Osteochondritis dissecans is a rare condition characterized by the deterioration of a small area of bone and cartilage without infection. Its exact cause is unclear, though factors such as abnormal bone development, joint pressure, repetitive injuries, inadequate blood supply, and genetic links have been observed. In this case, a 27-year-old woman experienced chronic right knee pain following a twisting injury, which led to reduced mobility and mild pain. Examination showed no swelling or tenderness, although X-rays and further imaging revealed irregularities in the medial femoral condyle, a 1.5 cm osteochondral defect, a loose fragment, and mild degenerative changes in the meniscus and partial ligament injuries. Post-surgical management included early gentle movements and a transition to running four months post-operatively. Follow-ups at 10 days and six weeks showed a full range of motion with no pain or complications. Successful graft integration and healing were confirmed without significant osteoarthritic changes, indicating effective joint preservation. This case illustrates the potential of autograft mosaicplasty in treating osteochondritis dissecans, underlining the importance of individualized treatment approaches to address articular cartilage injuries effectively. Long-term results and the factors contributing to the disorder remain areas for further research., Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Aljadaan et al.)