1,076 results on '"Magnani, C"'
Search Results
2. Congenital Anomalies and Risk of Childhood Leukemia: A Pooled Analysis from the Childhood Leukemia International Consortium (CLIC)
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Lupo, P, Mueller, B, Clavel, J, Dockerty, J, Ezzat, S, Hansen, J, Heck, J, Infante-Rivard, C, Magnani, C, Metayer, C, Milne, E, Mora, AM, Petridou, E, Pombo-de-Oliveira, M, Roman, E, Schuz, J, Vinceti, M, Spector, L, and Scheurer, M
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Oncology And Carcinogenesis ,Paediatrics And Reproductive Medicine ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis ,Paediatrics and Reproductive Medicine - Published
- 2018
3. Environmental asbestos exposure and clustering of malignant mesothelioma in community: a spatial analysis in a population-based case–control study
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Airoldi, C., Magnani, C., Lazzarato, F., Mirabelli, D., Tunesi, S., and Ferrante, D.
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- 2021
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4. Caspase 8-dependent inhibition of necroptosis prevents plaque necrotic core formation
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Pilot, T., primary, Solier, S., additional, Jalil, A., additional, Magnani, C., additional, Masson, D., additional, Solary, E., additional, and Thomas, C., additional
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- 2023
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5. Use of administrative health databases to estimate incidence and prevalence of acromegaly in Piedmont Region, Italy
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Caputo, M., Ucciero, A., Mele, C., De Marchi, L., Magnani, C., Cena, T., Marzullo, P., Barone-Adesi, F., and Aimaretti, G.
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- 2019
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6. Congenital Heart Defects: 15 Years of Experience of the Emilia-Romagna Registry (Italy)
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Calzolari, E., Garani, G., Cocchi, G., Magnani, C., Rivieri, F., Neville, A., Astolfi, G., Baroncini, A., Garavelli, L., Gualandi, F., Scorrano, M., and Bosi, G.
- Published
- 2003
7. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case–control study and epidemiological remarks
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Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I.F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., Iavicoli S., Dallari B., Pesatori A.C., Riboldi L., Merletti F., Gangemi M., Stura A., Brentisci C., Gilardetti M., Benfatto L., Canessa P.A., Malacarne D., Mazzucco G., Campi M.G., Fedeli U., Bressan V., Gioffre F., Ballarin M.N., Chermaz C., D'agostin F., De Michieli P., Mangone L., Storchi C., Sala O., Badiali A.M., Cacciarini V., Giovannetti L., Martini A., Calisti R., Pascucci C., Stracci F., Masanotti G., Davoli M., Cavariani F., Ancona L., Annunziata A., Menegozzo S., Napolitano F., Pelullo C.P., Vimercati L., Cascone G., Frasca G., Giurdanella M.C., Martorana C., Nicita C., Rollo C.P., Spata E., Dardanoni G., Scondotto S., Nieddu V., Pergola M., Stecchi S., Marinaccio, Alessandro, Consonni, Dario, Mensi, Carolina, Mirabelli, Dario, Migliore, Enrica, Magnani, Corrado, Di Marzio, Davide, Gennaro, Valerio, Mazzoleni, Guido, Girardi, Paolo, Negro, Corrado, Romanelli, Antonio, Chellini, Elisabetta, Grappasonni, Iolanda, Madeo, Gabriella, Romeo, Elisa, Ascoli, Valeria, Carrozza, Francesco, Angelillo, Italo Francesco, Cavone, Domenica, Tumino, Rosario, Melis, Massimo, Curti, Stefania, Brandi, Giovanni, Mattioli, Stefano, and Iavicoli, Sergio
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medicine.medical_specialty ,pericardial and tunica vaginalis testis ,Epidemiology ,Population ,rare disease ,national registry ,medicine.disease_cause ,Epidemiology, Italy, National registry, Rare disease ,Asbestos ,epidemiology, Italy, national registry, rare disease ,NO ,03 medical and health sciences ,0302 clinical medicine ,italy ,medicine ,epidemiology ,Italy ,Mesothelioma ,education ,Gynecology ,education.field_of_study ,business.industry ,Public Health, Environmental and Occupational Health ,Tunica vaginalis testis ,Case-control study ,case–control study ,Odds ratio ,medicine.disease ,asbestos ,030210 environmental & occupational health ,National registry ,exposure ,mesothelioma ,malignant mesothelioma ,Original Article ,Public aspects of medicine ,RA1-1270 ,business ,Rare disease - Abstract
Objectives: The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. Methods: Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993–2015, incidence rates, survival median period and prognostic factors have been evaluated. A case–control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. Results: Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis mesothelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85–7.31 and OR 3.42, 95% CI 1.93–6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. Conclusions: For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.
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- 2020
8. CDKN2A and BAP1 germline mutations predispose to melanoma and mesothelioma
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Betti, M., Aspesi, A., Biasi, A., Casalone, E., Ferrante, D., Ogliara, P., Gironi, L.C., Giorgione, R., Farinelli, P., Grosso, F., Libener, R., Rosato, S., Turchetti, D., Maffè, A., Casadio, C., Ascoli, V., Dianzani, C., Colombo, E., Piccolini, E., Pavesi, M., Miccoli, S., Mirabelli, D., Bracco, C., Righi, L., Boldorini, R., Papotti, M., Matullo, G., Magnani, C., Pasini, B., and Dianzani, I.
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- 2016
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9. The Third Italian Consensus Conference for Malignant Pleural Mesothelioma: State of the art and recommendations
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Novello, S., Pinto, C., Torri, V., Porcu, L., Di Maio, M., Tiseo, M., Ceresoli, G., Magnani, C., Silvestri, S., Veltri, A., Papotti, M., Rossi, G., Ricardi, U., Trodella, L., Rea, F., Facciolo, F., Granieri, A., Zagonel, V., and Scagliotti, G.
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- 2016
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10. Three‐dimensional assessment of umbilical vein deviation angle for prediction of liver herniation in left‐sided congenital diaphragmatic hernia
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Volpe, N., Mazzone, E., Muto, B., Suprani, A., Fanelli, T., Kaihura, C. T., DallʼAsta, A., Pedrazzi, G., Del Rossi, C., Silini, E. M., Magnani, C., Volpe, P., Ghi, T., and Frusca, T.
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- 2018
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11. Factors influencing place of death and disenrollment among patients receiving specialist palliative care
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Di Nitto M., Artico M., Piredda M., De Maria M., Magnani C., Marchetti A., Mastroianni C., Latina R., De Marinis M. G., D'Angelo D., Di Nitto M., Artico M., Piredda M., De Maria M., Magnani C., Marchetti A., Mastroianni C., Latina R., De Marinis M.G., and D'Angelo D.
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Male ,Hospice Care ,Palliative Care ,Hospices ,Infant, Newborn ,Quality of Life ,Humans ,Female ,Nursing ,Settore MED/45 - Scienze Infermieristiche Generali, Cliniche E Pediatriche ,Retrospective Studies - Abstract
BACKGROUND AND AIM OF THE WORK: Place of death and disenrollment from specialized palliative care services (SPCSs) are two aspects that determine service utilization. These aspects should be determined by patient needs and preferences, but they are often associated to patient sociodemographic or contextual characteristics. The aim of this study was to describe which factors are associated with utilizing SPCSs in terms of place of death and disenrollment. METHODS: Retrospective cohort study. Patients (>18 years) who died or were disenrolled during SPCSs utilization. Two hierarchical regression models were performed, and variables were categorized in predisposing, enabling, and need factors according to the Andersen behavioral model of health services use. RESULTS: We included 35,869 patients (52,5% male, mean age 74,6 ± 12,3 SD), where 17,225 patients died in hospice and 16,953 at home, while 1,691 patients were disenrolled. Dying at home was associated with older age, oncological diagnosis, painful symptoms and longer survival time. Instead, service disenrollment was associated with less education, longer wait time and longer length of stay. CONCLUSIONS: SPCS utilization was not influenced only by patient need, but also by other factors, such as social and contextual factors. These factors need to be considered by health care providers and efforts are needed for 1) identifying barriers and implementing effective interventions to support patients and caregivers in their preferred place of care and death and 2) for avoiding SPCS disenrollment with an increased probability of aggressive treatments and worse quality of life for patients.
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- 2021
12. Authors’ response: Mezei et al's 'comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis'
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Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I. F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., Iavicoli S., Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I.F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., and Iavicoli S.
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Mesothelioma ,Tunica vaginalis testis ,Economica ,Letter ,pericardial and tunica vaginalis testis (TVT) ,Socio-culturale ,Ambientale ,mesothelioma ,ReNaM ,Key terms: asbestos ,Key terms: asbesto ,Pericardium ,Malignant mesothelioma - Abstract
Mezei et al's letter (1) is an opportunity to provide more details about our study on pericardial and tunica vaginalis testis (TVT) mesothelioma (2), which is based on the Italian national mesothelioma registry (ReNaM): a surveillance system on mesothelioma, with individual asbestos exposure assessment. Incidence of pericardial mesothelioma has been estimated around 0.5 and 0.2 cases per 10 million person-years in men and women, respectively, and around 1 case for TVT mesothelioma. ReNaM collected 138 cases thanks to its long period of observation (1993-2015) and national coverage. Conducting a population-based case-control study with incidence-density sampling of controls across Italy and over a 23 year time-span should have been planned in 1993 and would have been beyond feasibility and ReNaM scope. We rather exploited two existing series of controls (3). The resulting incomplete time- and spatial matching of cases and controls is a limitation of our study and has been acknowledged in our article. The analysis of case-control studies can nevertheless be accomplished in logistic models accounting for the variables of interest, in both individually and frequency matched studies (4). Furthermore, analyses restricted to (i) regions with enrolled controls, (ii) cases with definite diagnosis, (iii) incidence period 2000-2015, and (iv) subjects born before 1950 have been provided in the manuscript, confirming the strength of the association with asbestos exposure (supplemental material tables S4-7). Following Mezei et al's suggestion, we performed further sensitivity analyses by restriction to regions with controls and fitting conditional regression models using risk-sets made of combinations of age and year of birth categories (5-year classes for both). We confirmed positive associations with occupational exposure to asbestos of pericardial mesothelioma, with odds ratios (OR) (adjusted for region) of 9.16 among women [95% confidence interval (CI) 0.56-150] and 5.63 (95% CI 1.02-31.0) among men; for TVT mesothelioma the OR was 7.70 (95% CI 2.89-20.5). Using risk sets of age categories and introducing year of birth (5-year categories) as a covariate (dummy variables) the OR were similar: OR (adjusted for region) of 9.17 among women (95% CI 0.56-150) and 5.76 (95% CI 1.07-31.0) among men; for TVT the OR was 9.86 (95% CI 3.46-28.1). Possible bias from incomplete geographical overlap between cases and controls has been addressed in the paper (table S4) and above. In spatially restricted analyses, OR were larger than in those including cases from the whole country, indicating that bias was towards the null. Mezei et al further noted that "the regional distribution of controls is different from that of person-time observed". This objection is not relevant because the above analyses were adjusted by region. Our controls were provided by a population-based study on pleural mesothelioma (called MISEM) and a hospital-based study on cholangiocarcinoma (called CARA). In MISEM, the response rate was 48.4%, a low but not unexpected rate as participation among population controls is usually lower and has been declining over time (5). It is important to underline that ReNaM applied the same questionnaire that was used for interviews and carried out the same exposure assessment as both MISEM and CARA. As repeatedly stated in ReNaM papers (6-7), each regional operating center assesses asbestos exposure based on the individual questionnaire, other available information, and knowledge of local industries. Occupational exposure to asbestos is classified as definite, probable or possible. Occupational exposure is (i) definite when the subject`s work was reported or otherwise known to have involved the use of asbestos or asbestos-containing materials (MCA); (ii) probable when subjects worked in factories where asbestos or MCA were used, but their personal exposure could not be documented; and (iii) possible when they were employed in industrial activities known to entail the use of asbestos or MCA. Hence, the definite and probable categories are closer to one another and were combined in our analyses. In any case, restricting analyses to subjects with definite occupational exposure and using each set of controls separately, as suggested by Mezei et al, yielded elevated OR for TVT and pericardial mesothelioma among men using both the above described modelling strategies; the OR could not be calculated for women. There were 70 (25 pericardial and 45 TVT) occupationally exposed mesothelioma cases. In population-based studies, analyses by occupation are limited by the low prevalence of most specific jobs. As briefly reported in our paper, for purely descriptive purposes, the industrial activity of exposure (cases may have multiple exposures), were construction (22 exposures, 7 and 15 for pericardial and TVT mesotheliomas, respectively), steel mills and other metal working industries (4 and 11), textile industries (2 and 3), and agriculture (2 and 5); other sectors had lower exposure frequencies. The absence of industries like asbestos-cement production, shipbuilding and railway carriages production/repair should not be surprising and had already been observed (7). In the Italian multicenter cohort study of asbestos workers (8), given the person-years of observation accrued by workers employed in these industries and gender- and site-specific crude incidence rates, approximately 0.1 case of pericardial and 0.2 of TVT mesothelioma would have been expected from 1970 to 2010. Even increasing ten-fold such figures to account for higher occupational risks among these workers would not change much. Asbestos exposure in agriculture has been repeatedly discussed in ReNaM reports (9: pages 70, 73, 128, 164 and 205). Exposure opportunities included the presence of asbestos in wine production, reuse of hessian bags previously containing asbestos, or construction and maintenance of rural buildings. Similarly, mesothelioma cases and agricultural workers exposed to asbestos have been noted in France (10). In conclusion, the additional analyses we performed according to Mezei et al's suggestions confirm the association between asbestos exposure and pericardial and TVT mesothelioma, supporting the causal role of asbestos for all mesotheliomas. ReNaM`s continuing surveillance system with national coverage is a precious platform for launching analytical studies on pleural and extra pleural mesothelioma. References 1. Mezei G, Chang ET, Mowat FS, Moolgavkar SH. Comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis Scand J Work Environ Health. 2021;47(1):85-86. https://doi.org/10.5271/3909 2. Marinaccio A, Consonni D, Mensi C, Mirabelli D, Migliore E, Magnani C et al.; ReNaM Working Group. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case-control study and epidemiological remarks. Scand J Work Environ Health. 2020;46(6):609-617. https://doi.org/10.5271/sjweh.3895. 3. Greenland S. Control-initiated case-control studies. Int J Epidemiol 1985 Mar;14(1):130-4. https://doi.org/10.1093/ije/14.1.130. 4. Pearce N. Analysis of matched case-control studies. BMJ 2016 Feb;352:i969. https://doi.org/10.1136/bmj.i969. 5. Bigert C, Gustavsson P, Straif K, Pesch B, Brüning T, Kendzia B et al. Lung cancer risk among cooks when accounting for tobacco smoking: a pooled analysis of case-control studies from Europe, Canada, New Zealand, and China. J Occup Environ Med 2015 Feb;57(2):202-9. https://doi.org/10.1097/JOM.0000000000000337. 6. Marinaccio A, Binazzi A, Marzio DD, Scarselli A, Verardo M, Mirabelli D et al.; ReNaM Working Group. Pleural malignant mesothelioma epidemic: incidence, modalities of asbestos exposure and occupations involved from the Italian National Register. Int J Cancer 2012 May;130(9):2146-54. https://doi.org/10.1002/ijc.26229. 7. Marinaccio A, Binazzi A, Di Marzio D, Scarselli A, Verardo M, Mirabelli D et al. Incidence of extrapleural malignant mesothelioma and asbestos exposure, from the Italian national register. Occup Environ Med 2010 Nov;67(11):760-5. https://doi.org/10.1136/oem.2009.051466. 8. Ferrante D, Chellini E, Merler E, Pavone V, Silvestri S, Miligi L et al.; the working group. Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure. Occup Environ Med 2017 Dec;74(12):887-98. https://doi.org/10.1136/oemed-2016-104100. 9. ReNaM VI Report. Available from: https://www.inail.it/cs/internet/docs/alg-pubbl-registro-nazionale-mesoteliomi-6-rapporto.pdf. Italian 10. Marant Micallef C, Shield KD, Vignat J, Baldi I, Charbotel B, Fervers B et al. Cancers in France in 2015 attributable to occupational exposures. Int J Hyg Environ Health 2019 Jan;222(1):22-9. https://doi.org/10.1016/j.ijheh.2018.07.015.
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- 2021
13. Air pollution and childhood leukaemia: a nationwide case-control study in Italy
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SETIL Study Group, Badaloni, C, Ranucci, A, Cesaroni, G, Zanini, G, Vienneau, D, Al-Aidrous, F, De Hoogh, K, Magnani, C, and Forastiere, F
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- 2013
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- View/download PDF
14. Structural rehabilitation of the Kamoro suspension bridge in Madagascar
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Torricelli, L. Ferretti, primary, Magnani, C., additional, Marchiondelli, A., additional, and Oliva, G., additional
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- 2016
- Full Text
- View/download PDF
15. 218P Fear of cancer recurrence in long-term post-menopausal breast cancer survivors
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Bouhnik, Anne-Déborah, Magnani, C., Smith, A.B., Rey, D., Sarradon-Eck, Aline, Bendiane, M.K., Mancini, Julien, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Western Sydney University, and SENIOR investigators
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Oncology ,[SDV]Life Sciences [q-bio] ,Hematology - Abstract
International audience
- Published
- 2022
16. Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature
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Clodoveo Ferri a, Rossella De Angelis b, Dilia Giuggioli a, Gianluigi Bajocchi c, Lorenzo Dagna d, Giovanni Zanframundo e, Rosario Foti f, Fabio Cacciapaglia g, Giovanna Cuomo, Alarico Ariani i, Edoardo Rosato j, Serena Guiducci k, Francesco Girelli l, Valeria Riccieri m, Elisabetta Zanatta n, Silvia Bosello o, Ilaria Cavazzana p, Francesca Ingegnoli q, Maria De Santisr, Giuseppe Murdaca s, Giuseppina Abignano t, Nicoletta Romeo u, Alessandra Della Rossa v, Maurizio Caminiti w, Annamaria Iuliano x, Giovanni Ciano y, Lorenzo Beretta z, Gianluca Bagnato aa, Ennio Lubrano ab, Ilenia De Andres ac, Alessandro Giollo ad, Marta Saracco ae, Cecilia Agnes af, Federica Lumetti a, Amelia Spinella a, Luca Magnani c, Corrado Campochiaro d, Giacomo De Luca d, Veronica Codullo e, Elisa Visalli f, Francesco Masini h, Antonietta Gigante j, Silvia Bellando-Randone k, Greta Pellegrino m, Erika Pigatto ag, Maria Grazia Lazzaroni p, Franco Franceschini p, Elena Generali r, Gianna Mennillo t, Simone Barsotti v, Giuseppa Pagano Mariano w, Francesca Calabrese w, Federica Furini ah, Licia Vultaggio ah, Simone Parisi ai, Clara Lisa Peroni ai, Davide Rozza aj, Anna Zanetti aj, Greta Carrara aj, Giampiero Landolfi aj, Carlo Alberto Scir`e aj, Gerolamo Bianchi al, Enrico Fusaro ai, Gian Domenico Sebastiani x, Marcello Govoni ah, Salvatore D’Angelo t, Franco Cozzi ag, Andrea Doria n, Florenzo Iannone g, Carlo Salvarani c, Marco Matucci-Cerinic d, k, On behalf of SPRING-SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society of Rheumatology), A, Clodoveo Ferri, B, Rossella De Angeli, A, Dilia Giuggioli, C, Gianluigi Bajocchi, D, Lorenzo Dagna, E, Giovanni Zanframundo, F, Rosario Foti, G, Fabio Cacciapaglia, Cuomo, Giovanna, I, Alarico Ariani, J, Edoardo Rosato, K, Serena Guiducci, L, Francesco Girelli, M, Valeria Riccieri, N, Elisabetta Zanatta, O, Silvia Bosello, P, Ilaria Cavazzana, Q, Francesca Ingegnoli, De Santisr, Maria, S, Giuseppe Murdaca, T, Giuseppina Abignano, U, Nicoletta Romeo, V, Alessandra Della Rossa, W, Maurizio Caminiti, X, Annamaria Iuliano, Y, Giovanni Ciano, Z, Lorenzo Beretta, Bagnato aa, Gianluca, Lubrano ab, Ennio, De Andres ac, Ilenia, Giollo ad, Alessandro, Saracco ae, Marta, Agnes af, Cecilia, A, Federica Lumetti, A, Amelia Spinella, C, Luca Magnani, D, Corrado Campochiaro, D, Giacomo De Luca, E, Veronica Codullo, F, Elisa Visalli, H, Francesco Masini, J, Antonietta Gigante, K, Silvia Bellando-Randone, M, Greta Pellegrino, Pigatto ag, Erika, P, Maria Grazia Lazzaroni, P, Franco Franceschini, R, Elena Generali, T, Gianna Mennillo, V, Simone Barsotti, W, Giuseppa Pagano Mariano, W, Francesca Calabrese, Furini ah, Federica, Vultaggio ah, Licia, Parisi ai, Simone, Lisa Peroni ai, Clara, Rozza aj, Davide, Zanetti aj, Anna, Carrara aj, Greta, Landolfi aj, Giampiero, Alberto Scir`e aj, Carlo, Ak, Bianchi al, Gerolamo, Fusaro ai, Enrico, X, Gian Domenico Sebastiani, Govoni ah, Marcello, T, Salvatore D’Angelo, Cozzi ag, Franco, N, Andrea Doria, G, Florenzo Iannone, C, Carlo Salvarani, D, Marco Matucci-Cerinic, K, and behalf of SPRING-SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society of Rheumatology), On
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Systemic sclerosis Scleroderma Geographical areas Macro-areas Environmental Referral - Published
- 2022
17. A regional audit system for stillbirth: a way to better understand the phenomenon
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Po G., Monari F., Zanni F., Grandi G., Lupi C., Facchinetti F., Mancini L., Lugli L., Lanzoni C., Sgarbi L., Chiossi C., Ricchieri F., Roberta C., Contiero R., Garani G., Pedriali M., Rossi S., Fini S., Di Bartolo M., Radi D., Vancini A., Donati A., Guadalupi E., Righetti F., Salerno A., Cocchi G., Morandi R., Gabrielli L., Graziano C., Seri M., Caprara G., Mario S. N. C., Fantuz F., Ferlini F., Righi E., Silvestrini D., Foschi F., Fieni S., Frusca T., Ferretti A., Galli L., Magnani C., Silini E., Balduzzi L., Bellini M., Rodolfi A. M., Sgarabotto M. P., Fragni G., Comitini G., Bonasoni M. P., Fioroni L., Rozzi C., Tuzio A., Vito I., Mammoliti P., De Ambrosi E., Ricci M., Bandini A., Belosi C., Muratori C., Zago S., Turci A., Vitarelli M., Po G., Monari F., Zanni F., Grandi G., Lupi C., Facchinetti F., Mancini L., Lugli L., Lanzoni C., Sgarbi L., Chiossi C., Ricchieri F., Roberta C., Contiero R., Garani G., Pedriali M., Rossi S., Fini S., Di Bartolo M., Radi D., Vancini A., Donati A., Guadalupi E., Righetti F., Salerno A., Cocchi G., Morandi R., Gabrielli L., Graziano C., Seri M., Caprara G., Mario S.N.C., Fantuz F., Ferlini F., Righi E., Silvestrini D., Foschi F., Fieni S., Frusca T., Ferretti A., Galli L., Magnani C., Silini E., Balduzzi L., Bellini M., Rodolfi A.M., Sgarabotto M.P., Fragni G., Comitini G., Bonasoni M.P., Fioroni L., Rozzi C., Tuzio A., Vito I., Mammoliti P., De Ambrosi E., Ricci M., Bandini A., Belosi C., Muratori C., Zago S., Turci A., and Vitarelli M.
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Clinical audit ,Multivariate analysis ,Placenta Diseases ,Perinatal Death ,Eastern ,Umbilical Cord ,Africa, Northern ,Pregnancy ,Risk Factors ,Cause of Death ,Northern ,Europe, Eastern ,Pregnancy Complications, Infectious ,Multivariate Analysi ,Causes of death ,Cause of death ,Fetal Growth Retardation ,Obstetrics ,Placenta Disease ,Infectious ,Obstetrics and Gynecology ,Stillbirth ,Perinatal audit ,Quality of care ,Adult ,Africa South of the Sahara ,Clinical Audit ,Female ,Fetal Death ,Fetal Diseases ,Humans ,India ,Italy ,Multivariate Analysis ,Pregnancy Complications ,Quality of Health Care ,Pregnancy Complication ,Europe ,Gestation ,Human ,Research Article ,medicine.medical_specialty ,Reproductive medicine ,Fetal Disease ,Audit ,lcsh:Gynecology and obstetrics ,medicine ,lcsh:RG1-991 ,Late Stillbirth ,business.industry ,Risk Factor ,medicine.disease ,Africa ,Pregnancy Complications, Infectiou ,business - Abstract
Background Implementation of high-quality national audits for perinatal mortality are needed to improve the registration of all perinatal deaths and the identification of the causes of death. This study aims to evaluate the implementation of a Regional Audit System for Stillbirth in Emilia-Romagna Region, Italy. Methods For each stillbirth (≥ 22 weeks of gestation, ≥ 500 g) occurred between January 1, 2014 to December 1, 2016 (n = 332), the same diagnostic workup was performed and a clinical record with data about mother and stillborn was completed. Every case was discussed in a multidisciplinary local audit to assess both the cause of death (ReCoDe classification) and the quality of care. Data were reviewed by the Regional Audit Group. Stillbirth rates, causes of death and the quality of care were established for each case. Results Total stillbirth rate was 3.09 per 1000 births (332/107,528). Late stillbirth rate was 2.3 per 1000 (251/107,087). Sixteen stillbirths were not registered by the Regional Birth Register. The most prevalent cause of death was placental disorder (33.3%), followed by fetal (17.6%), cord (14.2%) and maternal disorders (7.6%). Unexplained cases were 14%. Compared to local audits, the regional group attributed different causes of death in 17% of cases. At multivariate analysis, infections were associated with early stillbirths (OR 3.38, CI95% 1.62–7.03) and intrapartum cases (OR 6.64, CI95% 2.61–17.02). Placental disorders were related to growth restriction (OR 1.89, CI95% 1.06–3.36) and were more frequent before term (OR 1.86, CI95% 1.11–3.15). Stillbirths judged possibly/probably preventable with a different management (10.9%) occurred more frequently in non-Italian women and were mainly related to maternal disorders (OR 6.64, CI95% 2.61–17.02). Conclusions Regional Audit System for Stillbirth improves the registration of stillbirth and allows to define the causes of death. Moreover, sub-optimal care was recognized, allowing to identify populations which could benefit from preventive measures.
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- 2019
18. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting
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Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, Massimiliano, Lombardi, Andrea, Colaneri, Marta, Del Poggio, Paolo, Perini, Paolo, D'Ambrosio, Roberta, Degasperi, Elisabetta, Dibenedetto, Clara, Giorgini, Alessia, Pasulo, Luisa, Maggiolo, Franco, Castelli, Francesco, Brambilla, Paola, Spinelli, Ombretta, Tiziana, Re, Lleo, Ana, Rumi, Mariagrazia, Uberti-Foppa, Caterina, Soria, Alessandro, Aghemo, Alessio, Lampertico, Pietro, Baiguera, Chiara, Schiavini, Monica, Fagiuoli, Stefano, Bruno, Raffaele, Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, and Giani, P
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Simeprevir ,Male ,medicine.medical_specialty ,Cirrhosis ,SVR ,Sofosbuvir ,Sustained Virologic Response ,liver cirrhosis ,antiviral treatment ,Hepacivirus ,Antiviral Agents ,law.invention ,Randomized controlled trial ,law ,Virology ,Internal medicine ,Medicine ,Humans ,chronic hepatitis C ,Prospective cohort study ,DAA ,Retrospective Studies ,Hepatology ,liver cirrhosi ,business.industry ,Hepatitis C ,Hepatitis C, Chronic ,Middle Aged ,medicine.disease ,Discontinuation ,Regimen ,Infectious Diseases ,Treatment Outcome ,business ,medicine.drug - Abstract
In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n=168, 46%) and 3 (n=59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for
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- 2021
19. Excess of mesotheliomas after exposure to chrysotile in Balangero, Italy
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Mirabelli, D, Calisti, R, Barone-Adesi, F, Fornero, E, Merletti, F, and Magnani, C
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- 2008
20. Cancer risk after cessation of asbestos exposure: a cohort study of Italian asbestos cement workers
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Magnani, C, Ferrante, D, Barone-Adesi, F, Bertolotti, M, Todesco, A, Mirabelli, D, and Terracini, B
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- 2008
21. Epidemiology of HIV-1 subtypes in an urban area of northern Italy
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De Paschale, M., Cagnin, D., Cerulli, T., Mena, M., Magnani, C., Perini, P., Re, T., Villa, M., Viganò, P., Maltempo, C., Manco, M.T., Agrappi, C., Mirri, P., Gatti, A., Rescaldani, C., and Clerici, P.
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- 2011
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22. Treatment of Acute Leukemias by CAR-engineered CIK cells through an improved non viral platform: WP15
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Biagi, E., Magnani, C. F., Tettamanti, S., and Biondi, A.
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- 2016
23. Insights into genotype–phenotype correlations from CREBBP point mutation screening in a cohort of 46 Rubinstein–Taybi syndrome patients
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Spena, S., Milani, D., Rusconi, D., Negri, G., Colapietro, P., Elcioglu, N., Bedeschi, F., Pilotta, A., Spaccini, L., Ficcadenti, A., Magnani, C., Scarano, G., Selicorni, A., Larizza, L., and Gervasini, C.
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- 2015
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24. Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure
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Magnani C., Silvestri S., Angelini A., Ranucci A., Azzolina D., Cena T., Chellini E., Merler E., Pavone V., Miligi L., Gorini G., Bressan V., Girardi P., Bauleo L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Mattioli S., Baldassarre A., Barone-Adesi F., Musti M., Mirabelli D., Pirastu R., Marinaccio A., Massari S., Ferrante D, Working Group, Ballarin MN, Brentisci C, Cortini B, Curti S, Gangemi M, Gioffrè F, Legittimo P, Mangone L, Marinelli F, Marinilli P, Panato C, Roncaglia F, Storchi C, Stura A, Vicentini M, Verdi S, Nannavecchia AM, Bisceglia L, Magnani C., Silvestri S., Angelini A., Ranucci A., Azzolina D., Cena T., Chellini E., Merler E., Pavone V., Miligi L., Gorini G., Bressan V., Girardi P., Bauleo L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Mattioli S., Baldassarre A., Barone-Adesi F., Musti M., Mirabelli D., Pirastu R., Marinaccio A., Massari S., Ferrante D, Working Group, Ballarin MN, Brentisci C, Cortini B, Curti S, Gangemi M, Gioffrè F, Legittimo P, Mangone L, Marinelli F, Marinilli P, Panato C, Roncaglia F, Storchi C, Stura A, Vicentini M, Verdi S, Nannavecchia AM, and Bisceglia L
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Risk ,Mesothelioma ,Lung Neoplasms ,Pleural Neoplasms ,Socio-culturale ,Asbesto ,Cohort Studies ,Cause of Death ,Occupational Exposure ,Asbestos ,Glassworks ,Rolling stock ,Shipyards ,Humans ,Industry ,Peritoneal Neoplasms ,Retrospective Studies ,Mineral Fibers ,Ovarian Neoplasms ,Construction Materials ,Ambientale ,Italy ,Urinary Bladder Neoplasms ,Asbestosis ,Glasswork ,Female - Abstract
Italy has been a large user of asbestos and asbestos containing materials until the 1992 ban. We present a pooled cohort study on long-term mortality in exposed workers.Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period.The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increased. All industrial sectors showed increased mortality from pleural malignancies, and most also from peritoneal and lung cancer and asbestosis, with exposure related trend. Increased mortality was also observed for ovarian cancer and for bladder cancer.The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. A large increase in mortality from asbestosis was observed.
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- 2020
25. Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy
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Girardi P., Merler E., Ferrante D., Silvestri S., Chellini E., Angelini A., Luberto F., Fedeli U., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Miligi L., Perticaroli P., Pettinari A., Cuccaro F., Nannavecchia A. M., Bisceglia L., Marinaccio A., Pavone V. L. M., Magnani C., Working Group, Ancona L., Baldassarre A., Brentisci C., Cortini B., Curti S., Gangemi M., Gorini G., Legittimo P., Marinelli F., Marinilli P., Bressan V., Mattioli S., Ranucci A., Romeo E., Scarnato C., Storchi C., Stura A., Verdi S., Girardi P., Merler E., Ferrante D., Silvestri S., Chellini E., Angelini A., Luberto F., Fedeli U., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Miligi L., Perticaroli P., Pettinari A., Cuccaro F., Nannavecchia A.M., Bisceglia L., Marinaccio A., Pavone V.L.M., Magnani C., Working Group, Ancona L., Baldassarre A., Brentisci C., Cortini B., Curti S., Gangemi M., Gorini G., Legittimo P., Marinelli F., Marinilli P., Bressan V., Mattioli S., Ranucci A., Romeo E., Scarnato C., Storchi C., Stura A., and Verdi S.
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Male ,Asbestos, Serpentine ,Asbestosis ,Cumulative Exposure ,Asbesto ,cohort mortality study ,medicine.disease_cause ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,asbestos exposure ,0302 clinical medicine ,Occupational Exposure ,Chrysotile ,Medicine ,Humans ,030212 general & internal medicine ,Asbestos-related diseases ,Asbestos-related disease ,business.industry ,Asbestos exposure ,Cohort mortality study ,Retrospective assessment ,asbestos-related diseases ,asbestosis ,retrospective assessment ,Public Health, Environmental and Occupational Health ,Asbestosi ,Middle Aged ,medicine.disease ,030210 environmental & occupational health ,Asbestos cement ,Cohort effect ,Italy ,Cohort ,Female ,business ,Settore SECS-S/01 - Statistica ,Demography ,Human - Abstract
Objectives This study was performed with the aim of investigating the temporal patterns and determinants associated with mortality from asbestosis among 21 cohorts of Asbestos-Cement (AC) workers who were heavily exposed to asbestos fibres. Methods Mortality for asbestosis was analysed for a cohort of 13 076 Italian AC workers (18.1% women). Individual cumulative asbestos exposure index was calculated by factory and period of work weighting by the different composition of asbestos used (crocidolite, amosite, and chrysotile). Two different approaches to analysis, based on Standardized Mortality Ratios (SMRs) and Age-Period-Cohort (APC) models were applied. Results Among the considered AC facilities, asbestos exposure was extremely high until the end of the 1970s and, due to the long latency, a peak of asbestosis mortality was observed after the 1990s. Mortality for asbestosis reached extremely high SMR values [SMR: males 508, 95% confidence interval (CI): 446–563; females 1027, 95% CI: 771–1336]. SMR increased steeply with the increasing values of cumulative asbestos exposure and with Time Since the First Exposure. APC analysis reported a clear age effect with a mortality peak at 75–80 years; the mortality for asbestosis increased in the last three quintiles of the cumulative exposure; calendar period did not have a significant temporal component while the cohort effect disappeared if we included in the model the cumulative exposure to asbestos. Conclusions Among heaviest exposed workers, mortality risk for asbestosis began to increase before 50 years of age. Mortality for asbestosis was mainly determined by cumulative exposure to asbestos.
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- 2019
26. Clinical and molecular characterization of Rubinstein-Taybi syndrome patients carrying distinct novel mutations of the EP300 gene
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Negri, G., Milani, D., Colapietro, P., Forzano, F., Monica, Della M., Rusconi, D., Consonni, L., Caffi, L. G., Finelli, P., Scarano, G., Magnani, C., Selicorni, A., Spena, S., Larizza, L., and Gervasini, C.
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- 2015
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27. Prevalence and Clinical Relevance of Occult Hepatitis B Virus Infection in Patients on the Waiting List for Kidney Transplantation
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Stratta, P., Bruschetta, E., Minisini, R., Barbè, M.C., Cornella, C., Tognarelli, G., Cena, T., Magnani, C., Fenoglio, R., Toffolo, K., Airoldi, A., and Pirisi, M.
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- 2009
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28. Congenital Malformations in 100,000 Consecutive Birth in Emilia Romagna Region Northern Italy: Comparison with the Eurocat Data
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Calzolari, E., Cavazzuti, G. B., Cocchi, G., Contrino, C., Magnani, C., Moretti, M., Roncarati, E., Salvioli, G. P., and Volpato, S.
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- 1987
29. Additional file 1 of Environmental asbestos exposure and clustering of malignant mesothelioma in community: a spatial analysis in a population-based case–control study
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Airoldi, C., Magnani, C., Lazzarato, F., Mirabelli, D., Tunesi, S., and Ferrante, D.
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Additional file 1: Table S1.1. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**), and age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S1.2. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories. Logistic models adjusted by age, sex, type of interview (*); age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) and age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S1.3. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview, occupational exposure in a dichotomous way (*) and age, sex, type of interview and domestic exposure in a dichotomous way (**) and age, sex, type of interview and asbestos exposure (occupational, domestic and environmental) as continuous covariate (***) and age, sex, type of interview and asbestos exposure (domestic and environmental) as continuous covariate (****); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Figure S1. Case control study on MM in Casale Monferrato area. Spatial distribution of the residences of cases (triangles) and controls (circles) in a geographic area of approximately 2500 km2 around Casale Monferrato (solid line). Residences are the longest-held among all residences of each individual after excluding 20 years before the date of diagnosis of the index case. The location of the AC plant (red triangle) and the center of the cluster found using the Kulldorf test (green triangle) in the town of Casale Monferrato are also indicated. [R Spatstat]. Table S2. Case control study on MM in Casale Monferrato area. Cuzick Edward test statistics (Tq) and associate p-values based on 999 random labelling simulations for a variety of q values (3, 5, 7, 9, 11, 13, 15). Table S3.1. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 10 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) or age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S3.2. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of shorter residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) or age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC).
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- 2021
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30. Epidemiology of hepatitis D virus (HDV) infection in an urban area of Northern Italy
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De Paschale, M., Manco, M. T., Belvisi, L., Magnani, C., Re, T., Viganò, P., Biagiotti, S., Capelli, F., Mazzone, A., Baldacci, M. P., Ferrara, A., Neri, A. L., Guastoni, C. M., Bonazzina, R. A., Brando, B., and Clerici, P.
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- 2012
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31. The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation
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Stratta, P., Quaglia, M., Cena, T., Antoniotti, R., Fenoglio, R., Menegotto, A., Ferrante, D., Genazzani, A., Terrazzino, S., and Magnani, C.
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- 2012
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32. Mesothelioma risk after 40 years since first exposure to asbestos: a pooled analysis
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Reid, A, de Klerk, N H, Magnani, C, Ferrante, D, Berry, G, Musk, A W, and Merler, E
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- 2014
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33. Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy
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Luberto F., Ferrante D., Silvestri S., Angelini A., Cuccaro F., Nannavecchia A. M., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Chellini E., Miligi L., Perticaroli P., Pettinari A., Bressan V., Merler E., Girardi P., Bisceglia L., Marinaccio A., Massari S., Magnani C., Working group, Curti S., Mattioli S., Luberto F., Ferrante D., Silvestri S., Angelini A., Cuccaro F., Nannavecchia A.M., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Chellini E., Miligi L., Perticaroli P., Pettinari A., Bressan V., Merler E., Girardi P., Bisceglia L., Marinaccio A., Massari S., Magnani C., Working group, Curti S., and Mattioli S.
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Male ,Mesothelioma ,Asbestos, Asbestos-cement, Dose response relationship, Mesothelioma, Lung cancer, Ovarian Cancer, Epidemiology ,Time Factors ,Epidemiology ,Health, Toxicology and Mutagenesis ,Asbestosis ,Physiology ,Cumulative Exposure ,medicine.disease_cause ,Cohort Studies ,Neoplasms ,Chrysotile ,Asbestos-related diseases ,0303 health sciences ,lcsh:Public aspects of medicine ,Middle Aged ,Asbestos-cement ,Asbestos cement ,Ovarian Cancer ,Italy ,Dose response relationship ,lcsh:Industrial medicine. Industrial hygiene ,Female ,Lung cancer ,Settore SECS-S/01 - Statistica ,Adult ,Asbesto ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,lcsh:RC963-969 ,Young Adult ,Sex Factors ,Occupational Exposure ,medicine ,Humans ,business.industry ,Research ,Public Health, Environmental and Occupational Health ,030311 toxicology ,lcsh:RA1-1270 ,medicine.disease ,business - Abstract
Background Despite the available information on cancer risk, asbestos is used in large areas in the world, mostly in the production of asbestos cement. Moreover, questions are raised regarding the shape of the dose response relation, the relation with time since exposure and the association with neoplasms in various organs. We conducted a study on the relationship between cumulative asbestos exposure and mortality from asbestos related diseases in a large Italian pool of 21 cohorts of asbestos-cement workers with protracted exposure to both chrysotile and amphibole asbestos. Methods The cohort included 13,076 workers, 81.9% men and 18.1% women, working in 21 Italian asbestos-cement factories, with over 40 years of observation. Exposure was estimated by plant and period, and weighted for the type of asbestos used. Data were analysed with consideration of cause of death, cumulative exposure and time since first exposure (TSFE), and by gender. SMRs were computed using reference rates by region, gender and calendar time. Poisson regression models including cubic splines were used to analyse the effect of cumulative exposure to asbestos and TSFE on mortality for asbestos-related diseases. 95% Confidence Intervals (CI) were computed according to the Poisson distribution. Results Mortality was significantly increased for ‘All Causes’ and ‘All Malignant Neoplasm (MN)’, in both genders. Considering asbestos related diseases (ARDs), statistically significant excesses were observed for MN of peritoneum (SMR: men 14.19; women 15.14), pleura (SMR: 22.35 and 48.10), lung (SMR: 1.67 and 1.67), ovary (in the highest exposure class SMR 2.45), and asbestosis (SMR: 507 and 1023). Mortality for ARDs, in particular pleural and peritoneal malignancies, lung cancer, ovarian cancer and asbestosis increased monotonically with cumulative exposure. Pleural MN mortality increased progressively in the first 40 years of TSFE, then reached a plateau, while peritoneal MN showed a continuous increase. The trend of lung cancer SMRs also showed a flattening after 40 years of TSFE. Attributable proportions for pleural, peritoneal, and lung MN were respectively 96, 93 and 40%. Conclusions Mortality for ARDs was associated with cumulative exposure to asbestos. Risk of death from pleural MN did not increase indefinitely with TSFE but eventually reached a plateau, consistently with reports from other recent studies. Electronic supplementary material The online version of this article (10.1186/s12940-019-0510-6) contains supplementary material, which is available to authorized users.
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- 2019
34. Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies
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Barone-Adesi F., Ferrante D., Chellini E., Merler E., Pavone V., Silvestri S., Miligi L., Gorini G., Bressan V., Girardi P., Ancona L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Curti S., Baldassarre A., Cena T., Angelini A., Marinaccio A., Mirabelli D., Musti M., Pirastu R., Ranucci A., Magnani C., Working Group, Mattioli S., Barone-Adesi F., Ferrante D., Chellini E., Merler E., Pavone V., Silvestri S., Miligi L., Gorini G., Bressan V., Girardi P., Ancona L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Curti S., Baldassarre A., Cena T., Angelini A., Marinaccio A., Mirabelli D., Musti M., Pirastu R., Ranucci A., Magnani C., Working Group, and Mattioli S.
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Time Factors ,Time Factor ,Adolescent ,Pleural Neoplasms ,asbestos ,epidemiology ,mesothelioma ,Asbesto ,medicine.disease_cause ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,Peritoneal Neoplasm ,Young Adult ,0302 clinical medicine ,Internal medicine ,Occupational Exposure ,Epidemiology ,medicine ,Humans ,Pleural Neoplasm ,Mesothelioma ,Young adult ,Peritoneal Neoplasms ,business.industry ,Public Health, Environmental and Occupational Health ,Cancer ,asbestos, epidemiology, mesothelioma, Adolescent, Adult, Italy ,Middle Aged ,Models, Theoretical ,medicine.disease ,030210 environmental & occupational health ,Occupational Disease ,Occupational Diseases ,asbestos, epidemiology, mesothelioma ,Italy ,030220 oncology & carcinogenesis ,Female ,business ,Human ,Cohort study - Abstract
ObjectivesModels based on the multistage theory of cancer predict that rates of malignant mesothelioma continuously increase with time since first exposure (TSFE) to asbestos, even after the end of external exposure. However, recent epidemiological studies suggest that mesothelioma rates level off many years after first exposure to asbestos. A gradual clearance of asbestos from the lungs has been suggested as a possible explanation for this phenomenon. We analysed long-term trends of pleural and peritoneal cancer mortality in subjects exposed to asbestos to evaluate whether such trends were consistent with the clearance hypothesis.MethodsWe used data from a pool of 43 Italian asbestos cohorts (51 801 subjects). The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalised to include a term representing elimination of fibres over time.ResultsRates of pleural cancer increased until 40 years of TSFE, but remained stable thereafter. On the other hand, we observed a monotonic increase of peritoneal cancer with TSFE. The model taking into account asbestos clearance fitted the data better than the traditional one for pleural (p=0.004) but not for peritoneal (p=0.09) cancer.ConclusionsRates of pleural cancer do not increase indefinitely after the exposure to asbestos, but eventually reach a plateau. This trend is well described by a model accounting for a gradual elimination of the asbestos fibres. These results are relevant for the prediction of future rates of mesothelioma and in asbestos litigations.
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- 2019
35. Air pollution and childhood leukaemia: a nationwide case-control study in Italy
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Badaloni, C, Ranucci, A, Cesaroni, G, Zanini, G, Vienneau, D, Al-Aidrous, F, De Hoogh, K, Magnani, C, Forastiere, F, Magnani, Corrado, Mattioli, Stefano, Miligi, Lucia, Ranucci, Alessandra, Rondelli, Roberto, Salvan, Alberto, Masera, Giuseppe, Rizzari, Carmelo, Bisanti, Luigi, Zambon, Paola, Greco, Alessandra, Cannizzaro, Santina, Gafà, Lorenzo, Luzzatto, Lia Lidia, Benvenuti, Alessandra, Michelozzi, Paola, Kirchmayer, Ursula, Cocco, Pierluigi, Galassi, Claudia, Celentano, Egidio, Guarino, Erni, Assennato, Giorgio, de Nichilo, Gigliola, Merlo, Domenico Franco, Bocchini, Vittorio, Mosciatti, Paola, Minelli, Liliana, Chiavarini, Manuela, Cuttini, Marina, Casotto, Veronica, Torregrossa, Maria Valeria, Valenti, Rosaria Maria, Forastiere, Francesco, Haupt, Riccardo, Lagorio, Susanna, Risica, Serena, Polichetti, Alessandro, Bochicchio, Francesco, Nuccetelli, Cristina, Biddau, Pierfranco, Aricò, Maurizio, De Salvo, Gian Luca, Locatelli, Franco, Pession, Andrea, Varotto, Stefania, Poggi, Vincenzo, Massaglia, Pia, Monetti, Daniele, Targhetta, Roberto, Bernini, Gabriella, Pannelli, Franco, Sampietro, Giuseppe, Schilirò, Gino, and Pulsoni, Alessandro
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- 2013
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36. Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis
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Karalexi, M.A. Dessypris, N. Ma, X. Spector, L.G. Marcotte, E. Clavel, J. Pombo-de-Oliveira, M.S. Heck, J.E. Roman, E. Mueller, B.A. Hansen, J. Auvinen, A. Lee, P.-C. Schüz, J. Magnani, C. Mora, A.M. Dockerty, J.D. Scheurer, M.E. Wang, R. Bonaventure, A. Kane, E. Doody, D.R. Baka, M. Moschovi, M. Polychronopoulou, S. Kourti, M. Hatzipantelis, E. Pelagiadis, I. Dana, H. Kantzanou, M. Tzanoudaki, M. Anastasiou, T. Grenzelia, M. Gavriilaki, E. Sakellari, I. Anagnostopoulos, A. Kitra, V. Paisiou, A. Bouka, E. Nikkilä, A. Lohi, O. Erdmann, F. Kang, A.Y. Metayer, C. Milne, E. Petridou, E.T. NARECHEM-ST Group FRECCLE Group
- Abstract
Aim: Evidence for an association of foetal growth with acute myeloid leukaemia (AML) is inconclusive. AML is a rare childhood cancer, relatively more frequent in girls, with distinct features in infancy. In the context of the Childhood Leukemia International Consortium (CLIC), we examined the hypothesis that the association may vary by age, sex and disease subtype using data from 22 studies and a total of 3564 AML cases. Methods: Pooled estimates by age, sex and overall for harmonised foetal growth markers in association with AML were calculated using the International Fetal and Newborn Growth Consortium for the 21st Century Project for 17 studies contributing individual-level data; meta-analyses were, thereafter, conducted with estimates provided ad hoc by five more studies because of administrative constraints. Subanalyses by AML subtype were also performed. Results: A nearly 50% increased risk was observed among large-for-gestational-age infant boys (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03–2.14), reduced to 34% in boys aged
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- 2020
37. Life expectancy as an indicator of outcome in follow-up of population-based cancer registries: the example of childhood leukemia
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Viscomi, S., Pastore, G., Dama, E., Zuccolo, L., Pearce, N., Merletti, F., and Magnani, C.
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- 2006
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38. Overweight as an adverse prognostic factor for non-Hodgkin's lymphoma patients receiving high-dose chemotherapy and autograft
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Tarella, C, Caracciolo, D, Gavarotti, P, Argentino, C, Zallio, F, Corradini, P, Novero, D, Magnani, C, and Pileri, A
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- 2000
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39. Prevalence of anti-HDV antibodies in HBsAg negative subjects: P57
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De Paschale, M, Manco, M, Belvisi, L, Magnani, C, Re, T, Viganò, P, Agrappi, C, Mirri, P, Gatti, A, Banfi, B, and Clerici, P
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- 2012
40. Difference in the characteristics of HBV infection in Italian and non-Italian patients in northern Italy: P44
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De Paschale, M, Manco, M, Belvisi, L, Magnani, C, Re, T, Viganò, P, Biagiotti, S, Capelli, F, Mazzone, A, Baldacci, M, Ferrara, A, Neri, A, Guastoni, C, Bonazzina, R, Brando, B, and Clerici, P
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- 2012
41. The diagnostic reliability of urinary cytology: A retrospective study
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Raisi, O., Magnani, C., Bigiani, N., Cianciavicchia, E., DʼAmico, R., Muscatello, U., and Ghirardini, C.
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- 2012
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42. Turner's Syndrome: Cardiologic Profile According to the Different Chromosomal Patterns and Long-Term Clinical Follow-Up of 136 Nonpreselected Patients
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Prandstraller, D., Mazzanti, L., Picchio, F.M., Magnani, C., Bergamaschi, R., Perri, A., Tsingos, E., and Cacciari, E.
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- 1999
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43. Low-molecular-weight-heparin and pregnancy, when the dose does it: a nephrologistʼs opinion: a rebuttal
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STRATTA, P., CANAVESE, C., CENA, T., QUAGLIA, M., PERGOLINI, P., BELLOMO, G., and MAGNANI, C.
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- 2011
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44. Quantification of neutrophil and monocyte CD64 expression: a predictive biomarker for active tuberculosis
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Gatti, A., primary, Ceriani, C., additional, De Paschale, M., additional, Magnani, C., additional, Villa, M., additional, Viganò, P., additional, Clerici, P., additional, and Brando, B., additional
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- 2020
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45. High incidence of acute promyelocytic leukemia in children in northwest Italy, 1980–2003: a report from the Childhood Cancer Registry of Piedmont
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Maule, M M, Dama, E, Mosso, M L, Magnani, C, Pastore, G, and Merletti, F
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- 2008
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46. Trisomic rescue causing reduction to homozygosity for a novel ABCA12 mutation in harlequin ichthyosis
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Castiglia, D, Castori, M, Pisaneschi, E, Sommi, M, Covaciu, C, Zambruno, G, Fischer, J, and Magnani, C
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- 2009
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47. AMIANTO
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Comba, Pietro, Minoia, C, Carnevale, F, Marsili, Daniela, Ferrante, D., Chellini, E., Merler, E., Pavone, V., Silvestri, S., Miligi, L., Gorini, G., Bressan, V., Girardi, P., Ancona, L., Romeo, E., Luberto, F., Sala, O., Scarnato, C., Menegozzo, S., Oddone, E., Tunesi, S., Perticaroli, P., Pettinari, A., Cuccaro, F., Mattioli, S., Baldassarre, A., Angelini, A., Barone Adesi, F., Cena, T., Legittimo, P., Marinaccio, A., Mirabelli, D., Musti, M., Pirastu, R., and Ranucci, A. e Magnani C.
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- 2019
48. AMIANTO
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Comba, P, Minoia, C, Carnevale, F, Marsili, D, Ferrante, D., Chellini, E., Merler, E., Pavone, V., Silvestri, S., Miligi, L., Gorini, G., Bressan, V., Girardi, P., Ancona, L., Romeo, E., Luberto, F., Sala, O., Scarnato, C., Menegozzo, S., Oddone, E., Tunesi, S., Perticaroli, P., Pettinari, A., Cuccaro, F., Mattioli, S., Baldassarre, A., Angelini, A., Barone Adesi, F., Cena, T., Legittimo, P., Marinaccio, A., Mirabelli, D., Musti, M., Pirastu, R., and Ranucci, A. e Magnani C.
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Settore MED/01 - Statistica Medica - Published
- 2019
49. Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: Findings from the Childhood Leukaemia International Consortium (CLIC)
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Talibov, M. Olsson, A. Bailey, H. Erdmann, F. Metayer, C. Magnani, C. Petridou, E. Auvinen, A. Spector, L. Clavel, J. Roman, E. Dockerty, J. Nikkilä, A. Lohi, O. Kang, A. Psaltopoulou, T. Miligi, L. Vila, J. Cardis, E. Schüz, J.
- Abstract
Objectives Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium. Methods We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses. Results ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (μT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 μT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses. Conclusions In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia. © © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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- 2019
50. Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium
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Panagopoulou, P. Skalkidou, A. Marcotte, E. Erdmann, F. Ma, X. Heck, J.E. Auvinen, A. Mueller, B.A. Spector, L.G. Roman, E. Metayer, C. Magnani, C. Pombo-de-Oliveira, M.S. Scheurer, M.E. Mora, A.-M. Dockerty, J.D. Hansen, J. Kang, A.Y. Wang, R. Doody, D.R. Kane, E. Schüz, J. Christodoulakis, C. Ntzani, E. Petridou, E.T. FRECCLE group NARECHEM-ST group
- Abstract
Background: Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent. Aim: To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0–14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies. Material/methods: We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants
- Published
- 2019
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