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1. Tuberculosis in otherwise healthy adults with inherited TNF deficiency

2. A Novel Case of IFNAR1 Deficiency Identified a Common Canonical Splice Site Variant in DOCK8 in Western Polynesia: The Importance of Validating Variants of Unknown Significance in Under-Represented Ancestries

3. Role of IL-27 in Epstein–Barr virus infection revealed by IL-27RA deficiency

5. A Novel Heterozygous Variant in AICDA Impairs Ig Class Switching and Somatic Hypermutation in Human B Cells and is Associated with Autosomal Dominant HIGM2 Syndrome

7. Contributors

8. Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling

11. FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice

12. Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.

16. Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

17. An essential role for the Zn2+ transporter ZIP7 in B cell development

18. STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation

19. STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis

21. Helper T cell immunity in humans with inherited CD4 deficiency

23. Intrinsic Defects in B Cell Development and Differentiation, T Cell Exhaustion and Altered Unconventional T Cell Generation Characterize Human Adenosine Deaminase Type 2 Deficiency

25. Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy

27. Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

28. Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency

29. Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria

30. Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency

31. Expanded T cell clones with lymphoma driver somatic mutations in refractory celiac disease

32. A Novel Heterozygous Variant in AICDA Impairs Ig Class Switching and Somatic Hypermutation in Human B Cells and is Associated with Autosomal Dominant HIGM2 Syndrome

33. Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome

34. Everolimus-Induced Remission of Classic Kaposi’s Sarcoma Secondary to Cryptic Splicing Mediated CTLA4 Haploinsufficiency

37. Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells

38. Isolated Chronic Mucocutaneous Candidiasis due to a Novel Duplication Variant of IL17RC

40. Dedicator of cytokinesis 8–deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells

41. The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity.

43. Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

48. Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency

49. Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

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