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1,150 results on '"MacNee, William."'

1. Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS)

Author

Cotton, Seonaidh, Devereux, Graham, Abbas, Hassan, Briggs, Andrew, Campbell, Karen, Chaudhuri, Rekha, Choudhury, Gourab, Dawson, Dana, De Soyza, Anthony, Fielding, Shona, Gompertz, Simon, Haughney, John, Lang, Chim C., Lee, Amanda J., MacLennan, Graeme, MacNee, William, McCormack, Kirsty, McMeekin, Nicola, Mills, Nicholas L., Morice, Alyn, Norrie, John, Petrie, Mark C., Price, David, Short, Philip, Vestbo, Jorgen, Walker, Paul, Wedzicha, Jadwiga, Wilson, Andrew, and Lipworth, Brian J.

Published
2022
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2. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Author

Hobbs, Brian D, de Jong, Kim, Lamontagne, Maxime, Bossé, Yohan, Shrine, Nick, Artigas, María Soler, Wain, Louise V, Hall, Ian P, Jackson, Victoria E, Wyss, Annah B, London, Stephanie J, North, Kari E, Franceschini, Nora, Strachan, David P, Beaty, Terri H, Hokanson, John E, Crapo, James D, Castaldi, Peter J, Chase, Robert P, Bartz, Traci M, Heckbert, Susan R, Psaty, Bruce M, Gharib, Sina A, Zanen, Pieter, Lammers, Jan W, Oudkerk, Matthijs, Groen, HJ, Locantore, Nicholas, Tal-Singer, Ruth, Rennard, Stephen I, Vestbo, Jørgen, Timens, Wim, Paré, Peter D, Latourelle, Jeanne C, Dupuis, Josée, O'Connor, George T, Wilk, Jemma B, Kim, Woo Jin, Lee, Mi Kyeong, Oh, Yeon-Mok, Vonk, Judith M, de Koning, Harry J, Leng, Shuguang, Belinsky, Steven A, Tesfaigzi, Yohannes, Manichaikul, Ani, Wang, Xin-Qun, Rich, Stephen S, Barr, R Graham, Sparrow, David, Litonjua, Augusto A, Bakke, Per, Gulsvik, Amund, Lahousse, Lies, Brusselle, Guy G, Stricker, Bruno H, Uitterlinden, André G, Ampleford, Elizabeth J, Bleecker, Eugene R, Woodruff, Prescott G, Meyers, Deborah A, Qiao, Dandi, Lomas, David A, Yim, Jae-Joon, Kim, Deog Kyeom, Hawrylkiewicz, Iwona, Sliwinski, Pawel, Hardin, Megan, Fingerlin, Tasha E, Schwartz, David A, Postma, Dirkje S, MacNee, William, Tobin, Martin D, Silverman, Edwin K, Boezen, H Marike, and Cho, Michael H

Subjects
Biological Sciences, Genetics, Chronic Obstructive Pulmonary Disease, Lung, Human Genome, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Respiratory, Adult, Aged, Aged, 80 and over, Alleles, Asthma, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis, Risk Factors, Smoking, COPDGene Investigators, ECLIPSE Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, UK BiLEVE Investigators, International COPD Genetics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10-6) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity. We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases.

Published
2017

3. Association Between Interstitial Lung Abnormalities and All-Cause Mortality

Author

Putman, Rachel K, Hatabu, Hiroto, Araki, Tetsuro, Gudmundsson, Gunnar, Gao, Wei, Nishino, Mizuki, Okajima, Yuka, Dupuis, Josée, Latourelle, Jeanne C, Cho, Michael H, El-Chemaly, Souheil, Coxson, Harvey O, Celli, Bartolome R, Fernandez, Isis E, Zazueta, Oscar E, Ross, James C, Harmouche, Rola, San José Estépar, Raúl, Diaz, Alejandro A, Sigurdsson, Sigurdur, Gudmundsson, Elías F, Eiríksdottír, Gudny, Aspelund, Thor, Budoff, Matthew J, Kinney, Gregory L, Hokanson, John E, Williams, Michelle C, Murchison, John T, MacNee, William, Hoffmann, Udo, O’Donnell, Christopher J, Launer, Lenore J, Harrris, Tamara B, Gudnason, Vilmundur, Silverman, Edwin K, O’Connor, George T, Washko, George R, Rosas, Ivan O, and Hunninghake, Gary M

Subjects
Epidemiology, Health Sciences, Chronic Obstructive Pulmonary Disease, Lung, Human Genome, Clinical Research, Genetics, Aetiology, 2.4 Surveillance and distribution, Respiratory, Cause of Death, Cohort Studies, Coronary Artery Disease, Female, Humans, Male, Neoplasms, Prevalence, Proportional Hazards Models, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Radiography, Smoking, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators, COPDGene Investigators, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceInterstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our knowledge, an association with mortality has not been previously investigated.ObjectiveTo investigate whether interstitial lung abnormalities are associated with increased mortality.Design, setting, and populationProspective cohort studies of 2633 participants from the FHS (Framingham Heart Study; computed tomographic [CT] scans obtained September 2008-March 2011), 5320 from the AGES-Reykjavik Study (Age Gene/Environment Susceptibility; recruited January 2002-February 2006), 2068 from the COPDGene Study (Chronic Obstructive Pulmonary Disease; recruited November 2007-April 2010), and 1670 from ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; between December 2005-December 2006).ExposuresInterstitial lung abnormality status as determined by chest CT evaluation.Main outcomes and measuresAll-cause mortality over an approximate 3- to 9-year median follow-up time. Cause-of-death information was also examined in the AGES-Reykjavik cohort.ResultsInterstitial lung abnormalities were present in 177 (7%) of the 2633 participants from FHS, 378 (7%) of 5320 from AGES-Reykjavik, 156 (8%) of 2068 from COPDGene, and in 157 (9%) of 1670 from ECLIPSE. Over median follow-up times of approximately 3 to 9 years, there were more deaths (and a greater absolute rate of mortality) among participants with interstitial lung abnormalities when compared with those who did not have interstitial lung abnormalities in the following cohorts: 7% vs 1% in FHS (6% difference [95% CI, 2% to 10%]), 56% vs 33% in AGES-Reykjavik (23% difference [95% CI, 18% to 28%]), and 11% vs 5% in ECLIPSE (6% difference [95% CI, 1% to 11%]). After adjustment for covariates, interstitial lung abnormalities were associated with a higher risk of death in the FHS (hazard ratio [HR], 2.7 [95% CI, 1.1 to 6.5]; P = .03), AGES-Reykjavik (HR, 1.3 [95% CI, 1.2 to 1.4]; P

Published
2016

4. Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease

Author

McDonald, Merry-Lynn N, Cho, Michael H, Sørheim, Inga-Cecilie, Lutz, Sharon M, Castaldi, Peter J, Lomas, David A, Coxson, Harvey O, Edwards, Lisa D, MacNee, William, Vestbo, Jørgen, Yates, Julie C, Agusti, Alvar, Calverley, Peter MA, Celli, Bartolome, Crim, Courtney, Rennard, Stephen I, Wouters, Emiel FM, Bakke, Per, Tal-Singer, Ruth, Miller, Bruce E, Gulsvik, Amund, Casaburi, Richard, Wells, J Michael, Regan, Elizabeth A, Make, Barry J, Hokanson, John E, Lange, Christoph, Crapo, James D, Beaty, Terri H, Silverman, Edwin K, and Hersh, Craig P

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Lung, Prevention, Clinical Research, Chronic Obstructive Pulmonary Disease, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Black or African American, Aged, Aged, 80 and over, Chromosomes, Human, Pair 15, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Hypoxia, Male, Middle Aged, Oximetry, Oxygen, Polymorphism, Single Nucleotide, Prognosis, Pulmonary Disease, Chronic Obstructive, Rest, White People, chronic obstructive pulmonary disease, hypoxemia, pulse oximetry, genome-wide association study, oxygen saturation, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints and COPDGene Investigators, Cardiorespiratory Medicine and Haematology, Respiratory System, Biochemistry and cell biology, Cardiovascular medicine and haematology
Abstract

Hypoxemia is a major complication of chronic obstructive pulmonary disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among patients with COPD. However, previous genetic studies have been restricted to investigating COPD candidate genes for association with hypoxemia. To report results from the first genome-wide association study (GWAS) of resting oxygen saturation (as measured by pulse oximetry [Spo2]) in subjects with COPD, we performed a GWAS of Spo2 in two large, well characterized COPD populations: COPDGene, including both the non-Hispanic white (NHW) and African American (AA) groups, and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). We identified several suggestive loci (P < 1 × 10(-5)) associated with Spo2 in COPDGene in the NHW (n = 2810) and ECLIPSE (n = 1758) groups, and two loci on chromosomes 14 and 15 in the AA group (n = 820) from COPDGene achieving a level of genome-wide significance (P < 5 × 10(-8)). The chromosome 14 single-nucleotide polymorphism, rs6576132, located in an intergenic region, was nominally replicated (P < 0.05) in the NHW group from COPDGene. The chromosome 15 single-nucleotide polymorphisms were rare in subjects of European ancestry, so the results could not be replicated. The chromosome 15 region contains several genes, including TICRR and KIF7, and is proximal to RHCG (Rh family C glyocoprotein gene). We have identified two loci associated with resting oxygen saturation in AA subjects with COPD, and several suggestive regions in subjects of European descent with COPD. Our study highlights the importance of investigating the genetics of complex traits in different racial groups.

Published
2014

5. Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study.

Author

McDonald, Merry-Lynn N, Diaz, Alejandro A, Ross, James C, San Jose Estepar, Raul, Zhou, Linfu, Regan, Elizabeth A, Eckbo, Eric, Muralidhar, Nina, Come, Carolyn E, Cho, Michael H, Hersh, Craig P, Lange, Christoph, Wouters, Emiel, Casaburi, Richard H, Coxson, Harvey O, Macnee, William, Rennard, Stephen I, Lomas, David A, Agusti, Alvar, Celli, Bartolome R, Black-Shinn, Jennifer L, Kinney, Greg L, Lutz, Sharon M, Hokanson, John E, Silverman, Edwin K, and Washko, George R

Subjects
Pectoralis Muscles, Humans, Pulmonary Disease, Chronic Obstructive, Tomography, X-Ray Computed, Respiratory Function Tests, Body Mass Index, Severity of Illness Index, Case-Control Studies, Cohort Studies, Predictive Value of Tests, Smoking, Body Composition, Aged, Middle Aged, Female, Male, Chronic Obstructive Pulmonary Disease, Clinical Research, Obesity, Prevention, Nutrition, Lung, Musculoskeletal, Respiratory
Abstract

RationaleMuscle wasting in chronic obstructive pulmonary disease (COPD) is associated with a poor prognosis and is not readily assessed by measures of body mass index (BMI). BMI does not discriminate between relative proportions of adipose tissue and lean muscle and may be insensitive to early pathologic changes in body composition. Computed tomography (CT)-based assessments of the pectoralis muscles may provide insight into the clinical significance of skeletal muscles in smokers.ObjectivesWe hypothesized that objective assessment of the pectoralis muscle area on chest CT scans provides information that is clinically relevant and independent of BMI.MethodsData from the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) Study (n = 73) were used to assess the relationship between pectoralis muscle area and fat-free mass. We then used data in a subset (n = 966) of a larger cohort, the COPDGene (COPD Genetic Epidemiology) Study, to explore the relationship between pectoralis muscle area and COPD-related traits.Measurements and main resultsWe first investigated the correlation between pectoralis muscle area and fat-free mass, using data from a subset of participants in the ECLIPSE Study. We then further investigated pectoralis muscle area in COPDGene Study participants and found that higher pectoralis muscle area values were associated with greater height, male sex, and younger age. On subsequent clinical correlation, compared with BMI, pectoralis muscle area was more significantly associated with COPD-related traits, including spirometric measures, dyspnea, and 6-minute-walk distance (6MWD). For example, on average, each 10-cm(2) increase in pectoralis muscle area was associated with a 0.8-unit decrease in the BODE (Body mass index, Obstruction, Dyspnea, Exercise) index (95% confidence interval, -1.0 to -0.6; P < 0.001). Furthermore, statistically significant associations between pectoralis muscle area and COPD-related traits remained even after adjustment for BMI.ConclusionsCT-derived pectoralis muscle area provides relevant indices of COPD morbidity that may be more predictive of important COPD-related traits than BMI. However, the relationship with clinically relevant outcomes such as hospitalization and death requires additional investigation. Pectoralis muscle area is a convenient measure that can be collected in the clinical setting in addition to BMI.

Published
2014

10. Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study

Author

Andrianopoulos, Vasileios, Celli, Bartolome R., Franssen, Frits M.E., Pinto-Plata, Victor M., Calverley, Peter M.A., Vanfleteren, Lowie E.G.W., Vogiatzis, Ioannis, Vestbo, Jørgen, Agusti, Alvar, Bakke, Per S., Rennard, Stephen I., MacNee, William, Tal-Singer, Ruth, Yates, Julie C., Wouters, Emiel F.M., and Spruit, Martijn A.

Published
2016
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15. Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study

Author

Fisk, Marie, McEniery, Carmel M., Gale, Nichola, Mäki-Petäjä, Kaisa, Forman, Julia R., Munnery, Margaret, Woodcock-Smith, Jean, Cheriyan, Joseph, Mohan, Divya, Fuld, Jonathan, Tal-Singer, Ruth, Polkey, Michael I., Cockcroft, John R., Wilkinson, Ian B., Bolton, Charlotte, Calverley, Peter, Lomas, David, MacNee, William, Marchong, Mellone, Miller, Bruce, Nagarajan, Sridevi, Dhakam, Zahid, Hickson, Stacey, Howard, Julia, McDonnell, Barry, Miles, Karen, Munnery, Maggie, Pusalkar, Pawan, Retallick, Christopher, Smith, Jane, Thomas, Edna, Wallace, Sharon, Williams, Susannah, and Yasmin

Published
2018
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19. The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

Author

Coxson, Harvey O, Dirksen, Asger, Edwards, Lisa D, Yates, Julie C, Agusti, Alvar, Bakke, Per, Calverley, Peter MA, Celli, Bartolome, Crim, Courtney, Duvoix, Annelyse, Fauerbach, Paola Nasute, Lomas, David A, MacNee, William, Mayer, Ruth J, Miller, Bruce E, Müller, Nestor L, Rennard, Stephen I, Silverman, Edwin K, Tal-Singer, Ruth, Wouters, Emiel FM, and Vestbo, Jørgen

Published
2013
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28. Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity

Author

Chaudhuri, Rekha, McSharry, Charles, Brady, Jeffrey, Donnelly, Iona, Grierson, Christal, McGuinness, Stephen, Jolly, Lisa, Weir, Christopher J., Messow, C. Martina, Spears, Mark, Miele, Gino, Nocka, Karl, Crowther, Dan, Thompson, Joyce, Brannigan, Maureen, Lafferty, Jane, Sproule, Michael, MacNee, William, Connell, Martin, Murchison, John T., Shepherd, Malcolm C., Feuerstein, Giora, Miller, Douglas K., and Thomson, Neil C.

Published
2012
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29. Contributors

Author

Adams, Lewis, primary, Adler, Dan Elie, additional, Agusti, Alvar, additional, Akoumianaki, Evangelia, additional, Alberg, Anthony J., additional, Albertine, Kurt H., additional, Alexander, Barbara D., additional, Alfille, Paul H., additional, Anantham, Devanand, additional, Arenberg, Douglas A., additional, Ayas, Najib T., additional, Bagchi, Aranya, additional, Balmes, John Randolph, additional, Banaei, Niaz, additional, Barnett, Christopher F., additional, Baughman, Robert P., additional, Becklake, Margaret R., additional, Benditt, Joshua O., additional, Benowitz, Neal L., additional, Bhakta, Nirav R., additional, Bhave, Anant D., additional, Blanc, Paul D., additional, Bleecker, Eugene R., additional, Bove, Alfred A., additional, Bradley, T. Douglas, additional, Brambilla, Elisabeth, additional, Broaddus, V. Courtney, additional, Brochard, Laurent, additional, Brock, Malcolm V., additional, Brown, Kevin K., additional, Brunetta, Paul G., additional, Cadranel, Jacques, additional, Celli, Bartolome, additional, Chan, Edward D., additional, Channick, Richard N., additional, Chastre, Jean, additional, Cheng, Guang-Shing, additional, Chin, Kelly, additional, Chung, Kian Fan, additional, Clerici, Christine, additional, Colby, Thomas V., additional, Collard, Harold R., additional, Cool, Carlyne D., additional, Cordier, Jean-François, additional, Cordioli, Ricardo Luiz, additional, Corte, Tamera J., additional, Cottin, Vincent, additional, Courey, Mark S., additional, Cowie, Robert L., additional, Crothers, Kristina, additional, Curley, Gerard F., additional, Daley, Charles L., additional, Davis, J. Lucian, additional, De Marco, Teresa, additional, Deresinski, Stanley C., additional, Deroose, Christophe, additional, Dobbs, Leland G., additional, Dooms, Christophe, additional, Downey, Gregory P., additional, du Bois, Roland M., additional, Dulohery, Megan M., additional, Effros, Richard M., additional, Eisner, Mark D., additional, Elicker, Brett M., additional, Ernst, Armin, additional, Ernst, Joel D., additional, Fahy, John V., additional, Fedullo, Peter F., additional, Feller-Kopman, David, additional, Fenster, Brett E., additional, Fingerlin, Tasha E., additional, Fontenot, Andrew P., additional, Frankel, Stephen K., additional, Garcia, Joe G.N., additional, Gebhart, G.F., additional, Gilstrap, Daniel Lee, additional, Girard, Nicolas, additional, Gladwin, Mark T., additional, Glenny, Robb W., additional, Gold, Warren M., additional, Gotway, Michael B., additional, Grasselli, Giacomo, additional, Greenberg, James M., additional, Griffith, David E., additional, Gruden, James F., additional, Han, MeiLan King, additional, Henderson, William, additional, Hill, Nicholas S., additional, Hoover, Wynton, additional, Hopewell, Philip C., additional, Horan-Saullo, Jennifer L., additional, Horner, Richard L., additional, Huang, Laurence, additional, Huchon, Gérard, additional, Inoue, Yoshikazu, additional, Iseman, Michael D., additional, Jackson, James E., additional, Jakubzick, Claudia V., additional, Janssen, Julius P., additional, Jett, James R., additional, Jones, Kirk, additional, Judson, Marc A., additional, Kato-Maeda, Midori, additional, Kavanagh, Brian P., additional, Keshavjee, Shaf, additional, Kim, Kami, additional, Kimoff, R. John, additional, King, Talmadge E., additional, Klein, Jeffrey S., additional, Koth, Laura L., additional, Kotloff, Robert M., additional, Kraft, Monica, additional, Küpeli, Elif, additional, Laffey, John G., additional, Lapinsky, Stephen E., additional, Lazarus, Stephen C., additional, Lee, Frances Eun-Hyung, additional, Lee, Jarone, additional, Lee, Y.C. Gary, additional, Lee, Warren L., additional, Lee-Chiong, Teofilo L., additional, Lemière, Catherine, additional, Light, Richard W., additional, Limper, Andrew H., additional, Loddenkemper, Robert, additional, Lugogo, Njira, additional, Luisetti, Maurizio, additional, Luks, Andrew M., additional, Luyt, Charles-Edouard, additional, Machado, Roberto F., additional, MacIntyre, Neil R., additional, MacNee, William, additional, Madtes, David K., additional, Maier, Lisa A., additional, Maldonado, Fabien, additional, Malhotra, Atul, additional, Martin, Thomas R., additional, Maskell, Nick A., additional, Mason, Robert J., additional, Massion, Pierre P., additional, Matthay, Michael A., additional, Matthay, Richard A., additional, Mayer, Annyce S., additional, Mazzone, Stuart B., additional, McCool, F. Dennis, additional, McCormack, Francis Xavier, additional, Mehta, Atul C., additional, Menéndez, Rosario, additional, Morgenthau, Adam S., additional, Morris, Alison, additional, Morris, Timothy A., additional, Muncey, Aaron R., additional, Murray, John F., additional, Myers, Jeffrey L., additional, Nadel, Jay A., additional, Nelson-Piercy, Catherine, additional, Neuman, Tom S., additional, Nosanchuk, Joshua D., additional, O'Riordan, Thomas G., additional, Ortega, Victor Enrique, additional, Panse, Prasad M., additional, Pao, William, additional, Paré, Peter A., additional, Park, David R., additional, Pastis, Nicholas J., additional, Patroniti, Nicolò, additional, Patterson, Karen C., additional, Pesenti, Antonio, additional, Pickens, Allan, additional, Pinsky, Benjamin A., additional, Pletcher, Steven D., additional, Powell, Frank L., additional, Que, Loretta G., additional, Redente, Elizabeth F., additional, Riches, David W.H., additional, Robinson, Bruce W.S., additional, Rodriguez-Roisin, Roberto, additional, Rose, Cecile S., additional, Routes, John M., additional, Rowe, Steven M., additional, Ryan, Clodagh M., additional, Ryu, Jay H., additional, Samet, Jonathan M., additional, Sandrock, Christian E., additional, Schoene, Robert B., additional, Schwartz, David A., additional, Schwartzstein, Richard M., additional, Schwarz, Marvin I., additional, Selman, Moisés, additional, Sequist, Lecia V., additional, Shannon, John M., additional, Shovlin, Claire L., additional, Silvestri, Gerard A., additional, Simonian, Philip L., additional, Singer, Jonathan P., additional, Slutsky, Arthur S., additional, Smaldone, Gerald C., additional, Solomon, George M., additional, Sorscher, Eric J., additional, Swenson, Erik R., additional, Tanner, Nichole T., additional, Tanowitz, Herbert B., additional, Torres, Antoni, additional, Trapnell, Bruce C., additional, Travis, William David, additional, Treanor, John J., additional, Tzelepis, George E., additional, Vandenplas, Olivier, additional, Vansteenkiste, Johan F., additional, Varghese, Thomas K., additional, Vestbo, Jørgen, additional, Wagner, Peter D., additional, Wahidi, Momen M., additional, Wallace, W. Dean, additional, Weiss, Louis M., additional, Weiss, Scott T., additional, Wells, Athol U., additional, West, John B., additional, White, Douglas B., additional, Wiener-Kronish, Jeanine P., additional, Wikenheiser-Brokamp, Kathryn A., additional, Woodruff, Prescott G., additional, Wunderink, Richard G., additional, Yeh, D. Dante, additional, Zemans, Rachel L., additional, Zimmerman, Leslie, additional, and Zuwallack, Richard L., additional

Published
2016
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30. COPD

Author

Macnee, William, primary, Vestbo, Jørgen, additional, and Agusti, Alvar, additional

Published
2016
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31. Hospitalized Exacerbations of COPD: Risk Factors and Outcomes in the ECLIPSE Cohort

Author

Müllerova, Hana, Maselli, Diego J., Locantore, Nicholas, Vestbo, Jørgen, Hurst, John R., Wedzicha, Jadwiga A., Bakke, Per, Agusti, Alvar, Anzueto, Antonio, Ivanov, Yavor, Kostov, Kosta, Bourbeau, Jean, Fitzgerald, Mark, Hernández, Paul, Killian, Kieran, Levy, Robert, Maltais, Francois, O´Donnell, Denis, Krepelka, Jan, Vestbo, Jørgen, Wouters, Emiel F. M., Quinn, Dean, Bakke, Per, Kosnik, Mitja, Agusti, Alvar, Feschenko, Yuri, Gavrisyuk, Volodymyr, Yashina, Lyudmila, MacNee, William, Singh, S. David, Wedzicha, Jadwiga, Anzueto, Antonio, Braman, Sidney, Casaburi, Richard, Celli, Bart, Giessel, Glenn, Gotfried, Mark, Greenwald, Gary, Hanania, Nicola, Mahler, Don, Make, Barry, Rennard, Stephen, Rochester, Carolyn, Scanlon, Paul, Schuller, Dan, Sciurba, Frank, Sharafkhaneh, Amir, Siler, Thomas, Silverman, Edwin, Wanner, Adam, Wise, Robert, Zu Wallack, Richard, Bakke, Per, Coxson, Harvey, Edwards, Lisa, Lomas, David, MacNee, William, Silverman, Edwin, Tal-Singer, Ruth, Vestbo, Jørgen, Yates, Julie, Agusti, Alvar, Calverley, Peter, Celli, Bartolome, Crim, Courtney, Miller, Bruce, MacNee, William, Rennard, Stephen, Tal-Singer, Ruth, and Wouters, Emiel

Published
2015
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33. Additional file 1 of Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS)

Author

Cotton, Seonaidh, Devereux, Graham, Abbas, Hassan, Briggs, Andrew, Campbell, Karen, Chaudhuri, Rekha, Choudhury, Gourab, Dawson, Dana, De Soyza, Anthony, Fielding, Shona, Gompertz, Simon, Haughney, John, Lang, Chim C., Lee, Amanda J., MacLennan, Graeme, MacNee, William, McCormack, Kirsty, McMeekin, Nicola, Mills, Nicholas L., Morice, Alyn, Norrie, John, Petrie, Mark C., Price, David, Short, Philip, Vestbo, Jorgen, Walker, Paul, Wedzicha, Jadwiga, Wilson, Andrew, and Lipworth, Brian J.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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39. Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura

Author

Murphy, Fiona A., Poland, Craig A., Duffin, Rodger, Al-Jamal, Khuloud T., Ali-Boucetta, Hanene, Nunes, Antonio, Byrne, Fiona, Prina-Mello, Adriele, Volkov, Yuri, Li, Shouping, Mather, Stephen J., Bianco, Alberto, Prato, Maurizio, MacNee, William, Wallace, William A., Kostarelos, Kostas, and Donaldson, Ken

Published
2011
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42. Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)

Author

Cotton, Seonaidh, primary, Devereux, Graham, additional, Abbas, Hassan, additional, Briggs, Andrew, additional, Campbell, Karen, additional, Chaudhuri, Rekha, additional, Choudhury, Gourab, additional, Dawson, Dana, additional, De Soyza, Anthony, additional, Fielding, Shona, additional, Gompertz, Simon, additional, Haughney, John, additional, Lang, Chim, additional, Lee, Amanda, additional, MacLennan, Graeme, additional, MacNee, William, additional, McCormack, Kirsty, additional, McMeekin, Nicola, additional, Mills, Nicholas, additional, Morice, Alyn, additional, Norrie, John, additional, Petrie, Mark, additional, Price, David, additional, Short, Philip, additional, Vestbo, Jorgen, additional, Walker, Paul, additional, Wedzicha, Jadwiga, additional, Wilson, Andrew, additional, and Lipworth, Brian, additional

Published
2022
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48. One-year change in health status and subsequent outcomes in COPD

Author

Wilke, Sarah, Jones, Paul W, Müllerova, H, Vestbo, Jørgen, Tal-Singer, Ruth, Franssen, Frits ME, Agusti, Alvar, Bakke, Per, Calverley, Peter M, Coxson, Harvey O, Crim, Courtney, Edwards, Lisa D, Lomas, David A, MacNee, William, Rennard, Stephen I, Yates, Julie C, Wouters, Emiel FM, and Spruit, Martijn A

Published
2015
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49. An Official American Thoracic Society/European Respiratory Society Statement: Research Questions in Chronic Obstructive Pulmonary Disease

Author

Celli, Bartolome R., Decramer, Marc, Wedzicha, Jadwiga A., Wilson, Kevin C., Agustí, Alvar, Criner, Gerard J., MacNee, William, Make, Barry J., Rennard, Stephen I., Stockley, Robert A., Vogelmeier, Claus, Anzueto, Antonio, Au, David H., Barnes, Peter J., Burgel, Pierre-Regis, Calverley, Peter M., Casanova, Ciro, Clini, Enrico M., Cooper, Christopher B., Coxson, Harvey O., Dusser, Daniel J., Fabbri, Leonardo M., Fahy, Bonnie, Ferguson, Gary T., Fisher, Andrew, Fletcher, Monica J., Hayot, Maurice, Hurst, John R., Jones, Paul W., Mahler, Donald A., Maltais, François, Mannino, David M., Martinez, Fernando J., Miravitlles, Marc, Meek, Paula M., Papi, Alberto, Rabe, Klaus F., Roche, Nicolas, Sciurba, Frank C., Sethi, Sanjay, Siafakas, Nikos, Sin, Don D., Soriano, Joan B., Stoller, James K., Tashkin, Donald P., Troosters, Thierry, Verleden, Geert M., Verschakelen, Johny, Vestbo, Jorgen, Walsh, John W., Washko, George R., Wise, Robert A., Wouters, Emiel F. M., and ZuWallack, Richard L.

Published
2015
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50. Identification of Five Chronic Obstructive Pulmonary Disease Subgroups with Different Prognoses in the ECLIPSE Cohort Using Cluster Analysis

Author

Rennard, Stephen I., Locantore, Nicholas, Delafont, Bruno, Tal-Singer, Ruth, Silverman, Edwin K., Vestbo, Jørgen, Miller, Bruce E., Bakke, Per, Celli, Bartolomé, Calverley, Peter M. A., Coxson, Harvey, Crim, Courtney, Edwards, Lisa D., Lomas, David A., MacNee, William, Wouters, Emiel F. M., Yates, Julie C., Coca, Ignacio, and Agustí, Alvar

Published
2015
Full Text
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