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369 results on '"Macconaill, Laura E."'

1. Author Correction: Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer

Author

Forrest, Suzanne J., Gupta, Hersh, Ward, Abigail, Li, Yvonne Y., Doan, Duong, Al-Ibraheemi, Alyaa, Alexandrescu, Sanda, Bandopadhayay, Pratiti, Shusterman, Suzanne, Mullen, Elizabeth A., Collins, Natalie B., Chi, Susan N., Wright, Karen D., Kumari, Priti, Mazor, Tali, Ligon, Keith L., Shivdasani, Priyanka, Manam, Monica, MacConaill, Laura E., Ceca, Evelina, Benich, Sidney N., London, Wendy B., Schilsky, Richard L., Bruinooge, Suanna S., Guidry Auvil, Jaime M., Cerami, Ethan, Rollins, Barrett J., Meyerson, Matthew L., Lindeman, Neal I., Johnson, Bruce E., Cherniack, Andrew D., Church, Alanna J., and Janeway, Katherine A.

Published
2024
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2. Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer

Author

Forrest, Suzanne J., Gupta, Hersh, Ward, Abigail, Li, Yvonne Y., Doan, Duong, Al-Ibraheemi, Alyaa, Alexandrescu, Sanda, Bandopadhayay, Pratiti, Shusterman, Suzanne, Mullen, Elizabeth A., Collins, Natalie B., Chi, Susan N., Wright, Karen D., Kumari, Priti, Mazor, Tali, Ligon, Keith L., Shivdasani, Priyanka, Manam, Monica, MacConaill, Laura E., Ceca, Evelina, Benich, Sidney N., London, Wendy B., Schilsky, Richard L., Bruinooge, Suanna S., Guidry Auvil, Jaime M., Cerami, Ethan, Rollins, Barrett J., Meyerson, Matthew L., Lindeman, Neal I., Johnson, Bruce E., Cherniack, Andrew D., Church, Alanna J., and Janeway, Katherine A.

Published
2024
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4. Twists and Turns from 'Tumor in Tumor' Profiling: Surveillance of CLL leads to detection of a lung adenocarcinoma, whose genomic characterization alters the original hematologic diagnosis

Author

Terraf, Panieh, Sholl, Lynette M, Davids, Matthew S, Awad, Mark M, Garcia, Elizabeth P, MacConaill, Laura E, Dal Cin, Paola, Kim, Annette, Lindeman, Neal I, Stachler, Matthew, Hwang, David H, and Dubuc, Adrian M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Lymphoma, Lung, Cancer, Genetics, Lung Cancer, Hematology, Good Health and Well Being, Adenocarcinoma of Lung, Aged, Biomarkers, Tumor, Diagnostic Errors, Female, Gene Expression Profiling, Gene Rearrangement, High-Throughput Nucleotide Sequencing, Humans, In Situ Hybridization, Fluorescence, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Neoplasms, Lymphoma, Mantle-Cell, Neoplasms, Multiple Primary, Positron Emission Tomography Computed Tomography, chronic lymphatic leukemia, hematological neoplasm, lung adenocarcinoma, Pharmacology and pharmaceutical sciences
Abstract

Comprehensive characterization of somatic genomic alterations has led to fundamental shifts in our understanding of tumor biology. In clinical practice, these studies can lead to modifications of diagnosis and/or specific treatment implications, fulfilling the promise of personalized medicine. Herein, we describe a 78-yr-old woman under surveillance for long-standing untreated chronic lymphocytic leukemia (CLL). Molecular studies from a peripheral blood specimen revealed a TP53 p.V157F mutation, whereas karyotype and fluorescence in situ hybridization (FISH) identified a 17p deletion, trisomy 12, and no evidence of IGH-CCND1 rearrangement. Positron emission tomography-computed tomography scan identified multistation intra-abdominal lymphadenopathy and a pulmonary nodule, and subsequent pulmonary wedge resection confirmed the presence of a concurrent lung adenocarcinoma. Targeted next-generation sequencing of the lung tumor identified an EGFR in-frame exon 19 deletion, two TP53 mutations (p.P152Q, p.V157F), and, unexpectedly, a IGH-CCND1 rearrangement. Follow-up immunohistochemistry (IHC) studies demonstrated a cyclin D1-positive lymphoid aggregate within the lung adenocarcinoma. The presence of the TP53 p.V157F mutation in the lung resection, detection of an IGH-CCND1 rearrangement, and cyclin D1 positivity by IHC led to revision of the patient's hematologic diagnosis and confirmed the extranodal presence of mantle cell lymphoma within the lung mass, thus representing a "tumor in tumor." Manual review of the sequencing data suggested the IGH-CCND1 rearrangement occurred via an insertional event, whose size precluded detection by original FISH studies. Thus, routine imaging for this patient's known hematologic malignancy led to detection of an unexpected solid tumor, whose subsequent precision medicine studies in the solid tumor redefined the original hematological diagnosis.

Published
2021

5. Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer

Author

Church, Alanna J., Corson, Laura B., Kao, Pei-Chi, Imamovic-Tuco, Alma, Reidy, Deirdre, Doan, Duong, Kang, Wenjun, Pinto, Navin, Maese, Luke, Laetsch, Theodore W., Kim, AeRang, Colace, Susan I., Macy, Margaret E., Applebaum, Mark A., Bagatell, Rochelle, Sabnis, Amit J., Weiser, Daniel A., Glade-Bender, Julia L., Homans, Alan C., Hipps, John, Harris, Haley, Manning, Danielle, Al-Ibraheemi, Alyaa, Li, Yvonne, Gupta, Hersh, Cherniack, Andrew D., Lo, Ying-Chun, Strand, Gianna R., Lee, Lobin A., Pinches, R. Seth, Lazo De La Vega, Lorena, Harden, Maegan V., Lennon, Niall J., Choi, Seong, Comeau, Hannah, Harris, Marian H., Forrest, Suzanne J., Clinton, Catherine M., Crompton, Brian D., Kamihara, Junne, MacConaill, Laura E., Volchenboum, Samuel L., Lindeman, Neal I., Van Allen, Eliezer, DuBois, Steven G., London, Wendy B., and Janeway, Katherine A.

Published
2022
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6. MatchMiner: an open-source platform for cancer precision medicine

Author

Klein, Harry, Mazor, Tali, Siegel, Ethan, Trukhanov, Pavel, Ovalle, Andrea, Vecchio Fitz, Catherine Del, Zwiesler, Zachary, Kumari, Priti, Van Der Veen, Bernd, Marriott, Eric, Hansel, Jason, Yu, Joyce, Albayrak, Adem, Barry, Susan, Keller, Rachel B., MacConaill, Laura E., Lindeman, Neal, Johnson, Bruce E., Rollins, Barrett J., Do, Khanh T., Beardslee, Brian, Shapiro, Geoffrey, Hector-Barry, Suzanne, Methot, John, Sholl, Lynette, Lindsay, James, Hassett, Michael J., and Cerami, Ethan

Published
2022
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8. Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.

Author

Choy, Edwin, MacConaill, Laura E, Cote, Gregory M, Le, Long P, Shen, Jacson K, Nielsen, Gunnlaugur P, Iafrate, Anthony J, Garraway, Levi A, Hornicek, Francis J, and Duan, Zhenfeng

Subjects
Humans, Chordoma, Chromosome Deletion, GTP Phosphohydrolases, Receptor Protein-Tyrosine Kinases, DNA-Binding Proteins, Membrane Proteins, Chromosomal Proteins, Non-Histone, Transcription Factors, DNA Mutational Analysis, Mutation, Oncogenes, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Cyclin-Dependent Kinase Inhibitor p16, PTEN Phosphohydrolase, beta Catenin, Genes, Neoplasm, Phosphatidylinositol 3-Kinases, Genotyping Techniques, SMARCB1 Protein, Anaplastic Lymphoma Kinase, Class I Phosphatidylinositol 3-Kinases, and over, Chromosomal Proteins, Non-Histone, Genes, Neoplasm, General Science & Technology
Abstract

The molecular mechanisms underlying chordoma pathogenesis are unknown. We therefore sought to identify novel mutations to better understand chordoma biology and to potentially identify therapeutic targets. Given the relatively high costs of whole genome sequencing, we performed a focused genetic analysis using matrix-assisted laser desorption/ionization-time of flight mass spectrometer (Sequenom iPLEX genotyping). We tested 865 hotspot mutations in 111 oncogenes and selected tumor suppressor genes (OncoMap v. 3.0) of 45 human chordoma tumor samples. Of the analyzed samples, seven were identified with at least one mutation. Six of these were from fresh frozen samples, and one was from a paraffin embedded sample. These observations were validated using an independent platform using homogeneous mass extend MALDI-TOF (Sequenom hME Genotyping). These genetic alterations include: ALK (A877S), CTNNB1 (T41A), NRAS (Q61R), PIK3CA (E545K), PTEN (R130), CDKN2A (R58*), and SMARCB1 (R40*). This study reports on the largest comprehensive mutational analysis of chordomas performed to date. To focus on mutations that have the greatest chance of clinical relevance, we tested only oncogenes and tumor suppressor genes that have been previously implicated in the tumorigenesis of more common malignancies. We identified rare genetic changes that may have functional significance to the underlying biology and potential therapeutics for chordomas. Mutations in CDKN2A and PTEN occurred in areas of chromosomal copy loss. When this data is paired with the studies showing 18 of 21 chordoma samples displaying copy loss at the locus for CDKN2A, 17 of 21 chordoma samples displaying copy loss at PTEN, and 3 of 4 chordoma samples displaying deletion at the SMARCB1 locus, we can infer that a loss of heterozygosity at these three loci may play a significant role in chordoma pathogenesis.

Published
2014

9. Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific raf inhibitor PLX4032

Author

Søndergaard, Jonas N, Nazarian, Ramin, Wang, Qi, Guo, Deliang, Hsueh, Teli, Mok, Stephen, Sazegar, Hooman, MacConaill, Laura E, Barretina, Jordi G, Kehoe, Sarah M, Attar, Narsis, von Euw, Erika, Zuckerman, Jonathan E, Chmielowski, Bartosz, Comin-Anduix, Begoña, Koya, Richard C, Mischel, Paul S, Lo, Roger S, and Ribas, Antoni

Abstract

Abstract Blocking oncogenic signaling induced by the BRAF V600E mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma cell lines. PLX4032 decreased signaling through the MAPK pathway only in cell lines with the BRAF V600E mutation. Seven out of 10 BRAF V600E mutant cell lines displayed sensitivity based on cell viability assays and three were resistant at concentrations up to 10 μM. Among the sensitive cell lines, four were highly sensitive with IC50 values below 1 μM, and three were moderately sensitive with IC50 values between 1 and 10 μM. There was evidence of MAPK pathway inhibition and cell cycle arrest in both sensitive and resistant cell lines. Genomic analysis by sequencing, genotyping of close to 400 oncogeninc mutations by mass spectrometry, and SNP arrays demonstrated no major differences in BRAF locus amplification or in other oncogenic events between sensitive and resistant cell lines. However, metabolic tracer uptake studies demonstrated that sensitive cell lines had a more profound inhibition of FDG uptake upon exposure to PLX4032 than resistant cell lines. In conclusion, BRAF V600E mutant melanoma cell lines displayed a range of sensitivities to PLX4032 and metabolic imaging using PET probes can be used to assess sensitivity.

Published
2010

10. Supplementary Figures 1-3 from High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing

Author

Wagle, Nikhil, primary, Berger, Michael F., primary, Davis, Matthew J., primary, Blumenstiel, Brendan, primary, DeFelice, Matthew, primary, Pochanard, Panisa, primary, Ducar, Matthew, primary, Van Hummelen, Paul, primary, MacConaill, Laura E., primary, Hahn, William C., primary, Meyerson, Matthew, primary, Gabriel, Stacey B., primary, and Garraway, Levi A., primary

Published
2023
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11. Data from AACR Project GENIE: Powering Precision Medicine through an International Consortium

Author

André, Fabrice, primary, Arnedos, Monica, primary, Baras, Alexander S., primary, Baselga, José, primary, Bedard, Philippe L., primary, Berger, Michael F., primary, Bierkens, Mariska, primary, Calvo, Fabien, primary, Cerami, Ethan, primary, Chakravarty, Debyani, primary, Dang, Kristen K., primary, Davidson, Nancy E., primary, Del Vecchio Fitz, Catherine, primary, Dogan, Semih, primary, DuBois, Raymond N., primary, Ducar, Matthew D., primary, Futreal, P. Andrew, primary, Gao, Jianjiong, primary, Garcia, Francisco, primary, Gardos, Stu, primary, Gocke, Christopher D., primary, Gross, Benjamin E., primary, Guinney, Justin, primary, Heins, Zachary J., primary, Hintzen, Stephanie, primary, Horlings, Hugo, primary, Hudeček, Jan, primary, Hyman, David M., primary, Kamel-Reid, Suzanne, primary, Kandoth, Cyriac, primary, Kinyua, Walter, primary, Kumari, Priti, primary, Kundra, Ritika, primary, Ladanyi, Marc, primary, Lefebvre, Céline, primary, LeNoue-Newton, Michele L., primary, Lepisto, Eva M., primary, Levy, Mia A., primary, Lindeman, Neal I., primary, Lindsay, James, primary, Liu, David, primary, Lu, Zhibin, primary, MacConaill, Laura E., primary, Maurer, Ian, primary, Maxwell, David S., primary, Meijer, Gerrit A., primary, Meric-Bernstam, Funda, primary, Micheel, Christine M., primary, Miller, Clinton, primary, Mills, Gordon, primary, Moore, Nathanael D., primary, Nederlof, Petra M., primary, Omberg, Larsson, primary, Orechia, John A., primary, Park, Ben Ho, primary, Pugh, Trevor J., primary, Reardon, Brendan, primary, Rollins, Barrett J., primary, Routbort, Mark J., primary, Sawyers, Charles L., primary, Schrag, Deborah, primary, Schultz, Nikolaus, primary, Shaw, Kenna R Mills, primary, Shivdasani, Priyanka, primary, Siu, Lillian L., primary, Solit, David B., primary, Sonke, Gabe S., primary, Soria, Jean Charles, primary, Sripakdeevong, Parin, primary, Stickle, Natalie H., primary, Stricker, Thomas P., primary, Sweeney, Shawn M., primary, Taylor, Barry S., primary, ten Hoeve, Jelle J., primary, Thomas, Stacy B., primary, Van Allen, Eliezer M., primary, Van 'T Veer, Laura J., primary, van de Velde, Tony, primary, van Tinteren, Harm, primary, Velculescu, Victor E., primary, Virtanen, Carl, primary, Voest, Emile E., primary, Wang, Lucy L., primary, Wathoo, Chetna, primary, Watt, Stuart, primary, Yu, Celeste, primary, Yu, Thomas V., primary, Yu, Emily, primary, Zehir, Ahmet, primary, and Zhang, Hongxin, primary

Published
2023
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12. Table S3 from AACR Project GENIE: Powering Precision Medicine through an International Consortium

Author

André, Fabrice, primary, Arnedos, Monica, primary, Baras, Alexander S., primary, Baselga, José, primary, Bedard, Philippe L., primary, Berger, Michael F., primary, Bierkens, Mariska, primary, Calvo, Fabien, primary, Cerami, Ethan, primary, Chakravarty, Debyani, primary, Dang, Kristen K., primary, Davidson, Nancy E., primary, Del Vecchio Fitz, Catherine, primary, Dogan, Semih, primary, DuBois, Raymond N., primary, Ducar, Matthew D., primary, Futreal, P. Andrew, primary, Gao, Jianjiong, primary, Garcia, Francisco, primary, Gardos, Stu, primary, Gocke, Christopher D., primary, Gross, Benjamin E., primary, Guinney, Justin, primary, Heins, Zachary J., primary, Hintzen, Stephanie, primary, Horlings, Hugo, primary, Hudeček, Jan, primary, Hyman, David M., primary, Kamel-Reid, Suzanne, primary, Kandoth, Cyriac, primary, Kinyua, Walter, primary, Kumari, Priti, primary, Kundra, Ritika, primary, Ladanyi, Marc, primary, Lefebvre, Céline, primary, LeNoue-Newton, Michele L., primary, Lepisto, Eva M., primary, Levy, Mia A., primary, Lindeman, Neal I., primary, Lindsay, James, primary, Liu, David, primary, Lu, Zhibin, primary, MacConaill, Laura E., primary, Maurer, Ian, primary, Maxwell, David S., primary, Meijer, Gerrit A., primary, Meric-Bernstam, Funda, primary, Micheel, Christine M., primary, Miller, Clinton, primary, Mills, Gordon, primary, Moore, Nathanael D., primary, Nederlof, Petra M., primary, Omberg, Larsson, primary, Orechia, John A., primary, Park, Ben Ho, primary, Pugh, Trevor J., primary, Reardon, Brendan, primary, Rollins, Barrett J., primary, Routbort, Mark J., primary, Sawyers, Charles L., primary, Schrag, Deborah, primary, Schultz, Nikolaus, primary, Shaw, Kenna R Mills, primary, Shivdasani, Priyanka, primary, Siu, Lillian L., primary, Solit, David B., primary, Sonke, Gabe S., primary, Soria, Jean Charles, primary, Sripakdeevong, Parin, primary, Stickle, Natalie H., primary, Stricker, Thomas P., primary, Sweeney, Shawn M., primary, Taylor, Barry S., primary, ten Hoeve, Jelle J., primary, Thomas, Stacy B., primary, Van Allen, Eliezer M., primary, Van 'T Veer, Laura J., primary, van de Velde, Tony, primary, van Tinteren, Harm, primary, Velculescu, Victor E., primary, Virtanen, Carl, primary, Voest, Emile E., primary, Wang, Lucy L., primary, Wathoo, Chetna, primary, Watt, Stuart, primary, Yu, Celeste, primary, Yu, Thomas V., primary, Yu, Emily, primary, Zehir, Ahmet, primary, and Zhang, Hongxin, primary

Published
2023
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13. Supplementary Appendix from High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing

Author

Wagle, Nikhil, primary, Berger, Michael F., primary, Davis, Matthew J., primary, Blumenstiel, Brendan, primary, DeFelice, Matthew, primary, Pochanard, Panisa, primary, Ducar, Matthew, primary, Van Hummelen, Paul, primary, MacConaill, Laura E., primary, Hahn, William C., primary, Meyerson, Matthew, primary, Gabriel, Stacey B., primary, and Garraway, Levi A., primary

Published
2023
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14. Data from High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing

Author

Wagle, Nikhil, primary, Berger, Michael F., primary, Davis, Matthew J., primary, Blumenstiel, Brendan, primary, DeFelice, Matthew, primary, Pochanard, Panisa, primary, Ducar, Matthew, primary, Van Hummelen, Paul, primary, MacConaill, Laura E., primary, Hahn, William C., primary, Meyerson, Matthew, primary, Gabriel, Stacey B., primary, and Garraway, Levi A., primary

Published
2023
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15. Supplemental Methods, Supplemental Tables 1-2, Supplemental Figures 1-4 from AACR Project GENIE: Powering Precision Medicine through an International Consortium

Author

André, Fabrice, primary, Arnedos, Monica, primary, Baras, Alexander S., primary, Baselga, José, primary, Bedard, Philippe L., primary, Berger, Michael F., primary, Bierkens, Mariska, primary, Calvo, Fabien, primary, Cerami, Ethan, primary, Chakravarty, Debyani, primary, Dang, Kristen K., primary, Davidson, Nancy E., primary, Del Vecchio Fitz, Catherine, primary, Dogan, Semih, primary, DuBois, Raymond N., primary, Ducar, Matthew D., primary, Futreal, P. Andrew, primary, Gao, Jianjiong, primary, Garcia, Francisco, primary, Gardos, Stu, primary, Gocke, Christopher D., primary, Gross, Benjamin E., primary, Guinney, Justin, primary, Heins, Zachary J., primary, Hintzen, Stephanie, primary, Horlings, Hugo, primary, Hudeček, Jan, primary, Hyman, David M., primary, Kamel-Reid, Suzanne, primary, Kandoth, Cyriac, primary, Kinyua, Walter, primary, Kumari, Priti, primary, Kundra, Ritika, primary, Ladanyi, Marc, primary, Lefebvre, Céline, primary, LeNoue-Newton, Michele L., primary, Lepisto, Eva M., primary, Levy, Mia A., primary, Lindeman, Neal I., primary, Lindsay, James, primary, Liu, David, primary, Lu, Zhibin, primary, MacConaill, Laura E., primary, Maurer, Ian, primary, Maxwell, David S., primary, Meijer, Gerrit A., primary, Meric-Bernstam, Funda, primary, Micheel, Christine M., primary, Miller, Clinton, primary, Mills, Gordon, primary, Moore, Nathanael D., primary, Nederlof, Petra M., primary, Omberg, Larsson, primary, Orechia, John A., primary, Park, Ben Ho, primary, Pugh, Trevor J., primary, Reardon, Brendan, primary, Rollins, Barrett J., primary, Routbort, Mark J., primary, Sawyers, Charles L., primary, Schrag, Deborah, primary, Schultz, Nikolaus, primary, Shaw, Kenna R Mills, primary, Shivdasani, Priyanka, primary, Siu, Lillian L., primary, Solit, David B., primary, Sonke, Gabe S., primary, Soria, Jean Charles, primary, Sripakdeevong, Parin, primary, Stickle, Natalie H., primary, Stricker, Thomas P., primary, Sweeney, Shawn M., primary, Taylor, Barry S., primary, ten Hoeve, Jelle J., primary, Thomas, Stacy B., primary, Van Allen, Eliezer M., primary, Van 'T Veer, Laura J., primary, van de Velde, Tony, primary, van Tinteren, Harm, primary, Velculescu, Victor E., primary, Virtanen, Carl, primary, Voest, Emile E., primary, Wang, Lucy L., primary, Wathoo, Chetna, primary, Watt, Stuart, primary, Yu, Celeste, primary, Yu, Thomas V., primary, Yu, Emily, primary, Zehir, Ahmet, primary, and Zhang, Hongxin, primary

Published
2023
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16. Supplemental File 1 from AACR Project GENIE: Powering Precision Medicine through an International Consortium

Author

André, Fabrice, primary, Arnedos, Monica, primary, Baras, Alexander S., primary, Baselga, José, primary, Bedard, Philippe L., primary, Berger, Michael F., primary, Bierkens, Mariska, primary, Calvo, Fabien, primary, Cerami, Ethan, primary, Chakravarty, Debyani, primary, Dang, Kristen K., primary, Davidson, Nancy E., primary, Del Vecchio Fitz, Catherine, primary, Dogan, Semih, primary, DuBois, Raymond N., primary, Ducar, Matthew D., primary, Futreal, P. Andrew, primary, Gao, Jianjiong, primary, Garcia, Francisco, primary, Gardos, Stu, primary, Gocke, Christopher D., primary, Gross, Benjamin E., primary, Guinney, Justin, primary, Heins, Zachary J., primary, Hintzen, Stephanie, primary, Horlings, Hugo, primary, Hudeček, Jan, primary, Hyman, David M., primary, Kamel-Reid, Suzanne, primary, Kandoth, Cyriac, primary, Kinyua, Walter, primary, Kumari, Priti, primary, Kundra, Ritika, primary, Ladanyi, Marc, primary, Lefebvre, Céline, primary, LeNoue-Newton, Michele L., primary, Lepisto, Eva M., primary, Levy, Mia A., primary, Lindeman, Neal I., primary, Lindsay, James, primary, Liu, David, primary, Lu, Zhibin, primary, MacConaill, Laura E., primary, Maurer, Ian, primary, Maxwell, David S., primary, Meijer, Gerrit A., primary, Meric-Bernstam, Funda, primary, Micheel, Christine M., primary, Miller, Clinton, primary, Mills, Gordon, primary, Moore, Nathanael D., primary, Nederlof, Petra M., primary, Omberg, Larsson, primary, Orechia, John A., primary, Park, Ben Ho, primary, Pugh, Trevor J., primary, Reardon, Brendan, primary, Rollins, Barrett J., primary, Routbort, Mark J., primary, Sawyers, Charles L., primary, Schrag, Deborah, primary, Schultz, Nikolaus, primary, Shaw, Kenna R Mills, primary, Shivdasani, Priyanka, primary, Siu, Lillian L., primary, Solit, David B., primary, Sonke, Gabe S., primary, Soria, Jean Charles, primary, Sripakdeevong, Parin, primary, Stickle, Natalie H., primary, Stricker, Thomas P., primary, Sweeney, Shawn M., primary, Taylor, Barry S., primary, ten Hoeve, Jelle J., primary, Thomas, Stacy B., primary, Van Allen, Eliezer M., primary, Van 'T Veer, Laura J., primary, van de Velde, Tony, primary, van Tinteren, Harm, primary, Velculescu, Victor E., primary, Virtanen, Carl, primary, Voest, Emile E., primary, Wang, Lucy L., primary, Wathoo, Chetna, primary, Watt, Stuart, primary, Yu, Celeste, primary, Yu, Thomas V., primary, Yu, Emily, primary, Zehir, Ahmet, primary, and Zhang, Hongxin, primary

Published
2023
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17. Supplementary Methods, Tables 1-9, Figure Legends 1-3 from High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing

Author

Wagle, Nikhil, primary, Berger, Michael F., primary, Davis, Matthew J., primary, Blumenstiel, Brendan, primary, DeFelice, Matthew, primary, Pochanard, Panisa, primary, Ducar, Matthew, primary, Van Hummelen, Paul, primary, MacConaill, Laura E., primary, Hahn, William C., primary, Meyerson, Matthew, primary, Gabriel, Stacey B., primary, and Garraway, Levi A., primary

Published
2023
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20. eFigure1 from Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer

Author

Barroso-Sousa, Romualdo, primary, Keenan, Tanya E., primary, Pernas, Sonia, primary, Exman, Pedro, primary, Jain, Esha, primary, Garrido-Castro, Ana C., primary, Hughes, Melissa, primary, Bychkovsky, Brittany, primary, Umeton, Renato, primary, Files, Janet L., primary, Lindeman, Neal I., primary, MacConaill, Laura E., primary, Hodi, F. Stephen, primary, Krop, Ian E., primary, Dillon, Deborah, primary, Winer, Eric P., primary, Wagle, Nikhil, primary, Lin, Nancy U., primary, Mittendorf, Elizabeth A., primary, Van Allen, Eliezer M., primary, and Tolaney, Sara M., primary

Published
2023
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21. Supplementary Table from Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program

Author

Bychkovsky, Brittany L., primary, Li, Tianyu, primary, Sotelo, Jilliane, primary, Tayob, Nabihah, primary, Mercado, Joanna, primary, Gomy, Israel, primary, Chittenden, Anu, primary, Kane, Sarah, primary, Stokes, Samantha, primary, Hughes, Melissa E., primary, Kim, Ji Seok, primary, Umeton, Renato, primary, Awad, Mark M., primary, Konstantinopoulos, Panagiotis A., primary, Yurgelun, Matthew B., primary, Wolpin, Brian M., primary, Taplin, Mary-Ellen, primary, Newmark, Randall E., primary, Johnson, Bruce E., primary, Lindeman, Neal I., primary, MacConaill, Laura E., primary, Garber, Judy E., primary, and Lin, Nancy U., primary

Published
2023
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22. Supplementary Figure from Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program

Author

Bychkovsky, Brittany L., primary, Li, Tianyu, primary, Sotelo, Jilliane, primary, Tayob, Nabihah, primary, Mercado, Joanna, primary, Gomy, Israel, primary, Chittenden, Anu, primary, Kane, Sarah, primary, Stokes, Samantha, primary, Hughes, Melissa E., primary, Kim, Ji Seok, primary, Umeton, Renato, primary, Awad, Mark M., primary, Konstantinopoulos, Panagiotis A., primary, Yurgelun, Matthew B., primary, Wolpin, Brian M., primary, Taplin, Mary-Ellen, primary, Newmark, Randall E., primary, Johnson, Bruce E., primary, Lindeman, Neal I., primary, MacConaill, Laura E., primary, Garber, Judy E., primary, and Lin, Nancy U., primary

Published
2023
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23. Data from Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions

Author

Singh, Harshabad, primary, Li, Yvonne Y., primary, Spurr, Liam F., primary, Shinagare, Atul B., primary, Abhyankar, Ritika, primary, Reilly, Emma, primary, Brais, Lauren K., primary, Nag, Anwesha, primary, Ducar, Matthew D., primary, Thorner, Aaron R., primary, Shapiro, Geoffrey I., primary, Keller, Rachel B., primary, Siletti, Cheta, primary, Clark, Jeffrey W., primary, Farago, Anna F., primary, Lin, Jessica J., primary, Demetri, George D., primary, Gujrathi, Rahul, primary, Kulke, Matthew H., primary, MacConaill, Laura E., primary, Ligon, Azra H., primary, Sicinska, Ewa, primary, Meyerson, Matthew L., primary, Meyerhardt, Jeffrey A., primary, Cherniack, Andrew D., primary, Wolpin, Brian M., primary, Ng, Kimmie, primary, Giannakis, Marios, primary, Hornick, Jason L., primary, and Cleary, James M., primary

Published
2023
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24. Supplementary Data from Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions

Author

Singh, Harshabad, primary, Li, Yvonne Y., primary, Spurr, Liam F., primary, Shinagare, Atul B., primary, Abhyankar, Ritika, primary, Reilly, Emma, primary, Brais, Lauren K., primary, Nag, Anwesha, primary, Ducar, Matthew D., primary, Thorner, Aaron R., primary, Shapiro, Geoffrey I., primary, Keller, Rachel B., primary, Siletti, Cheta, primary, Clark, Jeffrey W., primary, Farago, Anna F., primary, Lin, Jessica J., primary, Demetri, George D., primary, Gujrathi, Rahul, primary, Kulke, Matthew H., primary, MacConaill, Laura E., primary, Ligon, Azra H., primary, Sicinska, Ewa, primary, Meyerson, Matthew L., primary, Meyerhardt, Jeffrey A., primary, Cherniack, Andrew D., primary, Wolpin, Brian M., primary, Ng, Kimmie, primary, Giannakis, Marios, primary, Hornick, Jason L., primary, and Cleary, James M., primary

Published
2023
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25. Supplementary Methods and Results from Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer

Author

Barroso-Sousa, Romualdo, primary, Keenan, Tanya E., primary, Pernas, Sonia, primary, Exman, Pedro, primary, Jain, Esha, primary, Garrido-Castro, Ana C., primary, Hughes, Melissa, primary, Bychkovsky, Brittany, primary, Umeton, Renato, primary, Files, Janet L., primary, Lindeman, Neal I., primary, MacConaill, Laura E., primary, Hodi, F. Stephen, primary, Krop, Ian E., primary, Dillon, Deborah, primary, Winer, Eric P., primary, Wagle, Nikhil, primary, Lin, Nancy U., primary, Mittendorf, Elizabeth A., primary, Van Allen, Eliezer M., primary, and Tolaney, Sara M., primary

Published
2023
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26. Supplementary Figures from Genomic Characterization of de novo Metastatic Breast Cancer

Author

Garrido-Castro, Ana C., primary, Spurr, Liam F., primary, Hughes, Melissa E., primary, Li, Yvonne Y., primary, Cherniack, Andrew D., primary, Kumari, Priti, primary, Lloyd, Maxwell R., primary, Bychkovsky, Brittany, primary, Barroso-Sousa, Romualdo, primary, Di Lascio, Simona, primary, Jain, Esha, primary, Files, Janet, primary, Mohammed-Abreu, Ayesha, primary, Krevalin, Max, primary, MacKichan, Colin, primary, Barry, William T., primary, Guo, Hao, primary, Xia, Daniel, primary, Cerami, Ethan, primary, Rollins, Barrett J., primary, MacConaill, Laura E., primary, Lindeman, Neal I., primary, Krop, Ian E., primary, Johnson, Bruce E., primary, Wagle, Nikhil, primary, Winer, Eric P., primary, Dillon, Deborah A., primary, and Lin, Nancy U., primary

Published
2023
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27. Supplementary File 3 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer

Author

Nikolsky, Yuri, primary, Sviridov, Evgeny, primary, Yao, Jun, primary, Dosymbekov, Damir, primary, Ustyansky, Vadim, primary, Kaznacheev, Valery, primary, Dezso, Zoltan, primary, Mulvey, Laura, primary, Macconaill, Laura E., primary, Winckler, Wendy, primary, Serebryiskaya, Tatiana, primary, Nikolskaya, Tatiana, primary, and Polyak, Kornelia, primary

Published
2023
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28. Supplementary File 2 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer

Author

Nikolsky, Yuri, primary, Sviridov, Evgeny, primary, Yao, Jun, primary, Dosymbekov, Damir, primary, Ustyansky, Vadim, primary, Kaznacheev, Valery, primary, Dezso, Zoltan, primary, Mulvey, Laura, primary, Macconaill, Laura E., primary, Winckler, Wendy, primary, Serebryiskaya, Tatiana, primary, Nikolskaya, Tatiana, primary, and Polyak, Kornelia, primary

Published
2023
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29. Supplementary File 1 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer

Author

Nikolsky, Yuri, primary, Sviridov, Evgeny, primary, Yao, Jun, primary, Dosymbekov, Damir, primary, Ustyansky, Vadim, primary, Kaznacheev, Valery, primary, Dezso, Zoltan, primary, Mulvey, Laura, primary, Macconaill, Laura E., primary, Winckler, Wendy, primary, Serebryiskaya, Tatiana, primary, Nikolskaya, Tatiana, primary, and Polyak, Kornelia, primary

Published
2023
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30. Supplementary File 5 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer

Author

Nikolsky, Yuri, primary, Sviridov, Evgeny, primary, Yao, Jun, primary, Dosymbekov, Damir, primary, Ustyansky, Vadim, primary, Kaznacheev, Valery, primary, Dezso, Zoltan, primary, Mulvey, Laura, primary, Macconaill, Laura E., primary, Winckler, Wendy, primary, Serebryiskaya, Tatiana, primary, Nikolskaya, Tatiana, primary, and Polyak, Kornelia, primary

Published
2023
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31. Supplementary File 4 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer

Author

Nikolsky, Yuri, primary, Sviridov, Evgeny, primary, Yao, Jun, primary, Dosymbekov, Damir, primary, Ustyansky, Vadim, primary, Kaznacheev, Valery, primary, Dezso, Zoltan, primary, Mulvey, Laura, primary, Macconaill, Laura E., primary, Winckler, Wendy, primary, Serebryiskaya, Tatiana, primary, Nikolskaya, Tatiana, primary, and Polyak, Kornelia, primary

Published
2023
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32. Supplementary File 6 from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer

Author

Nikolsky, Yuri, primary, Sviridov, Evgeny, primary, Yao, Jun, primary, Dosymbekov, Damir, primary, Ustyansky, Vadim, primary, Kaznacheev, Valery, primary, Dezso, Zoltan, primary, Mulvey, Laura, primary, Macconaill, Laura E., primary, Winckler, Wendy, primary, Serebryiskaya, Tatiana, primary, Nikolskaya, Tatiana, primary, and Polyak, Kornelia, primary

Published
2023
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33. Materials and Methods, Legends, Tables and Figures from Genome-Wide Functional Synergy between Amplified and Mutated Genes in Human Breast Cancer

Author

Nikolsky, Yuri, primary, Sviridov, Evgeny, primary, Yao, Jun, primary, Dosymbekov, Damir, primary, Ustyansky, Vadim, primary, Kaznacheev, Valery, primary, Dezso, Zoltan, primary, Mulvey, Laura, primary, Macconaill, Laura E., primary, Winckler, Wendy, primary, Serebryiskaya, Tatiana, primary, Nikolskaya, Tatiana, primary, and Polyak, Kornelia, primary

Published
2023
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35. Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors

Author

Nassar, Amin H., primary, Adib, Elio, additional, Abou Alaiwi, Sarah, additional, El Zarif, Talal, additional, Groha, Stefan, additional, Akl, Elie W., additional, Nuzzo, Pier Vitale, additional, Mouhieddine, Tarek H., additional, Perea-Chamblee, Tomin, additional, Taraszka, Kodi, additional, El-Khoury, Habib, additional, Labban, Muhieddine, additional, Fong, Christopher, additional, Arora, Kanika S., additional, Labaki, Chris, additional, Xu, Wenxin, additional, Sonpavde, Guru, additional, Haddad, Robert I., additional, Mouw, Kent W., additional, Giannakis, Marios, additional, Hodi, F. Stephen, additional, Zaitlen, Noah, additional, Schoenfeld, Adam J., additional, Schultz, Nikolaus, additional, Berger, Michael F., additional, MacConaill, Laura E., additional, Ananda, Guruprasad, additional, Kwiatkowski, David J., additional, Choueiri, Toni K., additional, Schrag, Deborah, additional, Carrot-Zhang, Jian, additional, and Gusev, Alexander, additional

Published
2022
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36. Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program

Author

Bychkovsky, Brittany L., primary, Li, Tianyu, additional, Sotelo, Jilliane, additional, Tayob, Nabihah, additional, Mercado, Joanna, additional, Gomy, Israel, additional, Chittenden, Anu, additional, Kane, Sarah, additional, Stokes, Samantha, additional, Hughes, Melissa E., additional, Kim, Ji Seok, additional, Umeton, Renato, additional, Awad, Mark M., additional, Konstantinopoulos, Panagiotis A., additional, Yurgelun, Matthew B., additional, Wolpin, Brian M., additional, Taplin, Mary-Ellen, additional, Newmark, Randall E., additional, Johnson, Bruce E., additional, Lindeman, Neal I., additional, MacConaill, Laura E., additional, Garber, Judy E., additional, and Lin, Nancy U., additional

Published
2022
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37. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

Author

Ramkissoon, Lori A., Horowitz, Peleg M., Craig, Justin M., Ramkissoon, Shakti H., Rich, Benjamin E., Schumacher, Steven E., McKenna, Aaron, Lawrence, Michael S., Bergthold, Guillaume, Brastianos, Priscilla K., Tabak, Barbara, Ducar, Matthew D., Van Hummelen, Paul, MacConaill, Laura E., Pouissant-Young, Tina, Cho, Yoon-Jae, Taha, Hala, Mahmoud, Madeha, Bowers, Daniel C., Margraf, Linda, Tabori, Uri, Hawkins, Cynthia, Packer, Roger J., Hill, D. Ashley, Pomeroy, Scott L., Eberhart, Charles G., Dunn, Ian F., Goumnerova, Liliana, Getz, Gad, Chan, Jennifer A., Santagata, Sandro, Hahn, William C., Stiles, Charles D., Ligon, Azra H., Kieran, Mark W., Beroukhim, Rameen, and Ligon, Keith L.

Published
2013

38. Integrated Clinico-Genomic Analysis of Genetic Ancestry in 1,614 Patients With Cancer Treated With Immune Checkpoint Inhibitors

Author

Nassar, Amin, primary, Adib, Elio, additional, Abou Alaiwi, Sarah, additional, El Zarif, Talal, additional, Groha, Stefan, additional, Akl, Elie W., additional, Nuzzo, Pier Vitale, additional, Mouhieddine, Tarek H., additional, El-Khoury, Habib, additional, Labban, Muhieddine, additional, Labaki, Chris, additional, Xu, Wenxin, additional, Sonpavde, Guru, additional, Haddad, Robert I., additional, Mouw, Kent W., additional, Giannakis, Marios, additional, Hodi, F. Stephen, additional, MacConaill, Laura E., additional, Ananda, Guruprasad, additional, Kwiatkowski, David J., additional, Choueiri, Toni K., additional, Schrag, Deborah, additional, and Gusev, Alexander, additional

Published
2022
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39. MEK1 Mutations Confer Resistance to MEK and B-RAF Inhibition

Author

Emery, Caroline M., Vijayendran, Krishna G., Zipser, Marie C., Sawyer, Allison M., Niu, Lili, Kim, Jessica J., Hatton, Charles, Chopra, Rajiv, Oberholzer, Patrick A., Karpova, Maria B., MacConaill, Laura E., Zhang, Jianming, Gray, Nathanael S., Sellers, William R., Dummer, Reinhard, and Garraway, Levi A.

Published
2009
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40. High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade

Author

Kießling, Michael K., Oberholzer, Patrick A., Mondal, Chandrani, Karpova, Maria B., Zipser, Marie C., Lin, William M., Girardi, Michael, MacConaill, Laura E., Kehoe, Sarah M., Hatton, Charlie, French, Lars E., Garraway, Levi A., Polier, Gernot, Süss, Dorothee, Klemke, Claus-Detlev, Krammer, Peter H., Gülow, Karsten, and Dummer, Reinhard

Published
2011
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41. Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study

Author

Harris, Marian H., DuBois, Steven G., Glade Bender, Julia L., Kim, AeRang, Crompton, Brian D., Parker, Erin, Dumont, Ian P., Hong, Andrew L., Guo, Dongjing, Church, Alanna, Stegmaier, Kimberly, Roberts, Charles W. M., Shusterman, Suzanne, London, Wendy B., MacConaill, Laura E., Lindeman, Neal I., Diller, Lisa, Rodriguez-Galindo, Carlos, and Janeway, Katherine A.

Published
2016
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44. Role of BRAFV600E in the First Preclinical Model of Multifocal Infiltrating Myopericytoma Development and Microenvironment

Author

Sadow, Peter M., Priolo, Carmen, Nanni, Simona, Karreth, Florian A., Duquette, Mark, Martinelli, Roberta, Husain, Amjad, Clohessy, John, Kutzner, Heinz, Mentzel, Thomas, Carman, Christopher V., Farsetti, Antonella, Henske, Elizabeth Petri, Palescandolo, Emanuele, Macconaill, Laura E., Chung, Seum, Fadda, Guido, Lombardi, Celestino Pio, De Angelis, Antonina M., Durante, Oreste, Parker, John A., Pontecorvi, Alfredo, Dvorak, Harold F., Fletcher, Christopher, Pandolfi, Pier Paolo, Lawler, Jack, and Nucera, Carmelo

Published
2014
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45. Genomic aberrations in cervical adenocarcinomas in Hong Kong Chinese women

Author

Chung, Tony K.H., Van Hummelen, Paul, Chan, Paul K.S., Cheung, Tak Hong, Yim, So Fan, Yu, Mei Y., Ducar, Matthew D., Thorner, Aaron R., MacConaill, Laura E., Doran, Graeme, Pedamallu, Chandra Sekhar, Ojesina, Akinyemi I., Wong, Raymond R.Y., Wang, Vivian W., Freeman, Samuel S., Lau, Tat San, Kwong, Joseph, Chan, Loucia K.Y., Fromer, Menachem, May, Taymaa, Worley, Michael J., Jr., Esselen, Katharine M., Elias, Kevin M., Lawrence, Michael, Getz, Gad, Smith, David I., Crum, Christopher P., Meyerson, Matthew, Berkowitz, Ross S., and Wong, Yick Fu

Published
2015
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47. Twists and turns from “tumor in tumor” profiling: surveillance of chronic lymphocytic leukemia (CLL) leads to detection of a lung adenocarcinoma, whose genomic characterization alters the original hematologic diagnosis

Author

Terraf, Panieh, primary, Sholl, Lynette M., additional, Davids, Matthew S., additional, Awad, Mark M., additional, Garcia, Elizabeth P., additional, MacConaill, Laura E., additional, Dal Cin, Paola, additional, Kim, Annette, additional, Lindeman, Neal I., additional, Stachler, Matthew, additional, Hwang, David H., additional, and Dubuc, Adrian M., additional

Published
2021
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48. Identification and management of pathogenic mutations in BRCA1, BRCA2, and PALB2 in a tumor-only genomic testing program.

Author

Bychkovsky, Brittany L., primary, Li, Tianyu, additional, Sotelo, Jilliane, additional, Tayob, Nabihah, additional, Mercado, Joanna, additional, Gomy, Israel, additional, Chittenden, Anu B., additional, Kane, Sarah R., additional, Stokes, Samantha, additional, Hughes, Melissa E, additional, Kim, Ji Seok, additional, Awad, Mark M., additional, Konstantinopoulos, Panagiotis A., additional, Wolpin, Brian M., additional, Taplin, Mary-Ellen, additional, Johnson, Bruce E., additional, Lindeman, Neal Ian, additional, MacConaill, Laura E, additional, Garber, Judy Ellen, additional, and Lin, Nancy U., additional

Published
2021
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49. Genetic ancestry and clinical outcomes to immune checkpoint inhibitors among seven common cancers.

Author

Nassar, Amin, primary, Adib, Elio, additional, Abou Alaiwi, Sarah, additional, Akl, Elie, additional, El Zarif, Talal, additional, Nuzzo, Pier Vitale, additional, Mouhieddine, Tarek H., additional, El-Khoury, Habib, additional, Groha, Stefan, additional, Sonpavde, Guru P., additional, Haddad, Robert I., additional, Mouw, Kent William, additional, Giannakis, Marios, additional, Ananda, Guruprasad, additional, Freedman, Matthew L., additional, Kwiatkowski, David J., additional, MacConaill, Laura E, additional, Choueiri, Toni K., additional, and Gusev, Alexander, additional

Published
2021
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