531 results on '"Machado-Neto, João Agostinho"'
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2. Autophagy and inflammasome activation are associated with poor response to FLT3 inhibitors in patients with FLT3-ITD acute myeloid leukemia
3. Autophagy as a Limiting Factor to the Effectiveness of Tyrosine Kinase Inhibitors in Blood Cancers
4. Pharmacological inhibition of ezrin reduces proliferative and invasive phenotype in acute lymphoblastic leukemia cells
5. The survivin/XIAP suppressant YM155 impairs clonal growth and induces apoptosis in JAK2V617F cells
6. NT157 exhibits antineoplastic effects by targeting IRS and STAT3/5 signaling in multiple myeloma
7. Acute myeloid leukemia-derived bone marrow mesenchymal cells exhibit improved support for leukemic cell proliferation
8. An updated outlook on autophagy mechanism and how it supports acute myeloid leukemia maintenance
9. Tartrolon D induces immunogenic cell death in melanoma
10. Potency and efficacy of pharmacological PIP4K2 inhibitors in acute lymphoblastic leukemia
11. Cyclopenta[b]indoles as novel antimicrotubule agents with antileukemia activity
12. Comprehensive analysis of the HCK gene in myeloid neoplasms: Insights into biological functions, prognosis, and response to antineoplastic agents
13. Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas.
14. Transcriptomics analysis identified ezrin as a potential druggable target in cervical and gastric cancer cells
15. Antineoplastic effects of pharmacological inhibitors of aurora kinases in CSF3RT618I-driven cells
16. Monoolein-based nanodispersions for cutaneous co-delivery of methylene blue and metformin: Thermal and structural characterization and effects on the cutaneous barrier, skin penetration and cytotoxicity
17. Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways
18. NSC305787, a pharmacological ezrin inhibitor, exhibits antineoplastic activity in pancreatic cancer cells
19. Ezrin is highly expressed and a druggable target in chronic lymphocytic leukemia
20. AD80, a multikinase inhibitor, as a potential drug candidate for colorectal cancer therapy
21. Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model
22. Effects of trabectedin in the zebrafish Danio rerio: from cells to larvae
23. Clinical significance of Philadelphia‐like‐related genes in a resource‐constrained setting of adult B‐acute lymphoblastic leukemia patients.
24. Expression of transforming growth factor β pathway components in chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation
25. STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells
26. NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells
27. The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy
28. NT157 as an Anticancer Drug Candidate That Targets Kinase- and Phosphatase-Mediated Signaling
29. Bismuth(III) triflate: an economical and environmentally friendly catalyst for the Nazarov reaction
30. Exploring redox vulnerabilities in JAK2V617F-positive cellular models
31. Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia
32. AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis
33. DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy
34. Synthetic cyclopenta[b]indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells
35. Proteolytic processing in autophagy
36. Contributors
37. NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia
38. Clinical and molecular profile of a Brazilian cohort of patients with classical BCR-ABL1-negative myeloproliferative neoplasms
39. Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia
40. Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours
41. Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2V617F cells
42. Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells
43. IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells
44. PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia
45. ARHGAP6 transcript levels are associated with molecular risk and impact survival outcomes in acute myeloid leukemia
46. Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in Cancer.
47. Acute myeloid leukemia-derived bone marrow mesenchymal cells exhibit improved support for leukemic cell proliferation
48. Serine peptidase inhibitor Kunitz type 2 (SPINT2) in cancer development and progression
49. The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation
50. Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
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