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4 results on '"Ma Teresa, Vargas"'

3. Fluorescence in situ hybridization of TP53 for the detection of chromosome 17 abnormalities in myelodysplastic syndromes

Author

Carmen Sanzo, Teresa Gonzalez Martinez, Elisabeth Talavera, Rosa Collado Nieto, Ana Batlle, Isabel Marugán, Xavier Gómez-Arbonés, Beatriz Blázquez Rios, Vera Adema, Ismael Buño, Víctor Marco-Betés, Judit Sánchez-Castro, Teresa Vallespi, Guillermo Sanz, Ma Teresa Vargas, María Luisa Martín Ramos, Francesc Solé, Josefa Marco Buades, Sara Fernández-Ruiz, Leonor Arenillas, Elisa Luño, Tomás García-Cerecedo, and Ricard López

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Myelodysplastic syndromes, In situ hybridization, Biology, cytogenetics, FISH, Complex Karyotype, medicine, Humans, In Situ Hybridization, Fluorescence, medicine.diagnostic_test, Cytogenetics, De novo Myelodysplastic Syndrome, Karyotype, Hematology, chromosome 17, medicine.disease, Molecular biology, Chromosome Banding, Chromosome 17 (human), Oncology, Myelodysplastic Syndromes, Chromosome Deletion, Tumor Suppressor Protein p53, Fluorescence in situ hybridization, Chromosomes, Human, Pair 17
Abstract

Conventional G-banding cytogenetics (CC) detects chromosome 17 (chr17) abnormalities in 2% of patients with de novo myelodysplastic syndromes (MDS). We used CC and fluorescence in situ hybridization (FISH) (LSI p53/17p13.1) to assess deletion of 17p in 531 patients with de novo MDS from the Spanish Group of Hematological Cytogenetics. FISH detected17 or 17p abnormalities in 13 cases (2.6%) in whom no 17p abnormalities were revealed by CC: 9% of patients with a normal karyotype, 0% in non-informative cytogenetics, 50% of patients with a chr17 abnormality without loss of 17p and in 4.7% of cases with an abnormal karyotype not involving chr17. Our results suggest that applying FISH of 17p13 to identify the number of copies of the TP53 gene could be beneficial in patients with a complex karyotype. We recommend using FISH of 17p13 in young patients with a normal karyotype or non-informative cytogenetics, and always in isolated del(17p)

Published
2015

4. Gains of 8q and losses of 8p is associated with the presence of complex karyotype improving prognosis in patients with lymphatic leukemia chronic and alterations of tp53

Author

Gonzalo, Blanco, Anna, Puiggros, Baliakas, Panagiotis, Anastasia, Athanasiadou, Ma Dolores, Garcia-Malo, Rosa, Collado, Aliki, Xochelli, Maria, Rodriguez-Rivera, Margarita, Ortega, Ma Jose, Calasanz, Elisa, Luno, Ma Teresa, Vargas, Javier, Grau, Carolina, Martinez-Laperche, Alberto, Valiente, Jose, Cervera, Jesus Ma, Hernandez-Rivas, Eva, Gimeno, Francisco Jose, Ortuno, Ana, Ferrer, Marcos, Gonzalez, Francesc, Bosch, Pau, Abrisqueta, Kostas, Stamatopoulos, Blanca, Espinet, Gonzalo, Blanco, Anna, Puiggros, Baliakas, Panagiotis, Anastasia, Athanasiadou, Ma Dolores, Garcia-Malo, Rosa, Collado, Aliki, Xochelli, Maria, Rodriguez-Rivera, Margarita, Ortega, Ma Jose, Calasanz, Elisa, Luno, Ma Teresa, Vargas, Javier, Grau, Carolina, Martinez-Laperche, Alberto, Valiente, Jose, Cervera, Jesus Ma, Hernandez-Rivas, Eva, Gimeno, Francisco Jose, Ortuno, Ana, Ferrer, Marcos, Gonzalez, Francesc, Bosch, Pau, Abrisqueta, Kostas, Stamatopoulos, and Blanca, Espinet

Published
2016

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