Search

Your search keyword '"Maassen, Sjors"' showing total 17 results
Start Over Author "Maassen, Sjors"
17 results on '"Maassen, Sjors"'

1. Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation

Author

Warner, Harry, Franciosa, Giulia, van der Borg, Guus, Coenen, Britt, Faas, Felix, Koenig, Claire, de Boer, Rinse, Classens, René, Maassen, Sjors, Baranov, Maksim V., Mahajan, Shweta, Dabral, Deepti, Bianchi, Frans, van Hilten, Niek, Risselada, Herre Jelger, Roos, Wouter H., Olsen, Jesper Velgaard, Cano, Laia Querol, and van den Bogaart, Geert

Published
2024
Full Text
View/download PDF

3. T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Author

Bazioti, Venetia, La Rose, Anouk M., Maassen, Sjors, Bianchi, Frans, de Boer, Rinse, Halmos, Benedek, Dabral, Deepti, Guilbaud, Emma, Flohr-Svendsen, Arthur, Groenen, Anouk G., Marmolejo-Garza, Alejandro, Koster, Mirjam H., Kloosterhuis, Niels J., Havinga, Rick, Pranger, Alle T., Langelaar-Makkinje, Miriam, de Bruin, Alain, van de Sluis, Bart, Kohan, Alison B., Yvan-Charvet, Laurent, van den Bogaart, Geert, and Westerterp, Marit

Published
2022
Full Text
View/download PDF

7. Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters

Author

Stempels, Femmy C., primary, Jiang, Muwei, additional, Warner, Harry M., additional, Moser, Magda-Lena, additional, Janssens, Maaike H., additional, Maassen, Sjors, additional, Nelen, Iris H., additional, de Boer, Rinse, additional, Jiemy, William F., additional, Knight, David, additional, Selley, Julian, additional, O’Cualain, Ronan, additional, Baranov, Maksim V., additional, Burgers, Thomas C.Q., additional, Sansevrino, Roberto, additional, Milovanovic, Dragomir, additional, Heeringa, Peter, additional, Jones, Matthew C., additional, Vlijm, Rifka, additional, ter Beest, Martin, additional, and van den Bogaart, Geert, additional

Published
2023
Full Text
View/download PDF

10. Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration Through the Extracellular Matrix

Author

Warner, Harry Marcus, primary, Franciosa, Giulia, additional, van der Borg, Guus, additional, Faas, Felix, additional, Koenig, Claire, additional, de Boer, Rinse, additional, Classens, Rene, additional, Maassen, Sjors, additional, Baranov, Maksim, additional, Mahajan, Shweta, additional, Dabral, Deepti, additional, Coenen, Britt, additional, Bianchi, Frans, additional, van Hilten, Niek, additional, Risselada, Herre Jelger, additional, Roos, Wouter, additional, Olsen, Jesper Velgaard, additional, Querol Cano, Laia, additional, and van den Bogaart, Geert, additional

Published
2023
Full Text
View/download PDF

11. Metabolic regulation of macrophage inflammation and collagen uptake: interactions with the extracellular matrix driven by metabolism

Author

Maassen, Sjors, van den Bogaart, Geert, El Aidy, Sahar, and Molecular Immunology

Abstract

The scope of this thesis is the immunomodulation by macrophages by metabolites and mRNA analogues used in vaccines. Human blood monocyte-derived macrophages are used as a model to study immune function. The work of this thesis shows how both the pro- and anti-inflammatory functions of macrophages are affected by different compounds with potential therapeutic applications. In chapter 2, we characterise the responses of macrophages to a new mRNA nucleotide analogue: 5-ethynyl uridine. This is particularly interesting because the mRNA is equipped with a chemical group from click-chemistry. The Nobel prize for click-chemistry was awarded this year to (among others) Carolyn Bertozzi. This technique will aid the development of mRNA vaccines by adding modality to mRNA therapies. The rest of the thesis focuses on the interaction of these immune cells with surrounding metabolites for potential therapeutic development. For instance, we found that the metabolite itaconate can contribute to a wound-healing phenotype, which could be interesting for wound treatment.

Published
2023

13. T-cell Abca1 and Abcg1 cholesterol efflux pathways suppress T-cell apoptosis and senescence and increase atherosclerosis in middle-agedLdlr-/-mice

Author

Bazioti, Venetia, primary, La Rose, Anouk M., additional, Maassen, Sjors, additional, Bianchi, Frans, additional, de Boer, Rinse, additional, Guilbaud, Emma, additional, Flohr-Svendsen, Arthur, additional, Groenen, Anouk G., additional, Marmolejo-Garza, Alejandro, additional, Koster, Mirjam H., additional, Kloosterhuis, Niels J., additional, Pranger, Alle T., additional, Langelaar-Makkinje, Miriam, additional, de Bruin, Alain, additional, van de Sluis, Bart, additional, Kohan, Alison B., additional, Yvan-Charvet, Laurent, additional, van den Bogaart, Geert, additional, and Westerterp, Marit, additional

Published
2022
Full Text
View/download PDF

16. Stabilization of a Virus-Like Particle and Its Application as a Nanoreactor at Physiological Conditions

Author

Schoonen, Lise, Maassen, Sjors, Nolte, Roeland J. M., and van Hest, Jan C. M.

Abstract

Virus-like particles are very interesting tools for application in bionanotechnology, due to their monodisperse features and biocompatibility. In particular, the cowpea chlorotic mottle virus (CCMV) capsid has been studied extensively as it can be assembled and disassembled reversibly, facilitating cargo encapsulation. CCMV is, however, only stable at physiological conditions when its endogenous nucleic acid cargo is present. To gain more flexibility in the type of cargo encapsulated and to broaden the window of operation, it is interesting to improve the stability of the empty virus-like particles. Here, a method is described to utilize the CCMV capsid at close to physiological conditions as a stable, enzyme-filled nanoreactor. As a proof-of-principle, the encapsulation of T4 lysozyme (T4L) was chosen; this enzyme is a promising antibiotic, but its clinical application is hampered by, for example, its cationic character. It was shown that four T4L molecules can successfully be encapsulated inside CCMV capsids, while remaining catalytically active, which could thus improve the enzyme’s application potential.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results