Search

Your search keyword '"Ma, Xiao‐jun"' showing total 699 results
Start Over Author "Ma, Xiao‐jun"
699 results on '"Ma, Xiao‐jun"'

1. NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing

Author

Feng, Wei, Beer, Joanne C., Hao, Qinyu, Ariyapala, Ishara S., Sahajan, Aparna, Komarov, Andrei, Cha, Katie, Moua, Mason, Qiu, Xiaolei, Xu, Xiaomei, Iyengar, Shweta, Yoshimura, Thu, Nagaraj, Rajini, Wang, Li, Yu, Ming, Engel, Kate, Zhen, Lucas, Xue, Wen, Lee, Chen-jung, Park, Chan Ho, Peng, Cheng, Zhang, Kaiyuan, Grzybowski, Adrian, Hahm, Johnnie, Schmidt, Susanne V., Odainic, Alexandru, Spitzer, Jasper, Buddika, Kasun, Kuo, Dwight, Fang, Lei, Zhang, Bingqing, Chen, Steve, Latz, Eicke, Yin, Yiyuan, Luo, Yuling, and Ma, Xiao-Jun

Published
2023
Full Text
View/download PDF

11. Ultrathin Sulfur‐Doped g‐C3N4 Nanosheets Controlled by Steam Activation for Enhanced Visible‐Light Photocatalytic Performance.

Author

Song, Wan‐Long, Zhang, Niu‐Niu, Ma, Xiao‐Jun, Liu, Xu‐Tong, Li, Dong‐Na, and Li, Jie

Subjects
NANOSTRUCTURED materials, NITRIDES, PHOTODEGRADATION, WASTEWATER treatment, ORGANIC compounds, THIOUREA
Abstract

Graphite carbon nitride (g‐C3N4) has garnered considerable attention due to its excellent photocatalytic properties for the degradation of organic matter in wastewater treatment. Herein, sulfur‐doped g‐C3N4 nanosheets (CN−S‐X) were successfully synthesized via physical steam activation using thiourea and urea as precursors. Comprehensive characterizations demonstrate that the enhanced photocatalysis is attributed to the ultrathin structure, highly active site, vacancy defects, and high specific surface area due to the synergy of S doping and steam activation. The as‐prepared CN−S‐25 photocatalyst exhibits a desirable degradation efficiency of 95.4 % for methylene blue dye with a high degradation rate of 2.65×10−2 min−1 under visible‐light irradiation, which are 2.1 and 5.52 times those for bulk g‐C3N4, respectively as well as good reusability and stability. This study provides a simple and promising strategy to regulate the nanostructure of g‐C3N4 for highly efficient photocatalytic degradation of organic pollutants. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Application of cottonseed meal instead of soybean meal protein diet in livestock and poultry production.

Author

TIAN Xiao-yu, MA Xiao-jun, LI Xue-mei, and ZHOU Yu-xiao

Subjects
*COTTONSEED meal, *DIETARY proteins, *SOY proteins, *SOYBEAN meal, *LIVESTOCK productivity, *COTTONSEED, *POULTRY breeding
Abstract

With the intensive development of animal husbandry, the demand for feed soybean meal increases. In order to promote the development of animal husbandry and ensure the supply and quality safety of feed in China, it is necessary to reduce the proportion of soybean meal and increase the development of protein feed resources and the supply of highquality feed. Cottonseed meal has high protein content, and the vitamin content is similar to that of soybean meal. Compared with soybean meal, cottonseed meal has a wide range of sources and is more affordable. However, cottonseed meal contains gossypol, which limits its application in animal production. Therefore, the dephenolization technology of cottonseed meal, the application of cottonseed meal instead of soybean meal in animal production and matters needing attention are summarized in the paper, which provides a reference for resource utilization of cottonseed meal, reducing livestock and poultry breeding cost and improving animal product quality. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

15. Study on quality and in vitro digestibility of mixed fermentation diets of reed grass and corn straw with different proportions.

Author

HE Yun, MA Si-rong, MA Xiao-jun, KONG Wei-hao, GAO Ya-jie, LI Xue-mei, TIAN Xiao-yu, and ZHOU Yu-xiang

Subjects
PHRAGMITES australis, CORN straw, WHEAT straw, CORNSTALKS, DIETARY fiber, PROBIOTICS, CORN as feed, FERMENTATION
Abstract

The experiment was to study the quality and in vitro digestibility of total mixed fermentation diet treated with different proportions of reed grass and corn straw. The concentrate to roughage ratio of the diet was 35:65, and each group has consistent composition of concentrate (corn 13%, soybean meal 7%, flax meal 6%, bran 4%, wolfberry residue 5%). The coarse materials were reed grass and corn straw in different proportions. Reed grass and corn stalk were mixed in fresh weight ratios of 0:10 (group A), 2:8 (group B), 4:6 (group C), 6:4 (group D), 8:2 (group E), and 10:0 (group F), respectively, and combined with 35% concentrate feed. Cellulase and compound probiotics were used to ferment the total mixed diet prepared with different proportions of reed grass and corn straw combined with concentrate. Each group was set with three replicates and fermented for 30 days. The results showed that when the ratio of concentrate to roughage was 35:65, and the daily feed underwent enzymatic complex treatment with a roughage composition of reed grass to corn stalk at a ratio of 2:8, the overall sensory quality of the feed was better, with higher conventional nutritional value, maximum gas production, and the best combined effect. The study indicates that the ratio of reed grass to corn straw in roughage is 2:8, which is helpful to improve the utilization rate of reed grass and straw feed, reduce feed cost, improve economic benefit. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

19. Supplementary Figure 4 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

Author

McDermott, Ultan, primary, Ames, Rachel Y., primary, Iafrate, A. John, primary, Maheswaran, Shyamala, primary, Stubbs, Hannah, primary, Greninger, Patricia, primary, McCutcheon, Kaitlin, primary, Milano, Randy, primary, Tam, Angela, primary, Lee, Diana Y., primary, Lucien, Laury, primary, Brannigan, Brian W., primary, Ulkus, Lindsey E., primary, Ma, Xiao-Jun, primary, Erlander, Mark G., primary, Haber, Daniel A., primary, Sharma, Sreenath V., primary, and Settleman, Jeffrey, primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figures 1-2 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

Author

McDermott, Ultan, primary, Ames, Rachel Y., primary, Iafrate, A. John, primary, Maheswaran, Shyamala, primary, Stubbs, Hannah, primary, Greninger, Patricia, primary, McCutcheon, Kaitlin, primary, Milano, Randy, primary, Tam, Angela, primary, Lee, Diana Y., primary, Lucien, Laury, primary, Brannigan, Brian W., primary, Ulkus, Lindsey E., primary, Ma, Xiao-Jun, primary, Erlander, Mark G., primary, Haber, Daniel A., primary, Sharma, Sreenath V., primary, and Settleman, Jeffrey, primary

Published
2023
Full Text
View/download PDF

21. Supplementary Figure 7 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

Author

McDermott, Ultan, primary, Ames, Rachel Y., primary, Iafrate, A. John, primary, Maheswaran, Shyamala, primary, Stubbs, Hannah, primary, Greninger, Patricia, primary, McCutcheon, Kaitlin, primary, Milano, Randy, primary, Tam, Angela, primary, Lee, Diana Y., primary, Lucien, Laury, primary, Brannigan, Brian W., primary, Ulkus, Lindsey E., primary, Ma, Xiao-Jun, primary, Erlander, Mark G., primary, Haber, Daniel A., primary, Sharma, Sreenath V., primary, and Settleman, Jeffrey, primary

Published
2023
Full Text
View/download PDF

22. Data from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

Author

McDermott, Ultan, primary, Ames, Rachel Y., primary, Iafrate, A. John, primary, Maheswaran, Shyamala, primary, Stubbs, Hannah, primary, Greninger, Patricia, primary, McCutcheon, Kaitlin, primary, Milano, Randy, primary, Tam, Angela, primary, Lee, Diana Y., primary, Lucien, Laury, primary, Brannigan, Brian W., primary, Ulkus, Lindsey E., primary, Ma, Xiao-Jun, primary, Erlander, Mark G., primary, Haber, Daniel A., primary, Sharma, Sreenath V., primary, and Settleman, Jeffrey, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 6 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

Author

McDermott, Ultan, primary, Ames, Rachel Y., primary, Iafrate, A. John, primary, Maheswaran, Shyamala, primary, Stubbs, Hannah, primary, Greninger, Patricia, primary, McCutcheon, Kaitlin, primary, Milano, Randy, primary, Tam, Angela, primary, Lee, Diana Y., primary, Lucien, Laury, primary, Brannigan, Brian W., primary, Ulkus, Lindsey E., primary, Ma, Xiao-Jun, primary, Erlander, Mark G., primary, Haber, Daniel A., primary, Sharma, Sreenath V., primary, and Settleman, Jeffrey, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Methods, Figures 1-8, Tables 1-3 from A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers

Author

Rothenberg, S. Michael, primary, Mohapatra, Gayatry, primary, Rivera, Miguel N., primary, Winokur, Daniel, primary, Greninger, Patricia, primary, Nitta, Mai, primary, Sadow, Peter M., primary, Sooriyakumar, Gaya, primary, Brannigan, Brian W., primary, Ulman, Matthew J., primary, Perera, Rushika M., primary, Wang, Rui, primary, Tam, Angela, primary, Ma, Xiao-Jun, primary, Erlander, Mark, primary, Sgroi, Dennis C., primary, Rocco, James W., primary, Lingen, Mark W., primary, Cohen, Ezra E.W., primary, Louis, David N., primary, Settleman, Jeffrey, primary, and Haber, Daniel A., primary

Published
2023
Full Text
View/download PDF

25. Supplementary Figure 5 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

Author

McDermott, Ultan, primary, Ames, Rachel Y., primary, Iafrate, A. John, primary, Maheswaran, Shyamala, primary, Stubbs, Hannah, primary, Greninger, Patricia, primary, McCutcheon, Kaitlin, primary, Milano, Randy, primary, Tam, Angela, primary, Lee, Diana Y., primary, Lucien, Laury, primary, Brannigan, Brian W., primary, Ulkus, Lindsey E., primary, Ma, Xiao-Jun, primary, Erlander, Mark G., primary, Haber, Daniel A., primary, Sharma, Sreenath V., primary, and Settleman, Jeffrey, primary

Published
2023
Full Text
View/download PDF

26. Supplementary Tables 1-2 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

Author

McDermott, Ultan, primary, Ames, Rachel Y., primary, Iafrate, A. John, primary, Maheswaran, Shyamala, primary, Stubbs, Hannah, primary, Greninger, Patricia, primary, McCutcheon, Kaitlin, primary, Milano, Randy, primary, Tam, Angela, primary, Lee, Diana Y., primary, Lucien, Laury, primary, Brannigan, Brian W., primary, Ulkus, Lindsey E., primary, Ma, Xiao-Jun, primary, Erlander, Mark G., primary, Haber, Daniel A., primary, Sharma, Sreenath V., primary, and Settleman, Jeffrey, primary

Published
2023
Full Text
View/download PDF

27. Data from A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers

Author

Rothenberg, S. Michael, primary, Mohapatra, Gayatry, primary, Rivera, Miguel N., primary, Winokur, Daniel, primary, Greninger, Patricia, primary, Nitta, Mai, primary, Sadow, Peter M., primary, Sooriyakumar, Gaya, primary, Brannigan, Brian W., primary, Ulman, Matthew J., primary, Perera, Rushika M., primary, Wang, Rui, primary, Tam, Angela, primary, Ma, Xiao-Jun, primary, Erlander, Mark, primary, Sgroi, Dennis C., primary, Rocco, James W., primary, Lingen, Mark W., primary, Cohen, Ezra E.W., primary, Louis, David N., primary, Settleman, Jeffrey, primary, and Haber, Daniel A., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figure 3 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors

Author

McDermott, Ultan, primary, Ames, Rachel Y., primary, Iafrate, A. John, primary, Maheswaran, Shyamala, primary, Stubbs, Hannah, primary, Greninger, Patricia, primary, McCutcheon, Kaitlin, primary, Milano, Randy, primary, Tam, Angela, primary, Lee, Diana Y., primary, Lucien, Laury, primary, Brannigan, Brian W., primary, Ulkus, Lindsey E., primary, Ma, Xiao-Jun, primary, Erlander, Mark G., primary, Haber, Daniel A., primary, Sharma, Sreenath V., primary, and Settleman, Jeffrey, primary

Published
2023
Full Text
View/download PDF

29. Gene Expression Profiles of Human Breast Cancer Progression

Author

Ma, Xiao-Jun, Salunga, Ranelle, Tuggle, J. Todd, Gaudet, Justin, Enright, Edward, McQuary, Philip, Payette, Terry, Pistone, Maria, Stecker, Kimberly, Zhang, Brian M., Zhou, Yi-Xiong, Varnholt, Heike, Smith, Barbara, Gadd, Michelle, Chatfield, Erica, Kessler, Jessica, Baer, Thomas M., Erlander, Mark G., and Sgroi, Dennis C.

Published
2003

31. NULISA: a novel proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing

Author

Feng, Wei, Beer, Joanne, Hao, Qinyu, Ariyapala, Ishara S, Sahajan, Aparna, Komarov, Andrei, Cha, Katie, Moua, Mason, Qiu, Xiaolei, Xu, Xiaomei, Iyengar, Shweta, Yoshimura, Thu, Nagaraj, Rajini, Wang, Li, Yu, Ming, Engel, Kate, Zhen, Lucas, Xue, Wen, Lee, Chen-jung, Park, Chan Ho, Peng, Cheng, Zhang, Kaiyuan, Grzybowski, Adrian, Hahm, Johnnie, Schmidt, Susanne V., Odainic, Alexandru, Spitzer, Jasper, Buddika, Kasun, Kuo, Dwight, Fang, Lei, Zhang, Bingqing, Chen, Steve, Latz, Eicke, Yin, Yiyuan, Luo, Yuling, and Ma, Xiao-Jun

Subjects
Article
Abstract

The blood proteome holds great promise for precision medicine but poses daunting challenges due to the low abundance of the majority of plasma proteins and the vast dynamic range across the proteome. We report the development and validation of a novel proteomic analysis technology – NUcleic acid Linked Immuno-Sandwich Assay (NULISA™) – that incorporates a dual capture and release mechanism to suppress the assay background to the minimum, thus drastically improving the signal-to-noise ratio. NULISA improves the sensitivity of the proximity ligation assay by over 10,000-fold to the attomolar level, which is enabled by antibody-conjugated DNA sequences that mediate the purification of immunocomplexes and contain target-and sample-specific barcodes for next-generation sequencing-based, highly multiplexed analysis. To demonstrate its performance and utility, we developed a 200-plex NULISA targeting 124 cytokines and chemokines and 80 other immune response-related proteins that demonstrated superior sensitivity for detecting low-abundance proteins and high concordance with other immunoassays. The ultra-high sensitivity enabled the detection of previously difficult-to-detect but biologically important, low-abundance biomarkers in patients with autoimmune diseases and COVID-19. Fully automated NULISA uniquely addresses longstanding challenges in the proteomic analysis of liquid biopsy samples and makes broad and in-depth proteomic analysis accessible to the general research community and future diagnostic applications.

Published
2023

39. Novel lncRNA‐prader willi/angelman region RNA, SNRPN neighbour( PWARSN)aggravates tubular epithelial cell pyroptosis by regulating TXNIP via dual way in diabetic kidney disease

Author

Song, Yi, primary, Guo, Feng, additional, Zhao, Yan‐yan, additional, Ma, Xiao‐jun, additional, Wu, Li‐na, additional, Yu, Ji‐feng, additional, Ji, Hong‐fei, additional, Shao, Ming‐wei, additional, Huang, Feng‐juan, additional, Zhao, Lin, additional, Fan, Xun‐jie, additional, Xu, Ya‐nan, additional, Wang, Qing‐zhu, additional, and Qin, Gui‐jun, additional

Published
2022
Full Text
View/download PDF

45. Novel lncRNA‐prader willi/angelman region RNA, SNRPN neighbour (PWARSN) aggravates tubular epithelial cell pyroptosis by regulating TXNIP via dual way in diabetic kidney disease.

Author

Song, Yi, Guo, Feng, Zhao, Yan‐yan, Ma, Xiao‐jun, Wu, Li‐na, Yu, Ji‐feng, Ji, Hong‐fei, Shao, Ming‐wei, Huang, Feng‐juan, Zhao, Lin, Fan, Xun‐jie, Xu, Ya‐nan, Wang, Qing‐zhu, and Qin, Gui‐jun

Subjects
DIABETIC nephropathies, EPITHELIAL cells, PYROPTOSIS, RNA-binding proteins, LINCRNA, NON-coding RNA, CIRCULAR RNA
Abstract

Objectives: Elevated thioredoxin‐interacting protein (TXNIP)‐induced pyroptosis contributes to the pathology of diabetic kidney disease (DKD). However, the molecular mechanisms in dysregulated TXNIP in DKD remain largely unclear. Materials and methods: Transcriptomic analysis identified a novel long noncoding RNA—Prader Willi/Angelman region RNA, SNRPN neighbour (PWARSN)—which was highly expressed in a proximal tubular epithelial cell (PTEC) under high glucose conditions. We focused on revealing the functions of PWARSN in regulating TXNIP‐mediated pyroptosis in PTECs by targeting PWARSN expression via lentivirus‐mediated overexpression and CRISPR‐Cas9‐based knockout in vitro and overexpressing PWARSN in the renal cortex by AAV‐9 targeted injection in vivo. A number of molecular techniques disclosed the mechanisms of PWARSN in regulating TXNIP induced‐pyroptosis in DKD. Results: TXNIP‐NOD‐like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome and PTEC pyroptosis were activated in the renal tubules of patients with DKD and in diabetic mice. Then we explored that PWARSN enhanced TXNIP‐driven PTECs pyroptosis in vitro and in vivo. Mechanistically, cytoplasmic PWARSN sponged miR‐372‐3p to promote TXNIP expression. Moreover, nuclear PWARSN interacted and facilitated RNA binding motif protein X‐linked (RBMX) degradation through ubiquitination, resulting in the initiation of TXNIP transcription by reducing H3K9me3‐enrichment at the TXNIP promoter. Further analysis indicated that PWARSN might be a potential biomarker for DKD. Conclusions: These findings illustrate distinct dual molecular mechanisms for PWARSN‐modulated TXNIP and PTECs pyroptosis in DKD, presenting PWARSN as a promising therapeutic target for DKD. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

48. Identification of Genotype-Correlated Sensitivity to Selective Kinase Inhibitors by Using High-Throughput Tumor Cell Line Profiling

Author

McDermott, Ultan, Sharma, Sreenath V., Dowell, Lori, Greninger, Patricia, Montagut, Clara, Lamb, Jennifer, Archibald, Heidi, Raudales, Raul, Tam, Angela, Lee, Diana, Rothenberg, S. Michael, Supko, Jeffrey G., Sordella, Raffaella, Ulkus, Lindsey E., Iafrate, A. John, Maheswaran, Shyamala, Njauw, Ching Ni, Tsao, Hensin, Drew, Lisa, Hanke, Jeff H., Ma, Xiao-Jun, Erlander, Mark G., Gray, Nathanael S., Haber, Daniel A., and Settleman, Jeffrey

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results