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In this paper, the effects of Brownian motion, thermophoresis, chemical reaction, heat generation, magnetohydrodynamic and thermal radiation has been included in the model of nanofluid flow and heat transfer over a moving surface with variable thickness. The similarity transformation is used to transform the governing boundary layer equations into ordinary differential equations (ODE). Both optimal homotopy asymptotic method (OHAM) and Runge-Kutta fourth order method with shooting technique are employed to solve the resulting ODEs. For different values of the pertinent parameters on the velocity, temperature and concentration profiles have been studied and details are given in tables and graphs respectively. A comparison with the previous study is made, where an excellent agreement is achieved. The results demonstrate that the radiation parameter N increases, with the increase in both the temperature and the thermal boundary layer thickness respectively. While the nanoparticles concentration profiles increase with the influence of generative chemical reaction γ<0, while it decreases with destructive chemical reaction γ> 0. [ABSTRACT FROM AUTHOR]