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1,144 results on '"Magnani C."'

2. Congenital Anomalies and Risk of Childhood Leukemia: A Pooled Analysis from the Childhood Leukemia International Consortium (CLIC)

Author

Lupo, P, Mueller, B, Clavel, J, Dockerty, J, Ezzat, S, Hansen, J, Heck, J, Infante-Rivard, C, Magnani, C, Metayer, C, Milne, E, Mora, AM, Petridou, E, Pombo-de-Oliveira, M, Roman, E, Schuz, J, Vinceti, M, Spector, L, and Scheurer, M

Subjects
Oncology And Carcinogenesis, Paediatrics And Reproductive Medicine, Oncology & Carcinogenesis, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine
Published
2018

7. Deep immunophenotypic characterization of CARCIK-CD19 pre-infusion cellular product by advanced multiparametric flow cytometry

Author

Buracchi, C, Belotti, D, Moretti, A, Calabretta, L, Risca, G, Capelli, C, Cabiati, B, Pedrini, O, Quaroni, M, Gotti, E, Matera, G, Cesana, S, Colombo, V, Rambaldi, B, Golay, J, Introna, M, Galimberti, S, Rambaldi, A, Biondi, A, Magnani, C, Gaipa, G, Magnani, CF, Gaipa, G., Buracchi, C, Belotti, D, Moretti, A, Calabretta, L, Risca, G, Capelli, C, Cabiati, B, Pedrini, O, Quaroni, M, Gotti, E, Matera, G, Cesana, S, Colombo, V, Rambaldi, B, Golay, J, Introna, M, Galimberti, S, Rambaldi, A, Biondi, A, Magnani, C, Gaipa, G, Magnani, CF, and Gaipa, G.

Published
2023

8. CDKN2A and BAP1 germline mutations predispose to melanoma and mesothelioma

Author

Betti, M., Aspesi, A., Biasi, A., Casalone, E., Ferrante, D., Ogliara, P., Gironi, L.C., Giorgione, R., Farinelli, P., Grosso, F., Libener, R., Rosato, S., Turchetti, D., Maffè, A., Casadio, C., Ascoli, V., Dianzani, C., Colombo, E., Piccolini, E., Pavesi, M., Miccoli, S., Mirabelli, D., Bracco, C., Righi, L., Boldorini, R., Papotti, M., Matullo, G., Magnani, C., Pasini, B., and Dianzani, I.

Published
2016
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10. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case–control study and epidemiological remarks

Author

Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I.F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., Iavicoli S., Dallari B., Pesatori A.C., Riboldi L., Merletti F., Gangemi M., Stura A., Brentisci C., Gilardetti M., Benfatto L., Canessa P.A., Malacarne D., Mazzucco G., Campi M.G., Fedeli U., Bressan V., Gioffre F., Ballarin M.N., Chermaz C., D'agostin F., De Michieli P., Mangone L., Storchi C., Sala O., Badiali A.M., Cacciarini V., Giovannetti L., Martini A., Calisti R., Pascucci C., Stracci F., Masanotti G., Davoli M., Cavariani F., Ancona L., Annunziata A., Menegozzo S., Napolitano F., Pelullo C.P., Vimercati L., Cascone G., Frasca G., Giurdanella M.C., Martorana C., Nicita C., Rollo C.P., Spata E., Dardanoni G., Scondotto S., Nieddu V., Pergola M., Stecchi S., Marinaccio, Alessandro, Consonni, Dario, Mensi, Carolina, Mirabelli, Dario, Migliore, Enrica, Magnani, Corrado, Di Marzio, Davide, Gennaro, Valerio, Mazzoleni, Guido, Girardi, Paolo, Negro, Corrado, Romanelli, Antonio, Chellini, Elisabetta, Grappasonni, Iolanda, Madeo, Gabriella, Romeo, Elisa, Ascoli, Valeria, Carrozza, Francesco, Angelillo, Italo Francesco, Cavone, Domenica, Tumino, Rosario, Melis, Massimo, Curti, Stefania, Brandi, Giovanni, Mattioli, Stefano, and Iavicoli, Sergio

Subjects
medicine.medical_specialty, pericardial and tunica vaginalis testis, Epidemiology, Population, rare disease, national registry, medicine.disease_cause, Epidemiology, Italy, National registry, Rare disease, Asbestos, epidemiology, Italy, national registry, rare disease, NO, 03 medical and health sciences, 0302 clinical medicine, italy, medicine, epidemiology, Italy, Mesothelioma, education, Gynecology, education.field_of_study, business.industry, Public Health, Environmental and Occupational Health, Tunica vaginalis testis, Case-control study, case–control study, Odds ratio, medicine.disease, asbestos, 030210 environmental & occupational health, National registry, exposure, mesothelioma, malignant mesothelioma, Original Article, Public aspects of medicine, RA1-1270, business, Rare disease
Abstract

Objectives: The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. Methods: Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993–2015, incidence rates, survival median period and prognostic factors have been evaluated. A case–control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. Results: Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis mesothelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85–7.31 and OR 3.42, 95% CI 1.93–6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. Conclusions: For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.

Published
2020

11. IDPlanT: the Italian database of plant translocation

Author

Abeli, T, D'Agostino, M, Orsenigo, S, Bartolucci, F, Accogli, R, Albani Rocchetti, G, Alessandrelli, C, Amadori, A, Amato, F, Angiolini, C, Assini, S, Bacchetta, G, Banfi, E, Bonini, I, Bonito, A, Borettini, M, Brancaleoni, L, Brusa, G, Buldrini, F, Carruggio, F, Carta, A, Castagnini, P, Cerabolini, B, Ceriani, R, Ciaschetti, G, Citterio, S, Clementi, U, Cogoni, D, Congiu, A, Conti, F, Crescente, M, Crosti, R, Cuena, A, D'Antraccoli, M, Dallai, D, De Andreis, R, Deidda, A, Dessi, C, De Vitis, M, Di Cecco, V, Di Cecco, M, Di Giustino, A, Di Martino, L, Di Noto, G, Domina, G, Fabrini, G, Farris, E, Fiorentin, R, Foggi, B, Forte, L, Galasso, G, Garfi, G, Gentile, C, Gentili, R, Geraci, A, Gerdol, R, Gheza, G, Giusso del Galdo, G, Gratani, L, La Placa, G, Landi, M, Loi, T, Luzzaro, A, Alfredo, M, Magnani, C, Magrini, S, Mantino, F, Mariotti, M, Martinelli, V, Mastrullo, S, Medagli, P, Minuto, L, Nonis, D, Palumbo, M, Paoli, L, Pasta, S, Peruzzi, L, Pierce, S, Pinna, M, Rainini, F, Ravera, S, Rossi, G, Sanna, N, Santini, C, Sau, S, Schettino, A, Schicchi, R, Sciandrello, S, Sgarbi, E, Gristina, A, Troia, A, Varone, L, Villa, M, Zappa, E, Fenu, G, Abeli T., D'Agostino M., Orsenigo S., Bartolucci F., Accogli R., Albani Rocchetti G., Alessandrelli C., Amadori A., Amato F., Angiolini C., Assini S., Bacchetta G., Banfi E., Bonini I., Bonito A., Borettini M. L., Brancaleoni L., Brusa G., Buldrini F., Carruggio F., Carta A., Castagnini P., Cerabolini B. E. L., Ceriani R. M., Ciaschetti G., Citterio S., Clementi U., Cogoni D., Congiu A., Conti F., Crescente M. F., Crosti R., Cuena A., D'Antraccoli M., Dallai D., De Andreis R., Deidda A., Dessi C., De Vitis M., Di Cecco V., Di Cecco M., Di Giustino A., Di Martino L., Di Noto G., Domina G., Fabrini G., Farris E., Fiorentin R., Foggi B., Forte L., Galasso G., Garfi G., Gentile C., Gentili R., Geraci A., Gerdol R., Gheza G., Giusso del Galdo G., Gratani L., La Placa G., Landi M., Loi T., Luzzaro A., Alfredo M., Magnani C., Magrini S., Mantino F., Mariotti M. G., Martinelli V., Mastrullo S., Medagli P., Minuto L., Nonis D., Palumbo M. E., Paoli L., Pasta S., Peruzzi L., Pierce S., Pinna M. S., Rainini F., Ravera S., Rossi G., Sanna N., Santini C., Sau S., Schettino A., Schicchi R., Sciandrello S., Sgarbi E., Gristina A. S., Troia A., Varone L., Villa M., Zappa E., Fenu G., Abeli, T, D'Agostino, M, Orsenigo, S, Bartolucci, F, Accogli, R, Albani Rocchetti, G, Alessandrelli, C, Amadori, A, Amato, F, Angiolini, C, Assini, S, Bacchetta, G, Banfi, E, Bonini, I, Bonito, A, Borettini, M, Brancaleoni, L, Brusa, G, Buldrini, F, Carruggio, F, Carta, A, Castagnini, P, Cerabolini, B, Ceriani, R, Ciaschetti, G, Citterio, S, Clementi, U, Cogoni, D, Congiu, A, Conti, F, Crescente, M, Crosti, R, Cuena, A, D'Antraccoli, M, Dallai, D, De Andreis, R, Deidda, A, Dessi, C, De Vitis, M, Di Cecco, V, Di Cecco, M, Di Giustino, A, Di Martino, L, Di Noto, G, Domina, G, Fabrini, G, Farris, E, Fiorentin, R, Foggi, B, Forte, L, Galasso, G, Garfi, G, Gentile, C, Gentili, R, Geraci, A, Gerdol, R, Gheza, G, Giusso del Galdo, G, Gratani, L, La Placa, G, Landi, M, Loi, T, Luzzaro, A, Alfredo, M, Magnani, C, Magrini, S, Mantino, F, Mariotti, M, Martinelli, V, Mastrullo, S, Medagli, P, Minuto, L, Nonis, D, Palumbo, M, Paoli, L, Pasta, S, Peruzzi, L, Pierce, S, Pinna, M, Rainini, F, Ravera, S, Rossi, G, Sanna, N, Santini, C, Sau, S, Schettino, A, Schicchi, R, Sciandrello, S, Sgarbi, E, Gristina, A, Troia, A, Varone, L, Villa, M, Zappa, E, Fenu, G, Abeli T., D'Agostino M., Orsenigo S., Bartolucci F., Accogli R., Albani Rocchetti G., Alessandrelli C., Amadori A., Amato F., Angiolini C., Assini S., Bacchetta G., Banfi E., Bonini I., Bonito A., Borettini M. L., Brancaleoni L., Brusa G., Buldrini F., Carruggio F., Carta A., Castagnini P., Cerabolini B. E. L., Ceriani R. M., Ciaschetti G., Citterio S., Clementi U., Cogoni D., Congiu A., Conti F., Crescente M. F., Crosti R., Cuena A., D'Antraccoli M., Dallai D., De Andreis R., Deidda A., Dessi C., De Vitis M., Di Cecco V., Di Cecco M., Di Giustino A., Di Martino L., Di Noto G., Domina G., Fabrini G., Farris E., Fiorentin R., Foggi B., Forte L., Galasso G., Garfi G., Gentile C., Gentili R., Geraci A., Gerdol R., Gheza G., Giusso del Galdo G., Gratani L., La Placa G., Landi M., Loi T., Luzzaro A., Alfredo M., Magnani C., Magrini S., Mantino F., Mariotti M. G., Martinelli V., Mastrullo S., Medagli P., Minuto L., Nonis D., Palumbo M. E., Paoli L., Pasta S., Peruzzi L., Pierce S., Pinna M. S., Rainini F., Ravera S., Rossi G., Sanna N., Santini C., Sau S., Schettino A., Schicchi R., Sciandrello S., Sgarbi E., Gristina A. S., Troia A., Varone L., Villa M., Zappa E., and Fenu G.

Abstract

IDPlanT is the Italian Database of Plant Translocation, an initiative of the Nature Conservation Working Group of the Italian Botanical Society. IDPlanT currently includes 185 plant translocations. The establishment of a national database on plant translocation is a key step forward in data sharing and techniques improvement in this field of plant conservation. Supplemental data for this article is available online at https://doi.org/10.1080/11263504.2021.1985004.

Published
2021

12. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, Giani, P, Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, Giani, P, Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., and Giani P.

Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5 years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n = 168, 46%) and 3 (n = 59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2 weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for <4 weeks: 50% (n = 2/4) vs. 99.1% (n = 109/110) for ≥4 weeks, p = 0.003. In patients with liver cirrhosis, lower rates of SVR12 were observed in patients treated <8 weeks: 83.3% (n = 25/30) vs. 94.6% (n = 209/221) for ≥8 weeks, p = 0.038. Despite premature discontinuation of DAA, high SVR12 rates were observed in a real-life setting for treatment lasting at least 4 weeks in patients with liver fibrosis F0–F3 and 8 weeks in those with liver cirrhosis. On this basis, feasibility of reducing DAA treatment duration should be explored in randomized clinical trials.

Published
2021

14. Authors’ response: Mezei et al's 'comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis'

Author

Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I. F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., Iavicoli S., Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I.F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., and Iavicoli S.

Subjects
Mesothelioma, Tunica vaginalis testis, Economica, Letter, pericardial and tunica vaginalis testis (TVT), Socio-culturale, Ambientale, mesothelioma, ReNaM, Key terms: asbestos, Key terms: asbesto, Pericardium, Malignant mesothelioma
Abstract

Mezei et al's letter (1) is an opportunity to provide more details about our study on pericardial and tunica vaginalis testis (TVT) mesothelioma (2), which is based on the Italian national mesothelioma registry (ReNaM): a surveillance system on mesothelioma, with individual asbestos exposure assessment. Incidence of pericardial mesothelioma has been estimated around 0.5 and 0.2 cases per 10 million person-years in men and women, respectively, and around 1 case for TVT mesothelioma. ReNaM collected 138 cases thanks to its long period of observation (1993-2015) and national coverage. Conducting a population-based case-control study with incidence-density sampling of controls across Italy and over a 23 year time-span should have been planned in 1993 and would have been beyond feasibility and ReNaM scope. We rather exploited two existing series of controls (3). The resulting incomplete time- and spatial matching of cases and controls is a limitation of our study and has been acknowledged in our article. The analysis of case-control studies can nevertheless be accomplished in logistic models accounting for the variables of interest, in both individually and frequency matched studies (4). Furthermore, analyses restricted to (i) regions with enrolled controls, (ii) cases with definite diagnosis, (iii) incidence period 2000-2015, and (iv) subjects born before 1950 have been provided in the manuscript, confirming the strength of the association with asbestos exposure (supplemental material tables S4-7). Following Mezei et al's suggestion, we performed further sensitivity analyses by restriction to regions with controls and fitting conditional regression models using risk-sets made of combinations of age and year of birth categories (5-year classes for both). We confirmed positive associations with occupational exposure to asbestos of pericardial mesothelioma, with odds ratios (OR) (adjusted for region) of 9.16 among women [95% confidence interval (CI) 0.56-150] and 5.63 (95% CI 1.02-31.0) among men; for TVT mesothelioma the OR was 7.70 (95% CI 2.89-20.5). Using risk sets of age categories and introducing year of birth (5-year categories) as a covariate (dummy variables) the OR were similar: OR (adjusted for region) of 9.17 among women (95% CI 0.56-150) and 5.76 (95% CI 1.07-31.0) among men; for TVT the OR was 9.86 (95% CI 3.46-28.1). Possible bias from incomplete geographical overlap between cases and controls has been addressed in the paper (table S4) and above. In spatially restricted analyses, OR were larger than in those including cases from the whole country, indicating that bias was towards the null. Mezei et al further noted that "the regional distribution of controls is different from that of person-time observed". This objection is not relevant because the above analyses were adjusted by region. Our controls were provided by a population-based study on pleural mesothelioma (called MISEM) and a hospital-based study on cholangiocarcinoma (called CARA). In MISEM, the response rate was 48.4%, a low but not unexpected rate as participation among population controls is usually lower and has been declining over time (5). It is important to underline that ReNaM applied the same questionnaire that was used for interviews and carried out the same exposure assessment as both MISEM and CARA. As repeatedly stated in ReNaM papers (6-7), each regional operating center assesses asbestos exposure based on the individual questionnaire, other available information, and knowledge of local industries. Occupational exposure to asbestos is classified as definite, probable or possible. Occupational exposure is (i) definite when the subject`s work was reported or otherwise known to have involved the use of asbestos or asbestos-containing materials (MCA); (ii) probable when subjects worked in factories where asbestos or MCA were used, but their personal exposure could not be documented; and (iii) possible when they were employed in industrial activities known to entail the use of asbestos or MCA. Hence, the definite and probable categories are closer to one another and were combined in our analyses. In any case, restricting analyses to subjects with definite occupational exposure and using each set of controls separately, as suggested by Mezei et al, yielded elevated OR for TVT and pericardial mesothelioma among men using both the above described modelling strategies; the OR could not be calculated for women. There were 70 (25 pericardial and 45 TVT) occupationally exposed mesothelioma cases. In population-based studies, analyses by occupation are limited by the low prevalence of most specific jobs. As briefly reported in our paper, for purely descriptive purposes, the industrial activity of exposure (cases may have multiple exposures), were construction (22 exposures, 7 and 15 for pericardial and TVT mesotheliomas, respectively), steel mills and other metal working industries (4 and 11), textile industries (2 and 3), and agriculture (2 and 5); other sectors had lower exposure frequencies. The absence of industries like asbestos-cement production, shipbuilding and railway carriages production/repair should not be surprising and had already been observed (7). In the Italian multicenter cohort study of asbestos workers (8), given the person-years of observation accrued by workers employed in these industries and gender- and site-specific crude incidence rates, approximately 0.1 case of pericardial and 0.2 of TVT mesothelioma would have been expected from 1970 to 2010. Even increasing ten-fold such figures to account for higher occupational risks among these workers would not change much. Asbestos exposure in agriculture has been repeatedly discussed in ReNaM reports (9: pages 70, 73, 128, 164 and 205). Exposure opportunities included the presence of asbestos in wine production, reuse of hessian bags previously containing asbestos, or construction and maintenance of rural buildings. Similarly, mesothelioma cases and agricultural workers exposed to asbestos have been noted in France (10). In conclusion, the additional analyses we performed according to Mezei et al's suggestions confirm the association between asbestos exposure and pericardial and TVT mesothelioma, supporting the causal role of asbestos for all mesotheliomas. ReNaM`s continuing surveillance system with national coverage is a precious platform for launching analytical studies on pleural and extra pleural mesothelioma. References 1. Mezei G, Chang ET, Mowat FS, Moolgavkar SH. Comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis Scand J Work Environ Health. 2021;47(1):85-86. https://doi.org/10.5271/3909 2. Marinaccio A, Consonni D, Mensi C, Mirabelli D, Migliore E, Magnani C et al.; ReNaM Working Group. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case-control study and epidemiological remarks. Scand J Work Environ Health. 2020;46(6):609-617. https://doi.org/10.5271/sjweh.3895. 3. Greenland S. Control-initiated case-control studies. Int J Epidemiol 1985 Mar;14(1):130-4. https://doi.org/10.1093/ije/14.1.130. 4. Pearce N. Analysis of matched case-control studies. BMJ 2016 Feb;352:i969. https://doi.org/10.1136/bmj.i969. 5. Bigert C, Gustavsson P, Straif K, Pesch B, Brüning T, Kendzia B et al. Lung cancer risk among cooks when accounting for tobacco smoking: a pooled analysis of case-control studies from Europe, Canada, New Zealand, and China. J Occup Environ Med 2015 Feb;57(2):202-9. https://doi.org/10.1097/JOM.0000000000000337. 6. Marinaccio A, Binazzi A, Marzio DD, Scarselli A, Verardo M, Mirabelli D et al.; ReNaM Working Group. Pleural malignant mesothelioma epidemic: incidence, modalities of asbestos exposure and occupations involved from the Italian National Register. Int J Cancer 2012 May;130(9):2146-54. https://doi.org/10.1002/ijc.26229. 7. Marinaccio A, Binazzi A, Di Marzio D, Scarselli A, Verardo M, Mirabelli D et al. Incidence of extrapleural malignant mesothelioma and asbestos exposure, from the Italian national register. Occup Environ Med 2010 Nov;67(11):760-5. https://doi.org/10.1136/oem.2009.051466. 8. Ferrante D, Chellini E, Merler E, Pavone V, Silvestri S, Miligi L et al.; the working group. Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure. Occup Environ Med 2017 Dec;74(12):887-98. https://doi.org/10.1136/oemed-2016-104100. 9. ReNaM VI Report. Available from: https://www.inail.it/cs/internet/docs/alg-pubbl-registro-nazionale-mesoteliomi-6-rapporto.pdf. Italian 10. Marant Micallef C, Shield KD, Vignat J, Baldi I, Charbotel B, Fervers B et al. Cancers in France in 2015 attributable to occupational exposures. Int J Hyg Environ Health 2019 Jan;222(1):22-9. https://doi.org/10.1016/j.ijheh.2018.07.015.

Published
2021

15. Factors influencing place of death and disenrollment among patients receiving specialist palliative care

Author

Di Nitto M., Artico M., Piredda M., De Maria M., Magnani C., Marchetti A., Mastroianni C., Latina R., De Marinis M. G., D'Angelo D., Di Nitto M., Artico M., Piredda M., De Maria M., Magnani C., Marchetti A., Mastroianni C., Latina R., De Marinis M.G., and D'Angelo D.

Subjects
Male, Hospice Care, Palliative Care, Hospices, Infant, Newborn, Quality of Life, Humans, Female, Nursing, Settore MED/45 - Scienze Infermieristiche Generali, Cliniche E Pediatriche, Retrospective Studies
Abstract

BACKGROUND AND AIM OF THE WORK: Place of death and disenrollment from specialized palliative care services (SPCSs) are two aspects that determine service utilization. These aspects should be determined by patient needs and preferences, but they are often associated to patient sociodemographic or contextual characteristics. The aim of this study was to describe which factors are associated with utilizing SPCSs in terms of place of death and disenrollment. METHODS: Retrospective cohort study. Patients (>18 years) who died or were disenrolled during SPCSs utilization. Two hierarchical regression models were performed, and variables were categorized in predisposing, enabling, and need factors according to the Andersen behavioral model of health services use. RESULTS: We included 35,869 patients (52,5% male, mean age 74,6 ± 12,3 SD), where 17,225 patients died in hospice and 16,953 at home, while 1,691 patients were disenrolled. Dying at home was associated with older age, oncological diagnosis, painful symptoms and longer survival time. Instead, service disenrollment was associated with less education, longer wait time and longer length of stay. CONCLUSIONS: SPCS utilization was not influenced only by patient need, but also by other factors, such as social and contextual factors. These factors need to be considered by health care providers and efforts are needed for 1) identifying barriers and implementing effective interventions to support patients and caregivers in their preferred place of care and death and 2) for avoiding SPCS disenrollment with an increased probability of aggressive treatments and worse quality of life for patients.

Published
2021

16. Transposon-Based CAR T Cells in Acute Leukemias: Where are We Going?

Author

Magnani, C, Tettamanti, S, Alberti, G, Pisani, I, Biondi, A, Serafini, M, Gaipa, G, Magnani C. F., Tettamanti S., Alberti G., Pisani I., Biondi A., Serafini M., Gaipa G., Magnani, C, Tettamanti, S, Alberti, G, Pisani, I, Biondi, A, Serafini, M, Gaipa, G, Magnani C. F., Tettamanti S., Alberti G., Pisani I., Biondi A., Serafini M., and Gaipa G.

Abstract

Chimeric Antigen Receptor (CAR) T-cell therapy has become a new therapeutic reality for refractory and relapsed leukemia patients and is also emerging as a potential therapeutic option in solid tumors. Viral vector-based CAR T-cells initially drove these successful efforts; however, high costs and cumbersome manufacturing processes have limited the widespread clinical implementation of CAR T-cell therapy. Here we will discuss the state of the art of the transposon-based gene transfer and its application in CAR T immunotherapy, specifically focusing on the Sleeping Beauty (SB) transposon system, as a valid cost-effective and safe option as compared to the viral vector-based systems. A general overview of SB transposon system applications will be provided, with an update of major developments, current clinical trials achievements and future perspectives exploiting SB for CAR T-cell engineering. After the first clinical successes achieved in the context of B-cell neoplasms, we are now facing a new era and it is paramount to advance gene transfer technology to fully exploit the potential of CAR T-cells towards next-generation immunotherapy.

Published
2020

18. 218P Fear of cancer recurrence in long-term post-menopausal breast cancer survivors

Author

Bouhnik, Anne-Déborah, Magnani, C., Smith, A.B., Rey, D., Sarradon-Eck, Aline, Bendiane, M.K., Mancini, Julien, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Western Sydney University, and SENIOR investigators

Subjects
Oncology, [SDV]Life Sciences [q-bio], Hematology
Abstract

International audience

Published
2022
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19. The Past, Present, and Future of Non-Viral CAR T Cells

Author

Moretti, A, Ponzo, M, Nicolette, C, Tcherepanova, I, Biondi, A, Magnani, C, Moretti, Alex, Ponzo, Marianna, Nicolette, Charles A, Tcherepanova, Irina Y, Biondi, Andrea, Magnani, Chiara F, Moretti, A, Ponzo, M, Nicolette, C, Tcherepanova, I, Biondi, A, Magnani, C, Moretti, Alex, Ponzo, Marianna, Nicolette, Charles A, Tcherepanova, Irina Y, Biondi, Andrea, and Magnani, Chiara F

Abstract

Adoptive transfer of chimeric antigen receptor (CAR) T lymphocytes is a powerful technology that has revolutionized the way we conceive immunotherapy. The impressive clinical results of complete and prolonged response in refractory and relapsed diseases have shifted the landscape of treatment for hematological malignancies, particularly those of lymphoid origin, and opens up new possibilities for the treatment of solid neoplasms. However, the widening use of cell therapy is hampered by the accessibility to viral vectors that are commonly used for T cell transfection. In the era of messenger RNA (mRNA) vaccines and CRISPR/Cas (clustered regularly interspaced short palindromic repeat–CRISPR-associated) precise genome editing, novel and virus-free methods for T cell engineering are emerging as a more versatile, flexible, and sustainable alternative for next-generation CAR T cell manufacturing. Here, we discuss how the use of non-viral vectors can address some of the limitations of the viral methods of gene transfer and allow us to deliver genetic information in a stable, effective and straightforward manner. In particular, we address the main transposon systems such as Sleeping Beauty (SB) and piggyBac (PB), the utilization of mRNA, and innovative approaches of nanotechnology like Lipid-based and Polymer-based DNA nanocarriers and nanovectors. We also describe the most relevant preclinical data that have recently led to the use of non-viral gene therapy in emerging clinical trials, and the related safety and efficacy aspects. We will also provide practical considerations for future trials to enable successful and safe cell therapy with non-viral methods for CAR T cell generation.

Published
2022

20. A regional audit system for stillbirth: a way to better understand the phenomenon

Author

Po G., Monari F., Zanni F., Grandi G., Lupi C., Facchinetti F., Mancini L., Lugli L., Lanzoni C., Sgarbi L., Chiossi C., Ricchieri F., Roberta C., Contiero R., Garani G., Pedriali M., Rossi S., Fini S., Di Bartolo M., Radi D., Vancini A., Donati A., Guadalupi E., Righetti F., Salerno A., Cocchi G., Morandi R., Gabrielli L., Graziano C., Seri M., Caprara G., Mario S. N. C., Fantuz F., Ferlini F., Righi E., Silvestrini D., Foschi F., Fieni S., Frusca T., Ferretti A., Galli L., Magnani C., Silini E., Balduzzi L., Bellini M., Rodolfi A. M., Sgarabotto M. P., Fragni G., Comitini G., Bonasoni M. P., Fioroni L., Rozzi C., Tuzio A., Vito I., Mammoliti P., De Ambrosi E., Ricci M., Bandini A., Belosi C., Muratori C., Zago S., Turci A., Vitarelli M., Po G., Monari F., Zanni F., Grandi G., Lupi C., Facchinetti F., Mancini L., Lugli L., Lanzoni C., Sgarbi L., Chiossi C., Ricchieri F., Roberta C., Contiero R., Garani G., Pedriali M., Rossi S., Fini S., Di Bartolo M., Radi D., Vancini A., Donati A., Guadalupi E., Righetti F., Salerno A., Cocchi G., Morandi R., Gabrielli L., Graziano C., Seri M., Caprara G., Mario S.N.C., Fantuz F., Ferlini F., Righi E., Silvestrini D., Foschi F., Fieni S., Frusca T., Ferretti A., Galli L., Magnani C., Silini E., Balduzzi L., Bellini M., Rodolfi A.M., Sgarabotto M.P., Fragni G., Comitini G., Bonasoni M.P., Fioroni L., Rozzi C., Tuzio A., Vito I., Mammoliti P., De Ambrosi E., Ricci M., Bandini A., Belosi C., Muratori C., Zago S., Turci A., and Vitarelli M.

Subjects
Clinical audit, Multivariate analysis, Placenta Diseases, Perinatal Death, Eastern, Umbilical Cord, Africa, Northern, Pregnancy, Risk Factors, Cause of Death, Northern, Europe, Eastern, Pregnancy Complications, Infectious, Multivariate Analysi, Causes of death, Cause of death, Fetal Growth Retardation, Obstetrics, Placenta Disease, Infectious, Obstetrics and Gynecology, Stillbirth, Perinatal audit, Quality of care, Adult, Africa South of the Sahara, Clinical Audit, Female, Fetal Death, Fetal Diseases, Humans, India, Italy, Multivariate Analysis, Pregnancy Complications, Quality of Health Care, Pregnancy Complication, Europe, Gestation, Human, Research Article, medicine.medical_specialty, Reproductive medicine, Fetal Disease, Audit, lcsh:Gynecology and obstetrics, medicine, lcsh:RG1-991, Late Stillbirth, business.industry, Risk Factor, medicine.disease, Africa, Pregnancy Complications, Infectiou, business
Abstract

Background Implementation of high-quality national audits for perinatal mortality are needed to improve the registration of all perinatal deaths and the identification of the causes of death. This study aims to evaluate the implementation of a Regional Audit System for Stillbirth in Emilia-Romagna Region, Italy. Methods For each stillbirth (≥ 22 weeks of gestation, ≥ 500 g) occurred between January 1, 2014 to December 1, 2016 (n = 332), the same diagnostic workup was performed and a clinical record with data about mother and stillborn was completed. Every case was discussed in a multidisciplinary local audit to assess both the cause of death (ReCoDe classification) and the quality of care. Data were reviewed by the Regional Audit Group. Stillbirth rates, causes of death and the quality of care were established for each case. Results Total stillbirth rate was 3.09 per 1000 births (332/107,528). Late stillbirth rate was 2.3 per 1000 (251/107,087). Sixteen stillbirths were not registered by the Regional Birth Register. The most prevalent cause of death was placental disorder (33.3%), followed by fetal (17.6%), cord (14.2%) and maternal disorders (7.6%). Unexplained cases were 14%. Compared to local audits, the regional group attributed different causes of death in 17% of cases. At multivariate analysis, infections were associated with early stillbirths (OR 3.38, CI95% 1.62–7.03) and intrapartum cases (OR 6.64, CI95% 2.61–17.02). Placental disorders were related to growth restriction (OR 1.89, CI95% 1.06–3.36) and were more frequent before term (OR 1.86, CI95% 1.11–3.15). Stillbirths judged possibly/probably preventable with a different management (10.9%) occurred more frequently in non-Italian women and were mainly related to maternal disorders (OR 6.64, CI95% 2.61–17.02). Conclusions Regional Audit System for Stillbirth improves the registration of stillbirth and allows to define the causes of death. Moreover, sub-optimal care was recognized, allowing to identify populations which could benefit from preventive measures.

Published
2019
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22. Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature

Author

Clodoveo Ferri a, Rossella De Angelis b, Dilia Giuggioli a, Gianluigi Bajocchi c, Lorenzo Dagna d, Giovanni Zanframundo e, Rosario Foti f, Fabio Cacciapaglia g, Giovanna Cuomo, Alarico Ariani i, Edoardo Rosato j, Serena Guiducci k, Francesco Girelli l, Valeria Riccieri m, Elisabetta Zanatta n, Silvia Bosello o, Ilaria Cavazzana p, Francesca Ingegnoli q, Maria De Santisr, Giuseppe Murdaca s, Giuseppina Abignano t, Nicoletta Romeo u, Alessandra Della Rossa v, Maurizio Caminiti w, Annamaria Iuliano x, Giovanni Ciano y, Lorenzo Beretta z, Gianluca Bagnato aa, Ennio Lubrano ab, Ilenia De Andres ac, Alessandro Giollo ad, Marta Saracco ae, Cecilia Agnes af, Federica Lumetti a, Amelia Spinella a, Luca Magnani c, Corrado Campochiaro d, Giacomo De Luca d, Veronica Codullo e, Elisa Visalli f, Francesco Masini h, Antonietta Gigante j, Silvia Bellando-Randone k, Greta Pellegrino m, Erika Pigatto ag, Maria Grazia Lazzaroni p, Franco Franceschini p, Elena Generali r, Gianna Mennillo t, Simone Barsotti v, Giuseppa Pagano Mariano w, Francesca Calabrese w, Federica Furini ah, Licia Vultaggio ah, Simone Parisi ai, Clara Lisa Peroni ai, Davide Rozza aj, Anna Zanetti aj, Greta Carrara aj, Giampiero Landolfi aj, Carlo Alberto Scir`e aj, Gerolamo Bianchi al, Enrico Fusaro ai, Gian Domenico Sebastiani x, Marcello Govoni ah, Salvatore D’Angelo t, Franco Cozzi ag, Andrea Doria n, Florenzo Iannone g, Carlo Salvarani c, Marco Matucci-Cerinic d, k, On behalf of SPRING-SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society of Rheumatology), A, Clodoveo Ferri, B, Rossella De Angeli, A, Dilia Giuggioli, C, Gianluigi Bajocchi, D, Lorenzo Dagna, E, Giovanni Zanframundo, F, Rosario Foti, G, Fabio Cacciapaglia, Cuomo, Giovanna, I, Alarico Ariani, J, Edoardo Rosato, K, Serena Guiducci, L, Francesco Girelli, M, Valeria Riccieri, N, Elisabetta Zanatta, O, Silvia Bosello, P, Ilaria Cavazzana, Q, Francesca Ingegnoli, De Santisr, Maria, S, Giuseppe Murdaca, T, Giuseppina Abignano, U, Nicoletta Romeo, V, Alessandra Della Rossa, W, Maurizio Caminiti, X, Annamaria Iuliano, Y, Giovanni Ciano, Z, Lorenzo Beretta, Bagnato aa, Gianluca, Lubrano ab, Ennio, De Andres ac, Ilenia, Giollo ad, Alessandro, Saracco ae, Marta, Agnes af, Cecilia, A, Federica Lumetti, A, Amelia Spinella, C, Luca Magnani, D, Corrado Campochiaro, D, Giacomo De Luca, E, Veronica Codullo, F, Elisa Visalli, H, Francesco Masini, J, Antonietta Gigante, K, Silvia Bellando-Randone, M, Greta Pellegrino, Pigatto ag, Erika, P, Maria Grazia Lazzaroni, P, Franco Franceschini, R, Elena Generali, T, Gianna Mennillo, V, Simone Barsotti, W, Giuseppa Pagano Mariano, W, Francesca Calabrese, Furini ah, Federica, Vultaggio ah, Licia, Parisi ai, Simone, Lisa Peroni ai, Clara, Rozza aj, Davide, Zanetti aj, Anna, Carrara aj, Greta, Landolfi aj, Giampiero, Alberto Scir`e aj, Carlo, Ak, Bianchi al, Gerolamo, Fusaro ai, Enrico, X, Gian Domenico Sebastiani, Govoni ah, Marcello, T, Salvatore D’Angelo, Cozzi ag, Franco, N, Andrea Doria, G, Florenzo Iannone, C, Carlo Salvarani, D, Marco Matucci-Cerinic, K, and behalf of SPRING-SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society of Rheumatology), On

Subjects
Systemic sclerosis Scleroderma Geographical areas Macro-areas Environmental Referral
Published
2022

25. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, Massimiliano, Lombardi, Andrea, Colaneri, Marta, Del Poggio, Paolo, Perini, Paolo, D'Ambrosio, Roberta, Degasperi, Elisabetta, Dibenedetto, Clara, Giorgini, Alessia, Pasulo, Luisa, Maggiolo, Franco, Castelli, Francesco, Brambilla, Paola, Spinelli, Ombretta, Tiziana, Re, Lleo, Ana, Rumi, Mariagrazia, Uberti-Foppa, Caterina, Soria, Alessandro, Aghemo, Alessio, Lampertico, Pietro, Baiguera, Chiara, Schiavini, Monica, Fagiuoli, Stefano, Bruno, Raffaele, Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, and Giani, P

Subjects
Simeprevir, Male, medicine.medical_specialty, Cirrhosis, SVR, Sofosbuvir, Sustained Virologic Response, liver cirrhosis, antiviral treatment, Hepacivirus, Antiviral Agents, law.invention, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Humans, chronic hepatitis C, Prospective cohort study, DAA, Retrospective Studies, Hepatology, liver cirrhosi, business.industry, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Discontinuation, Regimen, Infectious Diseases, Treatment Outcome, business, medicine.drug
Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n=168, 46%) and 3 (n=59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for

Published
2021

28. Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure

Author

Magnani C., Silvestri S., Angelini A., Ranucci A., Azzolina D., Cena T., Chellini E., Merler E., Pavone V., Miligi L., Gorini G., Bressan V., Girardi P., Bauleo L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Mattioli S., Baldassarre A., Barone-Adesi F., Musti M., Mirabelli D., Pirastu R., Marinaccio A., Massari S., Ferrante D, Working Group, Ballarin MN, Brentisci C, Cortini B, Curti S, Gangemi M, Gioffrè F, Legittimo P, Mangone L, Marinelli F, Marinilli P, Panato C, Roncaglia F, Storchi C, Stura A, Vicentini M, Verdi S, Nannavecchia AM, Bisceglia L, Magnani C., Silvestri S., Angelini A., Ranucci A., Azzolina D., Cena T., Chellini E., Merler E., Pavone V., Miligi L., Gorini G., Bressan V., Girardi P., Bauleo L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Mattioli S., Baldassarre A., Barone-Adesi F., Musti M., Mirabelli D., Pirastu R., Marinaccio A., Massari S., Ferrante D, Working Group, Ballarin MN, Brentisci C, Cortini B, Curti S, Gangemi M, Gioffrè F, Legittimo P, Mangone L, Marinelli F, Marinilli P, Panato C, Roncaglia F, Storchi C, Stura A, Vicentini M, Verdi S, Nannavecchia AM, and Bisceglia L

Subjects
Risk, Mesothelioma, Lung Neoplasms, Pleural Neoplasms, Socio-culturale, Asbesto, Cohort Studies, Cause of Death, Occupational Exposure, Asbestos, Glassworks, Rolling stock, Shipyards, Humans, Industry, Peritoneal Neoplasms, Retrospective Studies, Mineral Fibers, Ovarian Neoplasms, Construction Materials, Ambientale, Italy, Urinary Bladder Neoplasms, Asbestosis, Glasswork, Female
Abstract

Italy has been a large user of asbestos and asbestos containing materials until the 1992 ban. We present a pooled cohort study on long-term mortality in exposed workers.Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period.The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increased. All industrial sectors showed increased mortality from pleural malignancies, and most also from peritoneal and lung cancer and asbestosis, with exposure related trend. Increased mortality was also observed for ovarian cancer and for bladder cancer.The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. A large increase in mortality from asbestosis was observed.

Published
2020

33. Additional file 1 of Environmental asbestos exposure and clustering of malignant mesothelioma in community: a spatial analysis in a population-based case–control study

Author

Airoldi, C., Magnani, C., Lazzarato, F., Mirabelli, D., Tunesi, S., and Ferrante, D.

Abstract

Additional file 1: Table S1.1. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**), and age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S1.2. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories. Logistic models adjusted by age, sex, type of interview (*); age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) and age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S1.3. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview, occupational exposure in a dichotomous way (*) and age, sex, type of interview and domestic exposure in a dichotomous way (**) and age, sex, type of interview and asbestos exposure (occupational, domestic and environmental) as continuous covariate (***) and age, sex, type of interview and asbestos exposure (domestic and environmental) as continuous covariate (****); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Figure S1. Case control study on MM in Casale Monferrato area. Spatial distribution of the residences of cases (triangles) and controls (circles) in a geographic area of approximately 2500 km2 around Casale Monferrato (solid line). Residences are the longest-held among all residences of each individual after excluding 20 years before the date of diagnosis of the index case. The location of the AC plant (red triangle) and the center of the cluster found using the Kulldorf test (green triangle) in the town of Casale Monferrato are also indicated. [R Spatstat]. Table S2. Case control study on MM in Casale Monferrato area. Cuzick Edward test statistics (Tq) and associate p-values based on 999 random labelling simulations for a variety of q values (3, 5, 7, 9, 11, 13, 15). Table S3.1. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 10 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) or age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S3.2. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of shorter residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) or age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC).

Published
2021
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34. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns

Author

Olthof, AM, White, AK, Mieruszynski, S, Doggett, K, Lee, MF, Chakroun, A, Aleem, AKA, Rousseau, J, Magnani, C, Roifman, CM, Campeau, PM, Heath, JK, Kanadia, RN, Olthof, AM, White, AK, Mieruszynski, S, Doggett, K, Lee, MF, Chakroun, A, Aleem, AKA, Rousseau, J, Magnani, C, Roifman, CM, Campeau, PM, Heath, JK, and Kanadia, RN

Abstract

Vertebrate genomes contain major (>99.5%) and minor (<0.5%) introns that are spliced by the major and minor spliceosomes, respectively. Major intron splicing follows the exon-definition model, whereby major spliceosome components first assemble across exons. However, since most genes with minor introns predominately consist of major introns, formation of exon-definition complexes in these genes would require interaction between the major and minor spliceosomes. Here, we report that minor spliceosome protein U11-59K binds to the major spliceosome U2AF complex, thereby supporting a model in which the minor spliceosome interacts with the major spliceosome across an exon to regulate the splicing of minor introns. Inhibition of minor spliceosome snRNAs and U11-59K disrupted exon-bridging interactions, leading to exon skipping by the major spliceosome. The resulting aberrant isoforms contained a premature stop codon, yet were not subjected to nonsense-mediated decay, but rather bound to polysomes. Importantly, we detected elevated levels of these alternatively spliced transcripts in individuals with minor spliceosome-related diseases such as Roifman syndrome, Lowry-Wood syndrome and early-onset cerebellar ataxia. In all, we report that the minor spliceosome informs splicing by the major spliceosome through exon-definition interactions and show that minor spliceosome inhibition results in aberrant alternative splicing in disease.

Published
2021

38. Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy

Author

Girardi P., Merler E., Ferrante D., Silvestri S., Chellini E., Angelini A., Luberto F., Fedeli U., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Miligi L., Perticaroli P., Pettinari A., Cuccaro F., Nannavecchia A. M., Bisceglia L., Marinaccio A., Pavone V. L. M., Magnani C., Working Group, Ancona L., Baldassarre A., Brentisci C., Cortini B., Curti S., Gangemi M., Gorini G., Legittimo P., Marinelli F., Marinilli P., Bressan V., Mattioli S., Ranucci A., Romeo E., Scarnato C., Storchi C., Stura A., Verdi S., Girardi P., Merler E., Ferrante D., Silvestri S., Chellini E., Angelini A., Luberto F., Fedeli U., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Miligi L., Perticaroli P., Pettinari A., Cuccaro F., Nannavecchia A.M., Bisceglia L., Marinaccio A., Pavone V.L.M., Magnani C., Working Group, Ancona L., Baldassarre A., Brentisci C., Cortini B., Curti S., Gangemi M., Gorini G., Legittimo P., Marinelli F., Marinilli P., Bressan V., Mattioli S., Ranucci A., Romeo E., Scarnato C., Storchi C., Stura A., and Verdi S.

Subjects
Male, Asbestos, Serpentine, Asbestosis, Cumulative Exposure, Asbesto, cohort mortality study, medicine.disease_cause, Asbestos, Settore MED/01 - Statistica Medica, NO, 03 medical and health sciences, asbestos exposure, 0302 clinical medicine, Occupational Exposure, Chrysotile, Medicine, Humans, 030212 general & internal medicine, Asbestos-related diseases, Asbestos-related disease, business.industry, Asbestos exposure, Cohort mortality study, Retrospective assessment, asbestos-related diseases, asbestosis, retrospective assessment, Public Health, Environmental and Occupational Health, Asbestosi, Middle Aged, medicine.disease, 030210 environmental & occupational health, Asbestos cement, Cohort effect, Italy, Cohort, Female, business, Settore SECS-S/01 - Statistica, Demography, Human
Abstract

Objectives This study was performed with the aim of investigating the temporal patterns and determinants associated with mortality from asbestosis among 21 cohorts of Asbestos-Cement (AC) workers who were heavily exposed to asbestos fibres. Methods Mortality for asbestosis was analysed for a cohort of 13 076 Italian AC workers (18.1% women). Individual cumulative asbestos exposure index was calculated by factory and period of work weighting by the different composition of asbestos used (crocidolite, amosite, and chrysotile). Two different approaches to analysis, based on Standardized Mortality Ratios (SMRs) and Age-Period-Cohort (APC) models were applied. Results Among the considered AC facilities, asbestos exposure was extremely high until the end of the 1970s and, due to the long latency, a peak of asbestosis mortality was observed after the 1990s. Mortality for asbestosis reached extremely high SMR values [SMR: males 508, 95% confidence interval (CI): 446–563; females 1027, 95% CI: 771–1336]. SMR increased steeply with the increasing values of cumulative asbestos exposure and with Time Since the First Exposure. APC analysis reported a clear age effect with a mortality peak at 75–80 years; the mortality for asbestosis increased in the last three quintiles of the cumulative exposure; calendar period did not have a significant temporal component while the cohort effect disappeared if we included in the model the cumulative exposure to asbestos. Conclusions Among heaviest exposed workers, mortality risk for asbestosis began to increase before 50 years of age. Mortality for asbestosis was mainly determined by cumulative exposure to asbestos.

Published
2019

39. Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy

Author

Luberto F., Ferrante D., Silvestri S., Angelini A., Cuccaro F., Nannavecchia A. M., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Chellini E., Miligi L., Perticaroli P., Pettinari A., Bressan V., Merler E., Girardi P., Bisceglia L., Marinaccio A., Massari S., Magnani C., Working group, Curti S., Mattioli S., Luberto F., Ferrante D., Silvestri S., Angelini A., Cuccaro F., Nannavecchia A.M., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Chellini E., Miligi L., Perticaroli P., Pettinari A., Bressan V., Merler E., Girardi P., Bisceglia L., Marinaccio A., Massari S., Magnani C., Working group, Curti S., and Mattioli S.

Subjects
Male, Mesothelioma, Asbestos, Asbestos-cement, Dose response relationship, Mesothelioma, Lung cancer, Ovarian Cancer, Epidemiology, Time Factors, Epidemiology, Health, Toxicology and Mutagenesis, Asbestosis, Physiology, Cumulative Exposure, medicine.disease_cause, Cohort Studies, Neoplasms, Chrysotile, Asbestos-related diseases, 0303 health sciences, lcsh:Public aspects of medicine, Middle Aged, Asbestos-cement, Asbestos cement, Ovarian Cancer, Italy, Dose response relationship, lcsh:Industrial medicine. Industrial hygiene, Female, Lung cancer, Settore SECS-S/01 - Statistica, Adult, Asbesto, Asbestos, Settore MED/01 - Statistica Medica, NO, 03 medical and health sciences, lcsh:RC963-969, Young Adult, Sex Factors, Occupational Exposure, medicine, Humans, business.industry, Research, Public Health, Environmental and Occupational Health, 030311 toxicology, lcsh:RA1-1270, medicine.disease, business
Abstract

Background Despite the available information on cancer risk, asbestos is used in large areas in the world, mostly in the production of asbestos cement. Moreover, questions are raised regarding the shape of the dose response relation, the relation with time since exposure and the association with neoplasms in various organs. We conducted a study on the relationship between cumulative asbestos exposure and mortality from asbestos related diseases in a large Italian pool of 21 cohorts of asbestos-cement workers with protracted exposure to both chrysotile and amphibole asbestos. Methods The cohort included 13,076 workers, 81.9% men and 18.1% women, working in 21 Italian asbestos-cement factories, with over 40 years of observation. Exposure was estimated by plant and period, and weighted for the type of asbestos used. Data were analysed with consideration of cause of death, cumulative exposure and time since first exposure (TSFE), and by gender. SMRs were computed using reference rates by region, gender and calendar time. Poisson regression models including cubic splines were used to analyse the effect of cumulative exposure to asbestos and TSFE on mortality for asbestos-related diseases. 95% Confidence Intervals (CI) were computed according to the Poisson distribution. Results Mortality was significantly increased for ‘All Causes’ and ‘All Malignant Neoplasm (MN)’, in both genders. Considering asbestos related diseases (ARDs), statistically significant excesses were observed for MN of peritoneum (SMR: men 14.19; women 15.14), pleura (SMR: 22.35 and 48.10), lung (SMR: 1.67 and 1.67), ovary (in the highest exposure class SMR 2.45), and asbestosis (SMR: 507 and 1023). Mortality for ARDs, in particular pleural and peritoneal malignancies, lung cancer, ovarian cancer and asbestosis increased monotonically with cumulative exposure. Pleural MN mortality increased progressively in the first 40 years of TSFE, then reached a plateau, while peritoneal MN showed a continuous increase. The trend of lung cancer SMRs also showed a flattening after 40 years of TSFE. Attributable proportions for pleural, peritoneal, and lung MN were respectively 96, 93 and 40%. Conclusions Mortality for ARDs was associated with cumulative exposure to asbestos. Risk of death from pleural MN did not increase indefinitely with TSFE but eventually reached a plateau, consistently with reports from other recent studies. Electronic supplementary material The online version of this article (10.1186/s12940-019-0510-6) contains supplementary material, which is available to authorized users.

Published
2019

40. Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies

Author

Barone-Adesi F., Ferrante D., Chellini E., Merler E., Pavone V., Silvestri S., Miligi L., Gorini G., Bressan V., Girardi P., Ancona L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Curti S., Baldassarre A., Cena T., Angelini A., Marinaccio A., Mirabelli D., Musti M., Pirastu R., Ranucci A., Magnani C., Working Group, Mattioli S., Barone-Adesi F., Ferrante D., Chellini E., Merler E., Pavone V., Silvestri S., Miligi L., Gorini G., Bressan V., Girardi P., Ancona L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Curti S., Baldassarre A., Cena T., Angelini A., Marinaccio A., Mirabelli D., Musti M., Pirastu R., Ranucci A., Magnani C., Working Group, and Mattioli S.

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Time Factors, Time Factor, Adolescent, Pleural Neoplasms, asbestos, epidemiology, mesothelioma, Asbesto, medicine.disease_cause, Asbestos, Settore MED/01 - Statistica Medica, NO, 03 medical and health sciences, Peritoneal Neoplasm, Young Adult, 0302 clinical medicine, Internal medicine, Occupational Exposure, Epidemiology, medicine, Humans, Pleural Neoplasm, Mesothelioma, Young adult, Peritoneal Neoplasms, business.industry, Public Health, Environmental and Occupational Health, Cancer, asbestos, epidemiology, mesothelioma, Adolescent, Adult, Italy, Middle Aged, Models, Theoretical, medicine.disease, 030210 environmental & occupational health, Occupational Disease, Occupational Diseases, asbestos, epidemiology, mesothelioma, Italy, 030220 oncology & carcinogenesis, Female, business, Human, Cohort study
Abstract

ObjectivesModels based on the multistage theory of cancer predict that rates of malignant mesothelioma continuously increase with time since first exposure (TSFE) to asbestos, even after the end of external exposure. However, recent epidemiological studies suggest that mesothelioma rates level off many years after first exposure to asbestos. A gradual clearance of asbestos from the lungs has been suggested as a possible explanation for this phenomenon. We analysed long-term trends of pleural and peritoneal cancer mortality in subjects exposed to asbestos to evaluate whether such trends were consistent with the clearance hypothesis.MethodsWe used data from a pool of 43 Italian asbestos cohorts (51 801 subjects). The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalised to include a term representing elimination of fibres over time.ResultsRates of pleural cancer increased until 40 years of TSFE, but remained stable thereafter. On the other hand, we observed a monotonic increase of peritoneal cancer with TSFE. The model taking into account asbestos clearance fitted the data better than the traditional one for pleural (p=0.004) but not for peritoneal (p=0.09) cancer.ConclusionsRates of pleural cancer do not increase indefinitely after the exposure to asbestos, but eventually reach a plateau. This trend is well described by a model accounting for a gradual elimination of the asbestos fibres. These results are relevant for the prediction of future rates of mesothelioma and in asbestos litigations.

Published
2019

41. Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis

Author

Karalexi, M.A. Dessypris, N. Ma, X. Spector, L.G. Marcotte, E. Clavel, J. Pombo-de-Oliveira, M.S. Heck, J.E. Roman, E. Mueller, B.A. Hansen, J. Auvinen, A. Lee, P.-C. Schüz, J. Magnani, C. Mora, A.M. Dockerty, J.D. Scheurer, M.E. Wang, R. Bonaventure, A. Kane, E. Doody, D.R. Baka, M. Moschovi, M. Polychronopoulou, S. Kourti, M. Hatzipantelis, E. Pelagiadis, I. Dana, H. Kantzanou, M. Tzanoudaki, M. Anastasiou, T. Grenzelia, M. Gavriilaki, E. Sakellari, I. Anagnostopoulos, A. Kitra, V. Paisiou, A. Bouka, E. Nikkilä, A. Lohi, O. Erdmann, F. Kang, A.Y. Metayer, C. Milne, E. Petridou, E.T. NARECHEM-ST Group FRECCLE Group

Abstract

Aim: Evidence for an association of foetal growth with acute myeloid leukaemia (AML) is inconclusive. AML is a rare childhood cancer, relatively more frequent in girls, with distinct features in infancy. In the context of the Childhood Leukemia International Consortium (CLIC), we examined the hypothesis that the association may vary by age, sex and disease subtype using data from 22 studies and a total of 3564 AML cases. Methods: Pooled estimates by age, sex and overall for harmonised foetal growth markers in association with AML were calculated using the International Fetal and Newborn Growth Consortium for the 21st Century Project for 17 studies contributing individual-level data; meta-analyses were, thereafter, conducted with estimates provided ad hoc by five more studies because of administrative constraints. Subanalyses by AML subtype were also performed. Results: A nearly 50% increased risk was observed among large-for-gestational-age infant boys (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03–2.14), reduced to 34% in boys aged

Published
2020

42. Interphase Design of Cellulose Nanocrystals/Poly(hydroxybutyrate- ran-valerate) Bionanocomposites for Mechanical and Thermal Properties Tuning

Author

Magnani, C., Idström, A., Nordstierna, Lars, Müller, A. J., Dubois, P., Raquez, J. -M, Lo Re, G., Magnani, C., Idström, A., Nordstierna, Lars, Müller, A. J., Dubois, P., Raquez, J. -M, and Lo Re, G.

Abstract

Poly[(3-hydroxybutyrate)-ran-(3-hydroxyvalerate)] (PHBV) is a bacterial polyester with a strong potential as a substitute for oil-based thermoplastics due to its biodegradability and renewability. However, its inherent slow crystallization rate limits its thermomechanical properties and therefore its applications. In this work, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biosourced nucleating and reinforcing agent for PHBV matrix. Different ester moieties from the CNCs were thereby produced through a green one-pot hydrolysis/Fisher esterification. Beyond the improved dispersion, the CNCs surface esterification affected the thermal and thermomechanical properties of PHBV. The results demonstrate that butyrate-modified CNCs, mimicking the PHBV chemical structure, brought a considerable improvement toward the CNCs/matrix interface, leading to an enhancement of the PHBV thermomechanical properties via a more efficient stress transfer, especially above its glass transition., QC 20200612

Published
2020
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43. Sleeping Beauty-engineered CAR T cells achieve anti-leukemic activity without severe toxicities

Author

Magnani, C, Gaipa, G, Lussana, F, Belotti, D, Gritti, G, Napolitano, S, Matera, G, Cabiati, B, Buracchi, C, Borleri, G, Fazio, G, Zaninelli, S, Tettamanti, S, Cesana, S, Colombo, V, Quaroni, M, Cazzaniga, G, Rovelli, A, Biagi, E, Galimberti, S, Calabria, A, Benedicenti, F, Montini, E, Ferrari, S, Introna, M, Balduzzi, A, Valsecchi, M, Dastoli, G, Rambaldi, A, Biondi, A, Magnani, Chiara F, Gaipa, Giuseppe, Lussana, Federico, Belotti, Daniela, Gritti, Giuseppe, Napolitano, Sara, Matera, Giada, Cabiati, Benedetta, Buracchi, Chiara, Borleri, Gianmaria, Fazio, Grazia, Zaninelli, Silvia, Tettamanti, Sarah, Cesana, Stefania, Colombo, Valentina, Quaroni, Michele, Cazzaniga, Giovanni, Rovelli, Attilio, Biagi, Ettore, Galimberti, Stefania, Calabria, Andrea, Benedicenti, Fabrizio, Montini, Eugenio, Ferrari, Silvia, Introna, Martino, Balduzzi, Adriana, Valsecchi, Maria Grazia, Dastoli, Giuseppe, Rambaldi, Alessandro, Biondi, Andrea, Magnani, C, Gaipa, G, Lussana, F, Belotti, D, Gritti, G, Napolitano, S, Matera, G, Cabiati, B, Buracchi, C, Borleri, G, Fazio, G, Zaninelli, S, Tettamanti, S, Cesana, S, Colombo, V, Quaroni, M, Cazzaniga, G, Rovelli, A, Biagi, E, Galimberti, S, Calabria, A, Benedicenti, F, Montini, E, Ferrari, S, Introna, M, Balduzzi, A, Valsecchi, M, Dastoli, G, Rambaldi, A, Biondi, A, Magnani, Chiara F, Gaipa, Giuseppe, Lussana, Federico, Belotti, Daniela, Gritti, Giuseppe, Napolitano, Sara, Matera, Giada, Cabiati, Benedetta, Buracchi, Chiara, Borleri, Gianmaria, Fazio, Grazia, Zaninelli, Silvia, Tettamanti, Sarah, Cesana, Stefania, Colombo, Valentina, Quaroni, Michele, Cazzaniga, Giovanni, Rovelli, Attilio, Biagi, Ettore, Galimberti, Stefania, Calabria, Andrea, Benedicenti, Fabrizio, Montini, Eugenio, Ferrari, Silvia, Introna, Martino, Balduzzi, Adriana, Valsecchi, Maria Grazia, Dastoli, Giuseppe, Rambaldi, Alessandro, and Biondi, Andrea

Abstract

BACKGROUND. Chimeric antigen receptor (CAR) T cell immunotherapy has resulted in complete remission (CR) and durable response in highly refractory patients. However, logistical complexity and high costs of manufacturing autologous viral products limit CAR T cell availability. METHODS. We report the early results of a phase I/II trial in B cell acute lymphoblastic leukemia (B-ALL) patients relapsed after allogeneic hematopoietic stem cell transplantation (HSCT) using donor-derived CD19 CAR T cells generated with the Sleeping Beauty (SB) transposon and differentiated into cytokine-induced killer (CIK) cells. RESULTS. The cellular product was produced successfully for all patients from the donor peripheral blood (PB) and consisted mostly of CD3+ lymphocytes with 43% CAR expression. Four pediatric and 9 adult patients were infused with a single dose of CAR T cells. Toxicities reported were 2 grade I and 1 grade II cytokine-release syndrome (CRS) cases at the highest dose in the absence of graft-versus-host disease (GVHD), neurotoxicity, or dose-limiting toxicities. Six out of 7 patients receiving the highest doses achieved CR and CR with incomplete blood count recovery (CRi) at day 28. Five out of 6 patients in CR were also minimal residual disease negative (MRD–). Robust expansion was achieved in the majority of the patients. CAR T cells were measurable by transgene copy PCR up to 10 months. Integration site analysis showed a positive safety profile and highly polyclonal repertoire in vitro and at early time points after infusion. CONCLUSION. SB-engineered CAR T cells expand and persist in pediatric and adult B-ALL patients relapsed after HSCT. Antileukemic activity was achieved without severe toxicities.

Published
2020

44. Targeting CD33 in Chemoresistant AML Patient-Derived Xenografts by CAR-CIK Cells Modified with an Improved SB Transposon System

Author

Rotiroti, M, Buracchi, C, Arcangeli, S, Galimberti, S, Valsecchi, M, Perriello, V, Rasko, T, Alberti, G, Magnani, C, Cappuzzello, C, Lundberg, F, Pande, A, Dastoli, G, Introna, M, Serafini, M, Biagi, E, Izsvák, Z, Biondi, A, Tettamanti, S, Rotiroti, Maria Caterina, Buracchi, Chiara, Arcangeli, Silvia, Galimberti, Stefania, Valsecchi, Maria Grazia, Perriello, Vincenzo Maria, Rasko, Tamas, Alberti, Gaia, Magnani, Chiara Francesca, Cappuzzello, Claudia, Lundberg, Felix, Pande, Amit, Dastoli, Giuseppe, Introna, Martino, Serafini, Marta, Biagi, Ettore, Izsvák, Zsuzsanna, Biondi, Andrea, Tettamanti, Sarah, Rotiroti, M, Buracchi, C, Arcangeli, S, Galimberti, S, Valsecchi, M, Perriello, V, Rasko, T, Alberti, G, Magnani, C, Cappuzzello, C, Lundberg, F, Pande, A, Dastoli, G, Introna, M, Serafini, M, Biagi, E, Izsvák, Z, Biondi, A, Tettamanti, S, Rotiroti, Maria Caterina, Buracchi, Chiara, Arcangeli, Silvia, Galimberti, Stefania, Valsecchi, Maria Grazia, Perriello, Vincenzo Maria, Rasko, Tamas, Alberti, Gaia, Magnani, Chiara Francesca, Cappuzzello, Claudia, Lundberg, Felix, Pande, Amit, Dastoli, Giuseppe, Introna, Martino, Serafini, Marta, Biagi, Ettore, Izsvák, Zsuzsanna, Biondi, Andrea, and Tettamanti, Sarah

Abstract

The successful implementation of chimeric antigen receptor (CAR)-T cell therapy in the clinical context of B cell malignancies has paved the way for further development in the more critical setting of acute myeloid leukemia (AML). Among the potentially targetable AML antigens, CD33 is insofar one of the main validated molecules. Here, we describe the feasibility of engineering cytokine-induced killer (CIK) cells with a CD33.CAR by using the latest optimized version of the non-viral Sleeping Beauty (SB) transposon system "SB100X-pT4." This offers the advantage of improving CAR expression on CIK cells, while reducing the amount of DNA transposase as compared to the previously employed "SB11-pT" version. SB-modified CD33.CAR-CIK cells exhibited significant antileukemic activity in vitro and in vivo in patient-derived AML xenograft models, reducing AML development when administered as an "early treatment" and delaying AML progression in mice with established disease. Notably, by exploiting an already optimized xenograft chemotherapy model that mimics human induction therapy in mice, we demonstrated for the first time that CD33.CAR-CIK cells are also effective toward chemotherapy resistant/residual AML cells, further supporting its future clinical development and implementation within the current standard regimens.

Published
2020

45. Air pollution and childhood leukaemia: a nationwide case-control study in Italy

Author

Badaloni, C, Ranucci, A, Cesaroni, G, Zanini, G, Vienneau, D, Al-Aidrous, F, De Hoogh, K, Magnani, C, Forastiere, F, Magnani, Corrado, Mattioli, Stefano, Miligi, Lucia, Ranucci, Alessandra, Rondelli, Roberto, Salvan, Alberto, Masera, Giuseppe, Rizzari, Carmelo, Bisanti, Luigi, Zambon, Paola, Greco, Alessandra, Cannizzaro, Santina, Gafà, Lorenzo, Luzzatto, Lia Lidia, Benvenuti, Alessandra, Michelozzi, Paola, Kirchmayer, Ursula, Cocco, Pierluigi, Galassi, Claudia, Celentano, Egidio, Guarino, Erni, Assennato, Giorgio, de Nichilo, Gigliola, Merlo, Domenico Franco, Bocchini, Vittorio, Mosciatti, Paola, Minelli, Liliana, Chiavarini, Manuela, Cuttini, Marina, Casotto, Veronica, Torregrossa, Maria Valeria, Valenti, Rosaria Maria, Forastiere, Francesco, Haupt, Riccardo, Lagorio, Susanna, Risica, Serena, Polichetti, Alessandro, Bochicchio, Francesco, Nuccetelli, Cristina, Biddau, Pierfranco, Aricò, Maurizio, De Salvo, Gian Luca, Locatelli, Franco, Pession, Andrea, Varotto, Stefania, Poggi, Vincenzo, Massaglia, Pia, Monetti, Daniele, Targhetta, Roberto, Bernini, Gabriella, Pannelli, Franco, Sampietro, Giuseppe, Schilirò, Gino, and Pulsoni, Alessandro

Published
2013
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