tetraplegia, 2016 IFESS Conference, Video recording, business.industry, lcsh:R, Cuff electrode, Cell Biology, lcsh:Human anatomy, medicine.disease, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, 030104 developmental biology, medicine.anatomical_structure, Electrical stimulation, Upper limb, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

International audience; This article introduces a new approach of selective neural electrical stimulation of the upper limb nerves. Median and radial nerves of individuals with tetraplegia are stimulated via a multipolar cuff electrode to elicit movements of wrist and hand in acute conditions during a surgical intervention. Various configurations corresponding to various combinations of a 12-poles cuff electrode contacts are tested. Video recording and electromyographic (EMG) signals recorded via sterile surface electrodes are used to evaluate the selectivity of each stimulation configuration in terms of activated muscles. In this abstract we introduce the protocol and preliminary results will be presented during the conference.

Published
2016

14. Vagus nerve stimulation: State of the art of stimulation and recording strategies to address autonomic function neuromodulation

Author

Pascal Couderc, Charles-Henri Malbert, Nicole Karam, Jean-Luc Bonnet, Philippe Mabo, Albert Hagège, Eloi Marijon, David Andreu, David Guiraud, Alfredo Hernandez, Virginie Le Rolle, Chloé Picq, Stéphane Bonnet, Guy Carrault, Pawel Maciejasz, Sandrine Maubert, Olivier Rossel, Christine Henry, Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Traitement du Signal et de l'Image (LTSI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), 3D Plus, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Sorin Group [Clamart], Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], MXM-AXONIC, US 1395 ANI-SCAN [INRA], Institut National de la Recherche Agronomique (INRA), INTENSE project, partially supported by BPI France within the ‘Investments for the Future’ program in France., Control of Artificial Movement and Intuitive Neuroprosthesis ( CAMIN ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Laboratoire d'Electronique et des Technologies de l'Information ( CEA-LETI ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Grenoble Alpes [Saint Martin d'Hères], Laboratoire Traitement du Signal et de l'Image ( LTSI ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Paris-Centre de Recherche Cardiovasculaire ( PARCC - U970 ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de cardiologie et maladies vasculaires, Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Institut national de la recherche agronomique [Rennes] ( INRA Rennes Bretagne-Normandie ), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent

Subjects
Autonomic function, Vagus Nerve Stimulation, medicine.medical_treatment, Biomedical Engineering, Cardiology, Stimulation, Heart failure, 030204 cardiovascular system & hematology, Autonomic Nervous System, Vagus nerve, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Morbid obesity, 03 medical and health sciences, Cellular and Molecular Neuroscience, Epilepsy, 0302 clinical medicine, [ SPI.AUTO ] Engineering Sciences [physics]/Automatic, medicine, Animals, Humans, Nervous System Physiological Phenomena, Obesity, Nutrition, gastro intestinal disorders, business.industry, medicine.disease, Neuromodulation (medicine), 3. Good health, [SPI.AUTO] Engineering Sciences [physics]/Automatic, Closed-loop control, Animal studies, business, Neuroscience, 030217 neurology & neurosurgery, Vagus nerve stimulation
Abstract

International audience; Objective. Neural signals along the vagus nerve (VN) drive many somatic and autonomic functions. The clinical interest of VN stimulation (VNS) is thus potentially huge and has already been demonstrated in epilepsy. However, side effects are often elicited, in addition to the targeted neuromodulation. Approach. This review examines the state of the art of VNS applied to two emerging modulations of autonomic function: heart failure and obesity, especially morbid obesity. Main results. We report that VNS may benefit from improved stimulation delivery using very advanced technologies. However, most of the results from fundamental animal studies still need to be demonstrated in humans.

Published
2016

15. Ergonomics of the control by a quadriplegic of hand functions

Author

Charles Fattal, David Guiraud, Wafa Tigra, Christine Azevedo Coste, MXM-AXONIC, Artificial movement and gait restoration (DEMAR), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
030506 rehabilitation, medicine.medical_specialty, Grasping, Assistive devices, Deltoid curve, Orthotics, Electromyography, Contracts, Spinal cord injury, Biceps, 03 medical and health sciences, [SPI]Engineering Sciences [physics], 0302 clinical medicine, Physical medicine and rehabilitation, Forearm, medicine, Functional electrical stimulation, Injuries, medicine.diagnostic_test, business.industry, Muscles, body regions, medicine.anatomical_structure, Upper limb, 0305 other medical science, Trapezius muscle, business, 030217 neurology & neurosurgery
Abstract

International audience; In subjects with complete Spinal Cord Injury (SCI) above C7, the four limbs are paralyzed (quadriplegia). Recovery of grasping movements is then reported as a priority. Indeed, most activities of daily living are achieved through upper limbs. Thus, restoration of hand and forearm active mobility could significantly increase independence and quality of life of these people and decrease their need of human aid. Although most of the subjects plebiscite pharmacological or biological solutions, only orthotics and Functional Electrical Stimulation (FES) allow, so far, to restore hand movements but they are rarely used. Limited ergonomics and comfort of piloting modes could partly explain the low usage of these systems. In this context, our aim is to explore possible solutions for subjects to interact with such devices. In this article, we propose to evaluate the capacity of active upper limb muscles contraction to be used to intuitively control FES in tetraplegic subjects. In this study, we assessed the ability to gradually contract different muscles: trapezius, deltoid, platysma and biceps. Three subjects with C6 to C7 neurological levels of lesion were included. We show that over the active upper limb muscles tested, contraction of the trapezius muscle was considered by the subjects as the most comfortable and could be employed as an intuitive mode of control of functional assistive devices.

Published
2015

16. Dispositif et système de contrôle du corps humain

Author

Guiraud, David, Andreu, David, Divoux, Jean-Louis, Charvin, Guy, Guiraud, David, Artificial movement and gait restoration (DEMAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), AXONIC - OBELIA dept, MXM-Laboratoires de Techologies Médicales, MXM-AXONIC, Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
[INFO.INFO-AR]Computer Science [cs]/Hardware Architecture [cs.AR], [INFO.INFO-MC]Computer Science [cs]/Mobile Computing, [INFO.INFO-AR] Computer Science [cs]/Hardware Architecture [cs.AR], [SPI.AUTO] Engineering Sciences [physics]/Automatic, informatique embarquée, [INFO.INFO-MC] Computer Science [cs]/Mobile Computing, Neuroprothèse, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract

Extension : 22/06/12 AU2011239791 (A1) CN102971043 (A) EP2558157 (A1) US2013110200 (A1); Dispositif de contrôle implantable dans un corps humain, comprenant une unité de commande (12) et au moins une électrode, ladite unité de commande (12) étant reliée à la ou chaque électrode pour la commander en stimulation et/ou en mesure, caractérisé en ce que l'unité de commande (12) comprend : - une horloge (44) de cadencement, - une mémoire (52) stockant des données de configuration définies pour permettre la configuration de la ou chaque électrode en correspondance d'identifiants, - une mémoire (54) stockant des données de programme décrivant un profil temporel en correspondance d'identifiants, - un exécuteur (48) activable en vue d'envoyer à la ou chaque électrode (14) des impulsions électriques correspondant à un programme donné selon une configuration d'électrode donnée, en fonction de l'horloge (44), - un séquenceur (46) agencé pour recevoir une pluralité ordonnée de couples comprenant chacun un identifiant de configuration d'électrode et un identifiant de programme, et pour activer sélectivement l'exécuteur (48) avec les couples de configuration d'électrode et de programme désignés par les couples d'identifiants reçus en entrée, en fonction de leur ordre et de l'horloge (44). Système de contrôle du corps humain comprenant un tel dispositif.

Published
2012

17. Improving confidence in experimental systems through automated construction of argumentation diagrams

Author

Clément Duffau, Mireille Blay-Fornarino, Cécile Camillieri, Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and MXM-AXONIC

Subjects
Management science, business.industry, Computer science, 020207 software engineering, 02 engineering and technology, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], Field (computer science), accreditation, Argumentation theory, Domain (software engineering), Workflow, Empirical research, argumentation, 0202 electrical engineering, electronic engineering, information engineering, Overhead (computing), Use case, confidence, Software engineering, business, Accreditation, experiment system, software engineering
Abstract

International audience; Experimental and critical systems are two universes that are more and more tangling together in domains such as biotechnologies or aeronautics. Verification, Validation and Accreditation (VV&A) processes are an everyday issue for these domains and the large scale of experiments needed to work out a system leads to overhead issues. All internal V&V has to be documented and traced to ensure that confidence in the produced system is good enough for accreditation organism. This paper presents and proposes a practical approach to automate the construction of argumentation systems based on empirical studies in order to represent the reasoning and improve confidence in such systems. We illustrate our approach with two use cases, one in the biomedical field and the other one in machine learning workflow domain.

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