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24. Progress of Cancer Stem Cells in Retinoblastoma

Author

Wang, Nan and Ma, Jian-Min

Abstract

The theory of cancer stem cells is a breakthrough discovery that offers exciting possibilities for comprehending the biological behavior of tumors. More and more evidence suggests that retinoblastoma cancer stem cells promote tumor growth and are likely to be the origin of tumor formation, drug resistance, recurrence, and metastasis. At present, some progress has been made in the verification, biological behavior, and drug resistance mechanism of retinoblastoma cancer stem cells. This article aims to review the relevant research and explore future development direction.

Published
2024
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25. Clinical Analysis of 16 Distant Metastatic Retinoblastoma Cases with Event-Free Survival

Author

Li, Nan, Wang, Yi-Zhuo, Huang, Dong-Sheng, Zhang, Yi, Zhang, Wei-Ling, Ma, Jian-Min, Zhou, Yan, and Liu, Ting-Ting

Subjects
Oncology, distant metastasis, Cancer Management and Research, comprehensive treatment, retinoblastoma, Original Research
Abstract

Nan Li,1,* Yi-Zhuo Wang,1,* Dong-Sheng Huang,1 Yi Zhang,1 Wei-Ling Zhang,1 Jian-Min Ma,2 Yan Zhou,1 Ting-Ting Liu1 1Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, 100176, People’s Republic of China; 2Department of Ophthalmic Oncology, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong-Sheng HuangDepartment of Pediatrics, Beijing Tongren Hospital, Capital Medical University, No. 2, Xihuan South Road, Yizhuang Economic and Technological Development Zone, Beijing, 100176, People’s Republic of China, Email Hds5180@sina.comAim: This study aimed to summarize the clinical characteristics, treatment, and outcomes of distant metastatic retinoblastoma with event-free survival.Design: Retrospective interventional case series.Methods: We screened patients with retinoblastoma who survived without events after the comprehensive treatment of distant metastases from June 2015 to February 2021 and collected information regarding their basic characteristics, diagnosis, and treatment. All patients received systemic intravenous chemotherapy. Other treatments included surgical treatment, radiotherapy, intrathecal chemotherapy, and autologous stem cell transplantation.Results: Among 780 hospitalized patients with retinoblastoma in the pediatric ward, a total of 94 patients with retinoblastoma were diagnosed with distant metastases, and 16 patients with distant metastatic retinoblastoma who survived more than 6 months without events were screened, including eight male and eight female patients. The median age of onset was 29 (range, 11– 120) months. Among the 16 patients, central nervous system metastasis (8/16), bone metastasis (8/16), bone marrow infiltration (4/16), lymph node metastasis (4/16), and parotid gland metastasis (3/16) were presented. All patients received treatment for more than 6 months, completed their regimen by February 2021, and survived without events. The median survival time after the onset of retinoblastoma was 50.5 (range, 23– 102) months, the median survival time after metastasis was 43.5 (range, 16– 71) months, and the median event-free survival was 29.0 (range, 6– 59) months.Conclusion: Metastatic retinoblastoma may benefit from comprehensive treatments including systemic intravenous chemotherapy and hematopoietic stem cell transplantation. However, recurrence after treatment still needs attention, and patients in complete remission still need long-term follow-up.Keywords: retinoblastoma, distant metastasis, comprehensive treatment

Published
2022

27. Analysis of clinical and pathological features of ciliary body medulloepithelioma

Author

He, Jing, Pei, Cheng, Ge, Xin, Ma, Jian-Min, and Hu, Ya-Guang

Subjects
Clinical Research
Abstract

AIM: To analyze and summarize the clinical and pathological features of ciliary body medulloepithelioma. METHODS: The clinical and pathological data of 11 patients (11 eyes) who were diagnosed with ciliary body medulloepithelioma at Beijing Tongren Hospital, Capital Medical University, from 2007 to 2021 were retrospectively analyzed. RESULTS: The initial symptoms of 11 patients included vision loss (6 eyes), atrophia bulbi (1 eye), proptosis (2 eyes), and leukocoria (2 eyes). Most patients suffered with corneal opacity, anterior chamber flare and hyphema. Iris neovascularization and synechia, complicated cataract, and secondary glaucoma occurred in several cases. Three patients even had lens subluxation and retinal detachment. B-scan ultrasonography showed vitreous opacity and a medium-high uneven echo mass in the eyeball. Ultrasound biomicroscopy examination showed a spherical or hemispherical ciliary body mass with uneven internal echoes and irregular cystic spaces. All of the 11 patients were diagnosed with malignant ciliary body medulloepithelioma by pathological evidence. In this study, 6 patients had enucleation (2 patients had systemic chemotherapy after surgery), and the other 5 patients had local tumor resection (1 patient had plaque radiotherapy after surgery). CONCLUSION: Ciliary body medulloepithelioma is a rare intraocular tumor and may be easily confused with retinoblastoma. Analyzing the clinical and pathological features of ciliary body medulloepithelioma is useful to further understand ciliary body medulloepithelioma, and can make an accurate diagnosis and better treatment.

Published
2023

29. Dependence Space-Based Model for Constructing Dual Concept Lattice in Sub-formal Context

Author

Ma, Jian-Min, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Yao, JingTao, editor, Yang, Yan, editor, Słowiński, Roman, editor, Greco, Salvatore, editor, Li, Huaxiong, editor, Mitra, Sushmita, editor, and Polkowski, Lech, editor

Published
2012
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34. Variable Threshold Concept Lattice and Dependence Space

Author

Ma, Jian-Min, Zhang, Wen-Xiu, Cai, Sheng, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Wang, Lipo, editor, Jiao, Licheng, editor, Shi, Guanming, editor, Li, Xue, editor, and Liu, Jing, editor

Published
2006
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42. Long‐term survival outcomes of patients with primary ocular adnexal MALT lymphoma: A large single‐center cohort study.

Author

Liang, Yuanzheng, Fu, Rui‐ying, Liu, Xue‐lin, Liu, Xin‐di, Piao, Ying‐shi, Ma, Jian‐min, and Wang, Liang

Subjects
ADNEXAL diseases, MUCOSA-associated lymphoid tissue lymphoma, SURVIVAL rate, NON-Hodgkin's lymphoma, TREATMENT effectiveness, WATCHFUL waiting
Abstract

Background: Primary ocular adnexal extranodal marginal zone mucosa‐associated lymphoid tissue lymphoma (OAML) is a rare subtype of non‐Hodgkin's lymphoma, and no consensus has been defined concerning the optimal treatment strategies. This study aims to investigate the associations of disease characteristics and different treatments with long‐term outcomes of patients with localized OAML. Methods: A large retrospective cohort study was conducted in a single‐center of China, and 166 patients with newly diagnosed primary localized OAML were enrolled. Detailed data of disease characteristics at diagnosis and treatments were collected for all patients. We compared treatment response and progression‐free survival (PFS) among patients with different characteristics and treatments. Results: Of the 166 patients, 52 received complete resection of neoplasm, whereas 114 had residual lesion after surgery. Among the 114 patients, 61 underwent watchful waiting and 53 received further treatment including localized radiotherapy, chemotherapy, or combined radiotherapy and chemotherapy. Median follow‐up was 49 months. A total of 31 patients had disease progression or relapse, including four patients with such event more than five years after initial treatment. The 5‐year PFS was 73.9%, 70.6%, and 85.9%, whereas the 10‐year PFS was 69.3%, 59.2%, and 79.3%, among patients with complete resection of neoplasm, patients in the watchful waiting group and patients with further treatment, respectively. Patients with further treatment had longer PFS, compared with patients in the watchful waiting group (p = 0.011). Bilateral involvement at diagnosis was associated with significantly inferior PFS (p = 0.029), whereas age, IPI score, or TNM staging were not associated with PFS. No serious adverse reaction was reported among patients with further treatment. Conclusions: Bilateral involvement was associated with poor prognosis. Among patients with residual lesions after surgery, further treatment was associated with improved survival. Patients with OAML might experience disease progression or relapse more than five years after initial treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Electrolyte perspective on stabilizing LiNi0.8Co0.1Mn0.1O2 cathode for lithium-ion batteries.

Author

Zhu, Xiao-Feng, Li, Xiu, Liang, Tian-Quan, Liu, Xin-Hua, and Ma, Jian-Min

Abstract

Copyright of Rare Metals is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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