Search

Your search keyword '"Maas, Elke"' showing total 27 results
Start Over Author "Maas, Elke"
27 results on '"Maas, Elke"'

1. Favipiravir at high doses has potent antiviral activity in SARS-CoV-2–infected hamsters, whereas hydroxychloroquine lacks activity

Author

Kaptein, Suzanne J. F., Jacobs, Sofie, Langendries, Lana, Seldeslachts, Laura, ter Horst, Sebastiaan, Liesenborghs, Laurens, Hens, Bart, Vergote, Valentijn, Heylen, Elisabeth, Barthelemy, Karine, Maas, Elke, De Keyzer, Carolien, Bervoets, Lindsey, Rymenants, Jasper, Van Buyten, Tina, Zhang, Xin, Abdelnabi, Rana, Pang, Juanita, Williams, Rachel, Thibaut, Hendrik Jan, Dallmeier, Kai, Boudewijns, Robbert, Wouters, Jens, Augustijns, Patrick, Verougstraete, Nick, Cawthorne, Christopher, Breuer, Judith, Solas, Caroline, Weynand, Birgit, Annaert, Pieter, Spriet, Isabel, Velde, Greetje Vande, Neyts, Johan, Rocha-Pereira, Joana, and Delang, Leen

Published
2020

2. Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

Author

Conidi, Andrea, Cazzola, Silvia, Beets, Karen, Coddens, Kathleen, Collart, Clara, Cornelis, Frederique, Cox, Luk, Joke, Debruyn, Dobreva, Mariya P., Dries, Ruben, Esguerra, Camila, Francis, Annick, Ibrahimi, Abdelilah, Kroes, Roel, Lesage, Flore, Maas, Elke, Moya, Ivan, Pereira, Paulo N.G., Stappers, Elke, Stryjewska, Agata, van den Berghe, Veronique, Vermeire, Liesbeth, Verstappen, Griet, Seuntjens, Eve, Umans, Lieve, Zwijsen, An, and Huylebroeck, Danny

Published
2011
Full Text
View/download PDF

4. Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

Author

Kaptein, Suzanne J. F., primary, Jacobs, Sofie, additional, Langendries, Lana, additional, Seldeslachts, Laura, additional, ter Horst, Sebastiaan, additional, Liesenborghs, Laurens, additional, Hens, Bart, additional, Vergote, Valentijn, additional, Heylen, Elisabeth, additional, Barthelemy, Karine, additional, Maas, Elke, additional, De Keyzer, Carolien, additional, Bervoets, Lindsey, additional, Rymenants, Jasper, additional, Van Buyten, Tina, additional, Zhang, Xin, additional, Abdelnabi, Rana, additional, Pang, Juanita, additional, Williams, Rachel, additional, Thibaut, Hendrik Jan, additional, Dallmeier, Kai, additional, Boudewijns, Robbert, additional, Wouters, Jens, additional, Augustijns, Patrick, additional, Verougstraete, Nick, additional, Cawthorne, Christopher, additional, Breuer, Judith, additional, Solas, Caroline, additional, Weynand, Birgit, additional, Annaert, Pieter, additional, Spriet, Isabel, additional, Vande Velde, Greetje, additional, Neyts, Johan, additional, Rocha-Pereira, Joana, additional, and Delang, Leen, additional

Published
2020
Full Text
View/download PDF

5. Antiviral treatment of SARS-CoV-2-infected hamsters reveals a weak effect of favipiravir and a complete lack of effect for hydroxychloroquine

Author

Kaptein, Suzanne JF, primary, Jacobs, Sofie, additional, Langendries, Lana, additional, Seldeslachts, Laura, additional, ter Horst, Sebastiaan, additional, Liesenborghs, Laurens, additional, Hens, Bart, additional, Vergote, Valentijn, additional, Heylen, Elisabeth, additional, Maas, Elke, additional, De Keyzer, Carolien, additional, Bervoets, Lindsey, additional, Rymenants, Jasper, additional, Van Buyten, Tina, additional, Thibaut, Hendrik Jan, additional, Dallmeier, Kai, additional, Boudewijns, Robbert, additional, Wouters, Jens, additional, Augustijns, Patrick, additional, Verougstraete, Nick, additional, Cawthorne, Christopher, additional, Weynand, Birgit, additional, Annaert, Pieter, additional, Spriet, Isabel, additional, Velde, Greetje Vande, additional, Neyts, Johan, additional, Rocha-Pereira, Joana, additional, and Delang, Leen, additional

Published
2020
Full Text
View/download PDF

6. Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb

Author

Deryckere, Astrid, primary, Stappers, Elke, additional, Dries, Ruben, additional, Peyre, Elise, additional, van den Berghe, Veronique, additional, Conidi, Andrea, additional, Zampeta, F. Isabella, additional, Francis, Annick, additional, Bresseleers, Marjolein, additional, Stryjewska, Agata, additional, Vanlaer, Ria, additional, Maas, Elke, additional, Smal, Ihor V., additional, van IJcken, Wilfred F. J., additional, Grosveld, Frank G., additional, Nguyen, Laurent, additional, Huylebroeck, Danny, additional, and Seuntjens, Eve, additional

Published
2020
Full Text
View/download PDF

8. Ultra-sensitive detection of prion protein fibrils by flow cytometry in blood from cattle affected with bovine spongiform encephalopathy

Author

Maas Elke, Torkler Sandra, Kaschig Katja, Santos Alexander, Trieschmann Lothar, Schätzl Hermann, and Böhm Gerald

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract Background The definite diagnosis of prion diseases such as Creutzfeldt-Jakob disease (CJD) in humans or bovine spongiform encephalopathy (BSE) in cattle currently relies on the post mortem detection of the pathological form of the prion protein (PrPSc) in brain tissue. Infectivity studies indicate that PrPSc may also be present in body fluids, even at presymptomatic stages of the disease, albeit at concentrations well below the detection limits of currently available analytical methods. Results We developed a highly sensitive method for detecting prion protein aggregates that takes advantage of kinetic differences between seeded and unseeded polymerization of prion protein monomers. Detection of the aggregates was carried out by flow cytometry. In the presence of prion seeds, the association of labelled recombinant PrP monomers in plasma and serum proceeds much more efficiently than in the absence of seeds. In a diagnostic model system, synthetic PrP aggregates were detected down to a concentration of approximately 10-8 nM [0.24 fg/ml]. A specific signal was detected in six out of six available serum samples from BSE-positive cattle. Conclusion We have developed a method based on seed-dependent PrP fibril formation that shows promising results in differentiating a small number of BSE-positive serum samples from healthy controls. This method may provide the basis for an ante mortem diagnostic test for prion diseases.

Published
2005
Full Text
View/download PDF

9. Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricularsubventricular zone to the olfactory bulb.

Author

Deryckere, Astrid, Stappers, Elke, Dries, Ruben, Peyre, Elise, van den Berghe, Veronique, Conidi, Andrea, Zampeta, F. Isabella, Francis, Annick, Bresseleers, Marjolein, Stryjewska, Agata, Vanlaer, Ria, Maas, Elke, Smal, Ihor V., van IJcken, Wilfred F. J., Grosveld, Frank G., Nguyen, Laurent, Huylebroeck, Danny, and Seuntjens, Eve

Subjects
OLFACTORY bulb, DEVELOPMENTAL neurobiology, SMAD proteins, NEURONAL differentiation, INTERNEURONS, FETAL tissues, NEURAL stem cells
Abstract

The transcription factor Zeb2 controls fate specification and subsequent differentiation and maturation of multiple cell types in various embryonic tissues. It binds many protein partners, including activated Smad proteins and the NuRD co-repressor complex. How Zeb2 subdomains support cell differentiation in various contexts has remained elusive. Here, we have studied the role of Zeb2 and its domains in neurogenesis and neural differentiation in the young postnatal ventricular-subventricular zone (V-SVZ), where neural stem cells generate olfactory bulb-destined interneurons. Conditional Zeb2 knockouts and separate acute loss- and gain-of-function approaches indicated that Zeb2 is essential to control apoptosis and neuronal differentiation of V-SVZ progenitors before and after birth, and identified Sox6 as Zeb2-dependent and potential downstream target gene. Zeb2 genetic inactivation impaired the differentiation potential of the VSVZ niche in a cell-autonomous fashion. We also provide evidence that its normal function in the VSVZ involves non-autonomous mechanisms as well. Additionally, we could demonstrate distinct roles for Zeb2 protein-binding domains, suggesting that Zeb2 partners co-determine neuronal output from the mouse V-SVZ in both quantitative and qualitative manners in early postnatal life. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

10. Additional file 5: Figure S3. of BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Author

Beets, Karen, Staring, Michael, Criem, Nathan, Maas, Elke, Schellinx, Niels, Lopes, Susana De Sousa, Umans, Lieve, and Zwijsen, An

Subjects
fungi, cardiovascular system
Abstract

BRE::gfp transcriptional activity in the outflow tract and aortic and pulmonary valves. Transverse sections of E11.5 embryos with (immuno) detection of Isolectin B4 and GFP. DAPI is used to stain nuclei. (A) Ubiquitous GFP signal in the inflow tract valve, and mosaic GFP localisation in the aortic (B) and pulmonary (C) valve. Scale bars: 50Â Îźm (PDF 181Â kb)

Published
2016
Full Text
View/download PDF

11. Additional file 1: Table S1. of BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Author

Beets, Karen, Staring, Michael, Criem, Nathan, Maas, Elke, Schellinx, Niels, Lopes, Susana De Sousa, Umans, Lieve, and Zwijsen, An

Abstract

List of primary antibodies and glycoprotein stainings. Biotin amplification was only required for PROX1 detection. The same antibody concentration was used for whole mount analysis, paraffin sections and cryosections, unless otherwise indicated. (PDF 226Â kb)

Published
2016
Full Text
View/download PDF

12. Additional file 6: Figure S4. of BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Author

Beets, Karen, Staring, Michael, Criem, Nathan, Maas, Elke, Schellinx, Niels, Lopes, Susana De Sousa, Umans, Lieve, and Zwijsen, An

Subjects
animal structures, fungi, embryonic structures
Abstract

BRE::gfp transcriptional activity is similar in blood and lymphatic vessels. Transverse sections through the neck of E12.5 (A) and E14.5 (B) BRE::gfp embryos immunostained for GFP, Endomucin, PROX1 and DAPI. Boxed areas are enlarged in the right panels with the single GFP staining next to it. (C) Schematic overview shows the dorsal skin area taken from an E14.5 embryo. Scale bars: 50 μm (A-B, left panels); 25 μm (A–B, right panels). (PDF 136 kb)

Published
2016
Full Text
View/download PDF

13. Additional file 3: Figure S2. of BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Author

Beets, Karen, Staring, Michael, Criem, Nathan, Maas, Elke, Schellinx, Niels, Lopes, Susana De Sousa, Umans, Lieve, and Zwijsen, An

Subjects
nervous system, genetic structures, fungi, sense organs, eye diseases
Abstract

BRE::gfp localisation patterns in the P10 retina. (A–D) Immunodetection of Endomucin and GFP in the retina at P10. The retina has a multi-layered vasculature that consist of the vascular border (A) and centre (B) of the primary plexus, the perpendicular vessels (C) and outer plexus (D). Single staining for GFP is shown in the lower panels. Scale bars: 75 μm. (PDF 2844 kb)

Published
2016
Full Text
View/download PDF

14. Additional file 8: Figure S6. of BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Author

Beets, Karen, Staring, Michael, Criem, Nathan, Maas, Elke, Schellinx, Niels, Lopes, Susana De Sousa, Umans, Lieve, and Zwijsen, An

Subjects
fungi
Abstract

BRE::gfp transcriptional activity does not co-localise with Ki67 in ECs. (A) Skin biopsy of an E14.5 BRE::gfp mouse with immunodetection of GFP, pH3 and PROX1. The merged stack in the left panel is split up in some single z-stacks to show pH3-positive cells beneath or above vessel structures (arrows). E14.5 (B) and E16.5 (C) skin biopsies with immunodetection of a different proliferation marker (Ki67), GFP and PROX1. Boxed areas are enlarged in the right panels. Ki67-positive LECs (arrows) and blood ECs (arrowheads) can be observed. Scale bars: 75 μm (B–C, left panels); 25 μm (A; B–C, right panels). (PDF 184 kb)

Published
2016
Full Text
View/download PDF

15. Additional file 4: Table S2. of BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Author

Beets, Karen, Staring, Michael, Criem, Nathan, Maas, Elke, Schellinx, Niels, Lopes, Susana De Sousa, Umans, Lieve, and Zwijsen, An

Subjects
fungi
Abstract

GFP localisation patterns in embryonic hearts with emphasis on BRE::gfp activity in endocardial cells. The number of hearts analysed is indicated in the top row. Results are consistent for all hearts analysed, unless specifically indicated. (C) Continuous (100 %); (U) Ubiquitous (>70 %); (M) Mosaic (10–70 %); (O) Occasional cell (

Published
2016
Full Text
View/download PDF

16. Additional file 2: Figure S1. of BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Author

Beets, Karen, Staring, Michael, Criem, Nathan, Maas, Elke, Schellinx, Niels, Lopes, Susana De Sousa, Umans, Lieve, and Zwijsen, An

Subjects
animal structures, embryonic structures, cardiovascular system
Abstract

The BRE::gfp reporter is transcriptionally active in a subdomain of the pSMAD1/5/9-positive endothelial cells. (A–C) Immunodetection of SMAD1/5/9 and GFP in the AVC and OFT at E9.5 (A), the ventricular trabeculae (B) and the cardinal vein (C) at E11.5. DAPI is used to stain nuclei. Specificity of the pSMAD1/5/9 staining was confirmed in control embryos (D) and endothelium-specific Smad1; Smad5 double knockout embryos (Tie2cre+/0; Smad1fl/fl; Smad5fl/fl) (E). Embryos were analyzed at E8.5 to circumvent the embryonic lethality of mutant embryos at E9.5. The pSMAD1/5/9 levels were specifically reduced in endothelium of the EC-specific Smad1; Smad5 double knockouts, while levels remained unchanged in the non-endothelial cells. The myocardium was visualized by an anti-MF20 staining. Arrows indicate pSMAD1/5/9 deficient endothelium (E). At: atrium; AVC: atrioventricular canal; CV: cardinal vein; OFT: outflow tract. Scale bars: 100 μm (A–B;D–E); 50 μm (C). (PDF 2307 kb)

Published
2016
Full Text
View/download PDF

17. Additional file 7: Figure S5. of BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

Author

Beets, Karen, Staring, Michael, Criem, Nathan, Maas, Elke, Schellinx, Niels, Lopes, Susana De Sousa, Umans, Lieve, and Zwijsen, An

Subjects
fungi
Abstract

BRE::gfp transcriptional activity is not restricted to vessels. E14.5 skin biopsies with immunodetection of GFP, PROX1 and the extracellular matrix marker Collagen type IV. Boxed areas are enlarged in the right panels. Arrows show non-vessel structures. Scale bars: 75 μm (left panels); 25 μm (right panels). (PDF 184 kb)

Published
2016
Full Text
View/download PDF

19. BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

Author

Gomes Fernandes, Maria, primary, Dries, Ruben, additional, Roost, Matthias S., additional, Semrau, Stefan, additional, de Melo Bernardo, Ana, additional, Davis, Richard P., additional, Ramakrishnan, Ramprasad, additional, Szuhai, Karoly, additional, Maas, Elke, additional, Umans, Lieve, additional, Abon Escalona, Vanesa, additional, Salvatori, Daniela, additional, Deforce, Dieter, additional, Van Criekinge, Wim, additional, Huylebroeck, Danny, additional, Mummery, Christine, additional, Zwijsen, An, additional, and Chuva de Sousa Lopes, Susana M., additional

Published
2016
Full Text
View/download PDF

20. Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion

Author

Pereira, Paulo N. G., primary, Dobreva, Mariya P., additional, Maas, Elke, additional, Cornelis, Frederique M., additional, Moya, Iván M., additional, Umans, Lieve, additional, Verfaillie, Catherine M., additional, Camus, Anne, additional, de Sousa Lopes, Susana M. Chuva, additional, Huylebroeck, Danny, additional, and Zwijsen, An, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results