Author: "Maïté Rivollat" - Searchworks@Jio Institute Digital Library Search Results

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1. Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA

Author: Adam Benjamin Rohrlach, Maïté Rivollat, Patxuka de-Miguel-Ibáñez, Ulla Moilanen, Anne-Mari Liira, João C. Teixeira, Xavier Roca-Rada, Javier Armendáriz-Martija, Kamen Boyadzhiev, Yavor Boyadzhiev, Bastien Llamas, Anthi Tiliakou, Angela Mötsch, Jonathan Tuke, Eleni-Anna Prevedorou, Naya Polychronakou-Sgouritsa, Jane Buikstra, Päivi Onkamo, Philipp W. Stockhammer, Henrike O. Heyne, Johannes R. Lemke, Roberto Risch, Stephan Schiffels, Johannes Krause, Wolfgang Haak, and Kay Prüfer
Subjects: Science
Abstract: Abstract Aneuploidies, and in particular, trisomies represent the most common genetic aberrations observed in human genetics today. To explore the presence of trisomies in historic and prehistoric populations we screen nearly 10,000 ancient human individuals for the presence of three copies of any of the target autosomes. We find clear genetic evidence for six cases of trisomy 21 (Down syndrome) and one case of trisomy 18 (Edwards syndrome), and all cases are present in infant or perinatal burials. We perform comparative osteological examinations of the skeletal remains and find overlapping skeletal markers, many of which are consistent with these syndromes. Interestingly, three cases of trisomy 21, and the case of trisomy 18 were detected in two contemporaneous sites in early Iron Age Spain (800-400 BCE), potentially suggesting a higher frequency of burials of trisomy carriers in those societies. Notably, the care with which the burials were conducted, and the items found with these individuals indicate that ancient societies likely acknowledged these individuals with trisomy 18 and 21 as members of their communities, from the perspective of burial practice.
Published: 2024
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2. Étude biologique des sujets mésolithiques de l’Abri du Squelette (Les Eyzies, Dordogne, France)

Author: Patrice Courtaud, Maïté Rivollat, Gwénaëlle Goude, Adeline Le Cabec, Kevin Salesse, Christophe Snoeck, Diego López Onaindia, Nadine Tisnerat, Marie-France Deguilloux, Pierre Justeau, Dominique Henry-Gambier, Charlotte Debergue, Maëlle Couvrat, Nicolas Vanderesse, Mathilde Samsel, Jean-Pierre Chadelle, Catherine Cretin, and Alexandre Michel
Subjects: History of Civilization, CB3-482
Published: 2023

3. L’alimentation des premiers agropasteurs du Néolithique : apport de l’étude des microrestes du tartre dentaire des individus de la Roussille (Auvergne)

Author: Apolline Lambert, Robert C. Power, Laurent Bouby, Ivy Thomson, Sylvie Saintot, Domingo C. Salazar-García, Marie-France Deguilloux, Marie-Hélène Pemonge, Manon Lagoutte, Maïté Rivollat, Wolfgang Haak, Stéphane Rottier, Guillaume Leduc, and Gwénaëlle Goude
Subjects: History of Civilization, CB3-482
Published: 2023

4. Inférences sur les réseaux régionaux à partir d’arbres génétiques locaux, l’exemple du site néolithique de Gurgy 'les Noisats'

Author: Maïté Rivollat, Adam Benjamin Rohrlach, Harald Ringbauer, Ainash Childebayeva, Fanny Mendisco, Rodrigo Barquera, András Szolek, Heidi Colleran, Mélie Le Roy, Jonathan Tuke, Franziska Aron, Marie-Hélène Pemonge, Ellen Späth, Philippe Télouk, Léonie Rey, Gwénaëlle Goude, Vincent Balter, Johannes Krause, Stéphane Rottier, Marie-France Deguilloux, and Wolfgang Haak
Subjects: History of Civilization, CB3-482
Published: 2023

5. Les individus du dépôt multiple néolithique du site de Pontcharaud, Clermont-Ferrand (fouilles 1986) : guerriers ou morts d’accompagnement ?

Author: Aurore Schmitt, Maïté Rivollat, Aurore Lambert, Domingo Salazar-Garcia, Sébastien Villotte, Ana Arzelier, Antoine Sanz, Pauline Brige, Marie-Hélène Pemonge, Wolfgang Haak, Marie-France Deguilloux, and Gwénaëlle Goude
Subjects: History of Civilization, CB3-482
Published: 2023

6. Application de la morphométrie géométrique du labyrinthe osseux à l’analyse de la microévolution des humains en Europe de l’Ouest durant l’Holocène

Author: Charlotte Debergue, Patrice Courtaud, Bruno Maureille, Bernard Dedet, Henri Duday, Maïté Rivollat, Marie-France Deguilloux, Marta Lucas-Aragay, Christine Couture-Veschambre, Mélanie Pruvost, and Diego López-Onaindia
Subjects: History of Civilization, CB3-482
Published: 2023
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7. Neolithic genomic data from southern France showcase intensified interactions with hunter-gatherer communities

Author: Ana Arzelier, Maïté Rivollat, Harmony De Belvalet, Marie-Hélène Pemonge, Didier Binder, Fabien Convertini, Henri Duday, Muriel Gandelin, Jean Guilaine, Wolfgang Haak, Marie-France Deguilloux, and Mélanie Pruvost
Subjects: Biological sciences, Paleobiology, Paleogenetics, Science
Abstract: Summary: Archaeological research shows that the dispersal of the Neolithic took a more complex turn when reaching western Europe, painting a contrasted picture of interactions between autochthonous hunter-gatherers (HGs) and incoming farmers. In order to clarify the mode, the intensity, and the regional variability of biological exchanges implied in these processes, we report new palaeogenomic data from Occitanie, a key region in Southern France. Genomic data from 28 individuals originating from six sites spanning from c. 5,500 to c. 2,500 BCE allow us to characterize regional patterns of ancestries throughout the Neolithic period. Results highlight major differences between the Mediterranean and Continental Neolithic expansion routes regarding both migration and interaction processes. High proportions of HG ancestry in both Early and Late Neolithic groups in Southern France support multiple pulses of inter-group gene flow throughout time and space and confirm the need for regional studies to address the complexity of the processes involved.
Published: 2022
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8. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

Author: Adam B. Rohrlach, Luka Papac, Ainash Childebayeva, Maïté Rivollat, Vanessa Villalba-Mouco, Gunnar U. Neumann, Sandra Penske, Eirini Skourtanioti, Marieke van de Loosdrecht, Murat Akar, Kamen Boyadzhiev, Yavor Boyadzhiev, Marie-France Deguilloux, Miroslav Dobeš, Yilmaz S. Erdal, Michal Ernée, Marcella Frangipane, Mirosław Furmanek, Susanne Friederich, Emmanuel Ghesquière, Agata Hałuszko, Svend Hansen, Mario Küßner, Marcello Mannino, Rana Özbal, Sabine Reinhold, Stéphane Rottier, Domingo Carlos Salazar-García, Jorge Soler Diaz, Philipp W. Stockhammer, Consuelo Roca de Togores Muñoz, K. Aslihan Yener, Cosimo Posth, Johannes Krause, Alexander Herbig, and Wolfgang Haak
Subjects: Medicine, Science
Abstract: Abstract Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA studies often fail to utilize the unique perspective that the NRY can yield. Here we introduce a new DNA enrichment assay, coined YMCA (Y-mappable capture assay), that targets the "mappable" regions of the NRY. We show that compared to low-coverage shotgun sequencing and 1240 k capture, YMCA significantly improves the mean coverage and number of sites covered on the NRY, increasing the number of Y-haplogroup informative SNPs, and allowing for the identification of previously undiscovered variants. To illustrate the power of YMCA, we show that the analysis of ancient Y-chromosome lineages can help to resolve Y-chromosomal haplogroups. As a case study, we focus on H2, a haplogroup associated with a critical event in European human history: the Neolithic transition. By disentangling the evolutionary history of this haplogroup, we further elucidate the two separate paths by which early farmers expanded from Anatolia and the Near East to western Europe.
Published: 2021
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9. Origin and mobility of Iron Age Gaulish groups in present-day France revealed through archaeogenomics

Author: Claire-Elise Fischer, Marie-Hélène Pemonge, Isaure Ducoussau, Ana Arzelier, Maïté Rivollat, Frederic Santos, Hélène Barrand Emam, Alexandre Bertaud, Alexandre Beylier, Elsa Ciesielski, Bernard Dedet, Sophie Desenne, Henri Duday, Fanny Chenal, Eric Gailledrat, Sébastien Goepfert, Olivier Gorgé, Alexis Gorgues, Gertrud Kuhnle, François Lambach, Anthony Lefort, Amandine Mauduit, Florent Maziere, Sophie Oudry, Cécile Paresys, Estelle Pinard, Suzanne Plouin, Isabelle Richard, Muriel Roth-Zehner, Réjane Roure, Corinne Thevenet, Yohann Thomas, Stéphane Rottier, Marie-France Deguilloux, and Mélanie Pruvost
Subjects: Biological sciences, Evolutionary biology, Genetics, Genomics, Paleobiology, Paleogenetics, Science
Abstract: Summary: The Iron Age period occupies an important place in French history because the Gauls are regularly presented as the direct ancestors of the extant French population. We documented here the genomic diversity of Iron Age communities originating from six French regions. The 49 acquired genomes permitted us to highlight an absence of discontinuity between Bronze Age and Iron Age groups in France, lending support to a cultural transition linked to progressive local economic changes rather than to a massive influx of allochthone groups. Genomic analyses revealed strong genetic homogeneity among the regional groups associated with distinct archaeological cultures. This genomic homogenization appears to be linked to individuals’ mobility between regions and gene flow with neighbouring groups from England and Spain. Thus, the results globally support a common genomic legacy for the Iron Age population of modern-day France that could be linked to recurrent gene flow between culturally differentiated communities.
Published: 2022
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10. Explorer les structures sociales néolithiques grâce à la structure génétique de deux grandes familles à Gurgy 'les Noisats', France

Author: Maïté Rivollat, Harald Ringbauer, Adam Ben Rohrlach, Ainash Childebayeva, Mélie Le Roy, Léonie Rey, Gwenaëlle Goude, Vincent Balter, Stéphane Rottier, Marie-France Deguilloux, and Wolfgang Haak
Subjects: History of Civilization, CB3-482
Published: 2021
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11. Interactions biologiques entre chasseurs-cueilleurs et fermiers néolithiques : le cas remarquable des communautés du Sud de la France

Author: Ana Arzelier, Maïté Rivollat, Harmony De Belvalet, Marie-Hélène Pemonge, Didier Binder, Jean Guilaine, Fabien Convertini, Muriel Gandelin, Henri Duday, Wolfgang Haak, Marie-France Deguilloux, and Mélanie Pruvost
Subjects: History of Civilization, CB3-482
Published: 2021
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12. GENETIX : un état des lieux des populations de l’âge du Fer en France. Regards croisés de l’archéologie et de la génétique

Author: Claire-Elise Fischer, Marie-Hélène Pemonge, Isaure Ducoussau, Ana Arzelier, Maïté Rivollat, Frank Abert, Stéphanie Adroit, Hélène Barrand-Emam, Alexandre Bertaud, Alexandre Beylier, Anne Colin, Bernard Dedet, Stéphanie Desbrosse-Degobertiere, Sophie Desenne, Henri Duday, Antoine Dumas, Fanny Chenal, Eric Gailledrat, Sébastien Goepfert, Alexis Gorgues, Christian Jeunesse, Sophie Krausz, Gertrud Kuhnle, François Lambach, Amandine Mauduit, Florent Maziere, Sophie Oudry, Cécile Paresys, Estelle Pinard, Suzanne Plouin, Isabelle Richard, Muriel Roth-Zehner, Réjane Roure, Yohann Thomas, Florence Verdin, Stéphane Rottier, Marie-France Deguilloux, and Mélanie Pruvost
Subjects: History of Civilization, CB3-482
Published: 2020
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13. Multi-scale ancient DNA analyses confirm the western origin of Michelsberg farmers and document probable practices of human sacrifice.

Author: Alice Beau, Maïté Rivollat, Hélène Réveillas, Marie-Hélène Pemonge, Fanny Mendisco, Yohann Thomas, Philippe Lefranc, and Marie-France Deguilloux
Subjects: Medicine, Science
Abstract: In Europe, the Middle Neolithic is characterized by an important diversification of cultures. In northeastern France, the appearance of the Michelsberg culture has been correlated with major cultural changes and interpreted as the result of the settlement of new groups originating from the Paris Basin. This cultural transition has been accompanied by the expansion of particular funerary practices involving inhumations within circular pits and individuals in "non-conventional" positions (deposited in the pits without any particular treatment). If the status of such individuals has been highly debated, the sacrifice hypothesis has been retained for the site of Gougenheim (Alsace). At the regional level, the analysis of the Gougenheim mitochondrial gene pool (SNPs and HVR-I sequence analyses) permitted us to highlight a major genetic break associated with the emergence of the Michelsberg in the region. This genetic discontinuity appeared to be linked to new affinities with farmers from the Paris Basin, correlated to a noticeable hunter-gatherer legacy. All of the evidence gathered supports (i) the occidental origin of the Michelsberg groups and (ii) the potential implication of this migration in the progression of the hunter-gatherer legacy from the Paris Basin to Alsace / Western Germany at the beginning of the Late Neolithic. At the local level, we noted some differences in the maternal gene pool of individuals in "conventional" vs. "non-conventional" positions. The relative genetic isolation of these sub-groups nicely echoes both their social distinction and the hypothesis of sacrifices retained for the site. Our investigation demonstrates that a multi-scale aDNA study of ancient communities offers a unique opportunity to disentangle the complex relationships between cultural and biological evolution.
Published: 2017
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14. When the waves of European Neolithization met: first paleogenetic evidence from early farmers in the southern Paris Basin.

Author: Maïté Rivollat, Fanny Mendisco, Marie-Hélène Pemonge, Audrey Safi, Didier Saint-Marc, Antoine Brémond, Christine Couture-Veschambre, Stéphane Rottier, and Marie-France Deguilloux
Subjects: Medicine, Science
Abstract: An intense debate concerning the nature and mode of Neolithic transition in Europe has long received much attention. Recent publications of paleogenetic analyses focusing on ancient European farmers from Central Europe or the Iberian Peninsula have greatly contributed to this debate, providing arguments in favor of major migrations accompanying European Neolithization and highlighting noticeable genetic differentiation between farmers associated with two archaeologically defined migration routes: the Danube valley and the Mediterranean Sea. The aim of the present study was to fill a gap with the first paleogenetic data of Neolithic settlers from a region (France) where the two great currents came into both direct and indirect contact with each other. To this end, we analyzed the Gurgy 'Les Noisats' group, an Early/Middle Neolithic necropolis in the southern part of the Paris Basin. Interestingly, the archaeological record from this region highlighted a clear cultural influence from the Danubian cultural sphere but also notes exchanges with the Mediterranean cultural area. To unravel the processes implied in these cultural exchanges, we analyzed 102 individuals and obtained the largest Neolithic mitochondrial gene pool so far (39 HVS-I mitochondrial sequences and haplogroups for 55 individuals) from a single archaeological site from the Early/Middle Neolithic period. Pairwise FST values, haplogroup frequencies and shared informative haplotypes were calculated and compared with ancient and modern European and Near Eastern populations. These descriptive analyses provided patterns resulting from different evolutionary scenarios; however, the archaeological data available for the region suggest that the Gurgy group was formed through equivalent genetic contributions of farmer descendants from the Danubian and Mediterranean Neolithization waves. However, these results, that would constitute the most ancient genetic evidence of admixture between farmers from both Central and Mediterranean migration routes in the European Neolithization debate, are subject to confirmation through appropriate model-based approaches.
Published: 2015
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15. Ancient DNA gives new insights into a Norman Neolithic monumental cemetery dedicated to male elites

Author: Maïté Rivollat, Aline Thomas, Emmanuel Ghesquière, Adam Benjamin Rohrlach, Ellen Späth, Marie-Hélène Pemonge, Wolfgang Haak, Philippe Chambon, Marie-France Deguilloux, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, Max Planck Institute for Evolutionary Anthropology [Leipzig], Éco-Anthropologie (EA), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Institut national de recherches archéologiques préventives (Inrap), Centre de Recherche en Archéologie, Archéosciences, Histoire (CReAAH), Le Mans Université (UM)-Université de Rennes (UR)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Nantes Université - UFR Histoire, Histoire de l'Art et Archéologie (Nantes Univ - UFR HHAA), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), University of Adelaide, 2017-2018, Fondation Fyssen, ANR-17-FRAL-0010, ANR / DFG, 771234 - PALEoRIDER, European Union's Horizon 2020 research and innovation program, and ANR-17-FRAL-0010,INTERACT,Interactions entre groupes humains en Europe de l'Ouest durant la transition Mésolithique-Néolithique: la double perspective des échanges biologiques et culturels(2017)
Subjects: Male, Multidisciplinary, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Burial, History and Archaeology, Genomics, Middle Neolithic, monumental graves, DNA, Mitochondrial, Normandy, Archaeology, Humans, Cemeteries, Female, DNA, Ancient, ancient DNA, patrilineality, History, Ancient
Abstract: The Middle Neolithic in western Europe is characterized by monumental funerary structures, known as megaliths, along the Atlantic façade. The first manifestations of this phenomenon occurred in modern-day France with the long mounds of the Cerny culture. Here, we present genome-wide data from the fifth-millennium BCE site of Fleury-sur-Orne in Normandy (France), famous for its impressively long monuments built for selected individuals. The site encompasses 32 monuments of variable sizes, containing the burials of 19 individuals from the Neolithic period. To address who was buried at the site, we generated genome-wide data for 14 individuals, of whom 13 are males, completing previously published data [M. Rivollat et al., Sci. Adv. 6, eaaz5344 (2020)]. Population genetic and Y chromosome analyses show that the Fleury-sur-Orne group fits within western European Neolithic genetic diversity and that the arrival of a new group is detected after 4,000 calibrated BCE. The results of analyzing uniparentally inherited markers and an overall low number of long runs of homozygosity suggest a patrilineal group practicing female exogamy. We find two pairs of individuals to be father and son, buried together in the same monument/grave. No other biological relationship can link monuments together, suggesting that each monument was dedicated to a genetically independent lineage. The combined data and documented father–son line of descent suggest a male-mediated transmission of sociopolitical authority. However, a single female buried with an arrowhead, otherwise considered a symbol of power of the male elite of the Cerny culture, questions a strictly biological sex bias in the burial rites of this otherwise “masculine” monumental cemetery. Data Overview Genetic Identity, Demographic History Genetic Relatedness, Spatial Organization, and Social Inferences Concluding Remarks Materials and Methods
Published: 2022

16. New insights on Neolithic food and mobility patterns in Mediterranean coastal populations

Author: Lionel Gourichon, Laurent Bouby, Marie-France Deguilloux, Gwenaëlle Goude, Robert C. Power, Maïté Rivollat, Domingo C. Salazar-García, Marie-Hélène Pemonge, Didier Binder, Laboratoire méditerranéen de préhistoire Europe-Afrique (LAMPEA), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Gestion des ressources naturelles , environnements et sociétés (GReNES), Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre d'Études Préhistoire, Antiquité, Moyen-Age (CEPAM), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, and Université Nice Sophia Antipolis (... - 2019) (UNS)
Subjects: Mediterranean climate, 010506 paleontology, Provenance, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Range (biology), Human Migration, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Biodiversity, Biology, DNA, Mitochondrial, 01 natural sciences, Bone and Bones, Anthropology, Physical, [SHS]Humanities and Social Sciences, Isotopes, Animals, Humans, Dental Calculus, 0601 history and archaeology, Arqueologia Metodologia, 14. Life underwater, DNA, Ancient, History, Ancient, 0105 earth and related environmental sciences, 2. Zero hunger, 060102 archaeology, Mediterranean Region, Ecology, Stable isotope ratio, 06 humanities and the arts, Diet, Ancient DNA, Food, Phytolith, Anthropology, France, Species richness, Anatomy, Edible Grain
Abstract: OBJECTIVES The aims of this research are to explore the diet, mobility, social organization, and environmental exploitation patterns of early Mediterranean farmers, particularly the role of marine and plant resources in these foodways. In addition, this work strives to document possible gendered patterns of behavior linked to the neolithization of this ecologically rich area. To achieve this, a set of multiproxy analyses (isotopic analyses, dental calculus, microremains analysis, ancient DNA) were performed on an exceptional deposit (n = 61) of human remains from the Les Breguieres site (France), dating to the transition of the sixth to the fifth millennium BCE. MATERIALS AND METHODS The samples used in this study were excavated from the Les Breguieres site (Mougins, Alpes-Maritimes, France), located along the southeastern Mediterranean coastline of France. Stable isotope analyses (C, N) on bone collagen (17 coxal bones, 35 craniofacial elements) were performed as a means to infer protein intake during tissue development. Sulfur isotope ratios were used as indicators of geographical and environmental points of origin. The study of ancient dental calculus helped document the consumption of plants. Strontium isotope analysis on tooth enamel (n = 56) was conducted to infer human provenance and territorial mobility. Finally, ancient DNA analysis was performed to study maternal versus paternal diversity within this Neolithic group (n = 30). RESULTS Stable isotope ratios for human bones range from -20.3 to -18.1‰ for C, from 8.9 to 11.1‰ for N and from 6.4 to 15‰ for S. Domestic animal data range from -22.0 to -20.2‰ for C, from 4.1 to 6.9‰ for N, and from 10.2 to 12.5‰ for S. Human enamel 87 Sr/86 Sr range from 0.7081 to 0.7102, slightly wider than the animal range (between 0.7087 and 0.7096). Starch and phytolith microremains were recovered as well as other types of remains (e.g., hairs, diatoms, fungal spores). Starch grains include Triticeae type and phytolith includes dicotyledons and monocot types as panicoid grasses. Mitochondrial DNA characterized eight different maternal lineages: H1, H3, HV (5.26%), J (10.53%), J1, K, T (5.2%), and U5 (10.53%) but no sample yielded reproducible Y chromosome SNPs, preventing paternal lineage characterization. DISCUSSION Carbon and nitrogen stable isotope ratios indicate a consumption of protein by humans mainly focused on terrestrial animals and possible exploitation of marine resources for one male and one undetermined adult. Sulfur stable isotope ratios allowed distinguishing groups with different geographical origins, including two females possibly more exposed to the sea spray effect. While strontium isotope data do not indicate different origins for the individuals, mitochondrial lineage diversity from petrous bone DNA suggests the burial includes genetically differentiated groups or a group practicing patrilocality. Moreover, the diversity of plant microremains recorded in dental calculus provide the first evidence that the groups of Les Breguieres consumed a wide breadth of plant foods (as cereals and wild taxa) that required access to diverse environments. This transdisciplinary research paves the way for new perspectives and highlights the relevance for novel research of contexts (whether recently discovered or in museum collections) excavated near shorelines, due to the richness of the biodiversity and the wide range of edible resources available.
Published: 2020

17. Explorer les structures sociales néolithiques grâce à la structure génétique de deux grandes familles à Gurgy 'les Noisats', France

Author: Maïté Rivollat, Harald Ringbauer, Adam Ben Rohrlach, Ainash Childebayeva, Mélie Le Roy, Léonie Rey, Gwenaëlle Goude, Vincent Balter, Stéphane Rottier, Marie-France Deguilloux, and Wolfgang Haak
Subjects: Cultural Studies, Archeology, Anthropology
Abstract: L’exploration des structures de parenté dans les sociétés du passé a été au centre des études en archéologie et en anthropologie. Cependant, la reconstruction des liens de parenté biologique en contextes archéologiques a rarement été accessible. Avec le développement des méthodes d’analyses en ADN ancien, il est désormais possible d’obtenir des données génomiques pour de nombreux individus d’un même groupe, même dans le cas d’une faible conservation de l’ADN. Nous présentons ici de nouvelles ...
Published: 2022

18. Population genetics and signatures of selection in Early Neolithic European farmers

Author: Ainash Childebayeva, Adam Benjamin Rohrlach, Rodrigo Barquera, Maïté Rivollat, Franziska Aron, András Szolek, Oliver Kohlbacher, Nicole Nicklisch, Kurt W. Alt, Detlef Gronenborn, Harald Meller, Susanne Friederich, Kay Prüfer, Marie-France Deguilloux, Johannes Krause, and Wolfgang Haak
Subjects: PREDICTION, Human Migration, ANTIGEN, selection, SUSCEPTIBILITY, DNA, Mitochondrial, AGE, Genetics, Humans, COLOR, DNA, Ancient, GENOME-WIDE ASSOCIATION, Molecular Biology, neolithization, ancient DNA, History, Ancient, Ecology, Evolution, Behavior and Systematics, Farmers, BEHCETS-DISEASE, SORBS1 GENE, History and Archaeology, Linear Pottery culture, ANKYLOSING-SPONDYLITIS, Agriculture, DNA-BASED EYE, Europe, Genetics, Population, PATTERNS
Abstract: Human expansion in the course of the Neolithic transition in western Eurasia has been one of the major topics in ancient DNA research in the last 10 years. Multiple studies have shown that the spread of agriculture and animal husbandry from the Near East across Europe was accompanied by large-scale human expansions. Moreover, changes in subsistence and migration associated with the Neolithic transition have been hypothesized to involve genetic adaptation. Here, we present high quality genome-wide data from the Linear Pottery Culture site Derenburg-Meerenstieg II (DER) (N = 32 individuals) in Central Germany. Population genetic analyses show that the DER individuals carried predominantly Anatolian Neolithic-like ancestry and a very limited degree of local hunter-gatherer admixture, similar to other early European farmers. Increasing the Linear Pottery culture cohort size to ∼100 individuals allowed us to perform various frequency- and haplotype-based analyses to investigate signatures of selection associated with changes following the adoption of the Neolithic lifestyle. In addition, we developed a new method called Admixture-informed Maximum-likelihood Estimation for Selection Scans that allowed us test for selection signatures in an admixture-aware fashion. Focusing on the intersection of results from these selection scans, we identified various loci associated with immune function (JAK1, HLA-DQB1) and metabolism (LMF1, LEPR, SORBS1), as well as skin color (SLC24A5, CD82) and folate synthesis (MTHFR, NBPF3). Our findings shed light on the evolutionary pressures, such as infectious disease and changing diet, that were faced by the early farmers of Western Eurasia. Introduction New Approaches Results and discussion - Data generation and authentication. - Genome-wide data analysis. - Uniparentally inherited markers. - Biological Relatedness. - LBK inter-site comparisons. - Phenotypic analysis. - HLA class-I and II allele analysis. - Selection Scans Conclusions Material and methods - Archaeological background/site description. - Sample preparation. - Genotyping. - F-statistics - Biological Relatedness and ROH Analyses. - Mitochondrial and Y haplotype analysis. - Shotgun data. - HLA typing. - Selection scans. - AIMLESS Admixture-Informed Maximum-Likelihood Estimation for Selection Scans. - Haplotype-based scan.
Published: 2022

19. Origin and mobility of Iron Age Gaulish groups in present-day France revealed through archaeogenomics

Author: Claire-Elise Fischer, Marie-Hélène Pemonge, Isaure Ducoussau, Ana Arzelier, Maïté Rivollat, Frederic Santos, Hélène Barrand Emam, Alexandre Bertaud, Alexandre Beylier, Elsa Ciesielski, Bernard Dedet, Sophie Desenne, Henri Duday, Fanny Chenal, Eric Gailledrat, Sébastien Goepfert, Olivier Gorgé, Alexis Gorgues, Gertrud Kuhnle, François Lambach, Anthony Lefort, Amandine Mauduit, Florent Maziere, Sophie Oudry, Cécile Paresys, Estelle Pinard, Suzanne Plouin, Isabelle Richard, Muriel Roth-Zehner, Réjane Roure, Corinne Thevenet, Yohann Thomas, Stéphane Rottier, Marie-France Deguilloux, Mélanie Pruvost, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft, Archéologie et histoire ancienne : Méditerranée - Europe (ARCHIMEDE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Ausonius-Institut de recherche sur l'Antiquité et le Moyen âge, Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS), Archéologie des Sociétés Méditerranéennes (ASM), Université Paul-Valéry - Montpellier 3 (UPVM)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Trajectoires - UMR 8215, Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut national de recherches archéologiques préventives (Inrap), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)
Subjects: Multidisciplinary, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], STEPPE, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, History and Archaeology, GENOMIC HISTORY, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, DNA, ANCIENT
Abstract: Highlights•49 low coverage genomes from 27 sites from France, dated to ≈1200–80 years cal BCE•No major migration or population turnover between Bronze and Iron Age in France•A gradual North/South genetic structuration of IA populations•Evidence of individual mobility between regions and neighboring countriesSummaryThe Iron Age period occupies an important place in French history because the Gauls are regularly presented as the direct ancestors of the extant French population. We documented here the genomic diversity of Iron Age communities originating from six French regions. The 49 acquired genomes permitted us to highlight an absence of discontinuity between Bronze Age and Iron Age groups in France, lending support to a cultural transition linked to progressive local economic changes rather than to a massive influx of allochthone groups. Genomic analyses revealed strong genetic homogeneity among the regional groups associated with distinct archaeological cultures. This genomic homogenization appears to be linked to individuals’ mobility between regions and gene flow with neighbouring groups from England and Spain. Thus, the results globally support a common genomic legacy for the Iron Age population of modern-day France that could be linked to recurrent gene flow between culturally differentiated communities.
Published: 2021

20. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

Author: Marie-France Deguilloux, Agata Hałuszko, Maïté Rivollat, Sandra Penske, J. S. Díaz, Michal Ernée, Eirini Skourtanioti, Miroslav Dobeš, Cosimo Posth, Mario Küßner, Stéphane Rottier, Gunnar U. Neumann, Emmanuel Ghesquière, Susanne Friederich, Yılmaz Selim Erdal, Adam Ben Rohrlach, Rana Özbal, Svend Hansen, Marcella Frangipane, Marcello A. Mannino, Ainash Childebayeva, Consuelo Roca de Togores Muñoz, Sabine Reinhold, Murat Akar, Wolfgang Haak, Alexander Herbig, Luka Papac, Yavor Boyadzhiev, Domingo C. Salazar-García, Vanessa Villalba-Mouco, Kamen Boyadzhiev, Johannes Krause, K. Aslıhan Yener, Mirosław Furmanek, Marieke Sophia van de Loosdrecht, Philipp W. Stockhammer, European Commission, Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, University of Adelaide, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Spanish National Research Council (CSIC), Mustafa Kemal University, Bulgarian Academy of Sciences (BAS), Czech Academy of Sciences [Prague] (CAS), Hacettepe University = Hacettepe Üniversitesi, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], University of Wrocław [Poland] (UWr), State Office for Heritage Management and Archaeology Saxony-Anhalt - State Museum of Prehistory, Institut national de recherches archéologiques préventives (Inrap), Centre de Recherche en Archéologie, Archéosciences, Histoire (CReAAH), Le Mans Université (UM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Nantes Université (NU), German Archaeological Institute (DAI), Aarhus University [Aarhus], Koç University, Basque Foundation for Science (Ikerbasque), University of Cape Town, Departamento de Inteligencia Artificial [UPM, Spain] (DIA), Universidad Politécnica de Madrid (UPM), Universitat de València (UV), Medizinische Klinik und Poliklinik III [Bonn, Germany], Universitätsklinikum Bonn (UKB), MARQ - Museo Arqueológico Provincial de Alicante (MARQ), Ludwig Maximilian University [Munich] (LMU), New York University [New York] (NYU), NYU System (NYU), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, University of South Australia [Adelaide], Max Planck Society Foundation CELLEX, French (ANR) French National Research Agency (ANR), German (DFG) Research Foundations under the INTERACT project German Research Foundation (DFG) [ANR17-FRAL-0010, DFG-HA-5407/4-1], European Research Council (ERC) under the European Union European Research Council (ERC) [771234-PALEoRIDER], Czech Academy of Sciences Czech Academy of Sciences, Institute of Archaeology of the Czech Academy of Sciences, Prague Czech Academy of Sciences [RVO 67985912], Projekt DEAL, ANR-17-FRAL-0010,INTERACT,Interactions entre groupes humains en Europe de l'Ouest durant la transition Mésolithique-Néolithique: la double perspective des échanges biologiques et culturels(2017), Özbal, Rana (ORCID 0000-0001-6765-2765 & YÖK ID 55583), Rohrlach, A.B., Papac, L., Childebayeva, A., Rivollat, M., Villalba Mouco, V., Neumann, G.U., Penske, S., Skourtanioti, E., van de Loosdrecht, M., Akar, M., Boyadzhiev, K., Boyadzhiev, Y., Deguilloux, M.F., Dobes, M., Erdal, Y.S., Ernée, M., Frangipane, M., Furmanek, M., Friederich, S., Ghesquière, E., Ha?uszko, A., Hansen, S., Küßner, M., Mannino, M., Reinhold, S., Rottier, S., Salazar García, D.C., Diaz, J.S., Stockhammer, P.W., de Togores Muñoz, C.R., Yener, K.A., Posth, C., Krause, J., Herbig, A., Haak, W., College of Social Sciences and Humanities, Department of Archeology and History of Art, Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Université de Nantes (UN)-Le Mans Université (UM)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR Histoire, Histoire de l'Art et Archéologie (UFR HHAA), Université de Nantes (UN)-Université de Nantes (UN)-Ministère de la Culture (MC), Max Planck Society, Agence Nationale de la Recherche (France), German Research Foundation, European Research Council, Academy of Sciences of the Czech Republic, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Le Mans Université (UM)-Université de Rennes (UR)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR Histoire, Histoire de l'Art et Archéologie (UFR HHAA), and Ikerbasque - Basque Foundation for Science
Subjects: Czech, SELECTION, Population genetics, MITOCHONDRIAL-DNA, early farmers, DIVERSITY, mitochondrial DNA, shotgun sequencing, Prehistòria, Haplogroup, German, 0302 clinical medicine, Medicine and Health Sciences, DNA sequencing, Science and technology, media_common, 0303 health sciences, Multidisciplinary, Horizon (archaeology), Critical event, Shotgun sequencing, chromosomal haplogroups, European research, STEPPE, Western europe, language, Medicine, Genetic Markers, Mitochondrial DNA, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, uniparentally-inherited markers, Science, Library science, Biology, Y chromosome, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Target enrichment, Article, 03 medical and health sciences, Political science, Humans, media_common.cataloged_instance, ANCIENT DNA, Genetic Testing, European union, Alleles, 030304 developmental biology, MUTATION-RATE, Chromosomes, Human, Y, Saturation (genetic), History and Archaeology, Y-mappable capture assay, Ancient DNA, Neanderthals, Anatomically modern humans, language.human_language, Neolithic transition, Genetics, Population, Haplotypes, Evolutionary biology, GENOMIC HISTORY, 030217 neurology & neurosurgery
Abstract: Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA studies often fail to utilize the unique perspective that the NRY can yield. Here we introduce a new DNA enrichment assay, coined YMCA (Y-mappable capture assay), that targets the "mappable" regions of the NRY. We show that compared to low-coverage shotgun sequencing and 1240 k capture, YMCA significantly improves the mean coverage and number of sites covered on the NRY, increasing the number of Y-haplogroup informative SNPs, and allowing for the identification of previously undiscovered variants. To illustrate the power of YMCA, we show that the analysis of ancient Y-chromosome lineages can help to resolve Y-chromosomal haplogroups. As a case study, we focus on H2, a haplogroup associated with a critical event in European human history: the Neolithic transition. By disentangling the evolutionary history of this haplogroup, we further elucidate the two separate paths by which early farmers expanded from Anatolia and the Near East to western Europe., Open Access funding enabled and organized by Projekt DEAL. This study was funded by the Max Planck Society, the French (ANR) and German (DFG) Research Foundations under the INTERACT project (ANR-17-FRAL-0010, DFG-HA-5407/4-1, 2018-2021) to M.R. and W.H., the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under Grant agreement no. 771234-PALEoRIDER to W.H., the award Praemium Academiae of the Czech Academy of Sciences to M.E. and the project RVO 67985912 of the Institute of Archaeology of the Czech Academy of Sciences, Prague to M.S.
Published: 2021

21. Far from home: A multi-analytical approach revealing the journey of an African-born individual to imperial Rome

Author: Marie-France Deguilloux, Kevin Salesse, Robert H. Tykot, Marie-Hélène Pemonge, Arwa Kharobi, Nina Maaranen, Jaroslav Brůžek, Vincent Balter, Dominique Castex, Maïté Rivollat, Elise Dufour, History, Archeology, Arts, Philosophy and Ethics, Multidisciplinary Archaeological Research Institute, Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), and Université Bordeaux Montaigne (UBM)
Subjects: Archeology, dental morphology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, media_common.quotation_subject, Empire, Ancient history, Catacombs, Early life, mobility, Roman period, Capital (architecture), Forced migration, Ancient DNA, Geography, Residence, diet, ancient DNA, Lifeway, stable and radiogenic isotopes, media_common
Abstract: International audience; Rome saw its number of foreign individuals increase considerably as the empire expanded. These foreigners arrived as either free persons or slaves from the newly conquered provinces and nearfrontier zones and came to influence the whole life of the city. Yet relatively little is known about their life histories. In this study, we bring direct evidence for the first example of an African-born migrant, with an origin beyond the southern imperial border, discovered in Rome. Based on a multi-tissue sampling strategy including molar teeth and mandibular cortical bone, a multi-analytical approach including isotopic (δ 13 C, δ 15 N, δ 18 O, δ 34 S, 87 Sr/ 86 Sr), dental morphology (geometric morphometrics, nonmetric traits) and ancient DNA (mitochondrial DNA, Y chromosome) analyses allows reconstructing the journey and lifeway patterns of the individual US215/Mand1 buried in the mass grave from the catacombs of Saints Peter and Marcellinus. The successful isotopic and dental morphology analyses suggest that the individual was probably born in the vicinity of the Nile Valley or within the central Sahara Desert. Results also suggest a diachronic change of residence in the area during their early life. The way US215/Mand1 reached Rome is still hypothetical, although it seems likely that the individual could have undergone forced migration as a slave to the capital.
Published: 2021

22. GENETIX : un état des lieux des populations de l’âge du Fer en France. Regards croisés de l’archéologie et de la génétique

Author: Claire-Elise Fischer, Marie-Hélène Pemonge, Isaure Ducoussau, Ana Arzelier, Maïté Rivollat, Frank Abert, Stéphanie Adroit, Hélène Barrand-Emam, Alexandre Bertaud, Alexandre Beylier, Anne Colin, Bernard Dedet, Stéphanie Desbrosse-Degobertiere, Sophie Desenne, Henri Duday, Antoine Dumas, Fanny Chenal, Eric Gailledrat, Sébastien Goepfert, Alexis Gorgues, Christian Jeunesse, Sophie Krausz, Gertrud Kuhnle, François Lambach, Amandine Mauduit, Florent Maziere, Sophie Oudry, Cécile Paresys, Estelle Pinard, Suzanne Plouin, Isabelle Richard, Muriel Roth-Zehner, Réjane Roure, Yohann Thomas, Florence Verdin, Stéphane Rottier, Marie-France Deguilloux, and Mélanie Pruvost
Subjects: Cultural Studies, Archeology, Anthropology
Published: 2021

23. Ten millennia of hepatitis B virus evolution

Author: Oleg Balanovsky, Lourdes Marquez-Morfin, Magdalena Zoledziewska, Susannah J. Salter, Cody E. Parker, Kirsten I. Bos, Kathrin Nägele, Domingo C. Salazar-García, Kerttu Majander, Vittorio Mazzarello, Cosimo Posth, Kurt W. Alt, Elmira Khussainova, Silvia Teresita Hernández Godoy, Richard Mortimer, Ayshin Ghalichi, Alexander Herbig, Lars Fehren-Schmitz, Leyla B. Djansugurova, Dmitry A. Stashenkov, Raiko Krauß, Mikhail S. Chaplygin, Tiago Ferraz, Patrick Semal, Eva Rosenstock, Michal Kostka, Yavor Boyadzhiev, Harald Meller, Petr Limburský, Mario Küßner, Tara Ingman, Maïté Rivollat, Eva Fernández-Domínguez, Rodrigo Barquera, Robin Skeates, Kamen Boyadzhiev, Denise Kühnert, Mirjana Roksandic, Adam Ben Rohrlach, Alexandra P. Buzhilova, Alissa Mittnik, Yadira Chinique de Armas, Johannes Krause, Marie-France Deguilloux, Aleksandr Khokhlov, Rezeda I. Tukhbatova, Elizabeth Popescu, Lucy C. Salazar, Andrey A. Chizhevsky, Christopher Read, Hubert Steiner, Melanie Van Twest, Eveline Altena, Diana Iraíz Hernández-Zaragoza, Lyazzat Musralina, Megan Michel, Íñigo García-Martínez de Lagrán, Anatoly R. Kantorovich, Katrien Van de Vijver, Alžbeta Danielisová, Rachel Clarke, Duncan Sayer, Bastien Llamas, Nikolaj Makarov, Alejandro Romero, Luka Papac, Alessandra Sperduti, Vladimir E. Maslov, Rafael Garrido-Pena, Gunnar U. Neumann, Arman Z. Beisenov, Zainolla Samashev, Guido Alberto Gnecchi-Ruscone, Päivi Onkamo, Eduardo Carmona Ballestero, Javier Jimenez-Echevarria, Valery Khartanovich, Manuel Rojo-Guerra, Fredrik Hallgren, Eirini Skourtanioti, Natalia Shishlina, Luca Lai, Petr Velemínský, Antti Sajantila, Peter C. Ramsl, Claudia Sagona, Susanne Friederich, Miroslav Dobeš, Marcel Keller, Francesco Cucca, Sabine Reinhold, Florian van Bömmel, Luc Amkreutz, Vittoria Schimmenti, Raphaela Stahl, Douglas Baird, Marina K. Karapetian, Kurt Rademaker, Stephan Schiffels, Sacha Kacki, Evelyn K. Guevara, Michael Francken, Christina Warinner, Kay Prüfer, Karen Giffin, Felix M. Key, Joscha Gretzinger, Alexey Kalmykov, Svetlana Shnaider, Sandra Penske, Antje Wissgott, Tiffiny A. Tung, Biaslan Ch. Atabiev, Philippe Lefranc, Elizabeth A. Nelson, Peter de Knijff, Vladimir Slavchev, Jessica Pearson, Yılmaz Selim Erdal, Louise Loe, Jan Nováček, Micaela Alvarez Calmet, José I. Royo-Guillén, Richard L. Burger, Kristiina Mannermaa, K. Aslıhan Yener, Maria Pfefferkorn, Vyacheslav Moiseyev, Svend Hansen, Didier Binder, Michal Ernée, Maria A. Spyrou, Michal Feldman, Vladimir V. Kufterin, Murat Akar, Héctor Arcusa-Magallón, Andrej B. Belinskiy, Egor Kitov, Franziska Aron, Ron Hübler, Vanessa Villalba-Mouco, Sophie Beckett, Jessica Beckett, Arthur Kocher, Michael Schultz, Elena Batieva, Pilar Utrilla, Cristina Tejedor-Rodríguez, Kristin von Heyking, Masnav Navruzbekov, Michaela Langová, Maria Paz Miguel de Ibáñez, Stéphane Rottier, Maria V. Dobrovolskaya, Sandra Lösch, Emma D. Zilivinskaya, Dmitry V. Vasilev, Gabriel García Atiénzar, Marcello A. Mannino, Wolfgang Haak, Philipp W. Stockhammer, Sylvie Saintot, Alice Lyons, Ken Massy, Elena Kaverzneva, Susanna Sabin, Carmen Alonso-Fernández, Anna F. Kochkina, Marieke Sophia van de Loosdrecht, Stefanie Eisenmann, Max Planck Society, European Commission, Slovak Academy of Sciences, Academy of Sciences of the Czech Republic, Russian Foundation for Basic Research, German Research Foundation, Agence Nationale de la Recherche (France), Wenner-Gren Foundation, Ministry of Education and Science (Kazakhstan), Universidad de Alicante. Departamento de Prehistoria, Arqueología, Historia Antigua, Filología Griega y Filología Latina, Universidad de Alicante. Departamento de Biotecnología, Universidad de Alicante. Instituto Universitario de Investigación en Arqueología y Patrimonio Histórico, Prehistoria y Protohistoria, Grupo de Inmunología, Biología Celular y del Desarrollo, Ingman, Tara, Kocher, A., Papac, L., Barquera, R., Key, FM., Spyrou, MA., Hubler, R., Rohrlach, AB., Aron, F., Stahl, R., Wissgott, A., van Bommel, F., Pfefferkorn, M., Mittnik, A., Villalba-Mouco, V., Neumann, GU., Rivollat, M., van de Loosdrecht, MS., Majander, K., Tukhbatova, RI., Musralina, L., Ghalichi, A., Penske, S., Sabin, S., Michel, M., Gretzinger, J., Nelson, EA., Ferraz, T., Nagele, K., Parker, C., Keller, M., Guevara, EK., Feldman, M., Eisenmann, S., Skourtanioti, E., Giffin, K., Gnecchi-Ruscone, GA., Friederich, S., Schimmenti, V., Khartanovich, V., Karapetian, MK., Chaplygin, MS., Kufterin, VV., Khokhlov, AA., Chizhevsky, AA., Stashenkov, DA., Kochkina, AF., Tejedor-Rodriguez, C., de Lagran, IGM., Arcusa-Magallon, H., Garrido-Pena, R., Royo-Guillen, JI., Novacek, J., Rottier, S., Kacki, S., Saintot, S., Kaverzneva, E., Belinskiy, AB., Veleminsky, P., Limbursky, P., Kostka, M., Loe, L., Popescu, E., Clarke, R., Lyons, A., Mortimer, R., Sajantila, A., de Armas, YC., Godoy, STH., Hernandez-Zaragoza, DI., Pearson, J., Binder, D., Lefranc, P., Kantorovich, AR., Maslov, VE., Lai, L., Zoledziewska, M., Beckett, JF., Langova, M., Atienzar, GG., Ibanez, MPD, Romero, A., Sperduti, A., Beckett, S., Salter, SJ., Zilivinskaya, ED., Vasil, DV., von Heyking, K., Burger, RL., Salazar, LC., Amkreutz, L., Navruzbekov, M., Rosenstock, E., Alonso-Fernandez, C., Slavchev, V., Kalmykov, AA., Atabiev, BC., Batieva, E, Calmet, MA., Llamas, B., Schultz, M., Krauss, R., Jimenez-Echevarria, J., Francken, M., Shnaider, S., de Knijff, P., Altena, E., Van de Vijver, K., Fehren-Schmitz, L., Tung, TA., Losch, S., Dobrovolskaya, M., Makarov, N., Read, C., Van Twest, M., Sagona, C., Ramsl, PC., Akar, M., Yener, KA., Ballestero, EC., Cucca, F., Mazzarello, V., Utrilla, P., Rademaker, K., Fernandez-Dominguez, E., Baird, D., Semal, P., Marquez-Morfin, L, Roksandic, M., Steiner, H., Salazar-Garcia, DC., Shishlina, N. Erdal, YS., Hallgren, F., Boyadzhiev, Y., Boyadzhiev, K., Kussner, M., Sayer, D., Onkamo, P., Skeates, R., Rojo-Guerra, M., Buzhilova, A., Khussainova, E., Djansugurova, LB., Beisenov, AZ., Samashev, Z., Massy, K., Mannino, M., Moiseyev, V., Mannermaa, K., Balanovsky, O., Deguilloux, MF., Reinhold, S., Hansen, S., Kitov, EP., Dobes, M., Ernee, M., Meller, H., Prufer, Kay., Warinner, C., Schiffels, S., Stockhammer, PW., Bos, K., Posth, C., Herbig, A., Haak, W., Krause, J., Kuhnert, D., and Koç University Research Center for Anatolian Civilizations (ANAMED) / Koç Üniversitesi Anadolu Medeniyetleri Araştırma Merkezi (ANAMED)
Subjects: Phylogeographic history, Hepatitis B/history, 01 natural sciences, The Republic, Communicable Diseases, Emerging, German, Communicable Diseases, Emerging/history, Agency (sociology), Science and technology, ComputingMilieux_MISCELLANEOUS, History, Ancient, Phylogeny, media_common, 0303 health sciences, Multidisciplinary, Ancient DNA, European research, virus diseases, Genomics, Hepatitis B, 3. Good health, Europe, language, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Christian ministry, Paleogenomic analyses, Asian Continental Ancestry Group, 010506 paleontology, Hepatitis B virus, Asia, Hepatitis B virus/classification, European Continental Ancestry Group, Library science, Biología Celular, White People, Marie curie, Evolution, Molecular, 03 medical and health sciences, American Natives, Asian People, Political science, Genomic data, media_common.cataloged_instance, Humans, Slovak, European union, American Indian or Alaska Native, 030304 developmental biology, 0105 earth and related environmental sciences, Genetic Variation, Paleontology, Prehistoria, A300, language.human_language, digestive system diseases, American natives, Americas, Asian continental ancestry group, Communicable diseases, Emerging, European continental ancestry group, Evolution, molecular, Genetic variation
Abstract: Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic., The research was funded by the Max Planck Society, the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (771234–PALEoRIDER, to W.H.; 805268–CoDisEASe to K. Bos; 834616–ARCHCAUCASUS to S.H.), the Slovak Academy of Sciences and the European Union’s Seventh Framework Programme and Marie Curie Actions under the Programme SASPRO (1340/03/03 to P.C.R.), the ERA.NET RUS Plus–S&T programm of the European Union’s Seventh Framework Programme (277–BIOARCCAUCASUS to S.Re. and S.H.), the Werner Siemens Stiftung (“Paleobiochemistry”, to CW), the Award Praemium Academiae of the Czech Academy of Sciences (to M.E.), the Institute of Archaeology of the Czech Academy of Sciences (RVO 67985912, to M.Dobe.), the Russian Foundation for Basic Research (19-09-00354a, to M.K.K. and V.V.K.; 19-78-10053 to SSh), the German Research Foundation (DFG-HA-5407/4-1–INTERACT to W.H. and RE2688/2 to S.Re.), the French National Research Agency (ANR-17-FRAL-0010–INTERACT, to M.F.D., M.Ri., S.Ro., S.Sai., D.Bi., and P.Le.), the Wenner-Gren Dissertation Fieldwork Grant (9558 to S.Sab.), and the Ministry of Education and Science of the Republic of Kazakhstan (AP08856654 to L.B.D., L.M., and E.Kh. and AP08857177 to A.Z.B.).
Published: 2021

24. Ancient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmers

Author: Didier Binder, Joachim Wahl, Eva Rosenstock, Stéphane Rottier, Kurt W. Alt, Emmanuel Ghesquière, Philippe Lefranc, Choongwon Jeong, Hélène Réveillas, Adam Ben Rohrlach, Johannes Krause, Marie-Hélène Pemonge, Isil Kucukkalipci, Luc Laporte, Marie-France Deguilloux, Wolfgang Haak, Chris Scarre, Detlef Gronenborn, Harald Meller, Maïté Rivollat, Susanne Friederich, Ludovic Soler, Stephan Schiffels, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, Danube Private University, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), State Office for Heritage Management and Archaeology Saxony-Anhalt - State Museum of Prehistory, Institut national de recherches archéologiques préventives (Inrap), Centre de Recherche en Archéologie, Archéosciences, Histoire (CReAAH), Le Mans Université (UM)-Université de Rennes (UR)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR Histoire, Histoire de l'Art et Archéologie (UFR HHAA), Université de Nantes (UN)-Université de Nantes (UN)-Ministère de la Culture (MC), Römisch-Germanisches Zentralmuseum, Leibniz-Forschungsinstitut für Archäologie, Freie Universität Berlin, Durham University, University of Tübingen, 771234, H2020 European Research Council, DFG-HA-5407/4-1, Deutsche Forschungsgemeinschaft, ANR-17-FRAL-0010, Agence Nationale de la Recherche, New Faculty Startup Fund, Seoul National University, Fondation Fyssen, Max Planck Society, ANR-17-FRAL-0010,INTERACT,Interactions entre groupes humains en Europe de l'Ouest durant la transition Mésolithique-Néolithique: la double perspective des échanges biologiques et culturels(2017), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Université de Nantes (UN)-Le Mans Université (UM)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Department of Archaeology, Durham University, UK, Nantes Université (NU)-Ministère de la Culture (MC)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Le Mans Université (UM), Le Mans Université (UM)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR Histoire, Histoire de l'Art et Archéologie (UFR HHAA)
Subjects: Mediterranean climate, 0303 health sciences, Multidisciplinary, Middle East, 060102 archaeology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Ecology, Genomic data, SciAdv r-articles, Mosaic (geodemography), 06 humanities and the arts, Genome, 03 medical and health sciences, Geography, Anthropology, 0601 history and archaeology, Research Articles, Mesolithic, Hunter-gatherer, Research Article, 030304 developmental biology
Abstract: Shedding light on first encounters between late hunter-gatherers and early farmers in western Europe., Starting from 12,000 years ago in the Middle East, the Neolithic lifestyle spread across Europe via separate continental and Mediterranean routes. Genomes from early European farmers have shown a clear Near Eastern/Anatolian genetic affinity with limited contribution from hunter-gatherers. However, no genomic data are available from modern-day France, where both routes converged, as evidenced by a mosaic cultural pattern. Here, we present genome-wide data from 101 individuals from 12 sites covering today’s France and Germany from the Mesolithic (N = 3) to the Neolithic (N = 98) (7000–3000 BCE). Using the genetic substructure observed in European hunter-gatherers, we characterize diverse patterns of admixture in different regions, consistent with both routes of expansion. Early western European farmers show a higher proportion of distinctly western hunter-gatherer ancestry compared to central/southeastern farmers. Our data highlight the complexity of the biological interactions during the Neolithic expansion by revealing major regional variations.
Published: 2020

25. Investigating the kinship between individuals deposited in exceptional Merovingian multiple burials through aDNA analysis: The case of Hérange burial 41 (Northeast France)

Author: Maïté Rivollat, Marie-Hélène Pemonge, Marie-France Deguilloux, and Arnaud Lefebvre
Subjects: 0301 basic medicine, 03 medical and health sciences, Archeology, Interpersonal relationship, 030104 developmental biology, History, Ancient DNA, fungi, Kinship, Help document, Genetic data, Genealogy
Abstract: In funerary studies, “multiple burials” that have received several individuals in the same grave at the same time naturally raise questions concerning both the relationship linking the deceased and the cause of their simultaneous death. During the Merovingian period in Northeast France, multiple burials were revealed as highly rare and were consequently considered special burials linked to exceptional dramatic events. To help document the status of the deceased recovered from such special burials, we conducted ancient DNA analyses (mitochondrial and nuclear markers) to investigate the possible maternal kinship between a woman and three immature individuals simultaneously deposited in burial 41 at the Herange site (Lorraine, France). The genetic data obtained (i) strongly supported a maternal (genetic) kinship between the woman centrally deposited in the burial and the two immatures deposited right beside her but (ii) permitted the exclusion of a genetic link between the woman and the teenager deposited along her legs. Thus, these data support the view that survivors had intimate knowledge of the deceased relationship and buried these individuals in a manner to illustrate their biological connections. As a consequence, if a common cause of death was the presupposition for the special treatment of the deceased recovered from Herange burial 41, then interpersonal relationship was likely the deciding factor for setting this multiple burial.
Published: 2018

26. Investigating mitochondrial DNA relationships in Neolithic Western Europe through serial coalescent simulations

Author: Stéphane Rottier, Fanny Mendisco, Marie-France Deguilloux, Pascale Gerbault, Maïté Rivollat, Christine Couture, Marie Hélène Pemonge, and Mark G. Thomas
Subjects: Male, 0301 basic medicine, Mitochondrial DNA, Human Migration, Population, Short Report, Context (language use), Biology, DNA, Mitochondrial, White People, Coalescent theory, Evolution, Molecular, 03 medical and health sciences, 0302 clinical medicine, Effective population size, Genetic drift, Genetics, Humans, education, Genetics (clinical), education.field_of_study, Panmixia, Models, Genetic, Ecology, Genetic Drift, Pedigree, Europe, 030104 developmental biology, Ancient DNA, Female, 030217 neurology & neurosurgery
Abstract: Recent ancient DNA studies on European Neolithic human populations have provided persuasive evidence of a major migration of farmers originating from the Aegean, accompanied by sporadic hunter-gatherer admixture into early Neolithic populations, but increasing toward the Late Neolithic. In this context, ancient mitochondrial DNA data collected from the Neolithic necropolis of Gurgy (Paris Basin, France), the largest mitochondrial DNA sample obtained from a single archeological site for the Early/Middle Neolithic period, indicate little differentiation from farmers associated to both the Danubian and Mediterranean Neolithic migration routes, as well as from Western European hunter-gatherers. To test whether this pattern of differentiation could arise in a single unstructured population by genetic drift alone, we used serial coalescent simulations. We explore female effective population size parameter combinations at the time of the colonization of Europe 45000 years ago and the most recent of the Neolithic samples analyzed in this study 5900 years ago, and identify conditions under which population panmixia between hunter-gatherers/Early-Middle Neolithic farmers and Gurgy cannot be rejected. In relation to other studies on the current debate of the origins of Europeans, these results suggest increasing hunter-gatherer admixture into farmers' group migrating farther west in Europe.
Published: 2016

27. Ancient mitochondrial DNA from the middle neolithic necropolis of Obernai extends the genetic influence of the LBK to west of the Rhine

Author: Marie-Hélène Pemonge, Clément Féliu, Fanny Mendisco, Marie-France Deguilloux, Hélène Réveillas, Philippe Lefranc, Christine Couture, Maïté Rivollat, and Pierre Justeau
Subjects: 0106 biological sciences, 0301 basic medicine, Mediterranean climate, Mitochondrial DNA, Paleogenetics, Structural basin, 010603 evolutionary biology, 01 natural sciences, Archaeology, Haplogroup, 03 medical and health sciences, 030104 developmental biology, Geography, Extant taxon, Expansion wave, Anthropology, Gene pool, Anatomy
Abstract: Objectives The arrival of Neolithic farmers in Europe was the source of major cultural and genetic transitions. Neolithic settlers brought a new set of maternal lineages (mitochondrial DNA), recently well-characterized on the continental road, from the Balkans to West Germany (Rhine River). In the present study, the first mitochondrial DNA data from groups associated with this continental expansion wave located west of the Rhine River has been provided and their genetic affinities with contemporary groups have been discussed. Material and methods The mitochondrial DNA analysis of 27 human remains originating from Obernai (5,000–4,400 cal. BC), a necropolis located in French Alsace Region and attributed to Grossgartach, Planig–Friedberg, and Roessen cultures was conducted. Results and discussion Among the 27 individuals studied, 15 HVR-I sequences and 17 mitochondrial haplogroups could be determined. The analysis of the Obernai gene pool clearly confirmed the genetic homogeneity of Linearbandkeramik (LBK) groups on both sides of the Rhine River. Notably, one N1a sequence found in Obernai is shared with LBK farmers from Central Europe, including one individual from the Flomborn site located approximately 200 km north-east of Obernai. On the whole, data gathered so far showed major genetic influence of the Danubian wave from Transdanubia to Atlantic French Coast, going by Alsace Region. However, the genetic influence of descendants from the Mediterranean Neolithic expansion and the significant hunter-gatherer admixture detected further west in the Paris Basin were not perceived in the Obernai necropolis. Conclusions Genetic homogeneity and continuity within LBK groups can be proposed on both sides of the Rhine River for the middle Neolithic groups. Nevertheless, mitochondrial data gathered so far for Neolithic groups from the entire extant French Territory clearly point out the complexity and the variability of Neolithic communities interactions that is worthy of further investigation.
Published: 2016

28. A multidisciplinary approach to Neolithic life reconstruction

Author: Maïté Rivollat, Marie-France Deguilloux, Marie-Hélène Pemonge, Arnaud Coutelas, Johanna Terrom, Gwenaëlle Goude, Anne Hauzeur, Domingo C. Salazar-García, Guy André, Matthieu Le Bailly, Robert C. Power, Laboratoire méditerranéen de préhistoire Europe-Afrique ( LAMPEA ), Centre National de la Recherche Scientifique ( CNRS ) -Institut national de recherches archéologiques préventives ( Inrap ) -Ministère de la Culture et de la Communication ( MCC ) -Aix Marseille Université ( AMU ), Laboratoire méditerranéen de préhistoire Europe-Afrique (LAMPEA), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), and Laboratoire Chrono-environnement (UMR 6249) (LCE)
Subjects: 010506 paleontology, Archeology, Provenance, education.field_of_study, 060102 archaeology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Stable isotope ratio, Population, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Zoology, 06 humanities and the arts, Biology, Food Patterns, 01 natural sciences, Isotopes of nitrogen, Ancient DNA, Calculus analysis, [ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and Prehistory, [ SHS.ANTHRO-BIO ] Humanities and Social Sciences/Biological anthropology, Local environment, 0601 history and archaeology, education, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: The expansion of Neolithic stable isotope studies in France now allows distinct regional population-scale food patterns to be linked to both local environment influences and specific economic choices. Carbon and nitrogen isotope values of more than 500 humans and of animal samples also permit hypotheses on sex-biased human provenance. To advance population scale research, we here present the first study that draws together carbon (C), nitrogen (N), sulphur (S) and strontium (Sr), dental calculus, aDNA, and palaeoparasitology analysis to infer intra-population patterns of diet and provenance in a Middle Neolithic population from Le Vigneau 2 (human = 40; fauna = 12; 4720–4350 cal. BC) from north-western France. The data of the different studies, such as palaeoparasitology to detect diet and hygiene, CNS isotopes and dental calculus analysis to examine dietary staples, Sr and S isotopes to discriminate non-locals, and aDNA to detect maternal (mtDNA) versus paternal lineages (Y chromosome), were compared to anthropological information of sex and age. Collagen isotope data suggest a similar diet for all individuals except for one child. The provenance isotopic studies suggest no clear differences between sexes, suggesting both males and females used the territory in a similar pattern and had access to foods from the same environments.
Published: 2018

29. Ancient mitochondrial DNA from the middle neolithic necropolis of Obernai extends the genetic influence of the LBK to west of the Rhine

Author: Maïté, Rivollat, Hélène, Réveillas, Fanny, Mendisco, Marie-Hélène, Pemonge, Pierre, Justeau, Christine, Couture, Philippe, Lefranc, Clément, Féliu, and Marie-France, Deguilloux
Subjects: Haplotypes, Humans, Agriculture, France, DNA, Ancient, DNA, Mitochondrial, History, Ancient, Anthropology, Physical
Abstract: The arrival of Neolithic farmers in Europe was the source of major cultural and genetic transitions. Neolithic settlers brought a new set of maternal lineages (mitochondrial DNA), recently well-characterized on the continental road, from the Balkans to West Germany (Rhine River). In the present study, the first mitochondrial DNA data from groups associated with this continental expansion wave located west of the Rhine River has been provided and their genetic affinities with contemporary groups have been discussed.The mitochondrial DNA analysis of 27 human remains originating from Obernai (5,000-4,400 cal. BC), a necropolis located in French Alsace Region and attributed to Grossgartach, Planig-Friedberg, and Roessen cultures was conducted.Among the 27 individuals studied, 15 HVR-I sequences and 17 mitochondrial haplogroups could be determined. The analysis of the Obernai gene pool clearly confirmed the genetic homogeneity of Linearbandkeramik (LBK) groups on both sides of the Rhine River. Notably, one N1a sequence found in Obernai is shared with LBK farmers from Central Europe, including one individual from the Flomborn site located approximately 200 km north-east of Obernai. On the whole, data gathered so far showed major genetic influence of the Danubian wave from Transdanubia to Atlantic French Coast, going by Alsace Region. However, the genetic influence of descendants from the Mediterranean Neolithic expansion and the significant hunter-gatherer admixture detected further west in the Paris Basin were not perceived in the Obernai necropolis.Genetic homogeneity and continuity within LBK groups can be proposed on both sides of the Rhine River for the middle Neolithic groups. Nevertheless, mitochondrial data gathered so far for Neolithic groups from the entire extant French Territory clearly point out the complexity and the variability of Neolithic communities interactions that is worthy of further investigation.
Published: 2016

30. Distinct ancestries for similar funerary practices ,? A GIS analysis that compares funerary with osteological and aDNA data from the Middle Neolithic necropolis Gurgy 'Les Noisats' (Yonne, France)

Author: Marie-France Deguilloux, Fanny Mendisco, Melie Le Roy, Marie-Hélène Pemonge, Clément Coutelier, Stéphane Rottier, Maïté Rivollat, Christine Couture, Anne-marie Tillier, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Ausonius-Institut de recherche sur l'Antiquité et le Moyen âge, Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne
Subjects: 0301 basic medicine, Archeology, 060102 archaeology, Cultural area, Osteology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, media_common.quotation_subject, 06 humanities and the arts, Archaeology, Acculturation, 03 medical and health sciences, 030104 developmental biology, Geography, préhistoire, 0601 history and archaeology, Spatial organization, ComputingMilieux_MISCELLANEOUS, Diversity (politics), media_common
Abstract: The French Paris Basin is well known as a complex cultural area of the Early/Middle Neolithic, particularly with respect to funerary practices. Gurgy “Les Noisats”, which is an important necropolis in the southern Paris basin, is a burial site (N = 128) associated with the first Neolithic groups established in that area. The understanding of the necropolis composition and organization is complicated given the substantial homogeneity of the site's spatial organization in relation to a great diversity of characterized funerary traits. The unprecedented quantity of genetic (mitochondrial DNA), osteological (sex, age), and archaeological (funerary) data obtained for the Gurgy necropolis facilitates the search for potential correlations between cultural and biological (i.e. genetic and osteological) diversity at the site level. Despite the application of the powerful geographic information system, no correlation could be detected (i) between individual maternal lineages and specific bioarchaeological profiles (ii) or between maternal lineages and spatially identified bio-archaeological clusters. Therefore, analyses were performed to test for a correlation between the maternal ancestries of the individuals (i.e., hunter-gatherer/Central European farmer and Southern European farmer ancestries) and specific funerary traits. Again, the homogeneity of the funerary treatment of all of the individuals regardless of their potential maternal ancestries is striking. Taken together, our results regarding the way in which the Gurgy necropolis functioned provide strong evidence for the acculturation of all maternal ancestries groups, at least in terms of funerary practice. In addition, the demonstration of a recurrent association of adult men and immature individuals suggests a patrilocal system, which could be consistent with the detected acculturation of women who present a hunter-gatherer ancestry.
Published: 2016

31. When the waves of European Neolithization met : First paleogenetic evidence from early farmers in the Southern Paris Basin

Author: Marie-France Deguilloux, Audrey Safi, Maïté Rivollat, Stéphane Rottier, Fanny Mendisco, Didier Saint-Marc, Antoine Brémond, Christine Couture-Veschambre, Marie-Hélène Pemonge, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), and Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Mediterranean climate, Paris, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Molecular Sequence Data, Archaeological record, lcsh:Medicine, Biology, DNA, Mitochondrial, White People, Haplogroup, Mediterranean sea, préhistoire, Peninsula, Humans, lcsh:Science, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, geography, Farmers, Multidisciplinary, geography.geographical_feature_category, Cultural area, lcsh:R, Paleogenetics, Europe, Archaeology, Haplotypes, Period (geology), Ethnology, lcsh:Q, France, Research Article
Abstract: An intense debate concerning the nature and mode of Neolithic transition in Europe has long received much attention. Recent publications of paleogenetic analyses focusing on ancient European farmers from Central Europe or the Iberian Peninsula have greatly contributed to this debate, providing arguments in favor of major migrations accompanying European Neolithization and highlighting noticeable genetic differentiation between farmers associated with two archaeologically defined migration routes: the Danube valley and the Mediterranean Sea. The aim of the present study was to fill a gap with the first paleogenetic data of Neolithic settlers from a region (France) where the two great currents came into both direct and indirect contact with each other. To this end, we analyzed the Gurgy 'Les Noisats' group, an Early/Middle Neolithic necropolis in the southern part of the Paris Basin. Interestingly, the archaeological record from this region highlighted a clear cultural influence from the Danubian cultural sphere but also notes exchanges with the Mediterranean cultural area. To unravel the processes implied in these cultural exchanges, we analyzed 102 individuals and obtained the largest Neolithic mitochondrial gene pool so far (39 HVS-I mitochondrial sequences and haplogroups for 55 individuals) from a single archaeological site from the Early/Middle Neolithic period. Pairwise F ST values, haplogroup frequencies and shared informative haplotypes were calculated and compared with ancient and modern European and Near Eastern populations. These descriptive analyses provided patterns resulting from different evolutionary scenarios; however, the archaeological data available for the region suggest that the Gurgy group was formed through equivalent genetic contributions of farmer descendants from the Danubian and Mediterranean Neolithization waves. However, these results, that would constitute the most ancient genetic evidence of admixture between farmers from both Central and Mediterranean migration routes in the European Neolithization debate, are subject to confirmation through appropriate model-based approaches.
Published: 2015

32. Ancient Down syndrome: An osteological case from Saint-Jean-des-Vignes, northeastern France, from the 5-6th century AD

Author: Anne-marie Tillier, Dominique Castex, Maïté Rivollat, and Laurent Hauret
Subjects: Archeology, Down syndrome, History, Osteology, Archaeological record, Context (language use), SAINT, Ancient history, medicine.disease, Genealogy, Pathology and Forensic Medicine, Hypodontia, Skull, medicine.anatomical_structure, Pathognomonic, medicine
Abstract: The pathological skull of a 5-7 year old child from Saint-Jean-des-Vignes (Saone-et-Loire, north-eastern France) dated to the 5-6th century AD is described. Morphological and radiographic features, metrical data and Computed Tomography (CT) scans are used to study the osteological abnormalities in comparison with normal skulls of individuals of similar age and geographic origin. The combination of features is consistent with the diagnosis of Down syndrome (e.g. brachycrany, metopism, hypodontia, periodontitis, a flattened occiput, vault thinness, and an open cranial base angle), although none is pathognomonic of the disease in isolation. Cases of Down syndrome in past populations are rare, frequently poorly described or discovered out of context. This case represents the earliest and youngest example of the condition in the archaeological record. The context and funerary treatment of this child suggests that he/she was not stigmatized by other members of the community, who afforded a normal mode of burial.
Published: 2014

33. C. Bourgain, P. Darlu, ADN superstar ou superflic ? Les citoyens face à une molécule envahissante. Éd. Seuil, Science ouverte, 2013, ISBN: 978-2-02-109365-0, 170 pages, 19 €

Author: Maïté Rivollat
Subjects: Cultural Studies, Archeology, Anthropology, Philosophy, Humanities
Published: 2015

34. Ancient DNA gives new insights into a Norman Neolithic monumental cemetery dedicated to male elites

Author: 'Maïté Rivollat

35. Obernai (Bas-Rhin), Parc d'activités économiques intercommunal : 6000 ans d'Histoire au pied du Mont Sainte-Odile

Author: Clément Féliu, Pierre Adam, Géraldine Alberti, Rose-Marie Arbogast, Fanny Bricka, David Cambou, Madeleine Châtelet, Fanny Chenal, Patrick Clerc, Blandine Courel, Marie-France Deguilloux, Frédérique Durand, Quentin Ebert, Pierre Girard, Bernard GRATUZE, Christophe Grazi, Sylvain Griselin, Sylviane Humbert, Lydie Joan, Florent Jodry, Pierre Justeau, Philippe Lefranc, Christel Leyenberger, Fabienne Médard, Fanny Mendisco, Delphine Minni, Emile Moser, Amélie Pélissier, Marie-Hélène Pemonge, Hélène Réveillas, Maïté Rivollat, Élisabeth Rousseau, Philippe Schaeffer, Nathalie Schneider, Marieke van Es, Cécile Véber, Institut national de recherches archéologiques préventives (Inrap), Archéologie et histoire ancienne : Méditerranée - Europe (ARCHIMEDE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Maison Interuniversitaire des Sciences de l'Homme - Alsace (MISHA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Archéologie, Terre, Histoire, Sociétés [Dijon] (ARTeHiS), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Ministère de la Culture et de la Communication (MCC), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB), Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés (TRACES), École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA), IRAMAT - Centre Ernest Babelon (IRAMAT-CEB), Institut de Recherches sur les Archéomatériaux (IRAMAT), Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Archéologie d'Alsace, Ausonius-Institut de recherche sur l'Antiquité et le Moyen âge, Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Inrap, Institut national de recherches archéologiques préventives ( Inrap ), Archéologie et histoire ancienne : Méditerranée - Europe ( ARCHIMEDE ), Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Ministère de la Culture et de la Communication ( MCC ) -Institut national de recherches archéologiques préventives ( Inrap ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut National de Recherches Archéologiques Préventives ( INRAP ), Maison Interuniversitaire des Sciences de l'Homme - Alsace ( MISHA ), Archéologie, Terre, Histoire, Sociétés [Dijon] ( ARTeHiS ), Ministère de la Culture et de la Communication ( MCC ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie ( PACEA ), Université de Bordeaux ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Bordeaux ( UB ), Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés ( TRACES ), École des hautes études en sciences sociales ( EHESS ) -Université Toulouse - Jean Jaurès ( UT2J ) -Ministère de la Culture et de la Communication ( MCC ) -Institut national de recherches archéologiques préventives ( Inrap ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Strasbourg ( UNISTRA ), Institut de Recherches sur les Archéomatériaux ( IRAMAT ), Université de Technologie de Belfort-Montbeliard ( UTBM ) -Université d'Orléans ( UO ) -Université Bordeaux Montaigne-Centre National de la Recherche Scientifique ( CNRS ), de la Préhistoire à l'Actuel, Cultures, Environnement, Anthropologie ( PACEA ), Université Sciences et Technologies - Bordeaux 1-Ministère de la Culture et de la Communication ( MCC ) -Centre National de la Recherche Scientifique ( CNRS ), Université Bordeaux Montaigne-Centre National de la Recherche Scientifique ( CNRS ), Ministère de la Culture et de la Communication (MCC)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), and Féliu, Clément
Subjects: [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and Prehistory

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35 results on '"Maïté Rivollat"'

1. Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA

2. Étude biologique des sujets mésolithiques de l’Abri du Squelette (Les Eyzies, Dordogne, France)

3. L’alimentation des premiers agropasteurs du Néolithique : apport de l’étude des microrestes du tartre dentaire des individus de la Roussille (Auvergne)

4. Inférences sur les réseaux régionaux à partir d’arbres génétiques locaux, l’exemple du site néolithique de Gurgy 'les Noisats'

5. Les individus du dépôt multiple néolithique du site de Pontcharaud, Clermont-Ferrand (fouilles 1986) : guerriers ou morts d’accompagnement ?

6. Application de la morphométrie géométrique du labyrinthe osseux à l’analyse de la microévolution des humains en Europe de l’Ouest durant l’Holocène

7. Neolithic genomic data from southern France showcase intensified interactions with hunter-gatherer communities

8. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

9. Origin and mobility of Iron Age Gaulish groups in present-day France revealed through archaeogenomics

10. Explorer les structures sociales néolithiques grâce à la structure génétique de deux grandes familles à Gurgy 'les Noisats', France

11. Interactions biologiques entre chasseurs-cueilleurs et fermiers néolithiques : le cas remarquable des communautés du Sud de la France

12. GENETIX : un état des lieux des populations de l’âge du Fer en France. Regards croisés de l’archéologie et de la génétique

13. Multi-scale ancient DNA analyses confirm the western origin of Michelsberg farmers and document probable practices of human sacrifice.

14. When the waves of European Neolithization met: first paleogenetic evidence from early farmers in the southern Paris Basin.

15. Ancient DNA gives new insights into a Norman Neolithic monumental cemetery dedicated to male elites

16. New insights on Neolithic food and mobility patterns in Mediterranean coastal populations

17. Explorer les structures sociales néolithiques grâce à la structure génétique de deux grandes familles à Gurgy 'les Noisats', France

18. Population genetics and signatures of selection in Early Neolithic European farmers

19. Origin and mobility of Iron Age Gaulish groups in present-day France revealed through archaeogenomics

20. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

21. Far from home: A multi-analytical approach revealing the journey of an African-born individual to imperial Rome

22. GENETIX : un état des lieux des populations de l’âge du Fer en France. Regards croisés de l’archéologie et de la génétique

23. Ten millennia of hepatitis B virus evolution

24. Ancient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmers

25. Investigating the kinship between individuals deposited in exceptional Merovingian multiple burials through aDNA analysis: The case of Hérange burial 41 (Northeast France)

26. Investigating mitochondrial DNA relationships in Neolithic Western Europe through serial coalescent simulations

27. Ancient mitochondrial DNA from the middle neolithic necropolis of Obernai extends the genetic influence of the LBK to west of the Rhine

28. A multidisciplinary approach to Neolithic life reconstruction

29. Ancient mitochondrial DNA from the middle neolithic necropolis of Obernai extends the genetic influence of the LBK to west of the Rhine

30. Distinct ancestries for similar funerary practices ,? A GIS analysis that compares funerary with osteological and aDNA data from the Middle Neolithic necropolis Gurgy 'Les Noisats' (Yonne, France)

31. When the waves of European Neolithization met : First paleogenetic evidence from early farmers in the Southern Paris Basin

32. Ancient Down syndrome: An osteological case from Saint-Jean-des-Vignes, northeastern France, from the 5-6th century AD

33. C. Bourgain, P. Darlu, ADN superstar ou superflic ? Les citoyens face à une molécule envahissante. Éd. Seuil, Science ouverte, 2013, ISBN: 978-2-02-109365-0, 170 pages, 19 €

34. Ancient DNA gives new insights into a Norman Neolithic monumental cemetery dedicated to male elites

35. Obernai (Bas-Rhin), Parc d'activités économiques intercommunal : 6000 ans d'Histoire au pied du Mont Sainte-Odile

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35 results on '"Maïté Rivollat"'

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