This thesis explores the use of skin iron concentration, assessed using a portable x- ray fluorescence (PXRF) analyzer, as an indicator of liver iron concentration. Ultrasound images were acquired from four sites on human cadavers: thenar eminence (TE), between the metacarpophalangeal joint 1 and 2 (MJ), patella (P), and plantar arch (PA). Skin thickness was subsequently measured using boundary detection software applied to the ultrasound images. Skin iron concentrations, from the same sites, were obtained directly from 13 cadavers using a PXRF analyzer. As the iron concentrations determined using PXRF may have been impacted due to beam attenuation through the skin, these iron concentrations were subsequently corrected using the Beer-Lambert Law accounting for the skin thickness at each site. Huber XRF is a bulk tissue measurement system that was used to measure iron concentrations from the extracted samples of the four sites. The skin iron concentrations determined using both PXRF and Huber XRF were compared to evaluate the agreement between the two methods. As such, samples from the four sites were extracted and the iron concentrations of the extracted samples were measured using a Huber X-Ray Fluorescence (XRF) analyzer as the control. A statistically significant relationship with a p-value of