32 results on '"Madsen, Mia Gebauer"'
Search Results
2. Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database
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Dominguez-Valentin, Mev, Haupt, Saskia, Seppälä, Toni T., Sampson, Julian R., Sunde, Lone, Bernstein, Inge, Jenkins, Mark A., Engel, Christoph, Aretz, Stefan, Nielsen, Maartje, Capella, Gabriel, Balaguer, Francesc, Evans, Dafydd Gareth, Burn, John, Holinski-Feder, Elke, Bertario, Lucio, Bonanni, Bernardo, Lindblom, Annika, Levi, Zohar, Macrae, Finlay, Winship, Ingrid, Plazzer, John-Paul, Sijmons, Rolf, Laghi, Luigi, Della Valle, Adriana, Heinimann, Karl, Dębniak, Tadeusz, Fruscio, Robert, Lopez-Koestner, Francisco, Alvarez-Valenzuela, Karin, Katz, Lior H., Laish, Ido, Vainer, Elez, Vaccaro, Carlos, Carraro, Dirce Maria, Monahan, Kevin, Half, Elizabeth, Stakelum, Aine, Winter, Des, Kennelly, Rory, Gluck, Nathan, Sheth, Harsh, Abu-Freha, Naim, Greenblatt, Marc, Rossi, Benedito Mauro, Bohorquez, Mabel, Cavestro, Giulia Martina, Lino-Silva, Leonardo S., Horisberger, Karoline, Tibiletti, Maria Grazia, Nascimento, Ivana do, Thomas, Huw, Rossi, Norma Teresa, Apolinário da Silva, Leandro, Zaránd, Attila, Ruiz-Bañobre, Juan, Heuveline, Vincent, Mecklin, Jukka-Pekka, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Lepistö, Anna, Peltomäki, Päivi, Therkildsen, Christina, Madsen, Mia Gebauer, Burgdorf, Stefan Kobbelgaard, Hopper, John L., Win, Aung Ko, Haile, Robert W., Lindor, Noralane, Gallinger, Steven, Le Marchand, Loïc, Newcomb, Polly A., Figueiredo, Jane, Buchanan, Daniel D., Thibodeau, Stephen N., von Knebel Doeberitz, Magnus, Loeffler, Markus, Rahner, Nils, Schröck, Evelin, Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Perne, Claudia, Hüneburg, Robert, Redler, Silke, Büttner, Reinhard, Weitz, Jürgen, Pineda, Marta, Duenas, Nuria, Vidal, Joan Brunet, Moreira, Leticia, Sánchez, Ariadna, Hovig, Eivind, Nakken, Sigve, Green, Kate, Lalloo, Fiona, Hill, James, Crosbie, Emma, Mints, Miriam, Goldberg, Yael, Tjandra, Douglas, ten Broeke, Sanne W., Kariv, Revital, Rosner, Guy, Advani, Suresh H., Thomas, Lidiya, Shah, Pankaj, Shah, Mithun, Neffa, Florencia, Esperon, Patricia, Pavicic, Walter, Torrezan, Giovana Tardin, Bassaneze, Thiago, Martin, Claudia Alejandra, Moslein, Gabriela, and Moller, Pål
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- 2023
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3. von Hippel-Lindau disease: Updated guideline for diagnosis and surveillance
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Louise M Binderup, Marie, Smerdel, Maja, Borgwadt, Line, Beck Nielsen, Signe Sparre, Madsen, Mia Gebauer, Møller, Hans Ulrik, Kiilgaard, Jens Folke, Friis-Hansen, Lennart, Harbud, Vibeke, Cortnum, Søren, Owen, Hanne, Gimsing, Steen, Friis Juhl, Henning Anker, Munthe, Sune, Geilswijk, Marianne, Rasmussen, Åse Krogh, Møldrup, Ulla, Graumann, Ole, Donskov, Frede, Grønbæk, Henning, Stausbøl-Grøn, Brian, Schaffalitzky de Muckadell, Ove, Knigge, Ulrich, Dam, Gitte, Wadt, Karin AW., Bøgeskov, Lars, Bagi, Per, Lund, Lars, Stochholm, Kirstine, Ousager, Lilian Bomme, and Sunde, Lone
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- 2022
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4. Renal Angiomyolipoma in Pregnancy: a Case Report and Systematic Review
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Soerensen, Frederikke Eichner, Nielsen, Tommy Kjaergaard, and Madsen, Mia Gebauer
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- 2022
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5. Birt–Hogg–Dubé Syndrome
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Geilswijk, Marianne, primary, Sommerlund, Mette, additional, Madsen, Mia Gebauer, additional, Skytte, Anne-Bine, additional, and Bendstrup, Elisabeth, additional
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- 2020
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- View/download PDF
6. Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment:a report from the prospective Lynch syndrome database
- Author
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Dominguez-Valentin, Mev, Haupt, Saskia, Seppälä, Toni T., Sampson, Julian R., Sunde, Lone, Bernstein, Inge, Jenkins, Mark A., Engel, Christoph, Aretz, Stefan, Nielsen, Maartje, Capella, Gabriel, Balaguer, Francesc, Evans, Dafydd Gareth, Burn, John, Holinski-Feder, Elke, Bertario, Lucio, Bonanni, Bernardo, Lindblom, Annika, Levi, Zohar, Macrae, Finlay, Winship, Ingrid, Plazzer, John Paul, Sijmons, Rolf, Laghi, Luigi, Della Valle, Adriana, Heinimann, Karl, Dębniak, Tadeusz, Fruscio, Robert, Lopez-Koestner, Francisco, Alvarez-Valenzuela, Karin, Katz, Lior H., Laish, Ido, Vainer, Elez, Vaccaro, Carlos, Carraro, Dirce Maria, Monahan, Kevin, Half, Elizabeth, Stakelum, Aine, Winter, Des, Kennelly, Rory, Gluck, Nathan, Sheth, Harsh, Abu-Freha, Naim, Greenblatt, Marc, Rossi, Benedito Mauro, Bohorquez, Mabel, Cavestro, Giulia Martina, Lino-Silva, Leonardo S., Horisberger, Karoline, Tibiletti, Maria Grazia, Nascimento, Ivana do, Thomas, Huw, Rossi, Norma Teresa, Apolinário da Silva, Leandro, Zaránd, Attila, Ruiz-Bañobre, Juan, Heuveline, Vincent, Mecklin, Jukka Pekka, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Lepistö, Anna, Peltomäki, Päivi, Therkildsen, Christina, Madsen, Mia Gebauer, Burgdorf, Stefan Kobbelgaard, Hopper, John L., Win, Aung Ko, Haile, Robert W., Lindor, Noralane, Gallinger, Steven, Le Marchand, Loïc, Newcomb, Polly A., Figueiredo, Jane, Buchanan, Daniel D., Thibodeau, Stephen N., von Knebel Doeberitz, Magnus, Loeffler, Markus, Rahner, Nils, Schröck, Evelin, Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Perne, Claudia, Hüneburg, Robert, Redler, Silke, Büttner, Reinhard, Weitz, Jürgen, Pineda, Marta, Duenas, Nuria, Vidal, Joan Brunet, Moreira, Leticia, Sánchez, Ariadna, Hovig, Eivind, Nakken, Sigve, Green, Kate, Lalloo, Fiona, Hill, James, Crosbie, Emma, Mints, Miriam, Goldberg, Yael, Tjandra, Douglas, ten Broeke, Sanne W., Kariv, Revital, Rosner, Guy, Advani, Suresh H., Thomas, Lidiya, Shah, Pankaj, Shah, Mithun, Neffa, Florencia, Esperon, Patricia, Pavicic, Walter, Torrezan, Giovana Tardin, Bassaneze, Thiago, Martin, Claudia Alejandra, Moslein, Gabriela, Moller, Pål, Dominguez-Valentin, Mev, Haupt, Saskia, Seppälä, Toni T., Sampson, Julian R., Sunde, Lone, Bernstein, Inge, Jenkins, Mark A., Engel, Christoph, Aretz, Stefan, Nielsen, Maartje, Capella, Gabriel, Balaguer, Francesc, Evans, Dafydd Gareth, Burn, John, Holinski-Feder, Elke, Bertario, Lucio, Bonanni, Bernardo, Lindblom, Annika, Levi, Zohar, Macrae, Finlay, Winship, Ingrid, Plazzer, John Paul, Sijmons, Rolf, Laghi, Luigi, Della Valle, Adriana, Heinimann, Karl, Dębniak, Tadeusz, Fruscio, Robert, Lopez-Koestner, Francisco, Alvarez-Valenzuela, Karin, Katz, Lior H., Laish, Ido, Vainer, Elez, Vaccaro, Carlos, Carraro, Dirce Maria, Monahan, Kevin, Half, Elizabeth, Stakelum, Aine, Winter, Des, Kennelly, Rory, Gluck, Nathan, Sheth, Harsh, Abu-Freha, Naim, Greenblatt, Marc, Rossi, Benedito Mauro, Bohorquez, Mabel, Cavestro, Giulia Martina, Lino-Silva, Leonardo S., Horisberger, Karoline, Tibiletti, Maria Grazia, Nascimento, Ivana do, Thomas, Huw, Rossi, Norma Teresa, Apolinário da Silva, Leandro, Zaránd, Attila, Ruiz-Bañobre, Juan, Heuveline, Vincent, Mecklin, Jukka Pekka, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Lepistö, Anna, Peltomäki, Päivi, Therkildsen, Christina, Madsen, Mia Gebauer, Burgdorf, Stefan Kobbelgaard, Hopper, John L., Win, Aung Ko, Haile, Robert W., Lindor, Noralane, Gallinger, Steven, Le Marchand, Loïc, Newcomb, Polly A., Figueiredo, Jane, Buchanan, Daniel D., Thibodeau, Stephen N., von Knebel Doeberitz, Magnus, Loeffler, Markus, Rahner, Nils, Schröck, Evelin, Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Perne, Claudia, Hüneburg, Robert, Redler, Silke, Büttner, Reinhard, Weitz, Jürgen, Pineda, Marta, Duenas, Nuria, Vidal, Joan Brunet, Moreira, Leticia, Sánchez, Ariadna, Hovig, Eivind, Nakken, Sigve, Green, Kate, Lalloo, Fiona, Hill, James, Crosbie, Emma, Mints, Miriam, Goldberg, Yael, Tjandra, Douglas, ten Broeke, Sanne W., Kariv, Revital, Rosner, Guy, Advani, Suresh H., Thomas, Lidiya, Shah, Pankaj, Shah, Mithun, Neffa, Florencia, Esperon, Patricia, Pavicic, Walter, Torrezan, Giovana Tardin, Bassaneze, Thiago, Martin, Claudia Alejandra, Moslein, Gabriela, and Moller, Pål
- Abstract
Background The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time. Methods The PLSD is a prospective observational study without a control group that was designed in 2012 and updated up to October 2022. Data for 8500 carriers of path_MMR variants from 25 countries were included, providing 71,713 years of follow up. Cumulative cancer incidences at 65 years of age were combined with 10-year crude survival following cancer, to derive estimates of mortality up to 75 years of age by organ, gene, and gender. Findings Gynaecological cancers were more frequent than colorectal cancers in path_MSH2, path_MSH6 and path_PMS2 carriers [cumulative incidence: 53.3%, 49.6% and 23.3% at 75 years, respectively]. Endometrial, colon and ovarian cancer had low mortality [8%, 13% and 15%, respectively] and prostate cancers were frequent in male path_MSH2 carriers [cumulative incidence: 39.7% at 75 years]. Pancreatic, brain, biliary tract and ureter and kidney and urinary bladder cancers were associated with high mortality [83%, 66%, 58%, 27%, and 29%, respectively]. Among path_MMR carriers undergoing colonoscopy surveillance, particularly path_MSH2 carriers, more deaths followed non-colorectal Lynch syndrome cancers than colorectal cancers. Interpretation In path_MMR carriers undergoing colonoscopy surveillance, non-colorectal Lynch syndrome cancers were associated with more deaths than were colorectal cancers. Reducing deaths from non-colorectal cancers presents a key challenge in contemporary medical ca, Background: The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time. Methods: The PLSD is a prospective observational study without a control group that was designed in 2012 and updated up to October 2022. Data for 8500 carriers of path_MMR variants from 25 countries were included, providing 71,713 years of follow up. Cumulative cancer incidences at 65 years of age were combined with 10-year crude survival following cancer, to derive estimates of mortality up to 75 years of age by organ, gene, and gender. Findings: Gynaecological cancers were more frequent than colorectal cancers in path_MSH2, path_MSH6 and path_PMS2 carriers [cumulative incidence: 53.3%, 49.6% and 23.3% at 75 years, respectively]. Endometrial, colon and ovarian cancer had low mortality [8%, 13% and 15%, respectively] and prostate cancers were frequent in male path_MSH2 carriers [cumulative incidence: 39.7% at 75 years]. Pancreatic, brain, biliary tract and ureter and kidney and urinary bladder cancers were associated with high mortality [83%, 66%, 58%, 27%, and 29%, respectively]. Among path_MMR carriers undergoing colonoscopy surveillance, particularly path_MSH2 carriers, more deaths followed non-colorectal Lynch syndrome cancers than colorectal cancers. Interpretation: In path_MMR carriers undergoing colonoscopy surveillance, non-colorectal Lynch syndrome cancers were associated with more deaths than were colorectal cancers. Reducing deaths from non-colorectal cancers presents a key challenge in contemporary medical care in Lynch syndrome. Funding: We ac
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- 2023
7. Multiplex immunofluorescence staining of coverslip-mounted paraffin-embedded tissue sections
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Elsborg, Søren Hejgaard, Pedersen, Gitte Albinus, Madsen, Mia Gebauer, Keller, Anna Krarup, Nørregaard, Rikke, and Nejsum, Lene Niemann
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- 2023
8. ERN GENTURIS clinical practice guidelines for the diagnosis, surveillance and management of people with Birt-Hogg-Dubé syndrome
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Geilswijk, Marianne, Genuardi, Maurizio, Woodward, Emma R., Nightingale, Katie, Huber, Jazzmin, Madsen, Mia Gebauer, Liekelema - van der Heij, Dieke, Lisseman, Ian, Marlé-Ballangé, Jenny, McCarthy, Cormac, Menko, Fred H., Moorselaar, R. Jeroen A. van, Radzikowska, Elzbieta, Richard, Stéphane, Rajan, Neil, Sommerlund, Mette, Wetscherek, Maria T. A., Di Donato, Nataliya, Maher, Eamonn R., and Brunet, Joan
- Abstract
Birt-Hogg-Dubé syndrome (BHD syndrome) is an autosomal dominant multisystem disorder with variable expression due to pathogenic constitutional variants in the FLCNgene. Patients with BHD syndrome are predisposed to benign cutaneous fibrofolliculomas/trichodischomas, pulmonary cysts with an associated risk of spontaneous pneumothorax, and renal cell carcinoma. A requirement for updated International consensus recommendations for the diagnosis and management of BHD syndrome was identified. Based on a comprehensive literature review and expert consensus within the fields of respiratory medicine, urology, radiology, dermatology, clinical oncology and clinical genetics, updated recommendations for diagnosis, surveillance and management in BHD syndrome were developed. With the widespread availability of FLCNgenetic testing, clinical scenarios in which a diagnosis should be considered and criteria for genetic testing were defined. Following a clinical and/or molecular diagnosis of BHD syndrome, a multidisciplinary approach to disease management is required. Regular renal cancer surveillance is recommended in adulthood and life-long, but the evidence base for additional tumour surveillance is limited and further research warranted. Recommendations for the treatment of cutaneous, pulmonary and renal manifestations are provided. Awareness of BHD syndrome needs to be raised and better knowledge of the clinical settings in which the diagnosis should be considered should enable earlier diagnosis. Further details, including areas for future research topics are available at: https://www.genturis.eu/l=eng/Guidelines-and-pathways/Clinical-practice-guidelines.html.
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- 2024
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9. Additional file 1 of An animal-free preclinical drug screening platform based on human precision-cut kidney slices
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Mutsaers, Henricus A. M., Jensen, Michael Schou, Kresse, Jean-Claude, Tingskov, Stine Julie, Madsen, Mia Gebauer, and Nørregaard, Rikke
- Abstract
Supplementary Material 1
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- 2023
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10. Epidermal growth factor and monocyte chemotactic peptide-1: Potential biomarkers of urinary tract obstruction in children with hydronephrosis
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Madsen, Mia Gebauer, Nørregaard, Rikke, Palmfeldt, Johan, Olsen, Lars Henning, Frøkiær, Jørgen, and Jørgensen, Troels Munch
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- 2013
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11. Immunohistochemical Screening of Upper Tract Urothelial Carcinomas for Lynch Syndrome Diagnostics: A Systematic Review
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Rasmussen, Maria, primary, Madsen, Mia Gebauer, additional, and Therkildsen, Christina, additional
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- 2022
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12. Urinary biomarkers in prenatally diagnosed unilateral hydronephrosis
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Madsen, Mia Gebauer, Nørregaard, Rikke, Frøkiær, Jørgen, and Jørgensen, Troels Munch
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- 2011
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13. EP 1 receptor antagonism mitigates early and late stage renal fibrosis
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Kresse, Jean‐Claude, primary, Mutsaers, Henricus A. M., additional, Jensen, Michael Schou, additional, Tingskov, Stine Julie, additional, Madsen, Mia Gebauer, additional, Nejsum, Lene N., additional, Prætorius, Helle, additional, and Nørregaard, Rikke, additional
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- 2022
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14. Urinary NGAL, cystatin C, β2-microglobulin, and osteopontin significance in hydronephrotic children
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Madsen, Mia Gebauer, Nørregaard, Rikke, Palmfeldt, Johan, Olsen, Lars Henning, Frøkiær, Jørgen, and Jørgensen, Troels Munch
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- 2012
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15. Udredning, opfølgning og behandling af tuberøs sklerose-kompleks
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Reinhard, Mark, Sunde, Lone, Madsen, Mia Gebauer, Andersen, Brian Nauheimer, Bendstrup, Elisabeth, Sommerlund, Mette, Gjørup, Hans, Larsen, Dorte Ancher, Møller, Hans Ulrik, Nielsen, Dorte Guldbrand, Mortensen, Ulrik Markus, Handrup, Mette Møller, Aagaard, Niels Kristian Muff, Cortnum, Søren, Khatir, Dinah Sherzad, Bayat, Michael, Andersen, Gratien, Stausbøl-Grøn, Brian, and Christensen, Jakob
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congenital, hereditary, and neonatal diseases and abnormalities ,hemic and lymphatic diseases ,neoplasms ,nervous system diseases - Abstract
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder with highly varying disease manifestations, many of which cause extensive morbidity. There are international consensus criteria for the diagnosis, monitoring and treatment of TSC, and approved medical treatment for some of the most serious disease manifestations. However, organisation of a rational and coordinated care of TSC patients involves many different medical specialities and is only sparsely described. This review describes the interdisciplinary care of TSC patients at Aarhus University Hospital, Denmark.
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- 2020
16. EP1 receptor antagonism mitigates early and late stage renal fibrosis.
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Kresse, Jean‐Claude, Mutsaers, Henricus A. M., Jensen, Michael Schou, Tingskov, Stine Julie, Madsen, Mia Gebauer, Nejsum, Lene N., Prætorius, Helle, and Nørregaard, Rikke
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RENAL fibrosis ,FIBROSIS ,CHRONIC kidney failure ,URETERIC obstruction ,PROTEIN expression - Abstract
Aim: Renal fibrosis is a major driver of chronic kidney disease, yet current treatment strategies are ineffective in attenuating fibrogenesis. The cyclooxygenase/prostaglandin system plays a key role in renal injury and holds great promise as a therapeutic target. Here, we used a translational approach to evaluate the role of the PGE2‐EP1 receptor in the pathogenesis of renal fibrosis in several models of kidney injury, including human (fibrotic) kidney slices. Methods: The anti‐fibrotic efficacy of a selective EP1 receptor antagonist (SC‐19220) was studied in mice subjected to unilateral ureteral obstruction (UUO), healthy and fibrotic human precision‐cut kidney slices (PCKS), Madin‐Darby Canine Kidney (MDCK) cells and primary human renal fibroblasts (HRFs). Fibrosis was evaluated on gene and protein level using qPCR, western blot and immunostaining. Results: EP1 receptor inhibition diminished fibrosis in UUO mice, illustrated by a decreased protein expression of fibronectin (FN) and α‐smooth muscle actin (αSMA) and a reduction in collagen deposition. Moreover, treatment of healthy human PCKS with SC‐19220 reduced TGF‐β‐induced fibrosis as shown by decreased expression of collagen 1A1, FN and αSMA as well as reduced collagen deposition. Similar observations were made using fibrotic human PCKS. In addition, SC‐19220 reduced TGF‐β‐induced FN expression in MDCK cells and HRFs. Conclusion: This study highlights the EP1 receptor as a promising target for preventing both the onset and late stage of renal fibrosis. Moreover, we provide strong evidence that the effect of SC‐19220 may translate to clinical care since its effects were observed in UUO mice, cells and human kidney slices. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices
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Jensen, Michael Schou, primary, Mutsaers, Henricus A. M., additional, Tingskov, Stine Julie, additional, Christensen, Michael, additional, Madsen, Mia Gebauer, additional, Olinga, Peter, additional, Kwon, Tae‐Hwan, additional, and Nørregaard, Rikke, additional
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- 2019
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18. Administration of a selective prostaglandin E 2 receptor agonist attenuates renal fibrosis in vitro and in vivo
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Jensen, Michael Schou, primary, Mutsaers, Henricus A.M., additional, Tingskov, Stine Julie, additional, Christensen, Michael, additional, Madsen, Mia Gebauer, additional, Olinga, Peter, additional, Kwon, Tae‐Hwan, additional, and Norregaard, Rikke, additional
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- 2019
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19. Childhood pneumothorax in Birt-Hogg-Dubé syndrome: A cohort study and review of the literature
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Geilswijk, Marianne, primary, Bendstrup, Elisabeth, additional, Madsen, Mia Gebauer, additional, Sommerlund, Mette, additional, and Skytte, Anne-Bine, additional
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- 2018
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20. Cryoablation of Renal Angiomyolipoma: An Evaluation of Safety and Efficacy
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Makki, Ahmad, primary, Graumann, Ole, additional, Høyer, Søren, additional, Solvig, Jan, additional, Østraat, Øyvind, additional, Madsen, Mia Gebauer, additional, and Nielsen, Tommy Kjærgaard, additional
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- 2017
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21. Birt–Hogg–Dubé syndrome: a case report and a review of the literature
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Jensen, Dea Kejlberg, primary, Villumsen, Anders, additional, Skytte, Anne-Bine, additional, Madsen, Mia Gebauer, additional, Sommerlund, Mette, additional, and Bendstrup, Elisabeth, additional
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- 2017
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22. Urinary Biomarkers in Hydronephrosis
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Madsen, Mia Gebauer
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- 2012
23. Urinary proteome analysis in congenital bilateral hydronephrosis
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Stødkilde, Lene, primary, Madsen, Mia Gebauer, additional, Palmfeldt, Johan, additional, Topcu, Sükrü Oguzkan, additional, Nørregaard, Rikke, additional, Olsen, Lars Henning, additional, Jørgensen, Troels Munch, additional, and Frøkiær, Jørgen, additional
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- 2012
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24. Urine and kidney cytokine profiles in experimental unilateral acute and chronic hydronephrosis
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Madsen, Mia Gebauer, primary, Nørregaard, Rikke, additional, Stødkilde, Lene, additional, Christensen, Jane Hvarregaard, additional, Jørgensen, Troels Munch, additional, and Frøkiær, Jørgen, additional
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- 2011
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25. Urinary proteome analysis in congenital bilateral hydronephrosis.
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Stødkilde, Lene, Madsen, Mia Gebauer, Palmfeldt, Johan, Topcu, Sükrü Oguzkan, Nørregaard, Rikke, Olsen, Lars Henning, Jørgensen, Troels Munch, and Frøkiær, Jørgen
- Subjects
- *
PROTEOMICS , *HYDRONEPHROSIS , *ENZYME-linked immunosorbent assay , *TRANSFERRIN , *UROMODULIN , *TRANSTHYRETIN , *FIBRINOGEN , *THERAPEUTICS - Abstract
Objective. A proteomics strategy was applied to map protein changes in urine after relief of congenital bilateral hydronephrosis to identify proteins correlated with the pathophysiological processes in congenital obstructive nephropathy as potential urinary biomarkers. Material and methods. Urine samples from 10 infants with bilateral abnormal drainage from the kidneys were collected at the time of relief from obstruction, and after 2 and 4 weeks. Proteomics techniques were used on samples from three patients for identification of protein changes between the three time-points, and enzyme-linked immunosorbent assay (ELISA) was used on samples from all 10 patients for validation of five selected proteins. Results. Mass spectrometry quantified 315 protein hits, out of which 33 proteins showed significantly changed urinary excretion between the time-points. Validation by ELISA showed high urinary excretion of fibrinogen, plasminogen, transthyretin and transferrin at the time of relief from obstruction, followed by a significant reduction. In contrast, Tamm-Horsfall protein exhibited the reverse pattern. Conclusion. Using a mass spectrometry-based proteomics approach, this study identified 33 proteins related to congenital bilateral hydronephrosis, and pinpointed a panel of five proteins consistently linked to this congenital kidney disorder as potential urinary biomarkers. [ABSTRACT FROM AUTHOR]
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- 2013
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26. Urine and kidney cytokine profiles in experimental unilateral acute and chronic hydronephrosis.
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Madsen, Mia Gebauer, Nørregaard, Rikke, Stødkilde, Lene, Christensen, Jane Hvarregaard, Jørgensen, Troels Munch, and Frøkiær, Jørgen
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- *
CYTOKINES , *KIDNEY diseases , *INTERLEUKINS , *IMMUNOASSAY , *HYDRONEPHROSIS , *URETERIC obstruction , *URINALYSIS - Abstract
Objective. In search of potential urinary biomarkers of obstructive nephropathy, this study examined whether a potential change in the concentration of urinary cytokines [interferon-γ(IFN-γ), interleukin-1β (IL-1β), IL-2, IL-6, IL-10 and tumour necrosis factor-α (TNF-α)] reliably reflects changes in renal parenchymal levels of the same cytokines following the release of acute and chronic unilateral ureteral obstruction, respectively. Material and methods. Acute obstruction was performed in 12 adult rats. After 48 h, six rats were used for selective urine collection and six rats had their kidneys removed and dissected into inner medulla and cortex. Chronic obstruction was performed in newborn rats. After 10 weeks, a similar set-up to that of the acute study was implemented. Sham-operated rats were prepared in parallel. Urine and tissue cytokines were measured with a bead-based multiplex sandwich immunoassay and analysed on a Luminex 100 IS instrument. Results. In the acute study, there were significantly increased concentrations of IL-1β and IL-6 in inner medulla and in urine from the obstructed kidney, significantly increased concentrations of TNF-α in urine from the obstructed kidney and, importantly, significantly increased levels of IL-10 in cortex and in urine from the non-obstructed kidney. In the chronic study, there were similar changes in IL-1β and IL-6 (not significant) but no changes in TNF-α and IL-10. Conclusions. This study showed that inflammatory cytokines can be detected both in renal parenchyma and in urine from rats with experimental unilateral ureteral obstruction. Further studies are needed to confirm the diagnostic accuracy of IL-1β, IL-6, IL-10 and TNF-α in urine. [ABSTRACT FROM AUTHOR]
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- 2012
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27. Activation of the prostaglandin E2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices.
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Jensen, Michael Schou, Mutsaers, Henricus A. M., Tingskov, Stine Julie, Christensen, Michael, Madsen, Mia Gebauer, Olinga, Peter, Kwon, Tae‐Hwan, and Nørregaard, Rikke
- Subjects
RENAL fibrosis ,KIDNEYS ,URETERIC obstruction ,MICE ,PROTEIN expression ,WESTERN immunoblotting - Abstract
Aim: Renal fibrosis plays a pivotal role in the development and progression of chronic kidney disease, which affects 10% of the adult population. Previously, it has been demonstrated that the cyclooxygenase‐2 (COX‐2)/prostaglandin (PG) system influences the progression of renal injury. Here, we evaluated the impact of butaprost, a selective EP2 receptor agonist, on renal fibrosis in several models of kidney injury, including human tissue slices. Methods: We studied the anti‐fibrotic efficacy of butaprost using Madin‐Darby Canine Kidney (MDCK) cells, mice that underwent unilateral ureteral obstruction and human precision‐cut kidney slices. Fibrogenesis was evaluated on a gene and protein level by qPCR and Western blotting. Results: Butaprost (50 μM) reduced TGF‐β‐induced fibronectin (FN) expression, Smad2 phosphorylation and epithelial‐mesenchymal transition in MDCK cells. In addition, treatment with 4 mg/kg/day butaprost attenuated the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery, as illustrated by a reduction in the gene and protein expression of α‐smooth muscle actin, FN and collagen 1A1. More importantly, a similar anti‐fibrotic effect of butaprost was observed in human precision‐cut kidney slices exposed to TGF‐β. The mechanism of action of butaprost appeared to be a direct effect on TGF‐β/Smad signalling, which was independent of the cAMP/PKA pathway. Conclusion: In conclusion, this study demonstrates that stimulation of the EP2 receptor effectively mitigates renal fibrogenesis in various fibrosis models. These findings warrant further research into the clinical application of butaprost, or other EP2 agonists, for the inhibition of renal fibrosis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
28. Administration of a selective prostaglandin E-2 receptor agonist attenuates renal fibrosis in vitro and in vivo
- Author
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Jensen, Michael Schou, Mutsaers, Henricus A. M., Tingskov, Stine Julie, Christensen, Michael, Madsen, Mia Gebauer, Olinga, Peter, Kwon, Tae-Hwan, Norregaard, Rikke, Pharmaceutical Technology and Biopharmacy, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), and Groningen Institute for Organ Transplantation (GIOT)
29. Pulmonary embolisms and infections after renal trauma.
- Author
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Voss NCS, Nielsen TK, Madsen MG, Chynau Y, Cao T, Møldrup U, and Keller AK
- Subjects
- Humans, Adult, Electronic Health Records, Hospitalization, Hospitals, University, Kidney diagnostic imaging, Pulmonary Embolism diagnostic imaging, Pulmonary Embolism etiology, Pulmonary Embolism therapy
- Abstract
Introduction: The objective of this study was to describe and evaluate the management of patients with renal trauma and their complications at the Department of Urology at Aarhus University Hospital (AUH), Denmark., Methods: All patients diagnosed with renal injury due to trauma and with contact to the Department of Urology at the AUH, Denmark, between March 2016 and March 2021 were included. Patients were identified by the International Classification of Diseases, Tenth version, code and data obtained from electronic patient records., Results: A total of 58 patients were identified. The median age was 33 years (7-95 years) and the median length of hospitalisation was five days (range: 0-52 days). All patients were evaluated with a multiphase computed tomography upon admission. Injuries to the kidney were graded using the American Association for the Surgery of Trauma kidney injury scale. Twelve percent had grade I injury, 26% had grade II injury, 26% had grade III injury, 36% had grade IV injury and 3% had grade V injury. In the acute phase, all patients were managed non-operatively. Early complications were found in 24% of patients. Pulmonary embolism was diagnosed in 7%. Furthermore, 7% had an infection as a late complication and all of these patients had also had an early infection. A total of 60% were followed up with a renal-scintigraphy three months after their renal trauma. This examination had no consequence for any of the patients., Conclusions: No patients died due to the renal trauma. However, many experienced complications in terms of infections and pulmonary embolisms. These data support earlier findings and suggest that a renal scintigraphy after renal traumas may be obsolete., Funding: None., Trial Registration: Not relevant., (Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.)
- Published
- 2023
30. [Diagnosis, monitoring and treatment of tuberous sclerosis complex].
- Author
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Reinhard M, Sunde L, Madsen MG, Andersen BN, Bendstrup E, Sommerlund M, Gjørup H, Larsen DA, Møller HU, Nielsen DG, Mortensen UM, Handrup MM, Aagaard NKM, Cortnum S, Khatir DS, Bayat M, Andersen G, Stausbøl-Grøn B, and Christensen J
- Subjects
- Consensus, Denmark, Humans, Tuberous Sclerosis diagnosis, Tuberous Sclerosis therapy
- Abstract
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder with highly varying disease manifestations, many of which cause extensive morbidity. There are international consensus criteria for the diagnosis, monitoring and treatment of TSC, and approved medical treatment for some of the most serious disease manifestations. However, organisation of a rational and coordinated care of TSC patients involves many different medical specialities and is only sparsely described. This review describes the interdisciplinary care of TSC patients at Aarhus University Hospital, Denmark.
- Published
- 2019
31. [Foreign objects in the urethra].
- Author
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Hyldgaard J, Nielsen TK, and Madsen MG
- Subjects
- Adult, Cystoscopy, Humans, Male, Sexual Behavior, Foreign Bodies surgery, Urethral Obstruction etiology, Urethral Obstruction surgery
- Abstract
Foreign objects in the urethra are rare. Most cases are often caused by self-mutilating behaviour, in which the patient inserts an object into the urethra. Usually this is performed in a sexual context, and many different objects have been used. This case report presents a patient who used a 4 cm bullet-looking metal object for sexual pleasure. Cystoscopy revealed an object deep in the urethra, penetrating through the urethral mucosa. The object was removed endoscopically. At follow-up the patient experienced no sequelae, although infections, urethral stricture or fistula may occur in these cases.
- Published
- 2016
32. Urinary biomarkers in hydronephrosis.
- Author
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Madsen MG
- Subjects
- Acute-Phase Proteins urine, Adolescent, Animals, Biomarkers urine, Child, Child, Preschool, Cystatin C urine, Cytokines genetics, Female, Flank Pain etiology, Humans, Hydronephrosis etiology, Hydronephrosis physiopathology, Lipocalin-2, Lipocalins urine, Male, Osteopontin urine, Proto-Oncogene Proteins urine, RNA, Messenger urine, ROC Curve, Rats, Ureteral Obstruction complications, beta 2-Microglobulin urine, Cytokines urine, Hydronephrosis surgery, Hydronephrosis urine, Patient Selection, Ureteral Obstruction urine
- Abstract
Unlabelled: Hydronephrosis is diagnosed in 0.5-1% of all newborns, and ureteropelvic junction obstruction (UPJO) accounts for 35% of those cases. A urinary tract obstruction that occurs during early kidney development affects renal morphogenesis, maturation, and growth, and in the most severe cases, this will ultimately lead to progressive renal tubular atrophy and interstitial fibrosis with the loss of nephrons. The clinical management of these patients remains a controversial topic. The aim is to preserve renal function by identifying the 15-20% of children who require early surgical intervention from those for whom watchful waiting may be appropriate because of spontaneous resolving/stabilization without significant loss of renal function. Although the patients attend regular follow-ups, including repetitive blood tests, ultrasonographies, and the more invasive diuretic renograms, the surgeons still miss reliably biomarkers that could be used as predictors for renal parenchymal damage and decreased renal function, and thereby provide more clear indications for surgical intervention. The aim of this PhD thesis was to further elucidate the pathophysiology of obstructive nephropathy (study I) and to search for potential candidate biomarkers that may have a predictive and/or diagnostic value in the management of hydronephrosis (study II). Study I: Urine and kidney cytokine profiles in experimental unilateral acute and chronic hydronephrosis., Aim: To study the dynamics of the urinary secretion of cytokines after the release of unilateral ureteral obstruction, and to study whether the urinary concentrations of these compounds reliably reflects changes in the renal parenchyma. This was tested in 2 experimental rat models: an acute obstruction model and a chronic obstruction model., Results: The acute obstruction model demonstrated significant differences in the renal levels of IL-1β, IL-6, TNF-α, and IL-10 in comparison with controls, and these differences were associated with similar differences in their urinary excretion. Such results were not obtained in the chronic obstruction model in which significant differences were only demonstrated in the urinary concentrations of IL-6. Study II: Candidate urinary biomarkers in hydronephrosis - a clinical study., Aim: To study the dynamics of the urinary excretion of selected potential biomarkers in children after the relief of UPJO, and to compare their findings with healthy controls., Results: Twenty-eight children with UPJO were included in the study from 2007-2011 together with 13 healthy children. Pre-, peri- and post-operatively (1 year) urine samples were collected. The median age of the patients was 8.1 (3.5-14.5) years. Five proteins (EGF, IP-10, MCP-1, RANTES, and MIP-1α) were examined in study IIa, and 4 proteins (NGAL, CyC, βM-2, and OPN) were examined in study IIb. In brief, significantly increased urinary concentrations of EGF and MCP-1 were demonstrated in children with UPJO compared to controls, which was followed by a decline in the post-operative period to levels similar to the controls. This indicates that the urinary concentrations of EGF and MCP-1 are regulated as a response to the obstruction, suggesting that they may have a potential as urinary biomarkers in hydronephrosis. In general, urine from the obstructed kidney exhibited higher concentrations of the proteins compared to urine from the nonobstructed kidney. Furthermore, CyC, β-2M, and OPN were negatively correlated with age, and IP-10 and MCP-1 were negatively correlated with DRF. In conclusion, this PhD study confirmed increased concentrations of selected proteins in urine from kidneys suffering from obstruction. Interestingly, it was observed that some urinary proteins had an age-dependent excretion. Further investigations are required to test the ability of the examined proteins to identify an obstruction and reveal disease progression and, thereby, be useful clinical tools.
- Published
- 2013
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