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44 results on '"Maeda, Shinichiro"'

6. Abstract 10926: Warfarin Dosing Algorithms With the Information on Genotype and Amiodarone for Patients Without Extracorporeal Circulation Devices Could Be Beneficial for Those With Left Ventricular Assist Devices

Author

Makiguchi, Misaki, Maeda, Makiko, Saito, Marika, Ito, Yoshito, Sera, Fusako, Samura, Takaaki, Kawamura, Takuji, Kawamura, Ai, Kubota, Kaoru, Maeda, Shinichiro, Kashiyama, Noriyuki, Kainuma, Satoshi, Ohtani, Tomohito, Yoshioka, Daisuke, Takeda, Toshihiro, Sawa, Yoshiki, Miyagawa, Shigeru, Sakata, Yasushi, and Fujio, Yasushi

Published
2022
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10. Model‐Informed Vancomycin Dosing Optimization to Address Delayed Renal Maturation in Infants and Young Children with Critical Congenital Heart Disease.

Author

Shimamoto, Yuko, Fukushima, Keizo, Mizuno, Tomoyuki, Ichikawa, Hajime, Kurosaki, Kenichi, Maeda, Shinichiro, and Okuda, Masahiro

Subjects
CONGENITAL heart disease, INFANTS, CHILD patients, VANCOMYCIN, GLOMERULAR filtration rate, MORPHOGENESIS, INFANT diseases
Abstract

Ensuring safe and effective drug therapy in infants and young children often requires accounting for growth and organ development; however, data on organ function maturation are scarce for special populations, such as infants with congenital diseases. Children with critical congenital heart disease (CCHD) often require multiple staged surgeries depending on their age and disease severity. Vancomycin (VCM) is used to treat postoperative infections; however, the standard pediatric dose (60–80 mg/kg/day) frequently results in overexposure in children with CCHD. In this study, we characterized the maturation of VCM clearance in pediatric patients with CCHD and determined the appropriate dosing regimen using population pharmacokinetic (PK) modeling and simulations. We analyzed 1,254 VCM serum concentrations from 152 postoperative patients (3 days–13 years old) for population PK analysis. The PK model was developed using a two‐compartment model with allometrically scaled body weight, estimated glomerular filtration rate (eGFR), and postmenstrual age as covariates. The observed clearance in patients aged ≤ 1 year and 1–2 years was 33% and 40% lower compared with that of non‐CCHD patients, respectively, indicating delayed renal maturation in patients with CCHD. Simulation analyses suggested VCM doses of 25 mg/kg/day (age ≤ 3 months, eGFR 40 mL/min/1.73 m2) and 35 mg/kg/day (3 months < age ≤ 3 years, eGFR 60 mL/min/1.73 m2). In conclusion, this study revealed delayed renal maturation in children with CCHD, could be due to cyanosis and low cardiac output. Model‐informed simulations identified the lower VCM doses for children with CCHD compared with standard pediatric guidelines. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Efficient and multiplexable genome editing using Platinum TALENs in oleaginous microalga, Nannochloropsis oceanica NIES‐2145

Author

Kurita, Tomokazu, primary, Moroi, Keishi, additional, Iwai, Masako, additional, Okazaki, Kumiko, additional, Shimizu, Shinsuke, additional, Nomura, Seiji, additional, Saito, Fumihiko, additional, Maeda, Shinichiro, additional, Takami, Akihide, additional, Sakamoto, Atsushi, additional, Ohta, Hiroyuki, additional, Sakuma, Tetsushi, additional, and Yamamoto, Takashi, additional

Published
2020
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25. Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer

Author

Shintani, Takuya, primary, Higashisaka, Kazuma, additional, Maeda, Makiko, additional, Hamada, Masaya, additional, Tsuji, Ryosuke, additional, Kurihara, Koudai, additional, Kashiwagi, Yuri, additional, Sato, Atsuhiro, additional, Obana, Masanori, additional, Yamamoto, Ayaha, additional, Kawasaki, Keisuke, additional, Lin, Ying, additional, Kijima, Takashi, additional, Kinehara, Yuhei, additional, Miwa, Yoshihiro, additional, Maeda, Shinichiro, additional, Morii, Eiichi, additional, Kumanogoh, Atsushi, additional, Tsutsumi, Yasuo, additional, Nagatomo, Izumi, additional, and Fujio, Yasushi, additional

Published
2018
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33. The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells

Author

Sasabe, Tetsuo, Maeda, Shinichiro, Kishida, Kenichi, Yamano, Mariko, Miwa, Yoshihiro, and Sugiyama, Toshihiro

Abstract

Objective: Drug therapy is occasionally accompanied by an idiosyncratic severe toxicity, which occurs very rarely, but can lead to patient mortality. Methazolamide, an anti-glaucomatous agent, could cause severe skin eruptions called Stevens-Johnson syndrome/toxic epidermal necrolyis (SJS/TEN). Its precise etiology is still uncertain. In this study, the metabolism of methazolamide was investigated in immortalized human keratinocytes to reveal the possible mechanism which causes SJS/TEN. Methods: The metabolism of methazolamide was studied using immortalized human keratinocytes, HaCaT cells. HPLC was used to isolate a metabolite from the culture medium. Mass spectrometry (LCMS/ MS) was employed for its characterization. Three typical chemical inducers were assessed for the inducibility of cytochrome P450, and methimazole was used as the inhibitor of flavin-containing monooxygenase (FMO). Results: A sulfonic acid, N-[3-methyl-5-sulfo-1,3,4-thiadiazol-2(3H)-ylidene]acetamide (MSO) was identified as the final metabolite. Dexamethasone and β-naphthoflavone behaved as an inducer of cytochrome P450 in the metabolism, but isoniazid did not. The effect of methimazole was not consistent. We did not detect any glucuronide nor any mercapturic acid (N-acetylcysteine conjugate). Conclusion: N-[3-methyl-5-sulfo-1,3,4-thiadiazol-2(3H)-ylidene]acetamide (MSO) is not considered to be a direct product of an enzymatic reaction, but rather an auto-oxidation product of N-[3-methyl-5- sulfe-1,3,4-thiadiazol-2(3H)-ylidene]acetamide, a chemically unstable sulfenic acid, which is produced by cytochrome P450 from the β-lyase product of cysteine conjugate of methazolamide. MSO is considered to be susceptible to glutathione and to return to glutathione conjugate of methazolamide, forming a futile cycle. A hypothetical scenario is presented as to the onset of the disease.

Published
2016

40. The Japanese journal of ergonomics

Author

Ochiai, Naoki, primary, Maeda, Shinichiro, additional, Kojima, Shigeyuki, additional, Wagata, Shigeki, additional, Ogura, Yumi, additional, Fujita, Etsunori, additional, Murata, Kohji, additional, Kamei, Tsutomu, additional, Ueno, Yoshiyuki, additional, and Kaneko, Shigehiko, additional

Published
2007
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