1. Liver Injury in Patients Hospitalized with Coronavirus Disease 2019 Correlates with Hyperinflammatory Response and Elevated Interleukin‐6
- Author
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Ben L. Da, Tatyana Kushner, Maan El Halabi, Pavan Paka, Mian Khalid, Angad Uberoi, Brian T. Lee, Ponni V. Perumalswami, Stephanie M. Rutledge, Thomas D. Schiano, Scott L. Friedman, and Behnam Saberi
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Liver injury is commonly seen in coronavirus disease 2019 (COVID‐19); however, the mechanism behind liver injury, particularly in patients with severe and critical COVID‐19, remains unclear, and the clinical course is poorly described. We conducted a single‐center retrospective cohort study of consecutive patients hospitalized with severe and critical COVID‐19 with or without liver injury and who underwent immunologic testing (interleukin [IL]‐6, IL‐8, tumor necrosis factor alpha [TNF‐α], and IL‐1β). Liver injury was defined as peak aminotransferases ≥3 times the upper limit of normal (40 U/L) or ≥120 U/L. Patients with liver injury were compared to those who had normal aminotransferases throughout the hospital course. We studied 176 patients: 109 with liver injury and 67 controls. Patients with liver injury were more likely to be men (71.6% vs. 37.3%, P
- Published
- 2021
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