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Your search keyword '"Macirella, Rachele"' showing total 26 results
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26 results on '"Macirella, Rachele"'

1. The Ephrin tyrosine kinase a3 (EphA3) is a novel mediator of RAGE-prompted motility of breast cancer cells

Author

Talia, Marianna, Cirillo, Francesca, Spinelli, Asia, Zicarelli, Azzurra, Scordamaglia, Domenica, Muglia, Lucia, De Rosis, Salvatore, Rigiracciolo, Damiano Cosimo, Filippelli, Gianfranco, Perrotta, Ida Daniela, Davoli, Mariano, De Rosa, Rosanna, Macirella, Rachele, Brunelli, Elvira, Miglietta, Anna Maria, Nardo, Bruno, Tosoni, Daniela, Pece, Salvatore, De Francesco, Ernestina Marianna, Belfiore, Antonino, Maggiolini, Marcello, and Lappano, Rosamaria

Published
2023
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21. Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-Inflammatory Activity

Author

Parafati, Maddalena, primary, Lascala, Antonella, additional, La Russa, Daniele, additional, Mignogna, Chiara, additional, Trimboli, Francesca, additional, Morittu, Valeria, additional, Riillo, Concetta, additional, Macirella, Rachele, additional, Mollace, Vincenzo, additional, Brunelli, Elvira, additional, and Janda, Elzbieta, additional

Published
2018
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26. The differential role of Leydig cells in the skin and gills of Lissotriton italicus larvae

Author

Elvira Brunelli, Rachele Macirella, Vittoria Curcio, Biagio D'Aniello, Anna Di Cosmo, Brunelli, Elvira, Macirella, Rachele, Curcio, Vittoria, D'Aniello, Biagio, and Di Cosmo, Anna

Subjects
Gills, Male, Medical Laboratory Technology, Histology, Larva, Animals, Leydig Cells, Anatomy, Aquaporins, Instrumentation, Skin
Abstract

Larval urodeles are provided with external gills involved, along with the skin, in gas exchange and osmoregulation. Gills and skin epithelia are different, each showing a peculiar set of specialized cells but both provided with Leydig cells (LCs). Information on LCs in the gills is lacking as the literature has focused primarily on the epidermis. Contradictory and fragmentary results highlight that LCs origin, fate, and functions remain not fully understood. Here, we investigated the morpho-functional differences of LCs in the skin and gills of Lissotriton italicus larvae for the first time. LCs showed the same morphological and ultrastructural features in both tissues, even if LCs were significantly larger in the epidermis. Despite the uniform morphology within the LCs population, the proliferative ability was different. The putative diversity in the mucus composition was evaluated using a panel of 4 lectins as markers of specific carbohydrate moieties, revealing that sites of specific glycoconjugates were comparable in two tissues. To disclose the involvement of LCs in water storage and transport, immunofluorescence assay for aquaporin-3 has also been performed, demonstrating the expression of this protein only in gills epithelium. By demonstrating that LCs can multiply by cell division in gills, our results will also contribute to the discussion about their proliferative ability. Finally, we found that the LCs cytoplasm is rich in glycoconjugates, which are involved in many diverse and essential functions in vertebrates. RESEARCH HIGHLIGHTS: In gills LCs can multiply by cell division and express aquaporin-3 demonstrating a tissue-specific role of LCs. LCs cytoplasm is rich in glycoconjugates. LCs population show a uniform morphology in both gills and skin.

Published
2022

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