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162 results on '"Macedo, Arthur C."'

1. Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability

Author

Therriault, Joseph, Janelidze, Shorena, Benedet, Andréa Lessa, Ashton, Nicholas J., Arranz Martínez, Javier, Gonzalez-Escalante, Armand, Bellaver, Bruna, Alcolea, Daniel, Vrillon, Agathe, Karim, Helmet, Mielke, Michelle M., Hyung Hong, Chang, Roh, Hyun Woong, Contador, José, Puig Pijoan, Albert, Algeciras-Schimnich, Alicia, Vemuri, Prashanthi, Graff-Radford, Jonathan, Lowe, Val J., Karikari, Thomas K., Jonaitis, Erin, Brum, Wagner, Tissot, Cécile, Servaes, Stijn, Rahmouni, Nesrine, Macedo, Arthur C., Stevenson, Jenna, Fernandez-Arias, Jaime, Wang, Yi-Ting, Woo, Marcel S., Friese, Manuel A., Jia, Wan Lu, Dumurgier, Julien, Hourregue, Claire, Cognat, Emmanuel, Ferreira, Pamela Lukasewicz, Vitali, Paolo, Johnson, Sterling, Pascoal, Tharick A., Gauthier, Serge, Lleó, Alberto, Paquet, Claire, Petersen, Ronald C., Salmon, David, Mattsson-Carlgren, Niklas, Palmqvist, Sebastian, Stomrud, Erik, Galasko, Douglas, Son, Sang Joon, Zetterberg, Henrik, Fortea, Juan, Suárez-Calvet, Marc, Jack, Jr, Clifford R., Blennow, Kaj, Hansson, Oskar, and Rosa-Neto, Pedro

Published
2024
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2. Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Author

Therriault, Joseph, Woo, Marcel S., Salvadó, Gemma, Gobom, Johan, Karikari, Thomas K., Janelidze, Shorena, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Ashton, Nicholas J., Benedet, Andréa Lessa, Montoliu-Gaya, Laia, Macedo, Arthur C., Lussier, Firoza Z., Stevenson, Jenna, Vitali, Paolo, Friese, Manuel A., Massarweh, Gassan, Soucy, Jean-Paul, Pascoal, Tharick A., Stomrud, Erik, Palmqvist, Sebastian, Mattsson-Carlgren, Niklas, Gauthier, Serge, Zetterberg, Henrik, Hansson, Oskar, Blennow, Kaj, and Rosa-Neto, Pedro

Published
2024
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3. Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging

Author

Macedo, Arthur C., Therriault, Joseph, Tissot, Cécile, Aumont, Étienne, Servaes, Stijn, Rahmouni, Nesrine, Fernandez-Arias, Jaime, Lussier, Firoza Z., Wang, Yi-Ting, Ng, Kok Pin, Vermeiren, Marie, Bezgin, Gleb, Socualaya, Kely Quispialaya, Stevenson, Jenna, Hosseini, Seyyed Ali, Chamoun, Mira, Ferrari-Souza, João Pedro, Ferreira, Pâmela C.L., Bellaver, Bruna, Leffa, Douglas Teixeira, Vitali, Paolo, Zimmer, Eduardo R., Ismail, Zahinoor, Pascoal, Tharick A., Gauthier, Serge, and Rosa-Neto, Pedro

Published
2024
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4. Identification of late-stage tau accumulation using plasma phospho-tau217

Author

Woo, Marcel S., Therriault, Joseph, Jonaitis, Erin M., Wilson, Rachael, Langhough, Rebecca E., Rahmouni, Nesrine, Benedet, Andrea Lessa, Ashton, Nicholas J., Tissot, Cécile, Lantero-Rodriguez, Juan, Macedo, Arthur C., Servaes, Stijn, Wang, Yi-Ting, Arias, Jaime Fernandez, Hosseini, Seyyed Ali, Betthauser, Tobey J., Lussier, Firoza Z., Hopewell, Robert, Triana-Baltzer, Gallen, Kolb, Hartmuth C., Jeromin, Andreas, Kobayashi, Eliane, Massarweh, Gassan, Friese, Manuel A., Klostranec, Jesse, Vilali, Paolo, Pascoal, Tharick A., Gauthier, Serge, Zetterberg, Henrik, Blennow, Kaj, Johnson, Sterling C., and Rosa-Neto, Pedro

Published
2024
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6. APOEε4 potentiates amyloid β effects on longitudinal tau pathology

Author

Ferrari-Souza, João Pedro, Bellaver, Bruna, Ferreira, Pâmela C. L., Benedet, Andréa L., Povala, Guilherme, Lussier, Firoza Z., Leffa, Douglas T., Therriault, Joseph, Tissot, Cécile, Soares, Carolina, Wang, Yi-Ting, Chamoun, Mira, Servaes, Stijn, Macedo, Arthur C., Vermeiren, Marie, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Cohen, Ann, Lopez, Oscar L., Klunk, William E., Soucy, Jean-Paul, Gauthier, Serge, Souza, Diogo O., Triana-Baltzer, Gallen, Saad, Ziad S., Kolb, Hartmuth C., Karikari, Thomas K., Villemagne, Victor L., Tudorascu, Dana L., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Zimmer, Eduardo R., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2023
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7. 14-3-3 ζ/δ-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2

Author

Woo, Marcel S., Nilsson, Johanna, Therriault, Joseph, Rahmouni, Nesrine, Brinkmalm, Ann, Benedet, Andrea L., Ashton, Nicholas J., Macedo, Arthur C., Servaes, Stijn, Wang, Yi-Ting, Tissot, Cécile, Arias, Jaime Fernandez, Hosseini, Seyyed Ali, Chamoun, Mira, Lussier, Firoza Z., Karikari, Thomas K., Stevenson, Jenna, Mayer, Christina, Ferrari-Souza, João Pedro, Kobayashi, Eliane, Massarweh, Gassan, Friese, Manuel A., Pascoal, Tharick A., Gauthier, Serge, Zetterberg, Henrik, Blennow, Kaj, and Rosa-Neto, Pedro

Published
2023
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8. Comparison Between Brain and Cerebellar Autoradiography Using [18F]Flortaucipir, [18F]MK6240, and [18F]PI2620 in Postmortem Human Brain Tissue.

Author

Aliaga, Antonio, Therriault, Joseph, Quispialaya, Kely Monica, Aliaga, Arturo, Hopewell, Robert, Rahmouni, Nesrine, Macedo, Arthur C., Kunach, Peter, Soucy, Jean-Paul, Massarweh, Gassan, Diaz, Aida Abreu, Pascoal, Tharick A., Rocha, Andreia, Guiot, Marie-Christine, Machado, Luiza S., De Bastiani, Marco Antônio, de Souza, Débora Guerini, Souza, Diogo O., Gauthier, Serge, and Zimmer, Eduardo R.

Published
2025
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9. Plasma phosphorylated tau181 outperforms [18F] fluorodeoxyglucose positron emission tomography in the identification of early Alzheimer disease.

Author

Quispialaya, Kely Monica, Therriault, Joseph, Aliaga, Antonio, Tissot, Cécile, Servaes, Stijn, Rahmouni, Nesrine, Karikari, Thomas K., Benedet, Andrea L., Ashton, Nicholas J., Macedo, Arthur C., Lussier, Firoza Z., Stevenson, Jenna, Wang, Yi‐Ting, Arias, Jaime Fernandez, Hosseini, Ali, Matsudaira, Takashi, Jean‐Claude, Bertrand, Gilfix, Brian M., Zimmer, Eduardo R., and Soucy, Jean‐Paul

Subjects
POSITRON emission tomography, MONTREAL Cognitive Assessment, RECEIVER operating characteristic curves, ALZHEIMER'S disease, COGNITIVE testing, MINI-Mental State Examination
Abstract

Background and purpose: This study was undertaken to compare the performance of plasma p‐tau181 with that of [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in the identification of early biological Alzheimer disease (AD). Methods: We included 533 cognitively impaired participants from the Alzheimer's Disease Neuroimaging Initiative. Participants underwent PET scans, biofluid collection, and cognitive tests. Receiver operating characteristic analyses were used to determine the diagnostic accuracy of plasma p‐tau181 and [18F]FDG‐PET using clinical diagnosis and core AD biomarkers ([18F]florbetapir‐PET and cerebrospinal fluid [CSF] p‐tau181) as reference standards. Differences in the diagnostic accuracy between plasma p‐tau181 and [18F]FDG‐PET were determined by bootstrap‐based tests. Correlations of [18F]FDG‐PET and plasma p‐tau181 with CSF p‐tau181, amyloid β (Aβ) PET, and cognitive performance were evaluated to compare associations between measurements. Results: We observed that both plasma p‐tau181 and [18F]FDG‐PET identified individuals with positive AD biomarkers in CSF or on Aβ‐PET. In the MCI group, plasma p‐tau181 outperformed [18F]FDG‐PET in identifying AD measured by CSF (p = 0.0007) and by Aβ‐PET (p = 0.001). We also observed that both plasma p‐tau181 and [18F]FDG‐PET metabolism were associated with core AD biomarkers. However, [18F]FDG‐PET uptake was more closely associated with cognitive outcomes (Montreal Cognitive Assessment, Mini‐Mental State Examination, Clinical Dementia Rating Sum of Boxes, and logical memory delayed recall, p < 0.001) than plasma p‐tau181. Conclusions: Overall, although both plasma p‐tau181 and [18F]FDG‐PET were associated with core AD biomarkers, plasma p‐tau181 outperformed [18F]FDG‐PET in identifying individuals with early AD pathophysiology. Taken together, our study suggests that plasma p‐tau181 may aid in detecting individuals with underlying early AD. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Prevalence of orofacial pain in individuals with mild cognitive impairment or dementia: A systematic review and meta‐analysis.

Author

Macedo, Arthur C., Bitencourt, Fernando Valentim, Faria, André Oliveira Vilela de, Bizzi, Isabella Harb, Durço, Daniella de Freitas Pereira Ângelo, Azevedo, Claudia Britto, Morris, Martin, Ferreira, Karen dos Santos, De Souza, Leonardo Cruz, and Velly, Ana Miriam

Subjects
MILD cognitive impairment, PAIN measurement, ALZHEIMER'S disease, GREY literature, LITERARY sources, OROFACIAL pain
Abstract

Background: This systematic review investigated the prevalence of orofacial pain in patients with mild cognitive impairment (MCI) or dementia. Materials and methods: The search was conducted in five databases (Medline (Ovid), Embase (Ovid), CINAHL, Scopus and LILACS), in three grey literature sources and in included articles' reference lists. Three independent reviewers performed study selection, quality appraisal and data extraction. The risk of bias was assessed with the National Institutes of Health tool. Prevalence was calculated using the random‐effects model. Subgroup analysis and meta‐regression were used to explore the heterogeneity of results. Results: The database and grey literature search led to 12 246 results, from which nine studies were included; a further four were selected through citation searching. The total sample comprised 6115 patients with dementia and 84 with MCI. All studies had high risk of bias. The overall estimated pooled prevalence of orofacial pain among dementia participants was 19.0% (95% CI, 11.0%‐27.0%; I2, 97.1%, P <.001). Only one study included MCI participants, among which the prevalence of orofacial pain was 20.5%. Subgroup analysis demonstrated that the different sources of diagnosis might explain the heterogeneity. A higher prevalence of orofacial pain was observed in dementia participants aged over 80 years or living in nursing homes. Meta‐regression analysis showed a nonlinear relationship between age and the prevalence of orofacial pain. Conclusions: The pooled data from the primary studies revealed that 2 out of 10 patients with dementia have orofacial pain. Further research is needed to clarify the magnitude in individuals with MCI. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Predicting functional decline in aging and Alzheimer’s disease with PET-based Braak staging

Author

Macedo, Arthur C, primary, Therriault, Joseph, additional, Tissot, Cécile, additional, Fernandez Arias, Jaime, additional, Ferreira, Pamela C L, additional, Vitali, Paolo, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Lussier, Firoza Z, additional, Stevenson, Jenna, additional, Wang, Yi-Ting, additional, Socualaya, Kely Quispialaya, additional, Kunach, Peter, additional, Nazneen, Tahnia, additional, Hosseini, Seyyed Ali, additional, Pallen, Vanessa, additional, Stevenson, Alyssa, additional, Ferrari-Souza, João Pedro, additional, Bellaver, Bruna, additional, Leffa, Douglas Teixeira, additional, Ng, Kok Pin, additional, Zimmer, Eduardo R, additional, Pascoal, Tharick A, additional, Gauthier, Serge, additional, and Rosa-Neto, Pedro, additional

Published
2024
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12. Visual memory is primarily impacted by tau load in the right hemisphere.

Author

Arias, Jaime Fernandez, Therriault, Joseph, Servaes, Stijn, Macedo, Arthur C., Wang, Yi‐Ting, Rahmouni, Nesrine, Socualaya, Kely Monica Quispialaya, Aumont, Etienne, Trudel, Lydia, Hosseini, Seyyed Ali, Hall, Brandon J, Chan, Tevy, Kunach, Peter, Mathotaarachchi, Sulantha, Vitali, Paolo, and Rosa‐Neto, Pedro

Abstract

Background: Classical literature has pointed at lateralization of the relationship between memory scores and cerebral hemisphere injury. Epilepsy studies have suggested an association between left hippocampal damage and verbal memory deficits, and between right hippocampal damage and visual memory deficits. We aimed to explore this concept in the context of tauopathy due to Alzheimer's disease. Method: we assessed 132 cognitively unimpaired (CU) older adults, and 44 cognitively impaired (CI), amyloid‐β positive individuals from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort. All participants had amyloid‐PET with [18F]AZD4694 and tau‐PET with [18F]MK6240, verbal memory assessments with Rey Auditory Verbal Learning Test (RAVLT), and visual memory assessments with Aggie Figures Learning Test (AFLT). We conducted voxel‐wise analyses to explore the relationship between tau PET and memory modality. In addition, we run regression models with right or left tau temporal metaROI as predictor and memory scores as outcome variables. We entered global amyloid (PET), sex, age, years of education, ApoE status, grey matter volume and handedness as covariates. Finally, we used the laterality index (LI) to investigate correlations with memory modality. Right laterality is indicated by an LI below 0, while left laterality would be signaled by an LI above 0. Result: voxel‐wise analyses suggested a lateralized relationship between tau and visual memory scores on the right hemisphere, whereas tau and verbal memory scores were bilaterally associated. Regression analyses showed a trend towards a stronger relationship between temporal tau on the right and visual memory scores. The LI was significantly associated with visual memory performance. Further analyses showed that this relationship seems to be driven by tau positive individuals. Conclusion: visual memory performance might be more prominently affected by tau load on the right hemisphere in Alzheimer's disease. Furthermore, a hemispheric imbalance in the amount of tau is related to visual, but not verbal, memory scores. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Synaptic dysfunction, Tau pathology and Neurodegeneration

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Rohden, Francieli, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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14. CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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15. Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer’s disease

Author

Ferrari‐Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Benedet, Andrea Lessa, additional, Soares, Carolina, additional, Aguzzoli, Cristiano Schaffer, additional, Zalzale, Hussein, additional, Rohden, Francieli, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Souza, Diogo O., additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Triana‐Baltzer, Gallen, additional, Saad, Ziad S., additional, Kolb, Hartmuth C., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Pascoal, Tharick A., additional, and Zimmer, Eduardo R, additional

Published
2023
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16. Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer’s Disease

Author

Aguzzoli, Cristiano Schaffer, primary, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Soares, Carolina, additional, Ferrari‐Souza, João Pedro, additional, Bellaver, Bruna, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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18. Associations and interactions of synaptic and inflammatory biomarkers in Alzheimer's disease

Author

Rahmouni, Nesrine, primary, Tissot, Cécile, additional, Servaes, Stijn, additional, Therriault, Joseph, additional, Macedo, Arthur C., additional, Stevenson, Jenna, additional, Fernandez-Arias, Jaime, additional, Wang, Yi-Ting, additional, Gauthier, Serge, additional, Karikari, Thomas, additional, Benedet, Andrea, additional, Ashton, Nicholas, additional, Zetterberg, Henrik, additional, Pascoal, Tharick A., additional, Blennow, Kaj, additional, Zimmer, Eduardo R., additional, and Rosa-Neto, Pedro, additional

Published
2023
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19. APOEε4 potentiates the effects of Aβ pathology on the deposition of neurofibrillary tangles via tau phosphorylation

Author

Ferrari‐Souza, João Pedro, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Benedet, Andrea Lessa, additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Soares, Carolina, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Klunk, William E, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Triana‐Baltzer, Gallen, additional, Saad, Ziad S., additional, Kolb, Hartmuth C., additional, Karikari, Thomas K, additional, Villemagne, Victor L, additional, Tudorascu, Dana, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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20. Interactions of synaptic and inflammatory biomarkers in Alzheimer’s Disease

Author

Rahmouni, Nesrine, primary, Tissot, Cécile, additional, Servaes, Stijn, additional, Therriault, Joseph, additional, Macedo, Arthur C., additional, Stevenson, Jenna, additional, Lussier, Firoza Z, additional, Machado, Luiza Santos, additional, Arias, Jaime Fernandez, additional, Wang, Yi‐Ting, additional, Stevenson, Alyssa, additional, Socualaya, Kely Quispialaya, additional, Kunach, Peter, additional, Nazneen, Tahnia, additional, Hosseini, Seyyed Ali, additional, Gauthier, Serge, additional, Karikari, Thomas K, additional, Benedet, Andrea Lessa, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Pascoal, Tharick A., additional, Blennow, Kaj, additional, Zimmer, Eduardo R, additional, and Rosa‐Neto, Pedro, additional

Published
2023
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21. Assessment of brain oxygen extraction in aging and Alzheimer’s disease with MRI images

Author

Hosseini, Seyyed Ali, primary, Servaes, Stijn, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Lussier, Firoza Z, additional, Stevenson, Jenna, additional, Wang, Yi‐Ting, additional, Arias, Jaime Fernandez, additional, Aumont, Etienne, additional, Socualaya, Kely Quispialaya, additional, Nazneen, Tahnia, additional, Stevenson, Alyssa, additional, Gauthier, Serge, additional, Pascoal, Tharick A., additional, and Rosa‐Neto, Pedro, additional

Published
2023
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22. Fast accumulators of tau have higher levels of plasma pTau and stronger associations with amyloid in later Braak regions at baseline

Author

Servaes, Stijn, primary, Tissot, Cécile, additional, Therriault, Joseph, additional, Lussier, Firoza Z, additional, Ashton, Nicholas J., additional, Benedet, Andrea Lessa, additional, Karikari, Thomas K, additional, Wang, Yi‐Ting, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Stevenson, Alyssa, additional, Pallen, Vanessa, additional, Arias, Jaime Fernandez, additional, Macedo, Arthur C., additional, Nazneen, Tahnia, additional, Hosseini, Seyyed Ali, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rosa‐Neto, Pedro, additional

Published
2023
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23. The impact of young controls in the detection of tau load in cognitively impaired and asymptomatic elderly

Author

Macedo, Arthur C., primary, Tissot, Cécile, additional, Therriault, Joseph, additional, Rahmouni, Nesrine, additional, Servaes, Stijn, additional, Arias, Jaime Fernandez, additional, Wang, Yi‐Ting, additional, Aumont, Etienne, additional, Socualaya, Kely Quispialaya, additional, Lussier, Firoza Z, additional, Stevenson, Jenna, additional, Nazneen, Tahnia, additional, Hosseini, Seyyed Ali, additional, Karikari, Thomas K, additional, Benedet, Andrea Lessa, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Pascoal, Tharick A., additional, and Rosa‐Neto, Pedro, additional

Published
2023
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24. Plasma p‐tau 181 outperforms FDG‐PET and plasma‐NfL in the diagnosis of biological AD

Author

Socualaya, Kely Quispialaya, primary, Therriault, Joseph, additional, Aliaga, Antonio, additional, Servaes, Stijn, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Arias, Jaime Fernandez, additional, Hosseini, Seyyed Ali, additional, Vitali, Paolo, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, and Rosa‐Neto, Pedro, additional

Published
2023
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25. Plasma p-tau 181 outperforms FDG-PET in the early diagnosis of biological AD

Author

Quispialaya, Kely, primary, Therriault, Joseph, additional, Aliaga, Antonio, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Karikari, Tomas, additional, Benedet, Andrea, additional, Ashton, Nicholas, additional, Macedo, Arthur C., additional, Firoza, Lussier, additional, Stevenson, Jenna, additional, Wang, Yi-Ting, additional, Fernandez-Arias, Jaime, additional, Hosseini, Seyyed Ali, additional, Nazneen, Tahnia, additional, Jean-Claude, Bertrand, additional, Zimmer, Eduardo R., additional, Soucy, Jean-Paul, additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rosa-Neto, Pedro, additional

Published
2023
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26. Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau‐targeting therapies

Author

Ferrari‐Souza, João Pedro, primary, Ferreira, Pamela C.L., additional, Bellaver, Bruna, additional, Povala, Guilherme, additional, Lussier, Firoza Z, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Soares, Carolina, additional, Benedet, Andrea Lessa, additional, Wang, Yi‐Ting, additional, Chamoun, Mira, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Poltronetti, Nina Margherita, additional, Aguzzoli, Cristiano Schaffer, additional, Zalzale, Hussein, additional, Rohden, Francieli, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Souza, Diogo O., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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27. Sex impacts the association of plasma Glial Fibrillary Acidic Protein with neurodegeneration in Alzheimer’s disease

Author

Abbas, Sarah, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Ferrari‐Souza, João Pedro, additional, Lussier, Firoza Z, additional, Zalzale, Hussein, additional, Lemaire, Peter Charles, additional, Soares, Carolina, additional, Rohden, Francieli, additional, Aguzzoli, Cristiano Schaffer, additional, Cabrera, Arlec, additional, Leffa, Douglas Teixeira, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Chamoun, Mira, additional, Bezgin, Gleb, additional, Stevenson, Jenna, additional, Stevenson, Alyssa, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Benedet, Andrea Lessa, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick Ali, additional

Published
2023
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28. Independent associations of plasma GFAP with amyloid-Β and tau in Alzheimer's disease

Author

Jia, Wan Lu, primary, Rahmouni, Nesrine, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Therriault, Joseph, additional, Macedo, Arthur C., additional, Fernandez-Arias, Jaime, additional, Wang, Yi-Ting, additional, Lussier, Firoza, additional, Kunach, Peter, additional, Gauthier, Serge, additional, Zimmer, Eduardo R., additional, Karikari, Thomas, additional, Benedet, Andrea, additional, Ashton, Nicholas, additional, Zetterberg, Henrik, additional, Pascoal, Tharick A., additional, Blennow, Kaj, additional, and Rosa-Neto, Pedro, additional

Published
2023
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29. Plasma biomarkers of tau for the differentiation between slow and fast tau‐PET accumulators

Author

Tissot, Cécile, primary, Therriault, Joseph, additional, Rahmouni, Nesrine, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Wang, Yi‐Ting, additional, Stevenson, Jenna, additional, Snellman, Anniina, additional, Rodriguez, Juan Lantero, additional, Stevenson, Alyssa, additional, Arias, Jaime Fernandez, additional, Lussier, Firoza Z, additional, Chamoun, Mira, additional, Mathotaarachchi, Sulantha, additional, Bezgin, Gleb, additional, Kunach, Peter, additional, Triana‐Baltzer, Gallen, additional, Gauthier, Serge, additional, Karikari, Thomas K, additional, Kolb, Hartmuth C., additional, Benedet, Andrea Lessa, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Pascoal, Tharick Ali, additional, Ashton, Nicholas J., additional, and Rosa‐Neto, Pedro, additional

Published
2023
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30. Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer’s Disease

Author

Aguzzoli, Cristiano Schaffer, primary, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Soares, Carolina, additional, Ferrari‐Souza, João Pedro, additional, Bellaver, Bruna, additional, Zalzale, Hussein, additional, Lussier, Firoza Z, additional, Rohden, Francieli, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Poltronetti, Nina Margherita, additional, Soucy, Jean‐Paul, additional, Wang, Yi‐Ting, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Ashton, Nicholas J., additional, Schilling, Lucas Porcello, additional, Karikari, Thomas K, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Zimmer, Eduardo R, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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31. [18F]MK6240 and [18F]PI2620 autoradiography on postmortem human brain tissue in AD

Author

Aliaga, Antonio, primary, Therriault, Joseph, additional, Socualaya, Kely Quispialaya, additional, Aliaga, Arturo Aliaga, additional, Hopewell, Robert, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Massarweh, Gassan, additional, Pascoal, Tharick A., additional, Soucy, Jean‐Paul, additional, Rosa‐Neto, Pedro, additional, and Zimmer, Eduardo R, additional

Published
2023
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32. Quantitative evaluation of oxygen extraction fraction (OEF) in Alzheimer's disease: A correlation with tau and amyloid pathology and cognitive status

Author

Hosseini, Seyyed Ali, primary, Servaes, Stijn, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Firoza, Lussier, additional, Stevenson, Jenna, additional, Wang, Yi-Ting, additional, Fernandez-Arias, Jaime, additional, Socualaya, Kely Quispialaya, additional, Stevenson, Alyssa, additional, Gauthier, Serge, additional, Cho, Junghun, additional, Rudko, David, additional, Pascoal, Tharick A., additional, and Rosa-Neto, Pedro, additional

Published
2023
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33. Synaptic dysfunction in the presence of tau tangles is not a strong predictor of atrophy

Author

Soares, Carolina, primary, Bellaver, Bruna, additional, Ferreira, Pamela C.L., additional, Povala, Guilherme, additional, Aguzzoli, Cristiano Schaffer, additional, Rohden, Francieli, additional, Ferrari‐Souza, João Pedro, additional, Zalzale, Hussein, additional, Abbas, Sarah, additional, Lemaire, Peter Charles, additional, Leffa, Douglas Teixeira, additional, Cabrera, Arlec, additional, Therriault, Joseph, additional, Benedet, Andrea Lessa, additional, Tissot, Cécile, additional, Servaes, Stijn, additional, Macedo, Arthur C., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Kang, Min Su, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Pallen, Vanessa, additional, Cohen, Annie, additional, Lopez, Oscar L., additional, Tudorascu, Dana, additional, Klunk, William E, additional, Villemagne, Victor L, additional, Soucy, Jean‐Paul, additional, Gauthier, Serge, additional, Souza, Diogo O., additional, Karikari, Thomas K, additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Rosa‐Neto, Pedro, additional, Zimmer, Eduardo R, additional, and Pascoal, Tharick A., additional

Published
2023
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34. The evolution of randomized controlled trials in Alzheimer's disease: A systematic review and meta-analysis

Author

Kwan, Angela, primary, Therriault, Joseph, additional, Aumont, Etienne, additional, Woo, Marcel, additional, Arfaie, Saman, additional, Servaes, Stijn, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Vitali, Paolo, additional, Soucy, Jean-Paul, additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, and Rosa-Neto, Pedro, additional

Published
2023
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35. Assessment of quantitative susceptibility mapping (QSM) and oxygen extraction fraction (OEF) in the spectrum of Alzheimer’s disease clinical presentations

Author

Hosseini, Seyyed Ali, primary, Servaes, Stijn, additional, Therriault, Joseph, additional, Tissot, Cécile, additional, Rahmouni, Nesrine, additional, Macedo, Arthur C., additional, Lussier, Firoza Z, additional, Stevenson, Jenna, additional, Wang, Yi‐Ting, additional, Arias, Jaime Fernandez, additional, Aumont, Etienne, additional, Socualaya, Kely Quispialaya, additional, Nazneen, Tahnia, additional, Stevenson, Alyssa, additional, Gauthier, Serge, additional, Pascoal, Tharick A., additional, and Rosa‐Neto, Pedro, additional

Published
2023
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36. 14-3-3 $$\upzeta /\updelta$$-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2

Author

Woo, Marcel S., primary, Nilsson, Johanna, additional, Therriault, Joseph, additional, Rahmouni, Nesrine, additional, Brinkmalm, Ann, additional, Benedet, Andrea L., additional, Ashton, Nicholas J., additional, Macedo, Arthur C., additional, Servaes, Stijn, additional, Wang, Yi-Ting, additional, Tissot, Cécile, additional, Arias, Jaime Fernandez, additional, Hosseini, Seyyed Ali, additional, Chamoun, Mira, additional, Lussier, Firoza Z., additional, Karikari, Thomas K., additional, Stevenson, Jenna, additional, Mayer, Christina, additional, Ferrari-Souza, João Pedro, additional, Kobayashi, Eliane, additional, Massarweh, Gassan, additional, Friese, Manuel A., additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rosa-Neto, Pedro, additional

Published
2023
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37. Plasma p‐tau231 and p‐tau217 inform on tau tangles aggregation in cognitively impaired individuals

Author

Ferreira, Pamela C. L., primary, Therriault, Joseph, additional, Tissot, Cécile, additional, Ferrari‐Souza, João Pedro, additional, Benedet, Andréa L., additional, Povala, Guilherme, additional, Bellaver, Bruna, additional, Leffa, Douglas T., additional, Brum, Wagner S., additional, Lussier, Firoza Z., additional, Bezgin, Gleb, additional, Servaes, Stijn, additional, Vermeiren, Marie, additional, Macedo, Arthur C., additional, Cabrera, Arlec, additional, Stevenson, Jenna, additional, Triana‐Baltzer, Gallen, additional, Kolb, Hartmuth, additional, Rahmouni, Nesrine, additional, Klunk, William E., additional, Lopez, Oscar L., additional, Villemagne, Victor L., additional, Cohen, Ann, additional, Tudorascu, Dana L., additional, Zimmer, Eduardo R., additional, Karikari, Thomas K., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Gauthier, Serge, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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38. Plasma pTau‐217 and N‐terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid‐β positive individuals.

Author

Woo, Marcel S., Tissot, Cécile, Lantero‐Rodriguez, Juan, Snellman, Anniina, Therriault, Joseph, Rahmouni, Nesrine, Macedo, Arthur C., Servaes, Stijn, Wang, Yi‐Ting, Arias, Jaime Fernandez, Hosseini, Seyyed Ali, Chamoun, Mira, Lussier, Firoza Z., Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Triana‐Baltzer, Gallen, Kolb, Hartmuth C., Stevenson, Jenna, and Mayer, Christina

Abstract

INTRODUCTION: We set out to identify tau PET‐positive (A+T+) individuals among amyloid‐beta (Aβ) positive participants using plasma biomarkers. METHODS: In this cross‐sectional study we assessed 234 participants across the AD continuum who were evaluated by amyloid PET with [18F]AZD4694 and tau‐PET with [18F]MK6240 and measured plasma levels of total tau, pTau‐181, pTau‐217, pTau‐231, and N‐terminal tau (NTA‐tau). We evaluated the performances of plasma biomarkers to predict tau positivity in Aβ+ individuals. RESULTS: Highest associations with tau positivity in Aβ+ individuals were found for plasma pTau‐217 (AUC [CI95%] = 0.89 [0.82, 0.96]) and NTA‐tau (AUC [CI95%] = 0.88 [0.91, 0.95]). Combining pTau‐217 and NTA‐tau resulted in the strongest agreement (Cohen's Kappa = 0.74, CI95% = 0.57/0.90, sensitivity = 92%, specificity = 81%) with PET for classifying tau positivity. DISCUSSION: The potential for identifying tau accumulation in later Braak stages will be useful for patient stratification and prognostication in treatment trials and in clinical practice. Highlights: We found that in a cohort without pre‐selection pTau‐181, pTau‐217, and NTA‐tau showed the highest association with tau PET positivity.We found that in Aβ+ individuals pTau‐217 and NTA‐tau showed the highest association with tau PET positivity.Combining pTau‐217 and NTA‐tau resulted in the strongest agreement with the tau PET‐based classification. [ABSTRACT FROM AUTHOR]

Published
2024
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39. The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework

Author

Macedo, Arthur C., primary, Tissot, Cécile, additional, Therriault, Joseph, additional, Servaes, Stijn, additional, Wang, Yi-Ting, additional, Fernandez-Arias, Jaime, additional, Rahmouni, Nesrine, additional, Lussier, Firoza Z., additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Vitali, Paolo, additional, Ng, Kok Pin, additional, Zimmer, Eduardo R., additional, Guiot, Marie-Christine, additional, Pascoal, Tharick A., additional, Gauthier, Serge, additional, and Rosa-Neto, Pedro, additional

Published
2023
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40. Plasma and CSF concentrations of N‐terminal tau fragments associate with in vivo neurofibrillary tangle burden

Author

Lantero‐Rodriguez, Juan, primary, Tissot, Cécile, additional, Snellman, Anniina, additional, Servaes, Stijn, additional, Benedet, Andrea L., additional, Rahmouni, Nesrine, additional, Montoliu‐Gaya, Laia, additional, Therriault, Joseph, additional, Brum, Wagner S., additional, Stevenson, Jenna, additional, Lussier, Firoza Z., additional, Bezgin, Gleb, additional, Macedo, Arthur C., additional, Chamoun, Mira, additional, Mathotaarachi, Sulantha S., additional, Pascoal, Tharick A., additional, Ashton, Nicholas J., additional, Zetterberg, Henrik, additional, Neto, Pedro Rosa, additional, and Blennow, Kaj, additional

Published
2023
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41. Equivalence of plasma p‐tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease.

Author

Therriault, Joseph, Servaes, Stijn, Tissot, Cécile, Rahmouni, Nesrine, Ashton, Nicholas J., Benedet, Andréa Lessa, Karikari, Thomas K., Macedo, Arthur C., Lussier, Firoza Z., Stevenson, Jenna, Wang, Yi‐Ting, Fernandez‐Arias, Jaime, Stevenson, Alyssa, Socualaya, Kely Quispialaya, Haeger, Arlette, Nazneen, Tahnia, Aumont, Étienne, Hosseini, Ali, Rej, Soham, and Vitali, Paolo

Abstract

INTRODUCTION: Plasma biomarkers are promising tools for Alzheimer's disease (AD) diagnosis, but comparisons with more established biomarkers are needed. METHODS: We assessed the diagnostic performance of p‐tau181, p‐tau217, and p‐tau231 in plasma and CSF in 174 individuals evaluated by dementia specialists and assessed with amyloid‐PET and tau‐PET. Receiver operating characteristic (ROC) analyses assessed the performance of plasma and CSF biomarkers to identify amyloid‐PET and tau‐PET positivity. RESULTS: Plasma p‐tau biomarkers had lower dynamic ranges and effect sizes compared to CSF p‐tau. Plasma p‐tau181 (AUC = 76%) and p‐tau231 (AUC = 82%) assessments performed inferior to CSF p‐tau181 (AUC = 87%) and p‐tau231 (AUC = 95%) for amyloid‐PET positivity. However, plasma p‐tau217 (AUC = 91%) had diagnostic performance indistinguishable from CSF (AUC = 94%) for amyloid‐PET positivity. DISCUSSION: Plasma and CSF p‐tau217 had equivalent diagnostic performance for biomarker‐defined AD. Our results suggest that plasma p‐tau217 may help reduce the need for invasive lumbar punctures without compromising accuracy in the identification of AD. Highlights: p‐tau217 in plasma performed equivalent to p‐tau217 in CSF for the diagnosis of AD, suggesting the increased accessibility of plasma p‐tau217 is not offset by lower accuracy.p‐tau biomarkers in plasma had lower mean fold‐changes between amyloid‐PET negative and positive groups than p‐tau biomarkers in CSF.CSF p‐tau biomarkers had greater effect sizes than plasma p‐tau biomarkers when differentiating between amyloid‐PET positive and negative groups.Plasma p‐tau181 and plasma p‐tau231 performed worse than p‐tau181 and p‐tau231 in CSF for AD diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Blood‐brain barrier integrity impacts the use of plasma amyloid‐β as a proxy of brain amyloid‐β pathology

Author

Bellaver, Bruna, primary, Puig‐Pijoan, Albert, additional, Ferrari‐Souza, João Pedro, additional, Leffa, Douglas T., additional, Lussier, Firoza Z., additional, Ferreira, Pamela C. L., additional, Tissot, Cécile, additional, Povala, Guilherme, additional, Therriault, Joseph, additional, Benedet, Andréa L., additional, Ashton, Nicholas J., additional, Servaes, Stijn, additional, Chamoun, Mira, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Vermeiren, Marie, additional, Macedo, Arthur C., additional, Fernández‐Lebrero, Aida, additional, García‐Escobar, Greta, additional, Navalpotro‐Gómez, Irene, additional, Lopez, Oscar, additional, Tudorascu, Dana L., additional, Cohen, Ann, additional, Villemagne, Victor L., additional, Klunk, William E., additional, Gauthier, Serge, additional, Zimmer, Eduardo R., additional, Karikari, Thomas K., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Suárez‐Calvet, Marc, additional, Rosa‐Neto, Pedro, additional, and Pascoal, Tharick A., additional

Published
2023
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43. Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography

Author

Therriault, Joseph, primary, Vermeiren, Marie, additional, Servaes, Stijn, additional, Tissot, Cécile, additional, Ashton, Nicholas J., additional, Benedet, Andréa Lessa, additional, Karikari, Thomas K., additional, Lantero-Rodriguez, Juan, additional, Brum, Wagner S., additional, Lussier, Firoza Z., additional, Bezgin, Gleb, additional, Stevenson, Jenna, additional, Rahmouni, Nesrine, additional, Kunach, Peter, additional, Wang, Yi-Ting, additional, Fernandez-Arias, Jaime, additional, Socualaya, Kely Quispialaya, additional, Macedo, Arthur C., additional, Ferrari-Souza, João Pedro, additional, Ferreira, Pâmela C. L., additional, Bellaver, Bruna, additional, Leffa, Douglas T., additional, Zimmer, Eduardo R., additional, Vitali, Paolo, additional, Soucy, Jean-Paul, additional, Triana-Baltzer, Gallen, additional, Kolb, Hartmuth C., additional, Pascoal, Tharick A., additional, Saha-Chaudhuri, Paramita, additional, Gauthier, Serge, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rosa-Neto, Pedro, additional

Published
2023
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44. Manifold Component Analysis: a novel technique to spatially profile tau tangles across Alzheimer's disease stages.

Author

Bezgin, Gleb, Pascoal, Tharick Ali, Therriault, Joseph, Lussier, Firoza Z, Servaes, Stijn, Kang, Min Su, Savard, Melissa, Tissot, Cécile, Stevenson, Jenna, Wang, Yi‐Ting, Ottoy, Julie, Rahmouni, Nesrine, Arias, Jaime Fernandez, Macedo, Arthur C., Massarweh, Gassan, Vitali, Paolo, Soucy, Jean‐Paul, Medina, Yasser Iturria, Gauthier, Serge, and Rosa‐Neto, Pedro

Abstract

Background: Intracellular accumulation of tau tangles in the brain is one of the most prominent manifestations of Alzheimer's disease (AD). Progression thereof across the AD stages has specific temporal and spatial patterns, wherein time is informative of space and vice versa. Here we introduce a novel method, Manifold Component Analysis (MCA), to represent tangle accumulation in 2D, reflecting the spatial aspect of tau propagation stages to further relate it to the temporal aspect thereof. Method: MCA represents a neuroinformatics technique serving to smooth out transitions between neighbouring Braak stage regions (Fig. 1A) and thus creating "sub‐stages" (Fig. 1B) which are subsequently used to sample neocortical (tau tangle) data and represent them in a continuous 2D graph with the spatially earliest sub‐stage appearing in the leftmost, and the latest spatial sub‐stage appearing on the right (Fig. 1C). This method was applied to 18F‐MK‐6240 tau PET tracer data from the TRIAD cohort (https://triad.tnl‐mcgill.com/; N = 753; 123 AD, 170 MCI, 416 cognitively unimpaired). Result: We obtained MCA profiles of tau‐PET for each subject in the cohort, and evaluated them across multiple visits (Fig. 1D; mean inter‐visit interval 1.9 years), showing that the largest change (about 25%) occurs at stages 4 and 5. Partial correlations between sub‐stages within the MCA profiles for each subject, and their corresponding neuropsychological assessment measurements showed unique spatial signatures for each specific cognitive test, generally favouring earlier stage correlations for memory, and later stage correlations for higher cognition (Fig. 1E); the covariates included age, sex, APOEe4 status and years of education. Conclusion: The MCA method proves useful as an intuitive lookup tool for tau tangle accumulation across the brain in AD. The obtained profiles help resolve correspondence between "space" and "time" contexts of the pathology spread, as well as the spatial aspect of the timeline of cognitive decline. As MCA is a subject‐specific, easily applicable, fast and extensible technique, numerous new applications and extensions will follow, providing a necessary aid in staging, forecasting, and potentially treating AD. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Comparison of Two Plasma P-Tau217 Assays to Detect and Monitor Alzheimer's Pathology

Author

Therriault, Joseph, primary, Ashton, Nicholas J., additional, Pola, Ilaria, additional, Triana-Baltzer, Gallen, additional, Di Molfetta, Guglielmo, additional, Arslan, Burak, additional, Rahmouni, Nesrine, additional, Tissot, Cecile, additional, Servaes, Stijn, additional, Stevensson, Jenna, additional, Macedo, Arthur C., additional, Pascoal, Tharick A., additional, Kolb, Hartmuth C., additional, Jeromin, Andreas, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Rosa-Neto, Pedro, additional, and Benedet, Andrea L., additional

Published
2023
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46. [18F]MK6240 and [18F]PI2620 autoradiography on postmortem human brain tissue in AD.

Author

Aliaga, Antonio, Therriault, Joseph, Socualaya, Kely Quispialaya, Aliaga, Arturo Aliaga, Hopewell, Robert, Tissot, Cécile, Rahmouni, Nesrine, Macedo, Arthur C., Massarweh, Gassan, Pascoal, Tharick A., Soucy, Jean‐Paul, Rosa‐Neto, Pedro, and Zimmer, Eduardo R

Abstract

Background: To compare the post mortem uptake of [18F]MK6240 and [18F]PI2620 in the brain hemisphere, of A‐T‐ (CN) and A+T+ tissue Method: Autoradiography (ARG) imaging using [18F]MK6240 and [18F]PI2620 was used to assess uptake of CN and AD tissues. One study used sections of whole‐hemisphere of one CN tissue and one AD tissue. The uptake value of [18F]MK6240 was calculated from a regions of interest (ROI) drawn manually from the area of cortex gray matter (GM), cortex white matter (WM), and background (BG). Other study was 24 tissues from the prefrontal cortex (Pfc) (12CN, 12AD), hippocampus (Hip) (12 CN, 12 AD) and cerebellum (Cer) (12 CN, 12 AD) were evaluated with [18F]MK6240, and [18F]PI2620. The uptake value of [18F]MK6240 and [18F]PI2620 was calculated from ROI drawn manually from the area of pfc GM, hip GM and cer GM. Result: The ARG showed greater [18F]MK6240 uptake in AD than in CN tissue. There were significant differences between CN and AD tissue in terms of cortex gray GM distribution and cortex WM, but no significant differences in BG. These results also, there is no correlation between the specific activity of [18F]MK6240 and the uptake value in CN and AD tissues. In a second experiment, based on our findings there was a significant difference between CN and AD groups when assessed by [18F]MK6240 as well as [18F]PI2620 in the pfc_GM and hip_GM. Furthermore, we found no difference between AD and CN tissues when assessed by [18F]MK6240 and [18F]PI2620 in cerebellum GM. Ratio values Pfc/Cer and Hip/Cer assessed by [18F]MK6240 as well as there were significant differences between CN and AD. [18F]MK6240 and [18F]PI2620 were highly correlated in AD but not in CN brain tissues. Conclusion: We also found that [18F]PI2620 and [18F]MK6240 have similar brain uptake in post‐mortem tissue. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Independent associations of plasma GFAP with amyloid‐β and tau in Alzheimer's disease.

Author

Jia, Wan Lu, Rahmouni, Nesrine, Tissot, Cécile, Servaes, Stijn, Therriault, Joseph, Macedo, Arthur C., Arias, Jaime Fernandez, Wang, Yi‐Ting, Lussier, Firoza Z, Kunach, Peter, Gauthier, Serge, Zimmer, Eduardo R, Karikari, Thomas K, Benedet, Andrea L., Ashton, Nicholas J., Zetterberg, Henrik, Pascoal, Tharick A., Blennow, Kaj, and Rosa‐Neto, Pedro

Abstract

Background: Glial fibrillary acidic protein (GFAP) is a reactive astrogliosis biomarker, shown to increase in individuals with preclinical Alzheimer's disease (AD). First thought to be a great marker of amyloid‐β (Aβ) pathology, recent post‐mortem research has linked it to tau accumulation only. Here we investigate the independent associations of plasma GFAP with imaging markers of AD along the disease spectrum. Method: 126 individuals from TRIAD cohort underwent [18F]MK6240 tau‐PET and [18F]AZD4694 Aβ‐PET and plasma GFAP assessment using an in‐house assay. Voxel and region of interest regression models evaluated the relationship between PET tracers and plasma GFAP. Models with [18F]AZD4694‐PET as the outcome were adjusted for [18F]MK6240‐PET voxel‐wise and vice‐versa. All models were corrected for age and sex, and RFT was used to correct for multiple comparisons. Result: Plasma GFAP was associated with [18F]AZD4694 signal throughout the cortex (Figure1A), independently of [18F]MK6240. Additionally, it was positively correlated with [18F]MK6240 in the medial temporal and occipital lobes and the anterior cingulate cortex, independently of [18F]AZD4694 (Figure1B). Voxel‐wise findings were confirmed by region‐of‐interest‐based analyses. Conclusion: Our findings indicate that plasma GFAP is independently associated with both Aβ and tau pathologies in AD. Aβ‐PET showed associations throughout the entire cortex, suggesting its effectiveness as a reliable marker of Aβ pathology across the AD spectrum. On the other hand, tau‐PET correlations were observed in specific regions associated with memory and behavioral impairments that exhibit early deposition of tau. Overall, these results demonstrate that GFAP, an astrogliosis marker, is independently associated with Aβ and tau. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Comparison Between Brain and Cerebellar Autoradiography Using [ 18 F]Flortaucipir, [ 18 F]MK6240, and [ 18 F]PI2620 in Postmortem Human Brain Tissue.

Author

Aliaga A, Therriault J, Quispialaya KM, Aliaga A, Hopewell R, Rahmouni N, Macedo AC, Kunach P, Soucy JP, Massarweh G, Diaz AA, Pascoal TA, Rocha A, Guiot MC, Machado LS, De Bastiani MA, de Souza DG, Souza DO, Gauthier S, Zimmer ER, and Rosa-Neto P

Subjects
Humans, Male, Female, Aged, Autopsy, Isoquinolines pharmacokinetics, Isoquinolines metabolism, Aged, 80 and over, Middle Aged, Radiopharmaceuticals pharmacokinetics, Pyrrolidines pharmacokinetics, Pyrrolidines metabolism, Carbolines, Autoradiography, Cerebellum diagnostic imaging, Cerebellum metabolism, Brain diagnostic imaging, Brain metabolism, Alzheimer Disease diagnostic imaging, Alzheimer Disease metabolism
Abstract

Our objective was to evaluate the in vitro binding properties of [ 18 F]flortaucipir, 6-(fluoro- 18 F)-3-(1 H -pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([ 18 F]MK6240), and 2-(2-([ 18 F]fluoro)pyridin-4-yl)-9 H -pyrrolo[2,3-b:4,5c']dipyridine ([ 18 F]PI2620) head-to-head in postmortem human brain tissue. Methods: Autoradiography was used to assess uptake of [ 18 F]flortaucipir, [ 18 F]MK6240, and [ 18 F]PI2620 in control and Alzheimer disease (AD) autopsy-confirmed brain tissues. The study focused on the analysis of the prefrontal cortex, hippocampus, and cerebellum sections in 12 controls and 12 AD cases, as well as whole-brain hemisphere in 1 control and 1 AD sample, for each radiotracer. The binding values of [ 18 F]flortaucipir, [ 18 F]MK6240, and [ 18 F]PI2620 were calculated from regions of interest manually drawn in the prefrontal, hippocampal, and cerebellar cortices. Results: For all 3 radioligands investigated, we observed significant tracer binding differences between control and AD tissues in the whole-brain hemisphere, prefrontal cortex, and hippocampus but not in the cerebellar cortex. [ 18 F]MK6240 and [ 18 F]PI2620 had higher effect sizes to differentiate control and AD cases than did [ 18 F]flortaucipir. Bland-Altman analyses revealed strong correlations between [ 18 F]MK6240, [ 18 F]PI2620, and [ 18 F]flortaucipir, with the highest agreement found for [ 18 F]MK6240 versus [ 18 F]PI2620. Conclusion: The 3 radioligands showed comparable diagnostic properties to assess tau aggregates in vitro. Binding to AD brain tissues was higher for [ 18 F]MK6240 and [ 18 F]PI2620 than for [ 18 F]flortaucipir. Additionally, [ 18 F]MK6240 and [ 18 F]PI2620 had greater selectivity, displaying decreased uptake in control brain tissue compared with [ 18 F]flortaucipir. These results might provide insights on ongoing initiatives to create a universal scale for tau imaging studies., (© 2025 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2025
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50. Plasma pTau-217 and N-terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid-β positive individuals.

Author

Woo MS, Tissot C, Lantero-Rodriguez J, Snellman A, Therriault J, Rahmouni N, Macedo AC, Servaes S, Wang YT, Arias JF, Hosseini SA, Chamoun M, Lussier FZ, Benedet AL, Ashton NJ, Karikari TK, Triana-Baltzer G, Kolb HC, Stevenson J, Mayer C, Kobayashi E, Massarweh G, Friese MA, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, and Rosa-Neto P

Subjects
Humans, tau Proteins, Cross-Sectional Studies, Amyloid beta-Peptides, Biomarkers, Positron-Emission Tomography, Alzheimer Disease
Abstract

Introduction: We set out to identify tau PET-positive (A+T+) individuals among amyloid-beta (Aβ) positive participants using plasma biomarkers., Methods: In this cross-sectional study we assessed 234 participants across the AD continuum who were evaluated by amyloid PET with [ 18 F]AZD4694 and tau-PET with [ 18 F]MK6240 and measured plasma levels of total tau, pTau-181, pTau-217, pTau-231, and N-terminal tau (NTA-tau). We evaluated the performances of plasma biomarkers to predict tau positivity in Aβ+ individuals., Results: Highest associations with tau positivity in Aβ+ individuals were found for plasma pTau-217 (AUC [CI 95% ] = 0.89 [0.82, 0.96]) and NTA-tau (AUC [CI 95% ] = 0.88 [0.91, 0.95]). Combining pTau-217 and NTA-tau resulted in the strongest agreement (Cohen's Kappa = 0.74, CI 95%  = 0.57/0.90, sensitivity = 92%, specificity = 81%) with PET for classifying tau positivity., Discussion: The potential for identifying tau accumulation in later Braak stages will be useful for patient stratification and prognostication in treatment trials and in clinical practice., Highlights: We found that in a cohort without pre-selection pTau-181, pTau-217, and NTA-tau showed the highest association with tau PET positivity. We found that in Aβ+ individuals pTau-217 and NTA-tau showed the highest association with tau PET positivity. Combining pTau-217 and NTA-tau resulted in the strongest agreement with the tau PET-based classification., (© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Published
2024
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