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5. Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing.

Author

Maayah, Marah, Grubman, Scott, Allen, Stephanie, Ye, Zachary, Park, Dae Yong, Vemmou, Evangelia, Gokhan, Ilhan, Sun, Wendy W., Possick, Stephen, Kwan, Jennifer M., Gandhi, Parul U., and Hu, Jiun-Ruey

Subjects
*ACUTE coronary syndrome, *MYOCARDIAL injury, *TROPONIN, *MYOCARDIAL ischemia, *PROGNOSIS, *MYOCARDIAL infarction, *BRUGADA syndrome
Abstract

Cardiac troponin (Tn) plays a central role in the evaluation of patients with angina presenting with acute coronary syndrome. The advent of high-sensitivity assays has improved the analytic sensitivity and precision of serum Tn measurement, but this advancement has come at the cost of poorer specificity. The role of clinical judgment is of heightened importance because, more so than ever, the interpretation of serum Tn elevation hinges on the careful integration of findings from electrocardiographic, echocardiographic, physical exam, interview, and other imaging and laboratory data to formulate a weighted differential diagnosis. A thorough understanding of the epidemiology, mechanisms, and prognostic implications of Tn elevations in each cardiac and non-cardiac etiology allows the clinician to better distinguish between presentations of myocardial ischemia and myocardial injury—an important discernment to make, as the treatment of acute coronary syndrome is vastly different from the workup and management of myocardial injury and should be directed at the underlying cause. [ABSTRACT FROM AUTHOR]

Published
2024
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13. INSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY.

Author

Ye, Zachary, Maayah, Marah, Wang, Peter, See, Claudia, Grubman, Scott, Akhlaghi, Narjes, Allen, Stephanie, Dong, Weilai, Ghare, Mohammed Imran, Gokhan, Ilhan, Grubman, Daniel, Mezue, Kenechukwu, Mottola, Giorgio, Park, Dae Yong, Trejo-Paredes, Camila, Shen, Miles, Vemmou, Evangelia, Abdullah, Ahmed, Alaiwi, Sarah Abou, and Sharma, Shivi

Subjects
*MYOCARDIAL injury, *TROPONIN
Published
2024
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