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Introduction: Graves' disease is rare in childhood and adolescence., Patients and Methods: Six boys and 43 girls between the ages of 2 and 18 years were evaluated. All presented diffuse goiter and symptomatology of hyperthyroidism. Concentrations of T4, FT4, T3 and TSH were determined by RIA with various sensitivities during the study. Thyroid antibodies were determined by hemagglutination. All patients were treated with antithyroid drugs., Results: In five patients, growth velocity increased. In a further five patients association with other autoimmune diseases was detected. Quetelet's index was between the 90th and 97th percentiles in five patients and between 3rd and 10th in eight. Biochemical results were as follows: T4: 282.41 +/- 1.1 nmol/1; FT4: 62.98 +/- 1.1 pmol/l; T3: 4.92 +/- 0. 07 nmol/l) and TSH: > 0.002-0.001 mU/l. Values of TSI/TRAb were 33. 23 +/- 1.95 U/l. Four total remissions and 1 partial remission were observed. Four patients underwent surgery and eight received radioiodine., Conclusions: Few remissions were obtained with medical treatment. Radioiodine seems to be a therapeutic alternative.

We present the case of a 59-year-old man, with exertional angina, atrial fibrillation, electrocardiographic and scintigraphic signs of inferior necrosis and anterior ischemia. An abnormally high take off of the right coronary artery, with anomalous intraaortic initial pathway, was objectified in the patient by means of angiography and magnetic resonance imaging. The patient did not have coronary atherosclerosis or intracoronary lesions.