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Using the methods of light and electron microscopy, pancreas was studied in the experimental model of alloxan diabetes (AD) at various times of the experiment (1 and 6 month) at different degrees of AD and after the action of plaferon. The special emphasis was made on display of compensatory changes that is opportunity of occurrence in extra-islet cells special granules, characteristic for insulin producing B-cells. During the development of pathological processes, there were detected intermediate cells including exocrine and endocrine granules. Some of these cells were located near the acini and some of them were in close contact with duct cells. It is suggested that these intermediate extra-islet cells are especial cells with high functional activity, they are transitional form during the processes of transformation into endocrine ones, possibly these cells are precursors of islet cells. It is possible, that plaferon acts on processes of transformation and differentiation of extra-islet cells and takes part in neogenesis of B-cells.

Tissue and cellular atypia, changes of the mucus chemical composition, protein secreting function, ATPase activity, differentiation of the epithelial cells and DNA replication with the widening of proliferation zone were registered morphologically in colon microadenomas. A pronounced increase of labelled small lymphocytes capable of proliferation is observed in the stroma. Fibrocytes are practically absent, fibroblasts are represented by young 3H-labelled forms. All these changes are considered as dysplastic.