1,114 results on '"Mackay, Alan"'
Search Results
2. GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
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Liu, Ilon, Alencastro Veiga Cruzeiro, Gustavo, Bjerke, Lynn, Rogers, Rebecca F., Grabovska, Yura, Beck, Alexander, Mackay, Alan, Barron, Tara, Hack, Olivia A., Quezada, Michael A., Molinari, Valeria, Shaw, McKenzie L., Perez-Somarriba, Marta, Temelso, Sara, Raynaud, Florence, Ruddle, Ruth, Panditharatna, Eshini, Englinger, Bernhard, Mire, Hafsa M., Jiang, Li, Nascimento, Andrezza, LaBelle, Jenna, Haase, Rebecca, Rozowsky, Jacob, Neyazi, Sina, Baumgartner, Alicia-Christina, Castellani, Sophia, Hoffman, Samantha E., Cameron, Amy, Morrow, Murry, Nguyen, Quang-De, Pericoli, Giulia, Madlener, Sibylle, Mayr, Lisa, Dorfer, Christian, Geyeregger, Rene, Rota, Christopher, Ricken, Gerda, Ligon, Keith L., Alexandrescu, Sanda, Cartaxo, Rodrigo T., Lau, Benison, Uphadhyaya, Santhosh, Koschmann, Carl, Braun, Emelie, Danan-Gotthold, Miri, Hu, Lijuan, Siletti, Kimberly, Sundström, Erik, Hodge, Rebecca, Lein, Ed, Agnihotri, Sameer, Eisenstat, David D., Stapleton, Simon, King, Andrew, Bleil, Cristina, Mastronuzzi, Angela, Cole, Kristina A., Waanders, Angela J., Montero Carcaboso, Angel, Schüller, Ulrich, Hargrave, Darren, Vinci, Maria, Carceller, Fernando, Haberler, Christine, Slavc, Irene, Linnarsson, Sten, Gojo, Johannes, Monje, Michelle, Jones, Chris, and Filbin, Mariella G.
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- 2024
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3. Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas
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Pericoli, Giulia, Galardi, Angela, Paolini, Alessandro, Petrilli, Lucia Lisa, Pepe, Gerardo, Palma, Alessandro, Colletti, Marta, Ferretti, Roberta, Giorda, Ezio, Levi Mortera, Stefano, Burford, Anna, Carai, Andrea, Mastronuzzi, Angela, Mackay, Alan, Putignani, Lorenza, Jones, Chris, Pascucci, Luisa, Peinado, Hector, Helmer-Citterich, Manuela, de Billy, Emmanuel, Masotti, Andrea, Locatelli, Franco, Di Giannatale, Angela, and Vinci, Maria
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- 2023
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4. Automated software vulnerability detection with machine learning
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Harer, Jacob A., Kim, Louis Y., Russell, Rebecca L., Ozdemir, Onur, Kosta, Leonard R., Rangamani, Akshay, Hamilton, Lei H., Centeno, Gabriel I., Key, Jonathan R., Ellingwood, Paul M., Antelman, Erik, Mackay, Alan, McConley, Marc W., Opper, Jeffrey M., Chin, Peter, and Lazovich, Tomo
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Computer Science - Software Engineering ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Thousands of security vulnerabilities are discovered in production software each year, either reported publicly to the Common Vulnerabilities and Exposures database or discovered internally in proprietary code. Vulnerabilities often manifest themselves in subtle ways that are not obvious to code reviewers or the developers themselves. With the wealth of open source code available for analysis, there is an opportunity to learn the patterns of bugs that can lead to security vulnerabilities directly from data. In this paper, we present a data-driven approach to vulnerability detection using machine learning, specifically applied to C and C++ programs. We first compile a large dataset of hundreds of thousands of open-source functions labeled with the outputs of a static analyzer. We then compare methods applied directly to source code with methods applied to artifacts extracted from the build process, finding that source-based models perform better. We also compare the application of deep neural network models with more traditional models such as random forests and find the best performance comes from combining features learned by deep models with tree-based models. Ultimately, our highest performing model achieves an area under the precision-recall curve of 0.49 and an area under the ROC curve of 0.87.
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- 2018
5. An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene.
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Reisz, Zita, Pereira, Rita, Nevis, Smitha, Mackay, Alan, Bhaw, Leena, Grabovska, Yura, Laxton, Ross, Molinari, Valeria, Burford, Anna, Clark, Barnaby, Bleil, Cristina, Zebian, Bassel, Pace, Erika, Weiser, Annette, Carceller, Fernando, Marshall, Lynley, King, Andrew, Bodi, Istvan, Al-Sarraj, Safa, and Jones, Chris
- Abstract
Histone mutations (H3 K27M, H3 G34R/V) are molecular features defining subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), H3 K27-altered, diffuse hemispheric glioma (DHG), H3 G34-mutant). The WHO classification recognises in exceptional cases, these mutations co-occur. We report one such case of a 2-year-old female presenting with neurological symptoms; MRI imaging identified a brainstem lesion which was biopsied. Histology showed diffusely infiltrating pleomorphic astrocytes, multinucleated cells, and conspicuous mitotic activity; the diagnosis was DMG, H3 K27-altered (immunohistochemistry: H3K27me3 loss, H3K27M positivity). DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNP v12.5 R package)) classified the tumour as 'DMG, H3 K27-altered' (calibrated score = 0.99). Further molecular studies (whole exome, whole genome sequencing) revealed concurrent H3.1 K27M and G34R mutations (clonal, in the same reads) of H3C3, FGF11 and PIK3CA somatic variants, and a pathogenic germline NBN variant. The RNAseq profile clustered with H3K27M-mutant tumours. A patient-derived cell culture was established enabling unbiased in vitro drug screening; no selective sensitivities were identified. Chromatin immunoprecipitation assays with sequencing (ChIP-seq; H3K27ac, H3K27me3, H3K36me3, RNApol2 marks) showed features in keeping with DMG H3 K27M-mutant tumours (H3K27ac loci including OLIG2, IRX1/2, PKDCC). The patient was treated with adjuvant radiotherapy, but progressed and passed away 13 months post-diagnosis. This case is an exceptionally rare, complex variant of histone-mutant paediatric HGG, illustrating that the H3.1 K27M mutation demonstrates a dominance over the molecular and clinical profiles compared to G34R, and highlights the importance of broad molecular profiling to identify such examples for further study. [ABSTRACT FROM AUTHOR]
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- 2025
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6. Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile
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Nussbaumer, Gunther, primary, Benesch, Martin, additional, Grabovska, Yura, additional, Mackay, Alan, additional, Castel, David, additional, Grill, Jacques, additional, Alonso, Marta M, additional, Antonelli, Manila, additional, Bailey, Simon, additional, Baugh, Joshua N, additional, Biassoni, Veronica, additional, Blattner Johnson, Mirjam, additional, Broniscer, Alberto, additional, Carai, Andrea, additional, Colafati, Giovanna Stefania, additional, Colditz, Niclas, additional, Corbacioglu, Selim, additional, Crampsie, Shauna, additional, Entz-Werle, Natacha, additional, Eyrich, Matthias, additional, Friker, Lea L, additional, Frühwald, Michael C, additional, Garrè, Maria Luisa, additional, Gerber, Nicolas U, additional, Giangaspero, Felice, additional, Gil-da-Costa, Maria J, additional, Graf, Norbert, additional, Hargrave, Darren, additional, Hauser, Peter, additional, Herrlinger, Ulrich, additional, Hoffmann, Marion, additional, Hulleman, Esther, additional, Izquierdo, Elisa, additional, Jacobs, Sandra, additional, Karremann, Michael, additional, Kattamis, Antonis, additional, Kebudi, Rejin, additional, Kortmann, Rolf-Dieter, additional, Kwiecien, Robert, additional, Massimino, Maura, additional, Mastronuzzi, Angela, additional, Miele, Evelina, additional, Morana, Giovanni, additional, Noack, Claudia M, additional, Pentikainen, Virve, additional, Perwein, Thomas, additional, Pfister, Stefan M, additional, Pietsch, Torsten, additional, Roka, Kleoniki, additional, Rossi, Sabrina, additional, Rutkowski, Stefan, additional, Schiavello, Elisabetta, additional, Seidel, Clemens, additional, Štěrba, Jaroslav, additional, Sturm, Dominik, additional, Sumerauer, David, additional, Tacke, Anna, additional, Temelso, Sara, additional, Valentini, Chiara, additional, van Vuurden, Dannis, additional, Varlet, Pascale, additional, Veldhuijzen van Zanten, Sophie E M, additional, Vinci, Maria, additional, von Bueren, André O, additional, Warmuth-Metz, Monika, additional, Wesseling, Pieter, additional, Wiese, Maria, additional, Wolff, Johannes E A, additional, Zamecnik, Josef, additional, Morales La Madrid, Andrés, additional, Bison, Brigitte, additional, Gielen, Gerrit H, additional, Jones, David T W, additional, Jones, Chris, additional, and Kramm, Christof M, additional
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- 2024
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7. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
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Sturm, Dominik, Orr, Brent A, Toprak, Umut H, Hovestadt, Volker, Jones, David TW, Capper, David, Sill, Martin, Buchhalter, Ivo, Northcott, Paul A, Leis, Irina, Ryzhova, Marina, Koelsche, Christian, Pfaff, Elke, Allen, Sariah J, Balasubramanian, Gnanaprakash, Worst, Barbara C, Pajtler, Kristian W, Brabetz, Sebastian, Johann, Pascal D, Sahm, Felix, Reimand, Jüri, Mackay, Alan, Carvalho, Diana M, Remke, Marc, Phillips, Joanna J, Perry, Arie, Cowdrey, Cynthia, Drissi, Rachid, Fouladi, Maryam, Giangaspero, Felice, Łastowska, Maria, Grajkowska, Wiesława, Scheurlen, Wolfram, Pietsch, Torsten, Hagel, Christian, Gojo, Johannes, Lötsch, Daniela, Berger, Walter, Slavc, Irene, Haberler, Christine, Jouvet, Anne, Holm, Stefan, Hofer, Silvia, Prinz, Marco, Keohane, Catherine, Fried, Iris, Mawrin, Christian, Scheie, David, Mobley, Bret C, Schniederjan, Matthew J, Santi, Mariarita, Buccoliero, Anna M, Dahiya, Sonika, Kramm, Christof M, von Bueren, André O, von Hoff, Katja, Rutkowski, Stefan, Herold-Mende, Christel, Frühwald, Michael C, Milde, Till, Hasselblatt, Martin, Wesseling, Pieter, Rößler, Jochen, Schüller, Ulrich, Ebinger, Martin, Schittenhelm, Jens, Frank, Stephan, Grobholz, Rainer, Vajtai, Istvan, Hans, Volkmar, Schneppenheim, Reinhard, Zitterbart, Karel, Collins, V Peter, Aronica, Eleonora, Varlet, Pascale, Puget, Stephanie, Dufour, Christelle, Grill, Jacques, Figarella-Branger, Dominique, Wolter, Marietta, Schuhmann, Martin U, Shalaby, Tarek, Grotzer, Michael, van Meter, Timothy, Monoranu, Camelia-Maria, Felsberg, Jörg, Reifenberger, Guido, Snuderl, Matija, Forrester, Lynn Ann, Koster, Jan, Versteeg, Rogier, Volckmann, Richard, van Sluis, Peter, Wolf, Stephan, Mikkelsen, Tom, Gajjar, Amar, Aldape, Kenneth, Moore, Andrew S, Taylor, Michael D, and Jones, Chris
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Humans ,Neuroectodermal Tumors ,Central Nervous System Neoplasms ,Trans-Activators ,Proto-Oncogene Proteins ,Tumor Suppressor Proteins ,Repressor Proteins ,Gene Expression Profiling ,Signal Transduction ,DNA Methylation ,Gene Expression Regulation ,Neoplastic ,Amino Acid Sequence ,Molecular Sequence Data ,Child ,Forkhead Transcription Factors ,Neuroblastoma ,Cancer ,Pediatric ,Neurosciences ,Brain Disorders ,Rare Diseases ,Orphan Drug ,Brain Cancer ,Pediatric Research Initiative ,Pediatric Cancer ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.
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- 2016
8. Gliomatosis cerebri in children:A poor prognostic phenotype of diffuse gliomas with a distinct molecul profile
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Nussbaumer, Gunther, Benesch, Martin, Grabovska, Yura, Mackay, Alan, Castel, David, Grill, Jacques, Alonso, Marta M., Antonelli, Manila, Bailey, Simon, Baugh, Joshua N., Biassoni, Veronica, Blattner-Johnson, Mirjam, Broniscer, Alberto, Carai, Andrea, Colafati, Giovanna Stefania, Colditz, Niclas, Corbacioglu, Selim, Crampsie, Shauna, Entz-Werle, Natacha, Eyrich, Matthias, Friker, Lea L., Frühwald, Michael C., Garrè, Maria Luisa, Gerber, Nicolas U., Giangaspero, Felice, Gil-Da-Costa, Maria J., Graf, Norbert, Hargrave, Darren, Hauser, Peter, Herrlinger, Ulrich, Hoffmann, Marion, Hulleman, Esther, Izquierdo, Elisa, Jacobs, Sandra, Karremann, Michael, Kattamis, Antonis, Kebudi, Rejin, Kortmann, Rolf Dieter, Kwiecien, Robert, Massimino, Maura, Mastronuzzi, Angela, Miele, Evelina, Morana, Giovanni, Noack, Claudia M., Pentikainen, Virve, Perwein, Thomas, Pfister, Stefan M., Pietsch, Torsten, Roka, Kleoniki, Rossi, Sabrina, Rutkowski, Stefan, Schiavello, Elisabetta, Seidel, Clemens, Štěrba, Jaroslav, Sturm, Dominik, Sumerauer, David, Tacke, Anna, Temelso, Sara, Valentini, Chiara, van Vuurden, Dannis, Varlet, Pascale, Veldhuijzen van Zanten, Sophie E.M., Vinci, Maria, von Bueren, André O., Warmuth-Metz, Monika, Wesseling, Pieter, Wiese, Maria, Wolff, Johannes E.A., Zamecnik, Josef, La Madrid, Andrés Morales, Bison, Brigitte, Gielen, Gerrit H., Jones, David T.W., Jones, Chris, Kramm, Christof M., Nussbaumer, Gunther, Benesch, Martin, Grabovska, Yura, Mackay, Alan, Castel, David, Grill, Jacques, Alonso, Marta M., Antonelli, Manila, Bailey, Simon, Baugh, Joshua N., Biassoni, Veronica, Blattner-Johnson, Mirjam, Broniscer, Alberto, Carai, Andrea, Colafati, Giovanna Stefania, Colditz, Niclas, Corbacioglu, Selim, Crampsie, Shauna, Entz-Werle, Natacha, Eyrich, Matthias, Friker, Lea L., Frühwald, Michael C., Garrè, Maria Luisa, Gerber, Nicolas U., Giangaspero, Felice, Gil-Da-Costa, Maria J., Graf, Norbert, Hargrave, Darren, Hauser, Peter, Herrlinger, Ulrich, Hoffmann, Marion, Hulleman, Esther, Izquierdo, Elisa, Jacobs, Sandra, Karremann, Michael, Kattamis, Antonis, Kebudi, Rejin, Kortmann, Rolf Dieter, Kwiecien, Robert, Massimino, Maura, Mastronuzzi, Angela, Miele, Evelina, Morana, Giovanni, Noack, Claudia M., Pentikainen, Virve, Perwein, Thomas, Pfister, Stefan M., Pietsch, Torsten, Roka, Kleoniki, Rossi, Sabrina, Rutkowski, Stefan, Schiavello, Elisabetta, Seidel, Clemens, Štěrba, Jaroslav, Sturm, Dominik, Sumerauer, David, Tacke, Anna, Temelso, Sara, Valentini, Chiara, van Vuurden, Dannis, Varlet, Pascale, Veldhuijzen van Zanten, Sophie E.M., Vinci, Maria, von Bueren, André O., Warmuth-Metz, Monika, Wesseling, Pieter, Wiese, Maria, Wolff, Johannes E.A., Zamecnik, Josef, La Madrid, Andrés Morales, Bison, Brigitte, Gielen, Gerrit H., Jones, David T.W., Jones, Chris, and Kramm, Christof M.
- Abstract
Background: The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established. Methods: We conducted a multinational retrospective study of 104 children and adolescents with GC providing comprehensive clinical and (epi-)genetic characterization. Results: Median overall survival (OS) was 15.5 months (interquartile range, 10.9–27.7) with a 2-year survival rate of 28%. Histopathological grading correlated significantly with median OS: CNS WHO grade II: 47.8 months (25.2–55.7); grade III: 15.9 months (11.4–26.3); grade IV: 10.4 months (8.8–14.4). By DNA methylation profiling (n = 49), most tumors were classified as pediatric-type diffuse high-grade glioma (pedHGG), H3-/IDH-wild-type (n = 31/49, 63.3%) with enriched subclasses pedHGG_RTK2 (n = 19), pedHGG_A/B (n = 6), and pedHGG_MYCN (n = 5), but only one pedHGG_RTK1 case. Within the pedHGG, H3-/IDH-wild-type subgroup, recurrent alterations in EGFR (n = 10) and BCOR (n = 9) were identified. Additionally, we observed structural aberrations in chromosome 6 in 16/49 tumors (32.7%) across tumor types. In the pedHGG, H3-/IDH-wild-type subgroup TP53 alterations had a significant negative effect on OS. Conclusions: Contrary to previous studies, our representative pediatric GC study provides evidence that GC has a strong predilection to arise on the background of specific molecular features (especially pedHGG_ RTK2, pedHGG_A/B, EGFR and BCOR mutations, chromosome 6 rearrangements).
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- 2024
9. Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns
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Dodgshun, Andrew J., Fukuoka, Kohei, Edwards, Melissa, Bianchi, Vanessa J., Das, Anirban, Sexton-Oates, Alexandra, Larouche, Valérie, Vanan, Magimairajan I., Lindhorst, Scott, Yalon, Michal, Mason, Gary, Crooks, Bruce, Constantini, Shlomi, Massimino, Maura, Chiaravalli, Stefano, Ramdas, Jagadeesh, Mason, Warren, Ashraf, Shamvil, Farah, Roula, Van Damme, An, Opocher, Enrico, Hamid, Syed Ahmer, Ziegler, David S., Samuel, David, Cole, Kristina A., Tomboc, Patrick, Stearns, Duncan, Thomas, Gregory A., Lossos, Alexander, Sullivan, Michael, Hansford, Jordan R., Mackay, Alan, Jones, Chris, Jones, David T. W., Ramaswamy, Vijay, Hawkins, Cynthia, Bouffet, Eric, and Tabori, Uri
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- 2020
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10. Beyond crystals: the dialectic of materials and information
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Cartwright, Julyan H. E. and Mackay, Alan L.
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Nonlinear Sciences - Adaptation and Self-Organizing Systems ,Condensed Matter - Materials Science ,Quantitative Biology - Genomics - Abstract
We argue for a convergence of crystallography, materials science and biology, that will come about through asking materials questions about biology and biological questions about materials, illuminated by considerations of information. The complex structures now being studied in biology and produced in nanotechnology have outstripped the framework of classical crystallography, and a variety of organizing concepts are now taking shape into a more modern and dynamic science of structure, form and function. Absolute stability and equilibrium are replaced by metastable structures existing in a flux of energy-carrying information and moving within an energy landscape of complex topology. Structures give place to processes and processes to systems. The fundamental level is that of atoms. As smaller and smaller groups of atoms are used for their physical properties, quantum effects become important; already we see quantum computation taking shape. Concepts move towards those in life with the emergence of specifically informational structures. We now see the possibility of the artificial construction of a synthetic living system, different from biological life, but having many or all of the same properties. Interactions are essentially nonlinear and collective. Structures begin to have an evolutionary history with episodes of symbiosis. Underlying all the structures are constraints of time and space. Through hierarchization, a more general principle than the periodicity of crystals, structures may be found within structures on different scales. We must integrate unifying concepts from dynamical systems and information theory to form a coherent language and science of shape and structure beyond crystals. To this end, we discuss the idea of categorizing structures based on information according to the algorithmic complexity of their assembly.
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- 2012
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11. PATH-23. CLINICOPATHOLOGIC ANALYSIS OF NOVEL METHYLATION CLUSTERS OF IDH-WILDTYPE DIFFUSE GLIOMAS
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Singh, Omkar, primary, Aldape, Kenneth, additional, Abdullaev, Zied, additional, Turakulov, Rust, additional, Andreiuolo, Felipe, additional, Costa, Felipe D'Almeida, additional, Camelo-Piragua, Sandra, additional, Pytel, Peter, additional, Zhang, Daniel, additional, Borys, Ewa, additional, Nix, Stephen, additional, Fernandes, Igor, additional, Sloan, Emily, additional, Phillips, Kester, additional, Serafini, Luciano Neder, additional, Trejo-Lopez, Jorge, additional, Mendez, Joe, additional, Eberhart, Charles, additional, Smith-Cohn, Matthew, additional, Neill, Stewart, additional, Christensen, Brock, additional, Macaulay, Robert, additional, Colman, Howard, additional, Nguyen, Aivi, additional, Giannini, Caterina, additional, Li, Rong, additional, Mandell, James, additional, Kessler, Tobias, additional, Wick, Wolfgang, additional, Jones, Chris, additional, Clarke, Matthew, additional, MacKay, Alan, additional, Helgager, Jeffrey, additional, Lee, Han, additional, Lopez, Giselle, additional, Perry, Arie, additional, Ahmadian, Saman, additional, Haeri, Mohammad, additional, Wang, Shih-Hsiu, additional, Dahiya, Sonika, additional, Souza, Andrea, additional, Marques Gregorio, Joao Vitor Antunes, additional, Sterman, Hugo, additional, Nasrallah, MacLean P, additional, and Aboud, Orwa, additional
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- 2023
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12. Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, Mackay, Alan, Nandhabalan, Meera, Burford, Anna, Jury, Alexa, Popov, Sergey, Bax, Dorine A, Carvalho, Diana, Taylor, Kathryn R, Vinci, Maria, Bajrami, Ilirjana, McGonnell, Imelda M, Lord, Christopher J, Reis, Rui M, Hargrave, Darren, Ashworth, Alan, Workman, Paul, and Jones, Chris
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Neurosciences ,Rare Diseases ,Brain Cancer ,Cancer ,Brain Disorders ,Genetics ,Stem Cell Research - Nonembryonic - Non-Human ,Biotechnology ,Pediatric Research Initiative ,Pediatric ,Stem Cell Research ,Adolescent ,Cell Line ,Tumor ,Child ,Chromatin Immunoprecipitation ,Cluster Analysis ,Computational Biology ,DNA Mutational Analysis ,Databases ,Nucleic Acid ,Datasets as Topic ,Gene Expression Profiling ,Gene Expression Regulation ,Neoplastic ,Genotype ,Glioblastoma ,High-Throughput Nucleotide Sequencing ,Histones ,Humans ,Mutation ,N-Myc Proto-Oncogene Protein ,Nuclear Proteins ,Oncogene Proteins ,Protein Binding ,Transcription ,Genetic ,Up-Regulation ,Oncology and Carcinogenesis - Abstract
UnlabelledChildren and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs are clinically and biologically distinct from histologically similar cancers in older adults. They are defined by highly specific mutations in the gene encoding the histone H3.3 variant H3F3A , occurring either at or close to key residues marked by methylation for regulation of transcription—K27 and G34. Here, we show that the cerebral hemisphere-specific G34 mutation drives a distinct expression signature through differential genomic binding of the K36 trimethylation mark (H3K36me3). The transcriptional program induced recapitulates that of the developing forebrain, and involves numerous markers of stem-cell maintenance, cell-fate decisions, and self-renewal.Critically, H3F3A G34 mutations cause profound upregulation of MYCN , a potent oncogene that is causative of GBMs when expressed in the correct developmental context. This driving aberration is selectively targetable in this patient population through inhibiting kinases responsible for stabilization of the protein.SignificanceWe provide the mechanistic explanation for how the fi rst histone gene mutation inhuman disease biology acts to deliver MYCN, a potent tumorigenic initiator, into a stem-cell compartment of the developing forebrain, selectively giving rise to incurable cerebral hemispheric GBM. Using synthetic lethal approaches to these mutant tumor cells provides a rational way to develop novel and highly selective treatment strategies
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- 2013
13. Comprehensive Sampling of Gene Expression in Human Cell Lines with Massively Parallel Signature Sequencing
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Jongeneel, C. Victor, Iseli, Christian, Stevenson, Brian J., Riggins, Gregory J., Lal, Anita, Mackay, Alan, Harris, Robert A., O'Hare, Michael J., Neville, A. Munro, and Strausberg, Robert L.
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- 2003
14. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
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Mackay, Alan, Burford, Anna, Carvalho, Diana, Izquierdo, Elisa, Fazal-Salom, Janat, Taylor, Kathryn R., Bjerke, Lynn, Clarke, Matthew, Vinci, Mara, Nandhabalan, Meera, Temelso, Sara, Popov, Sergey, Molinari, Valeria, Raman, Pichai, Waanders, Angela J., Han, Harry J., Gupta, Saumya, Marshall, Lynley, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Ng, Ho-Keung, Li, Xingang, Mu, Kun, Trabelsi, Saoussen, Brahim, Dorra H’mida-Ben, Kisljakov, Alexei N., Konovalov, Dmitry M., Moore, Andrew S., Carcaboso, Angel Montero, Sunol, Mariona, de Torres, Carmen, Cruz, Ofelia, Mora, Jaume, Shats, Ludmila I., Stavale, João N., Bidinotto, Lucas T., Reis, Rui M., Entz-Werle, Natacha, Farrell, Michael, Cryan, Jane, Crimmins, Darach, Caird, John, Pears, Jane, Monje, Michelle, Debily, Marie-Anne, Castel, David, Grill, Jacques, Hawkins, Cynthia, Nikbakht, Hamid, Jabado, Nada, Baker, Suzanne J., Pfister, Stefan M., Jones, David T.W., Fouladi, Maryam, von Bueren, André O., Baudis, Michael, Resnick, Adam, and Jones, Chris
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- 2017
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15. Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma
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Qin, Elizabeth Y., Cooper, Dominique D., Abbott, Keene L., Lennon, James, Nagaraja, Surya, Mackay, Alan, Jones, Chris, Vogel, Hannes, Jackson, Peter K., and Monje, Michelle
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- 2017
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16. A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS
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Amodeo, Valeria, A, Deli, Betts, Joanne, Bartesaghi, Stefano, Zhang, Ying, Richard-Londt, Angela, Ellis, Matthew, Roshani, Rozita, Vouri, Mikaella, Galavotti, Sara, Oberndorfer, Sarah, Leite, Ana Paula, Mackay, Alan, Lampada, Aikaterini, Stratford, Eva Wessel, Li, Ningning, Dinsdale, David, Grimwade, David, Jones, Chris, Nicotera, Pierluigi, Michod, David, Brandner, Sebastian, and Salomoni, Paolo
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- 2017
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17. Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
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Grabovska, Yura, Mackay, Alan, O’Hare, Patricia, Crosier, Stephen, Finetti, Martina, Schwalbe, Edward C., Pickles, Jessica C., Fairchild, Amy R., Avery, Aimee, Cockle, Julia, Hill, Rebecca, Lindsey, Janet, Hicks, Debbie, Kristiansen, Mark, Chalker, Jane, Anderson, John, Hargrave, Darren, Jacques, Thomas S., Straathof, Karin, Bailey, Simon, Jones, Chris, Clifford, Steven C., and Williamson, Daniel
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- 2020
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18. Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers
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Smalley, Matthew J, Iravani, Marjan, Leao, Maria, Grigoriadis, Anita, Kendrick, Howard, Dexter, Tim, Fenwick, Kerry, Regan, Joseph L, Britt, Kara, McDonald, Sarah, Lord, Christopher J, MacKay, Alan, and Ashworth, Alan
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Genetics ,Biotechnology ,Breast Cancer ,Stem Cell Research ,Cancer ,Underpinning research ,Aetiology ,1.1 Normal biological development and functioning ,2.1 Biological and endogenous factors ,Animals ,Breast Neoplasms ,Epithelial Cells ,Female ,Flow Cytometry ,GTP-Binding Proteins ,Gene Expression Profiling ,Gene Expression Regulation ,Neoplastic ,Mammary Glands ,Animal ,Mice ,Oligonucleotide Array Sequence Analysis ,RGS Proteins ,RNA ,Messenger ,Receptors ,Oxytocin ,Reverse Transcriptase Polymerase Chain Reaction ,Signal Transduction ,Up-Regulation ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
IntroductionTo understand which signalling pathways become deregulated in breast cancer, it is necessary to identify functionally significant gene expression patterns in the stem, progenitor, transit amplifying and differentiated cells of the mammary epithelium. We have previously used the markers 33A10, CD24 and Sca-1 to identify mouse mammary epithelial cell subpopulations. We now investigate the relationship between cells expressing these markers and use gene expression microarray analysis to identify genes differentially expressed in the cell populations.MethodsFreshly isolated primary mouse mammary epithelial cells were separated on the basis of staining with the 33A10 antibody and an alpha-Sca-1 antibody. The populations identified were profiled using gene expression microarray analysis. Gene expression patterns were confirmed on normal mouse and human mammary epithelial subpopulations and were examined in a panel of breast cancer samples and cell lines.ResultsAnalysis of the separated populations demonstrated that Sca-1- 33A10High stained cells were estrogen receptor alpha (Esr1)- luminal epithelial cells, whereas Sca-1+ 33A10Low/- stained cells were a mix of nonepithelial cells and Esr1+ epithelial cells. Analysis of the gene expression data identified the gene Rgs2 (regulator of G-protein signalling 2) as being highly expressed in the Sca-1- 33A10Low/- population, which included myoepithelial/basal cells. RGS2 has previously been described as a regulator of angiotensin II receptor signalling. Gene expression analysis by quantitative real-time RT-PCR of cells separated on the basis of CD24 and Sca-1 expression confirmed that Rgs2 was more highly expressed in mouse myoepithelial/basal mammary cells than luminal cells. This expression pattern was conserved in normal human breast cells. Functional analysis demonstrated RGS2 to be a modulator of oxytocin receptor signalling. The potential significance of RGS2 expression in breast cancer was demonstrated by semi-quantitative RT-PCR analysis, data mining and quantitative real-time RT-PCR approaches, which showed that RGS2 was expressed in the majority of solid breast cancers at much higher levels than in normal human mammary cells.ConclusionMolecular analysis of prospectively isolated mammary epithelial cells identified RGS2 as a modulator of oxytocin receptor signalling, which is highly expressed in the myoepithelial cells. The RGS2 gene, but not the oxytocin receptor, was also shown to be over-expressed in the majority of breast cancers, identifying the product of this gene, or the pathway(s) it regulates, as potentially significant therapeutic targets.
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- 2007
19. Molecular response to aromatase inhibitor treatment in primary breast cancer
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Mackay, Alan, Urruticoechea, Ander, Dixon, J Michael, Dexter, Tim, Fenwick, Kerry, Ashworth, Alan, Drury, Suzanne, Larionov, Alexey, Young, Oliver, White, Sharon, Miller, William R, Evans, Dean B, and Dowsett, Mitch
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Genetics ,Estrogen ,Breast Cancer ,Cancer ,Aging ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Anastrozole ,Antineoplastic Agents ,Hormonal ,Aromatase Inhibitors ,Breast Neoplasms ,Combined Modality Therapy ,Female ,Gene Expression Regulation ,Neoplastic ,Humans ,Letrozole ,Nitriles ,Polymerase Chain Reaction ,Postmenopause ,Receptors ,Estrogen ,Triazoles ,Up-Regulation ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundAromatase inhibitors such as anastrozole and letrozole are highly effective suppressants of estrogen synthesis in postmenopausal women and are the most effective endocrine treatments for hormone receptor positive breast cancer in such women. Little is known of the molecular effects of these agents on human breast carcinomas in vivo.MethodsWe randomly assigned primary estrogen receptor positive breast cancer patients to treatment with anastrozole or letrozole for 2 weeks before surgery. Expression profiling using cDNA arrays was conducted on pretreatment and post-treatment biopsies. Sample pairs from 34 patients provided sufficient RNA for analysis.ResultsProfound changes in gene expression were seen with both aromatase inhibitors, including many classical estrogen-dependent genes such as TFF1, CCND1, PDZK1 and AGR2, but also many other genes that are likely to represent secondary responses; decrease in the expression of proliferation-related genes were particularly prominent. Many upregulated genes are involved in extracellular matrix remodelling, including collagens and members of the small leucine-rich proteoglycan family (LUM, DCN, and ASPN). No significant differences were seen between letrozole and anastrozole in terms of molecular effects. The gene changes were integrated into a Global Index of Dependence on Estrogen (GIDE), which enumerates the genes changing by at least twofold with therapy. The GIDE varied markedly between tumours and related significantly to pretreatment levels of HER2 and changes in immunohistochemically detected Ki67.ConclusionOur findings identify the transcriptional signatures associated with aromatase inhibitor treatment of primary breast tumours. Larger datasets using this approach should enable identification of estrogen-dependent molecular changes, which are the determinants of benefit or resistance to endocrine therapy.
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- 2007
20. Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data
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Grigoriadis, Anita, Mackay, Alan, Reis-Filho, Jorge S, Steele, Dawn, Iseli, Christian, Stevenson, Brian J, Jongeneel, C Victor, Valgeirsson, Haukur, Fenwick, Kerry, Iravani, Marjan, Leao, Maria, Simpson, Andrew JG, Strausberg, Robert L, Jat, Parmjit S, Ashworth, Alan, Neville, A Munro, and O'Hare, Michael J
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Cancer ,Genetics ,Human Genome ,Biotechnology ,Breast Cancer ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,2.1 Biological and endogenous factors ,Aetiology ,Biomarkers ,Tumor ,Breast ,Breast Neoplasms ,Cell Adhesion Molecules ,Cells ,Cultured ,Epithelial Cells ,Female ,Gene Expression Profiling ,Humans ,Oligonucleotide Array Sequence Analysis ,Prognosis ,Transcription ,Genetic ,Tumor Cells ,Cultured ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
IntroductionDiverse microarray and sequencing technologies have been widely used to characterise the molecular changes in malignant epithelial cells in breast cancers. Such gene expression studies to identify markers and targets in tumour cells are, however, compromised by the cellular heterogeneity of solid breast tumours and by the lack of appropriate counterparts representing normal breast epithelial cells.MethodsMalignant neoplastic epithelial cells from primary breast cancers and luminal and myoepithelial cells isolated from normal human breast tissue were isolated by immunomagnetic separation methods. Pools of RNA from highly enriched preparations of these cell types were subjected to expression profiling using massively parallel signature sequencing (MPSS) and four different genome wide microarray platforms. Functional related transcripts of the differential tumour epithelial transcriptome were used for gene set enrichment analysis to identify enrichment of luminal and myoepithelial type genes. Clinical pathological validation of a small number of genes was performed on tissue microarrays.ResultsMPSS identified 6,553 differentially expressed genes between the pool of normal luminal cells and that of primary tumours substantially enriched for epithelial cells, of which 98% were represented and 60% were confirmed by microarray profiling. Significant expression level changes between these two samples detected only by microarray technology were shown by 4,149 transcripts, resulting in a combined differential tumour epithelial transcriptome of 8,051 genes. Microarray gene signatures identified a comprehensive list of 907 and 955 transcripts whose expression differed between luminal epithelial cells and myoepithelial cells, respectively. Functional annotation and gene set enrichment analysis highlighted a group of genes related to skeletal development that were associated with the myoepithelial/basal cells and upregulated in the tumour sample. One of the most highly overexpressed genes in this category, that encoding periostin, was analysed immunohistochemically on breast cancer tissue microarrays and its expression in neoplastic cells correlated with poor outcome in a cohort of poor prognosis estrogen receptor-positive tumours.ConclusionUsing highly enriched cell populations in combination with multiplatform gene expression profiling studies, a comprehensive analysis of molecular changes between the normal and malignant breast tissue was established. This study provides a basis for the identification of novel and potentially important targets for diagnosis, prognosis and therapy in breast cancer.
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- 2006
21. A Dictionary of Scientific Quotations
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Mackay, Alan L, primary and Medawar, Peter, additional
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- 2019
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22. Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells
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Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R., Pemberton, Helen N., Lord, Christopher J., Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V., Qin, Elizabeth Y., Ingram, Wendy J., Moore, Andrew S., Ng, Ho-Keung, Trabelsi, Saoussen, H’mida-Ben Brahim, Dorra, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Carcaboso, Angel M., Monje, Michelle, Mackay, Alan, and Jones, Chris
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- 2018
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23. HGG-17. SINGLE-CELL AND SPATIAL ANALYSES DECIPHER THE UNIQUE INVASIVE GROWTH PATTERN OF GLIOMATOSIS CEREBRI
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Crampsie, Shauna, primary, Liu, Ilon, additional, Petrilli, Lucia Lisa, additional, Mackay, Alan, additional, Spinozzi, Giulio, additional, Grabovska, Yura, additional, Hack, Olivia A, additional, Kessler, Ketty, additional, Temelso, Sara, additional, Carvalho, Diana Martins, additional, Burford, Anna, additional, Sejdiu, Drenusha, additional, Molinari, Valeria, additional, Shaw, McKenzie L, additional, Mire, Hafsa M, additional, Pericoli, Giulia, additional, Cerimele, Alfredo, additional, Barry, Clémentine, additional, Cocito, Carolina, additional, Debily, Marie-Anne, additional, Kergrohen, Thomas, additional, Ajlil, Yassine, additional, Beccaria, Kévin, additional, Varlet, Pascale, additional, Tauziède-Espariat, Arnault, additional, Mastronuzzi, Angela, additional, Carai, Andrea, additional, Giovannoni, Isabella, additional, Rossi, Sabrina, additional, Miele, Evelina, additional, Grill, Jacques, additional, Jacques, Thomas S, additional, Greenfield, Jeffery P, additional, Castel, David, additional, Vinci, Maria, additional, Filbin, Mariella G, additional, and Jones, Chris, additional
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- 2023
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24. Curved Surfaces in Chemical Structure
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Klinowski, Jacek, Mackay, Alan L., and Terrones, Humberto
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- 1996
25. Generalized Crystallography
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Mackay, Alan L., Hargittai, Istvan, editor, and Hargittai, Balazs, editor
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- 2015
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26. The Lab
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Mackay, Alan L., Hargittai, Balazs, editor, and Hargittai, István, editor
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- 2015
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27. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
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Fons, Nathan R., Sundaram, Ranjini K., Breuer, Gregory A., Peng, Sen, McLean, Ryan L., Kalathil, Aravind N., Schmidt, Mark S., Carvalho, Diana M., Mackay, Alan, Jones, Chris, Carcaboso, Ángel M., Nazarian, Javad, Berens, Michael E., Brenner, Charles, and Bindra, Ranjit S.
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- 2019
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28. The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
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Martínez-Vélez, Naiara, Garcia-Moure, Marc, Marigil, Miguel, González-Huarriz, Marisol, Puigdelloses, Montse, Gallego Pérez-Larraya, Jaime, Zalacaín, Marta, Marrodán, Lucía, Varela-Guruceaga, Maider, Laspidea, Virginia, Aristu, Jose Javier, Ramos, Luis Isaac, Tejada-Solís, Sonia, Díez-Valle, Ricardo, Jones, Chris, Mackay, Alan, Martínez-Climent, Jose A., García-Barchino, Maria Jose, Raabe, Eric, Monje, Michelle, Becher, Oren J., Junier, Marie Pierre, El-Habr, Elias A., Chneiweiss, Herve, Aldave, Guillermo, Jiang, Hong, Fueyo, Juan, Patiño-García, Ana, Gomez-Manzano, Candelaria, and Alonso, Marta M.
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- 2019
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29. ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma
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Carvalho, Diana, Taylor, Kathryn R., Olaciregui, Nagore Gene, Molinari, Valeria, Clarke, Matthew, Mackay, Alan, Ruddle, Ruth, Henley, Alan, Valenti, Melanie, Hayes, Angela, Brandon, Alexis De Haven, Eccles, Suzanne A., Raynaud, Florence, Boudhar, Aicha, Monje, Michelle, Popov, Sergey, Moore, Andrew S., Mora, Jaume, Cruz, Ofelia, Vinci, Mara, Brennan, Paul E., Bullock, Alex N., Carcaboso, Angel Montero, and Jones, Chris
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- 2019
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30. Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
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Izquierdo, Elisa, primary, Carvalho, Diana M., primary, Mackay, Alan, primary, Temelso, Sara, primary, Boult, Jessica K.R., primary, Pericoli, Giulia, primary, Fernandez, Elisabet, primary, Das, Molina, primary, Molinari, Valeria, primary, Grabovska, Yura, primary, Rogers, Rebecca F., primary, Ajmone-Cat, Maria Antonietta, primary, Proszek, Paula Z., primary, Stubbs, Mark, primary, Depani, Sarita, primary, O'Hare, Patricia, primary, Yu, Lu, primary, Roumelioti, Georgia, primary, Choudhary, Jyoti S., primary, Clarke, Matthew, primary, Fairchild, Amy R., primary, Jacques, Thomas S., primary, Grundy, Richard G., primary, Howell, Lisa, primary, Picton, Susan, primary, Adamski, Jenny, primary, Wilson, Shaun, primary, Gray, Juliet C., primary, Zebian, Bassel, primary, Marshall, Lynley V., primary, Carceller, Fernando, primary, Grill, Jacques, primary, Vinci, Maria, primary, Robinson, Simon P., primary, Hubank, Michael, primary, Hargrave, Darren, primary, and Jones, Chris, primary
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- 2023
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31. Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
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Izquierdo, Elisa, primary, Carvalho, Diana M., primary, Mackay, Alan, primary, Temelso, Sara, primary, Boult, Jessica K.R., primary, Pericoli, Giulia, primary, Fernandez, Elisabet, primary, Das, Molina, primary, Molinari, Valeria, primary, Grabovska, Yura, primary, Rogers, Rebecca F., primary, Ajmone-Cat, Maria Antonietta, primary, Proszek, Paula Z., primary, Stubbs, Mark, primary, Depani, Sarita, primary, O'Hare, Patricia, primary, Yu, Lu, primary, Roumelioti, Georgia, primary, Choudhary, Jyoti S., primary, Clarke, Matthew, primary, Fairchild, Amy R., primary, Jacques, Thomas S., primary, Grundy, Richard G., primary, Howell, Lisa, primary, Picton, Susan, primary, Adamski, Jenny, primary, Wilson, Shaun, primary, Gray, Juliet C., primary, Zebian, Bassel, primary, Marshall, Lynley V., primary, Carceller, Fernando, primary, Grill, Jacques, primary, Vinci, Maria, primary, Robinson, Simon P., primary, Hubank, Michael, primary, Hargrave, Darren, primary, and Jones, Chris, primary
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- 2023
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32. Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing
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Gopisetty, Apurva, primary, Federico, Aniello, additional, Surdez, Didier, additional, Iddir, Yasmine, additional, Zaidi, Sakina, additional, Saint-Charles, Alexandra, additional, Waterfall, Joshua, additional, Saberi-Ansari, Elnaz, additional, Wierzbinska, Justyna, additional, Schlicker, Andreas, additional, Mack, Norman, additional, Schwalm, Benjamin, additional, Previti, Christopher, additional, Weiser, Lena, additional, Buchhalter, Ivo, additional, Böttcher, Anna-Lisa, additional, Sill, Martin, additional, Autry, Robert, additional, Estermann, Frank, additional, Jones, David, additional, Volckmann, Richard, additional, Zwijnenburg, Danny, additional, Eggert, Angelika, additional, Heidenreich, Olaf, additional, Iradier, Fatima, additional, Jeremias, Irmela, additional, Kovar, Heinrich, additional, Klusmann, Jan-Henning, additional, Debatin, Klaus-Michael, additional, Bomken, Simon, additional, Hamerlik, Petra, additional, Hattersley, Maureen, additional, Witt, Olaf, additional, Chesler, Louis, additional, Mackay, Alan, additional, Gojo, Johannes, additional, Cairo, Stefano, additional, Schueler, Julia, additional, Schulte, Johannes, additional, Geoerger, Birgit, additional, Molenaar, Jan J., additional, Shields, David J., additional, Caron, Hubert N., additional, Vassal, Gilles, additional, Stancato, Louis F., additional, Pfister, Stefan M., additional, Jaeger, Natalie, additional, Koster, Jan, additional, Kool, Marcel, additional, and Schleiermacher, Gudrun, additional
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- 2023
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33. Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
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Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary
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- 2023
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34. Supplementary Table 3 from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, primary, Mackay, Alan, primary, Nandhabalan, Meera, primary, Burford, Anna, primary, Jury, Alexa, primary, Popov, Sergey, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Taylor, Kathryn R., primary, Vinci, Maria, primary, Bajrami, Ilirjana, primary, McGonnell, Imelda M., primary, Lord, Christopher J., primary, Reis, Rui M., primary, Hargrave, Darren, primary, Ashworth, Alan, primary, Workman, Paul, primary, and Jones, Chris, primary
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- 2023
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35. Supplementary Table 2 from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, primary, Mackay, Alan, primary, Nandhabalan, Meera, primary, Burford, Anna, primary, Jury, Alexa, primary, Popov, Sergey, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Taylor, Kathryn R., primary, Vinci, Maria, primary, Bajrami, Ilirjana, primary, McGonnell, Imelda M., primary, Lord, Christopher J., primary, Reis, Rui M., primary, Hargrave, Darren, primary, Ashworth, Alan, primary, Workman, Paul, primary, and Jones, Chris, primary
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- 2023
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36. Data from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, primary, Mackay, Alan, primary, Nandhabalan, Meera, primary, Burford, Anna, primary, Jury, Alexa, primary, Popov, Sergey, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Taylor, Kathryn R., primary, Vinci, Maria, primary, Bajrami, Ilirjana, primary, McGonnell, Imelda M., primary, Lord, Christopher J., primary, Reis, Rui M., primary, Hargrave, Darren, primary, Ashworth, Alan, primary, Workman, Paul, primary, and Jones, Chris, primary
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- 2023
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37. Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
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Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary
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- 2023
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38. Press Conference from Functional Viability Profiles of Breast Cancer
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Brough, Rachel, primary, Frankum, Jessica R., primary, Sims, David, primary, Mackay, Alan, primary, Mendes-Pereira, Ana M., primary, Bajrami, Ilirjana, primary, Costa-Cabral, Sara, primary, Rafiq, Rumana, primary, Ahmad, Amar S., primary, Cerone, Maria Antonietta, primary, Natrajan, Rachael, primary, Sharpe, Rachel, primary, Shiu, Kai-Keen, primary, Wetterskog, Daniel, primary, Dedes, Konstantine J., primary, Lambros, Maryou B., primary, Rawjee, Teeara, primary, Linardopoulos, Spiros, primary, Reis-Filho, Jorge S., primary, Turner, Nicholas C., primary, Lord, Christopher J., primary, and Ashworth, Alan, primary
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- 2023
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39. Data from Functional Viability Profiles of Breast Cancer
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Brough, Rachel, primary, Frankum, Jessica R., primary, Sims, David, primary, Mackay, Alan, primary, Mendes-Pereira, Ana M., primary, Bajrami, Ilirjana, primary, Costa-Cabral, Sara, primary, Rafiq, Rumana, primary, Ahmad, Amar S., primary, Cerone, Maria Antonietta, primary, Natrajan, Rachael, primary, Sharpe, Rachel, primary, Shiu, Kai-Keen, primary, Wetterskog, Daniel, primary, Dedes, Konstantine J., primary, Lambros, Maryou B., primary, Rawjee, Teeara, primary, Linardopoulos, Spiros, primary, Reis-Filho, Jorge S., primary, Turner, Nicholas C., primary, Lord, Christopher J., primary, and Ashworth, Alan, primary
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- 2023
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40. Supplementary Methods from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, primary, Mackay, Alan, primary, Nandhabalan, Meera, primary, Burford, Anna, primary, Jury, Alexa, primary, Popov, Sergey, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Taylor, Kathryn R., primary, Vinci, Maria, primary, Bajrami, Ilirjana, primary, McGonnell, Imelda M., primary, Lord, Christopher J., primary, Reis, Rui M., primary, Hargrave, Darren, primary, Ashworth, Alan, primary, Workman, Paul, primary, and Jones, Chris, primary
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- 2023
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41. Supplementary Table S3 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
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Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary
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- 2023
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42. Supplementary Figures 1-8, Tables 1-9 from Functional Viability Profiles of Breast Cancer
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Brough, Rachel, primary, Frankum, Jessica R., primary, Sims, David, primary, Mackay, Alan, primary, Mendes-Pereira, Ana M., primary, Bajrami, Ilirjana, primary, Costa-Cabral, Sara, primary, Rafiq, Rumana, primary, Ahmad, Amar S., primary, Cerone, Maria Antonietta, primary, Natrajan, Rachael, primary, Sharpe, Rachel, primary, Shiu, Kai-Keen, primary, Wetterskog, Daniel, primary, Dedes, Konstantine J., primary, Lambros, Maryou B., primary, Rawjee, Teeara, primary, Linardopoulos, Spiros, primary, Reis-Filho, Jorge S., primary, Turner, Nicholas C., primary, Lord, Christopher J., primary, and Ashworth, Alan, primary
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- 2023
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43. Supplementary Figures S1-S3 from Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma
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Carvalho, Diana M., primary, Richardson, Peter J., primary, Olaciregui, Nagore, primary, Stankunaite, Reda, primary, Lavarino, Cinzia, primary, Molinari, Valeria, primary, Corley, Elizabeth A., primary, Smith, Daniel P., primary, Ruddle, Ruth, primary, Donovan, Adam, primary, Pal, Akos, primary, Raynaud, Florence I., primary, Temelso, Sara, primary, Mackay, Alan, primary, Overington, John P., primary, Phelan, Anne, primary, Sheppard, David, primary, Mackinnon, Andrew, primary, Zebian, Bassel, primary, Al-Sarraj, Safa, primary, Merve, Ashirwad, primary, Pryce, Jeremy, primary, Grill, Jacques, primary, Hubank, Michael, primary, Cruz, Ofelia, primary, Morales La Madrid, Andres, primary, Mueller, Sabine, primary, Carcaboso, Angel M., primary, Carceller, Fernando, primary, and Jones, Chris, primary
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- 2023
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44. Data from Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma
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Carvalho, Diana M., primary, Richardson, Peter J., primary, Olaciregui, Nagore, primary, Stankunaite, Reda, primary, Lavarino, Cinzia, primary, Molinari, Valeria, primary, Corley, Elizabeth A., primary, Smith, Daniel P., primary, Ruddle, Ruth, primary, Donovan, Adam, primary, Pal, Akos, primary, Raynaud, Florence I., primary, Temelso, Sara, primary, Mackay, Alan, primary, Overington, John P., primary, Phelan, Anne, primary, Sheppard, David, primary, Mackinnon, Andrew, primary, Zebian, Bassel, primary, Al-Sarraj, Safa, primary, Merve, Ashirwad, primary, Pryce, Jeremy, primary, Grill, Jacques, primary, Hubank, Michael, primary, Cruz, Ofelia, primary, Morales La Madrid, Andres, primary, Mueller, Sabine, primary, Carcaboso, Angel M., primary, Carceller, Fernando, primary, and Jones, Chris, primary
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- 2023
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45. Supplementary Figure Legends from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, primary, Mackay, Alan, primary, Nandhabalan, Meera, primary, Burford, Anna, primary, Jury, Alexa, primary, Popov, Sergey, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Taylor, Kathryn R., primary, Vinci, Maria, primary, Bajrami, Ilirjana, primary, McGonnell, Imelda M., primary, Lord, Christopher J., primary, Reis, Rui M., primary, Hargrave, Darren, primary, Ashworth, Alan, primary, Workman, Paul, primary, and Jones, Chris, primary
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- 2023
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46. Supplementary Table 1 from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, primary, Mackay, Alan, primary, Nandhabalan, Meera, primary, Burford, Anna, primary, Jury, Alexa, primary, Popov, Sergey, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Taylor, Kathryn R., primary, Vinci, Maria, primary, Bajrami, Ilirjana, primary, McGonnell, Imelda M., primary, Lord, Christopher J., primary, Reis, Rui M., primary, Hargrave, Darren, primary, Ashworth, Alan, primary, Workman, Paul, primary, and Jones, Chris, primary
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- 2023
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47. Supplementary Table 4 from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, primary, Mackay, Alan, primary, Nandhabalan, Meera, primary, Burford, Anna, primary, Jury, Alexa, primary, Popov, Sergey, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Taylor, Kathryn R., primary, Vinci, Maria, primary, Bajrami, Ilirjana, primary, McGonnell, Imelda M., primary, Lord, Christopher J., primary, Reis, Rui M., primary, Hargrave, Darren, primary, Ashworth, Alan, primary, Workman, Paul, primary, and Jones, Chris, primary
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- 2023
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48. Supplementary Figures 1 - 13 from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Bjerke, Lynn, primary, Mackay, Alan, primary, Nandhabalan, Meera, primary, Burford, Anna, primary, Jury, Alexa, primary, Popov, Sergey, primary, Bax, Dorine A., primary, Carvalho, Diana, primary, Taylor, Kathryn R., primary, Vinci, Maria, primary, Bajrami, Ilirjana, primary, McGonnell, Imelda M., primary, Lord, Christopher J., primary, Reis, Rui M., primary, Hargrave, Darren, primary, Ashworth, Alan, primary, Workman, Paul, primary, and Jones, Chris, primary
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- 2023
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49. Table S2 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis
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Lambros, Maryou B., primary, Seed, George, primary, Sumanasuriya, Semini, primary, Gil, Veronica, primary, Crespo, Mateus, primary, Fontes, Mariane, primary, Chandler, Rob, primary, Mehra, Niven, primary, Fowler, Gemma, primary, Ebbs, Berni, primary, Flohr, Penny, primary, Miranda, Susana, primary, Yuan, Wei, primary, Mackay, Alan, primary, Ferreira, Ana, primary, Pereira, Rita, primary, Bertan, Claudia, primary, Figueiredo, Ines, primary, Riisnaes, Ruth, primary, Rodrigues, Daniel Nava, primary, Sharp, Adam, primary, Goodall, Jane, primary, Boysen, Gunther, primary, Carreira, Suzanne, primary, Bianchini, Diletta, primary, Rescigno, Pasquale, primary, Zafeiriou, Zafeiris, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Hamilton, Lucy, primary, Neves, Rui P., primary, Swennenhuis, Joost, primary, Andree, Kiki, primary, Stoecklein, Nikolas H., primary, Terstappen, Leon W.M.M., primary, and de Bono, Johann S., primary
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- 2023
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50. Supplementary Figure SF2 from Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial
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Rodriguez Gutierrez, Daniel, primary, Jones, Chris, primary, Varlet, Pascale, primary, Mackay, Alan, primary, Warren, Daniel, primary, Warmuth-Metz, Monika, primary, Aliaga, Esther Sánchez, primary, Calmon, Raphael, primary, Hargrave, Darren R., primary, Cañete, Adela, primary, Massimino, Maura, primary, Azizi, Amedeo A., primary, Le Deley, Marie-Cécile, primary, Saran, Frank, primary, Rousseau, Raphael F., primary, Zahlmann, Gudrun, primary, Garcia, Josep, primary, Vassal, Gilles, primary, Grill, Jacques, primary, Morgan, Paul S., primary, and Jaspan, Tim, primary
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- 2023
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