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The results of relativistic calculations of nuclear magnetic resonance shielding tensors (σ) for the thallium monocation (Tl+), thallium hydride (TlH), and thallium halides (TlF, TlCl, TlBr, TlI, and TlAt) are presented as obtained within a four-component polarization propagator formalism and a two-component linear response approach within the zeroth-order regular approximation. In addition to a detailed analysis of relativistic effects performed in this work, some quantum electrodynamical (QED) effects on those nuclear magnetic resonance shieldings and other small contributions are estimated. A strong dependence of σ(Tl) on the bonding partner is found, together with a very weak dependence of QED effects with them. In order to explain the trends observed, the excitation patterns associated with relativistic ee (or paramagnetic-like) and pp (or diamagnetic-like) contributions to σ are analyzed. For this purpose, the electronic spin-free and spin-dependent contributions are separated within the two-component zeroth-order regular approximation, and the influence of spin–orbit coupling on involved molecular orbitals is studied, which allows for a thorough understanding of the underlying mechanisms. [ABSTRACT FROM AUTHOR]

Eddy current shielding by a Faraday cage is an effective way to shield alternating-current magnetic fields in scientific instrumentation. In a strong static magnetic field, however, the eddy current in the conductive shield is subject to the Lorentz force, which causes the shield to vibrate. In addition to mechanical issues (e.g., acoustic noise), such vibration induces motional eddy current in the shield that can dominate the original, electromagnetic eddy current to undermine the conductor's shielding capability. In this work, we investigate a method to control motional eddy current by making cut-out patterns in the conductor that follow the electromagnetic eddy current image. This effectively limits the surface current of the plate to a single mode and prevents the proliferation of uncontrolled motion-induced surface currents that disrupts eddy current shielding. After developing a comprehensive theory of magneto-mechanical interaction in a conductive plate, the proposed method was tested on a flat-geometry testbed experiment inside a 3 T magnetic resonance imaging (MRI) magnet. It was found that the magnetic field generated by the motional eddy current was much more localized in space and frequency for a patterned-copper shield compared to a solid copper. The magnetic field of the patterned shield could be accurately predicted from the impedance measurement in the magnet. Implications of our results for improved shielding of gradient fields in high-field MRI are discussed. [ABSTRACT FROM AUTHOR]

Near-zero magnetic shielding systems (MSSs) can provide basic experimental environments for extremely weak magnetic measurements. Reducing the internal magnetic field of MSS is the crucial element of high-sensitivity measurements, which is related to the shielding material flux. As an effective way to regulate the material remanence, degaussing reconstructs the magnetic balance with the geomagnetic field. However, previous research studies mainly focused on the optimization of material degaussing, with few considering the practical application scenarios of MSS. In this work, a numerical modeling method is proposed to realistically depict the balancing process, and the mapping relationship between the internal magnetic field of the MSS and the degaussing current is established. First, the magnetic field source analysis is carried out, and the internal magnetic field fluctuations of the MSS during degaussing are decomposed into multi-harmonic components. Then, the phase and amplitude changes of the hysteresis loop are simulated to predict the residual field. Thereafter, the effectiveness of the method is verified by a magnetic shielding cylinder. The experimental results indicate that the slight difference in material remanence has a negligible effect on the residual field. This work has potential application value in the research of degaussing technology. [ABSTRACT FROM AUTHOR]

In this manuscript we study the magnetic MAOX phases (M = Mn, Cr; A = Ga, Al, X = C) obtained by the replacement of the A-layer in the parent MAX phase by the AO2 layer. The screening analysis of the magnetic and electronic properties of Mn- and Cr-based MAOX phases is performed using DFT calculations. All MAOX are thermodynamically stable. It was found that in MAOX phases Cr magnetic moments are pronounced increased in compare to corresponding MAX phase. Moreover, drastically changes in the electronic structure arise in Cr2AlO2C and Cr2GaO2C MAOX phases. The metal behavior in Cr2GaC MAX phase changes for the near to half-metallic behavior with 90% spin polarization at the Fermi energy in Cr2GaO2C MAOX phases. We have found that in Cr2AlO2C, the change in the electronic structure leads to the formation of the spin-gapless semiconductor state under slight extension in the ab plane. The obtained results make Cr2GaO2C and especially Cr2AlO2C prospective candidates for application as functional elements of electronics and spintronics. [ABSTRACT FROM AUTHOR]

Copyright of Zhejiang Electric Power is the property of Zhejiang Electric Power Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The electronic structure characteristics of bilayer graphyne, bilayer graphdiyne, and bilayer graphtriyne were systematically studied using molecular orbital (MO) analysis, density of states (DOS), and interaction region indicator (IRI) methods. The delocalization characteristics of the out-of-plane and in-plane π electrons (i.e., πout and πin electrons) of these materials were analyzed using the localized orbital locator (LOL). In addition, their responses to external magnetic fields were investigated through anisotropic induced current density (AICD) and isoscalar chemical shielding surfaces (ICSSs) to compare the induced ring currents and magnetic shielding effects, further exploring the aromaticity of the three bilayer materials. The research results indicate that as the number of alkyne groups increases, the aromaticity of the bilayer graphyne structure gradually weakens. Finally, their photophysical properties were studied through TD-DFT calculations. The results show that they exhibit strong localized excitation characteristics. [ABSTRACT FROM AUTHOR]

Depending on high permeability, high Curie temperature, and low eddy current loss noise, nanocrystalline alloys, as the innermost layer, exhibit great potential in the construction of cylindrical magnetic shielding systems with a high shielding coefficient and low magnetic noise. This study compares a magnetic noise of 1 Hz, simulated by the finite element method (FEM), of a cylindrical nanocrystalline magnetic shield with different structural parameters based on the measured initial permeability of commercial Fe-based nanocrystalline (1K107). The simulated results demonstrate that the magnetic noise is irrelevant to the pump and probe hole diameter. The magnetic noise of a nanocrystalline cylinder with a fixed length gradually increases with the rise in aspect ratio. The radial and axial magnetic noise of a nanocrystalline cylinder with a fixed diameter can reach optimal values when the aspect ratio is 1.3 and 1.4, respectively. The layer thickness of a nanocrystalline cylinder is negatively correlated to magnetic noise. Additionally, by comparing the 1 Hz magnetic noise of a cylindrical nanocrystalline magnetic shield with varying initial permeability, it can be concluded that an increase in loss factor results in an increase in magnetic noise. These results are useful for the design of a high-performance passive magnetic shield with low magnetic noise. [ABSTRACT FROM AUTHOR]

In this paper, a method to predict near-field magnetic shielding effectiveness (NSE) of ferrite sheets is proposed by measuring their relative permeability. The NSE prediction for ferrite sheets is developed using eight regression models based on higher-order terms of permeability, extracted through Minitab's regression analysis using data from the measured NSE and relative permeabilities of the ferrite sheets. To analyze the accuracy of the predicted NSE in comparison to the measured NSE, the mean square error (MSE) was computed. As a result, the extracted regression models enable fast and accurate NSE predictions for ferrite sheets up to 100 MHz, achieving an MSE of less than 1.0, in contrast to numerical simulation methods that require several hours. [ABSTRACT FROM AUTHOR]

Background: The authors assessed the feasibility, acceptability, and impact on cancer worry of a cancer screening program using multicancer early detection (MCED) tests and whole‐body magnetic resonance imaging (WBM) in individuals at high cancer risk because of family history or germline variants in cancer‐susceptibility genes. Methods: This prospective trial enrolled participants aged 50 years and older who had a significant family history of cancer or a cancer‐susceptibility gene variant. Participants underwent noncontrast WBM and MCED testing. The results were shared with participants, and further imaging or consultations were conducted as needed. Surveys assessing anxiety, cancer worry, and acceptability of the intervention were completed at baseline and 6 months after testing. Results: One hundred participants were enrolled: 98 completed both WBM and MCED testing, and 89 completed their 6‐month follow‐up. The median age of participants was 62 years (range, 51–83 years), and 64% were women. Four participants (4%) were diagnosed with cancer based on WBM findings and subsequent work‐up, and all four underwent surgical resection. Two intraductal papillary mucinous neoplasms of the pancreas were detected and are being monitored. MCED testing was positive in four participants, none of whom had suspicious findings on magnetic resonance imaging. One participant with a JAK2 mutation and thrombocytosis is under monitoring for potential hematologic malignancy. Sixty‐two participants (85%) somewhat/strongly agreed that study participation reduced cancer worry. Composite Cancer Worry Scale scores demonstrated decreased worry at 6 months compared with baseline (51% vs. high worry in 69%; p <.001). Conclusions: MCED and WBM testing were feasible, acceptable, and were associated with decreased cancer worry at 6 months (clinical trials registration: NCT05868486). In this trial of whole‐body magnetic resonance imaging (WBM) and multicancer early detection (MCED) testing in people with a strong family history of cancer, WBM and MCED testing were feasible, acceptable, and led to reduced worry about cancer. Cancer screening with WBM and MCED testing may reduce cancer worry in high‐risk individuals. [ABSTRACT FROM AUTHOR]

The coupling coefficient determines the transfer efficiency of the wireless power transfer (WPT) system. The magnetic leakage can be reduced, and the coupling coefficient of the coil can be enhanced by adding a magnetic shield. Thus, the transfer efficiency of the WPT system can be improved. However, when the receiving coil is added with magnetic shield and occurs horizontally misaligned, the coupling coefficients between the coils with the magnetic shield can only be calculated by finite element simulation, and there is no calculation method for the coupling coefficient of two circular coils with bilateral finite magnetic shield at horizontal misalignment. Therefore, based on Maxwell's equations and Bessel's function, the formula of the coupling coefficient between circular coils at coaxial is derived by the subdomain hierarchical analysis (SHA) method. On this basis, the coupling coefficient calculation formula between circular coils at horizontal misalignment is further derived by using the boundary vector equivalence (BVE) method. The results show that the maximum experimental error is not more than 5.58%, and the longest average time of the algorithm is not more than 1.282 s, which verifies the effectiveness and rapidity of the proposed method. [ABSTRACT FROM AUTHOR]

In wireless power transfer systems, the relative positional misalignment between transmitting and receiving coils significantly impacts the system's mutual inductance characteristics, thereby constraining the system's output power stability and transmission efficiency optimization potential. Hence, accurate formulas for calculating mutual inductance are crucial for optimizing coil structures and achieving mutual inductance stability. This study focuses on the mutual inductance characteristics of rectangular coils under positional misalignment conditions in a dual-sided electromagnetic shielding environment. Initially, the research deduces the incident magnetic flux density induced by the current in rectangular coils through the dual Fourier transform and magnetic vector potential method. Subsequently, Maxwell's equations and boundary conditions are employed to analytically examine the induced eddy currents within the shielding layer, allowing for the calculation of reflected magnetic flux density. Based on these analyses, the study derives a formula for mutual inductance using the magnetic flux density method. A prototype was built for experimental verification. The experiment results show that the maximum error between the measured mutual inductance and the calculated result is less than 3.8%, which verifies the feasibility and the accuracy of the proposed calculation method. Simulations and empirical validation demonstrate the superior accuracy and practicality of the proposed formula. This research not only offers an innovative technological pathway for enhancing the stability and efficiency of wireless power transfer systems but also provides a solid theoretical foundation and guiding framework for coil design and optimization. [ABSTRACT FROM AUTHOR]

Since the fiber optic gyroscope (FOG) is rigidly strapped down to the earth's crust, there are various errors that affect the universal time (UT1) measurements. In this paper, the errors caused by various physical factors and mechanisms are analyzed in detail, with precession and nutation errors being taken into account, and modeling of the observation equations based on precession and nutation error correction is proposed. The mapping relationship with UT1 is established based on this observation equation; after the corresponding error correction and VLBI calibration, the high-accuracy solution of UT1 is finally completed. Through 14-day measurement experiments under a room temperature environment without any vibration isolation and magnetic shielding devices, the error variation of UT1 solution compared with the earth orientation parameter (EOP) 14 C04 data is calculated at less than 3.57 ms, with UT1 solution accuracy improved by 56% compared with the traditional method. These results indicate that this work facilitates the study of giant FOG error modeling and correction, advancing our understanding of errors in giant FOG measurements and improving the accuracy of UT1 solution. [ABSTRACT FROM AUTHOR]

The icosahedral Au135+ core is a recurrent building block in ligand‐protected gold clusters involving an 8‐cluster electron 1S21P6 electronic shell. Such a prototypical structure enables a spherical aromatic behavior as given by long‐range magnetic shielding. Recently, the Au20(tBu3P)8 cluster featuring a contrasting cuboctahedral core with formally neutral gold atoms appears as a novel core architecture with the potential to be considered as another potential building block towards functional nanostructures. Here, we explore the ligand‐core interaction and spherical aromatic characteristics of Au20(tBu3P)8, in order to provide a direct connection to classical icosahedral spherical aromatic compounds, now involving a cuboctahedral core structure. Such characteristics suggest rationalization of their robustness in terms of certain electron counts, enabling a shielding cone property in ligand‐protected metallic clusters, which favors bridging organic and inorganic planar/spherical aromatic species towards the unification of the aromaticity concept and designing guidelines for further achievements. [ABSTRACT FROM AUTHOR]

We are developing an active shield for the measurement of neutron electric dipole moment using ultracold neutron. The disturbing geomagnetism and environmental magnetic fields are cancelled by the active shield. We introduced proportional-integral-differential control to the feedback loop of the system to improve the performance of the active shield. A quadrupole-coil arrangement was adopted to control the diagonal components of the field gradient. The influence of magnetic shielding inside the active shield was studied. It was found that this effect caused no critical problems in the detection of zero-field conditions. [ABSTRACT FROM AUTHOR]

The thermal and electrical responses of additive manufactured specimens were analysed for a additive manufactured steel magnetic shield as a case study. The analysis was based on the evidence that variations in the thermal properties of a material can be measured as a phase delay in thermal diffusion through the material bulk. The signal post-processing was performed, and the results were presented in a phase diagram. The results showed that after heat treatment, the slope of the phase diagram changed to less steep, indicating an increase in thermal diffusivity and hence thermal conductivity. The electrical conductivity was predicted using the thermal conductivity and the Weidemann-Franz law and validated by experimental measurements of the electrical conductivity. The same approach was applied to predict the electrical conductivity in the magnetic shielding, taking into consideration the scaling of the density due to porosity. The results showed that the thermographic non-destructive full field non-contact approach can be used to evaluate the electrical properties of a component and that the heat-treated specimens show better thermal diffusivity and hence thermal and electrical conductivity. [ABSTRACT FROM AUTHOR]

A novel screening platform based on an Fe3O4@C@PDA-Ni2+@COX-2 ligand fishing combination with high-performance liquid chromatography–mass spectrometry was first designed, synthesized, and employed to screen and identify COX-2 inhibitors from Panax notoginseng leaves. The obtained magnetic nanoparticles exhibit outstanding preconcentration ability that allows for controlling the enzyme orientation to avoid enzyme active site blocking, conformational changes, or denaturing during immobilization. The as-prepared Fe3O4@C@PDA-Ni2+@COX-2 composite was carefully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectrometry (FT-IR), Xray powder diffraction (XRD), thermal gravimetric analyzer (TGA), vibrating sample magnetometer (VSM), and Zeta potential analysis. The analytical parameters influencing the magnetic solid-phase fishing efficiency were optimized by univariate and multivariate methods (Box–Behnken design) by testing a positive control and celecoxib with active and inactive COX-2. Under the optimized ligand fishing conditions, twelve potential COX-2 inhibitors were screened and characterized in Panax notoginseng leaves. The results indicate that the proposed method provides a simple, feasible, selective, and effective platform for the efficient screening and identification of active compounds from Chinese herbal medicine. It has guiding significance for the synthesis and development of novel anti-inflammatory drugs, and provides a reference for the efficient discovery of anti-inflammatory drugs or lead compounds from the complex system of Chinese herbal medicine. [ABSTRACT FROM AUTHOR]

A demagnetization study was conducted on a magnetically shielded room (MSR) at Fraunhofer IPM, designed for applications such as magnetoencephalography (MEG) and material testing. With a composite of two layers of mu-metal and an intermediate aluminum layer, the MSR must provide a residual field under 5 nT for the successful operation of optically pumped magnetometers (OPMs). The degaussing process, employing six individual coils, reached the necessary residual magnetic field within the central 1 m3 volume in under four minutes. Due to the low-frequency shielding factor of 100, the obtained average residual field is shown to be limited by environmental residual field changes after degaussing and not by the degaussing procedure. [ABSTRACT FROM AUTHOR]

The mechanical properties, specifically ductility, of high performing soft magnets such as Fe-Co alloys are a limiting factor to their broader use in a number of systems. The understanding of the mechanical robustness in these materials is currently insufficient to be able to support the growing interest in applications such as magnetic shielding or electric motors. Fe-Co alloys provide the highest commercially available magnetic saturation and high magnetic permeability but have very poor ductility. The addition of vanadium to these alloys has allowed for significant commercialization and some ductility improvements, but the fundamental reasons for the observed improvements are not well understood. In most published work on mechanical properties in these alloys, the precise chemistry of the alloys investigated, often a critical aspect of intermetallics, is not reported or controlled and thermal history is unclear. This work creates a ductility model that is sensitive to changes in chemistry and can predict relative strain to failure as well as brittle fracture mode for intermetallics and is applied to Fe-Co alloys. Through the application of density functional theory (DFT), this model identifies defect stabilities, anti-phase boundary (APB) energies, the energy necessary to cross-slip, and cleavage energies and combines them through energetic competition to determine a relative failure strain. The model correctly predicts ductility improvements with the addition of vanadium as well as the transition from intergranular to transgranular cleavage, though more precise experiments are necessary to appropriately validate the various improvements observed. [ABSTRACT FROM AUTHOR]

In the field of wireless power transmission (WPT) for electric vehicles, the challenge of magnetic shielding technology is particularly prominent. Achieving effective magnetic shielding often comes at the cost of transmission efficiency, creating a significant technical bottleneck. As a result, research into improving transmission efficiency while minimizing magnetic leakage has become a primary focus in the industry. This is seen as critical for driving the sustainable development of the electric vehicle sector. In response to this challenge, this paper presents the construction of an active magnetic shield using an isotropic coil configuration, which not only optimizes system efficiency but also significantly reduces magnetic leakage in WPT systems. The paper begins by introducing the concept of an active magnetically shielded isotropic coil structure for wireless power transmission. Next, it details the design methodology and operational principles of the structure, followed by the derivation of the mathematical model and equivalent circuit. The effectiveness of the magnetic shielding mechanism is examined from a theoretical standpoint, and the influence of coil parameters on both shielding performance and transmission efficiency is analyzed. Finally, based on the optimized coil parameters, the design of the wireless charging system incorporating the magnetic shielding structure is completed. This includes relevant theoretical calculations, simulation analyses, and experimental validation to confirm the feasibility of the design. The results demonstrate that the active magnetically shielded isotropic coil significantly reduces magnetic leakage, lowering it by approximately 95.68% compared to traditional coils, while achieving a transmission efficiency of 95.68% in experiments. [ABSTRACT FROM AUTHOR]

Despite the fact that most quantum chemistry basis sets are designed for accurately modeling valence chemistry, these general-purpose basis sets continue to be widely used to model core-dependent properties. Core-specialized basis sets are designed with specific features to accurately represent the behavior of the core region. This design typically incorporates Gaussian primitives with higher exponents to capture core behavior effectively, as well as some decontraction of basis functions to provide flexibility in describing the core electronic wave function. The highest Gaussian exponent and the degree of contraction for both s- and p-basis functions effectively characterize these design aspects. In this study, we compare the design and performance of general-purpose basis sets against several literature-based basis sets specifically designed for three core-dependent properties: J coupling constants, hyperfine coupling constants, and magnetic shielding constants (used for calculating chemical shifts). Our findings consistently demonstrate a significant reduction in error when employing core-specialized basis sets, often at a marginal increase in computational cost compared to the popular 6-31G** basis set. Notably, for expedient calculations of J coupling, hyperfine coupling, and magnetic shielding constants, we recommend the use of the pcJ-1, EPR-II, and pcSseg-1 basis sets, respectively. For higher accuracy, the pcJ-2, EPR-III, and pcSseg-2 basis sets are recommended. [ABSTRACT FROM AUTHOR]

Carborazine (B2C2N2H6) and borazine (B3N3H6) are isoelectronic analogues of benzene (C6H6). The aromatic character of borazine have basically reached a consensus after a long period of controversy, but the related properties of carborazine are even rarely reported. In this work, we systematically investigated the geometric structure, charge distribution, frontier molecular orbital characteristics, bonding, electronic delocalization, magnetic shielding effect, and induced ring current of carborazine and borazine, and compared the studied characteristics with those of benzene to determine the aromatic character of the two analogues. The combination of multiple properties shows that although they are isoelectronic, carborazine is evidently aromatic, while borazine only exhibits rather weak aromaticity. The C atom acting as a connecting bridge between B and N atoms in carborazine reduces the electronegativity difference on the molecular backbone and enhances the electronic delocalization over the conjugated path, which is the essence of the distinct disparity of aromaticity between carborazine and borazine. [ABSTRACT FROM AUTHOR]

Energy loss in shielding soft magnetic materials at low frequencies (1–100 Hz) can cause fluctuations in the material's magnetic field, and the resulting magnetic noise can interfere with the measurement accuracy and basic precision physics of biomagnetic signals. This places higher demands on the credibility and accuracy of loss separation predictions. The current statistical loss theory (STL) method tends to ignore the high impact of the excitation dependence of quasi-static loss in the low-frequency band on the prediction accuracy. STL simultaneously fits and predicts multiple unknown quantities, causing its results to occasionally fall into the value boundary, and the credibility is low in the low-frequency band and with less data. This paper proposes a progressive loss decomposition (PLD) method. Through multi-step progressive predictions, the hysteresis loss simulation coefficients are first determined. The experimental data of the test ring verifies the credibility of PLD's prediction of the two hysteresis coefficients, improving the inapplicability of the STL method. In addition, we use the proposed method to obtain the prediction results of the low-frequency characteristics of the loss of a variety of typical soft magnetic materials, providing a reference for analyzing the loss characteristics of materials. [ABSTRACT FROM AUTHOR]

Magnetic-shielding technologies play a crucial role in the field of ultra-sensitive physical measurement, medical imaging, quantum sensing, etc. With the increasing demand for the accuracy of magnetic measurement, the performance requirements of magnetic-shielding devices are also higher, such as the extremely weak magnetic field, gradient, and low-frequency noise. However, the conventional method to improve the shielding performance by adding layers of materials is restricted by complex construction and inherent materials noise. This paper provides a comprehensive review about the enhancement of magnetic shielding in three aspects, including low-noise materials, magnetization control, and active compensation. The generation theorem and theoretical calculation of materials magnetic noise is summarized first, focusing on the development of spinel ferrites, amorphous, and nanocrystalline. Next, the principles and applications of two magnetization control methods, degaussing and magnetic shaking, are introduced. In the review of the active magnetic compensation system, the forward and inverse design methods of coil and the calculation method of the coupling effect under the ferromagnetic boundary of magnetic shield are explained in detail, and their applications, especially in magnetocardiography (MCG) and magnetoencephalogram (MEG), are also mainly described. In conclusion, the unresolved challenges of different enhancement methods in materials preparation, optimization of practical implementation, and future applications are proposed, which provide comprehensive and instructive references for corresponding research. [ABSTRACT FROM AUTHOR]

The present study investigated the 1H Nuclear Magnetic Resonance (NMR) spectra of hydrogen-rich water (HRW) produced using the EVObooster device. The analyzed HRW has pH = 7.1 ± 0.11, oxidation–reduction potential (ORP) of (−450 ± 11) mV, and a dissolved hydrogen concentration of 1.2 ppm. The control sample was tap water filtered by patented technology. A 600 NMR spectrometer was used to measure NMR spectra. Isotropic 1H nuclear magnetic shielding constants of the most stable clusters (H2O)n with n from 3 to 28 have been calculated by employing the gauge-including-atomic-orbital (GIAO) method at the MPW1PW91/6-311+G(2d,p) density function level of theory (DFT). The HRW chemical shift is downfield (higher chemical shifts) due to increased hydrogen bonding. More extensive formations were formed in HRW than in control filtered tap water. The exchange of protons between water molecules is rapid in HRW, and the 1H NMR spectra are in fast exchange mode. Therefore, we averaged the calculated chemical shifts of the investigated water clusters. As the size of the clusters increases, the number of hydrogen bonds increases, which leads to an increase in the chemical shift. The dependence is an exponential saturation that occurs at about N = 10. The modeled clusters in HRW are structurally stabilized, suggesting well-ordered hydrogen bonds. In the article, different processes are described for the transport of water molecules and clusters. These processes are with aquaporins, fusion pores, gap-junction channels, and WAT FOUR model. The exponential trend of saturation shows the dynamics of water molecules in clusters. In our research, the chemical shift of 4.257 ppm indicates stable water clusters of 4–5 water molecules. The pentagonal rings in dodecahedron cage H3O+(H2O)20 allow for an optimal arrangement of hydrogen bonds that minimizes the potential energy. [ABSTRACT FROM AUTHOR]

A wearable microgrid that centralizes and distributes harvested energy across different body regions can optimize power utilization and reduce overall battery weight. This setup underscores the importance of developing cable-free wireless power transfer (WPT) systems for mobile and portable devices to eliminate the risks posed by wired connections, especially in dynamic and hazardous environments. We introduce a thin, stretchable, and safe hand band capable of watt-level wireless charging through the widely adopted Qi protocol operating at 130 kHz. The implementation of non-adhesive fabric encapsulation serves to protect the 50-μm-thin spiral copper antenna from mechanical strain, ensuring an overall hand band stretchability of 50%. We also create a stretchable "Ferrofabric", characterized by a magnetic permeability of 11.3 and a tensile modulus of 75.3 kPa, that provides magnetic shielding for the antenna without compromising wearability. The "Ferrofabric" improves the coil inductance but induces core loss in AC application. By fully understanding and managing loss mechanisms such as the skin effect, proximity effect, core loss, and joule heating, we achieve a wireless charging efficiency of 71% and power delivery of 3.81 W in the kHz frequency range. Our WPT hand band is unobstructive to hand motion and can charge a handheld smartphone as fast as a desktop charger or power a battery-free chest-laminated e-tattoo sensor, with well-managed thermal and electromagnetic safety. Through a holistic electromagnetic, structural, and thermal design, our device culminates in a safe, rugged, and versatile solution for wearable WPT systems. [ABSTRACT FROM AUTHOR]

This study experimentally analyzed the impact of air gaps between a magnetic sheet and a test board with a microstrip line, which is used to measure the near-field magnetic shielding effectiveness (NSE) of magnetic sheets made of metallic powder. To conduct the measurements, a material fixture equipped with a microstrip line to generate the near magnetic field, a rectangular loop probe, and an automatic probe positioning system capable of moving the loop probe along three axes were designed and fabricated. In addition, to systematically vary the thickness of the gaps, three paper spacers with a thickness of 0.11 mm per paper were used, and a 1.0 mm thick acrylic sheet, along with a specially designed material fixture, was used to press down the magnetic sheets during measurement. The magnetic shielding properties were measured and compared under various air gap conditions using a near-field magnetic loop probe. The effect of the gaps on the shielding performance of the magnetic sheets was quantitatively evaluated for three different magnetic sheets. The experimental results showed that as the gap thickness increased, NSE tended to improve up to a frequency around 1 GHz, while in the higher frequency range of a few GHz, NSE tended to decrease. The physical background of this phenomenon was explained using an equivalent magnetic circuit represented by reluctances for the structure, where the magnetic sheet is placed above the microstrip line with an air gap. This model helps to elucidate how the presence of the air gap affects the near-field magnetic shielding performance. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this paper, to address the low transmission efficiency problem caused by large magnetic leakage and insufficient antideviation performance, an integrated symmetrical coil (ISC) structure is proposed. The ISC structure eliminates the need for an external active shielding coil to counteract the leaked magnetic field, and enhances anti-offset performance by utilizing an integrated coil. Additionally, a deep learning-based method for optimizing the coil structure is employed to determine the optimal parameters. The theoretical simulation is validated using Maxwell software, and based on this, the design and parameters of the ferrite structure are adjusted to improve the magnetic shielding effect and transmission efficiency of the coil. Subsequently, a 2 kW prototype experiment is conducted to validate the findings. Results indicate that when the ISC structure is offset by 200 mm in the X-direction, the research demonstrates that the coupling coefficient fluctuation remains below 5%, achieving a transmission efficiency of up to 96.37%. Furthermore, the magnetic leakage is significantly reduced to below 27 µT at 800 mm on both sides of the door in the X-direction. [ABSTRACT FROM AUTHOR]

In present research article, we reported the synthesise of novel hetertocyclic ligand namely, 5-((3-((1H-benzimidazol-1-yl)methyl)-5-phenyl-1H-pyrazol-1-yl)methyl)-8-hydroxy quinoline (BIPPHQ) from 5-chloro methyl-8-hydroxy quinoline and 1-((5-phenyl-1H-pyrazol-3-yl) methyl)-1H-benzimidazole (BIPP). The BIPP was synthsised by the reaction between hydrazine hydrate with 1-(1H-benzimidazol-1-yl)-4-phenylbut-3-en-2-one (BIPB), which was synthesisd from 1-(1H-benzimidazol-1-yl)propan-2-one (BIP) and benzaldehyde. The transition metal complxes of 5-((3-((1H-benzimidazol-1-yl)methyl)-5-phenyl-1H-pyrazol-1-yl)methyl)-8-hydroxy quinoline (BIPPHQ) were sythsised and analysed with the help of elemen conten analysis, spectroscopic data analysis, ratio of metal and ligand and also magneic parameters. The BIPPHQ and etal coplexes also screened for antimicrobial study. [ABSTRACT FROM AUTHOR]

ABSTRACT Low‐power magnetic coupling resonant wireless power transfer (MCRWPT) systems are less efficient at long transmission distances due to magnetic leakage and losses. For this reason, combining ferrite‐nanocrystalline hybrid shielding and a relay coil, an improved MCRWPT system based on the LCC‐LCC compensation network is designed in this paper. Firstly, the transmission performance of the MCRWPT systems with S‐S and LCC‐LCC compensation networks are compared and analyzed. Secondly, the transfer efficiencies of the MCRWPT system are analyzed when the relay coil is added at different locations, and the transfer efficiencies of the system with single material shielding are compared. Finally, the transmission performance of the MCRWPT system with ferrite‐nanocrystalline hybrid shieling is analyzed using simulation and experiment. Experimental results show that the transfer efficiency of the low‐power MCRWPT system using relay coil and hybrid shielding increases from 40.38% to 69.17% when the input voltage is 40 V and the transmission distance is 250 mm. Compared with the MCRWPT system based on ferrite full shielding, the weight of the MCRWPT system has been reduced by 63.11%. The hybrid shielding method not only improves the transfer efficiency of the MCRWPT system and reduces its spatial magnetic leakage but also has certain cost advantages. [ABSTRACT FROM AUTHOR]

13C and 1H NMR spectra were observed as the function of density in 1,2-13C-enriched ethane and ethylene for the pure gaseous compounds and their binary mixtures with xenon and carbon dioxide gases as the solvents. All the chemical shifts and indirect spin–spin couplings were linearly dependent on the solvent density. The appropriate NMR parameters (σ and nJ) in isolated 13C2H6 and 13C2H4 molecules and the coefficients responsible for the binary molecular interactions were determined and compared with previous similar measurements and selected calculated shielding data. The newly obtained 13C shielding values in the isolated ethane and ethylene molecules suggest visible secondary isotope effects due to the additional carbon-13 atom. All the investigated shielding parameters depend on intermolecular interactions, and the dependence of 13C shielding is much more marked. In contrast, the indirect spin–spin couplings in 13C2H6 and 13C2H4 molecules are almost independent of solvent molecules. Their nJ values determined in liquids over sixty years ago are generally consistent with the same nJ parameters in isolated 13C2H6 and 13C2H4 molecules. [ABSTRACT FROM AUTHOR]

Caffeine is an alkaloid with a purine structure and has been well known for centuries due to its presence in popular drinks—tea and coffee. However, the structural and spectroscopic parameters of this compound, as well as its chemical and biological activities, are still not fully known. In this study, for the first time, we report on the measured oxygen-17 NMR spectra of this stimulant. To support the assignment of our experimental NMR data, extensive quantum chemical calculations of NMR parameters, including nuclear magnetic shielding constants and indirect spin–spin coupling constants, were performed. In a theoretical study, using nine efficient density functionals (B3LYP, BLYP, BP86, CAM-B3LYP, LC-BLYP, M06, PBE0, TPSSh, wB97x), and in combination with a large and flexible correlation-consistent aug-cc-pVTZ basis set, the structure and NMR parameters were predicted for a free molecule of caffeine and in chloroform, DMSO and water. A polarized continuum model (PCM) was used to include a solvent effect. As a result, an optimal methodology was developed for predicting reliable NMR data, suitable for studies of known, as well as newly discovered, purines and similar alkaloids. The results of the current work could be used in future basic and applied studies, including NMR identification and intermolecular interactions of caffeine in various raw materials, like plants and food, as well as in the structural and spectroscopic characterization of new compounds with similar structures. [ABSTRACT FROM AUTHOR]

We report direct measurements of the magnetic field screening at the limits of the Meissner phase for two superconducting niobium (Nb) samples. The samples are processed with two different surface treatments that have been developed for superconducting radio-frequency (SRF) cavity applications—a "baseline" treatment and an oxygen-doping ("O-doping") treatment. The measurements show: (1) that the screening length is significantly longer in the "O-doping" sample compared to the "baseline" sample; (2) that the screening length near the limits of the Meissner phase increases with applied field; (3) the evolution of the screening profile as the material transitions from the Meissner phase to the mixed phase; and (4) a demonstration of the absence of any screening profile for the highest applied field, indicative of the full flux entering the sample. Measurements are performed utilizing the β -detected nuclear magnetic resonance (β -NMR) technique that allows depth resolved studies of the local magnetic field within the first 100 nm of the surface. The study takes advantage of the β -SRF beamline, a new facility at TRIUMF, Canada, where field levels up to 200 mT are available parallel to the sample surface to replicate radio frequency fields near the Meissner breakdown limits of Nb. [ABSTRACT FROM AUTHOR]

Magnetoencephalography (MEG) systems are advanced neuroimaging tools used to measure the magnetic fields produced by neuronal activity in the human brain. However, they require significant amounts of liquid helium to keep the superconducting quantum interference device (SQUID) sensors in a stable superconducting state. Additionally, MEG systems must be installed in a magnetically shielded room to minimize interference from external magnetic fields. We have developed an advanced MEG system that incorporates a superconducting magnetic shield and a zero-boil-off system. This system overcomes the typical limitations of traditional MEG systems, such as the frequent need for liquid helium refills and the spatial constraints imposed by magnetically shielded rooms. To validate the system, we conducted an evaluation using signal source estimation. This involved a phantom with 50 current sources of known location and magnitude under active zero-boil-off conditions. Our evaluations focused on the precision of the magnetic field distribution and the quantification of estimation errors. We achieved a consistent magnetic field distribution that matched the source current, maintaining an estimation error margin within 3.5 mm, regardless of the frequency of the signal source current. These findings affirm the practicality and efficacy of the system. [ABSTRACT FROM AUTHOR]

Emerging miniaturized optically pumped magnetometers (OPMs) are becoming one of the most desirable approaches for biomagnetic imaging, especially for OPM with elliptically polarized light, which promises single‐light optical pumping and detection with high sensitivity. However, conventional schemes of this kind require a set of bulk polarization optics and tedious adjustment procedures, which compromise the system's compactness and practicality. In this paper, a novel chip‐scale OPM scheme that leverages the monolithic elliptical meta‐polarizer is presented and experimentally demonstrated. The meta‐polarizer with a side length of 3 mm is laid out on a 2 × 2 cm2 glass wafer. It offers the capability to convert arbitrary incident polarization into the desired elliptical polarization and exhibits a tailorable elliptical dichroism (ED) of ≈0.77 at the wavelength of 795 nm. A 4 × 4 × 4 mm3 vapor cell containing 87Rb and N2 is combined with this elliptical meta‐polarizer to construct a miniaturized OPM. The sensitivity of this sensor reaches approximately 13 fT/Hz1/2 in a four‐layer magnetic shield with a dynamic range near zero magnetic field ≈ ±0.55 nT. By exploiting the advantages of planar integrated optics, reduced footprints and scalability are promised. And this work paves the way for the integration of emerging quantum sensors on a chip. [ABSTRACT FROM AUTHOR]

Simple Summary: The effects of magnetic fields on health and disease have been subject to considerable research interest for the past few decades but still remain relatively poorly understood. Therefore, the identification of molecular and cellular pathways affected is of considerable importance. This study investigated the effects of very low magnetic field (LMF) exposure in a cellular model of prostate cancer (PCa), the second most common cancer diagnosed in men. Extracellular vesicles (EVs) are lipid structures released from and taken up by cells and play crucial roles in cell communication and in processes such as cancer spread via their protein and nucleic acid cargoes. Short-term (4 h) LMF exposure significantly altered the release profiles and protein content of EVs from PCa cells to a more pro-cancerous profile. We then investigated changes in several key micro-RNAs, which are regulators of cancer behaviour and indicators of cancer aggressiveness and metastasis. LMF exposure caused significant upregulation of three key oncogenic miRNAs (miR-155, miR-21, and miR-210) and significant downregulation of two key tumour-suppressive miRNAs (miR-126 and miR-200c) in the PCa cells. These changes were also associated with a significant increase in the cancer cells' invasion capability, which is a key indicator of cancer aggressiveness. We further verified the metastatic ability of the cancer cells caused by the LMF exposure by assessing two metastasis-related proteins, matrix metalloproteinases MMP2 and MMP9, which both were significantly increased. We compared these findings with normal prostate cells, which showed fewer changes in response to LMF exposure. Our findings suggest that LMF exposure may promote a more aggressive cancer phenotype by modulating key molecular and cellular pathways, highlighting the potential therapeutic implications of magnetic field modulation in cancer treatment. Prostate cancer is the second most common neoplasia and fifth-leading cause of cancer death in men worldwide. Electromagnetic and magnetic fields have been classified as possible human carcinogens, but current understanding of molecular and cellular pathways involved is very limited. Effects due to extremely low magnetic/hypomagnetic fields (LMF) are furthermore poorly understood. Extracellular vesicles (EVs) are crucial mediators of cellular communication with multifaceted roles in cancer progression, including via transport and uptake of various protein and microRNA (miRNA) EV-cargoes. miRNAs regulate gene expression and are implicated in cancer-related processes such as proliferation, metastasis, and chemoresistance. This study investigated the effects of LMF exposure (20 nT) by magnetic shielding on the prostate cancer cell line PC3 compared to the prostate epithelial cell line PNT2 under short-term (4 h) conditions. We examined EV profiles following a 4 h LMF exposure alongside associated functional enrichment KEGG and GO pathways for the EV proteomes. The 4 h LMF exposure significantly reduced cellular EV release and modified PC3 EV cargoes to a more inflammatory and metastatic profile, with 16 Disease Pathways and 95 Human Phenotypes associated specifically with the LMF-treated PC3 EV proteomes. These included cancerous, metabolic, blood, skin, cardiac and skeletal Disease Pathways, as well as pain and developmental disorders. In the normal PNT2 cells, less EV protein cargo was observed following LMF exposure compared with cells not exposed to LMF, and fewer associated functional enrichment pathways were identified. This pointed to some differences in various cellular functions, ageing, defence responses, oxidative stress, and disease phenotypes, including respiratory, digestive, immune, and developmental pathways. Furthermore, we analysed alterations in matrix metalloproteinases (MMPs) and miRNAs linked to metastasis, as this is crucial in cancer aggressiveness. The 4 h LMF exposure caused a significant increase in MMP2 and MMP9, as well as in onco-miRs miR-155, miR-210, miR-21, but a significant reduction in tumour-suppressor miRs (miR-200c and miR-126) in the metastatic PC3 cells, compared with normal PNT2 cells. In addition, 4 h LMF exposure significantly induced cellular invasion of PC3 cells. Overall, our findings suggest that changes in magnetic field exposures modulate EV-mediated and miR-regulatory processes in PCa metastasis, providing a basis for exploring novel therapeutic strategies. [ABSTRACT FROM AUTHOR]

Background: MR‐integrated proton therapy is under development. It consists of the unique challenge of integrating a proton pencil beam scanning (PBS) beam line nozzle with an magnetic resonance imaging (MRI) scanner. The magnetic interaction between these two components is deemed high risk as the MR images can be degraded if there is cross‐talk during beam delivery and image acquisition. Purpose: To create and benchmark a self‐consistent proton PBS nozzle model for empowering the next stages of MR‐integrated proton therapy development, namely exploring and de‐risking complete integrated prototype system designs including magnetic shielding of the PBS nozzle. Materials and Methods: Magnetic field (COMSOL Multiphysics${\text{Multiphysics}}$) and radiation transport (Geant4) models of a proton PBS nozzle located at OncoRay (Dresden, Germany) were developed according to the manufacturers specifications. Geant4 simulations of the PBS process were performed by using magnetic field data generated by the COMSOL Multiphysics${\text{Multiphysics}}$ simulations. In total 315 spots were simulated which consisted of a 40×30cm2$40\times 30\,{\text{cm}}^{2}$ scan pattern with 5 cm spot spacings and for proton energies of 70, 100, 150, 200, and 220 MeV. Analysis of the simulated deflection at the beam isocenter plane was performed to determine the self‐consistency of the model. The magnetic fringe field from a sub selection of 24 of the 315 spot simulations were directly compared with high precision magnetometer measurements. These focused on the maximum scanning setting of ±$\pm$ 20 cm beam deflection as generated from the second scanning magnet in the PBS for a proton beam energy of 220 MeV. Locations along the beam line central axis (CAX) were measured at beam isocenter and downstream of 22, 47, 72, 97, and 122 cm. Horizontal off‐axis positions were measured at 22 cm downstream of isocenter (±$\pm$ 50, ±$\pm$ 100, and ±$\pm$ 150 cm from CAX). Results: The proton PBS simulations had good spatial agreement to the theoretical values in all 315 spots examined at the beam line isocenter plane (0–2.9 mm differences or within 1.5 % of the local spot deflection amount). Careful analysis of the experimental measurements were able to isolate the changes in magnetic fields due solely to the scanning magnet contribution, and showed 1.9 ±$\pm$ 1.2 μT$\bf{\mu} {\text{T}}$–9.4 ±$\pm$ 1.2 μT$\bf{\mu} {\text{T}}$ changes over the range of measurement locations. Direct comparison with the equivalent simulations matched within the measurement apparatus and setup uncertainty in all but one measurement point. Conclusions: For the first time a robust, accurate and self‐consistent model of a proton PBS nozzle assembly has been created and successfully benchmarked for the purposes of advancing MR‐integrated proton therapy research. The model will enable confidence in further simulation based work on fully integrated designs including MRI scanners and PBS nozzle magnetic shielding in order to de‐risk and realize the full potential of MR‐integrated proton therapy. [ABSTRACT FROM AUTHOR]

The structure and 1H NMR chemical shifts of a new structural analogue of endogenous thyronamines, 4-[4-(2-aminoethoxy)benzyl]aniline, have been simulated in the framework of the density functional theory. The molecular geometry of the title compound has been optimized at the B3LYP level of theory using 6-31G(d,p), 6-31+G(d,p), and 6-311G(d,p) basis sets both for the isolated molecule and including solvent effect. The 1H NMR chemical shifts of 4-[4-(2-aminoethoxy)benzyl]aniline have been estimated on the basis of magnetic shielding constants calculated by the GIAO method. In the calculations of both optimal molecular geometry and magnetic shielding constants, nonspecific solvation with dimethyl sulfoxide and methanol was considered in terms of the polarizable continuum model (IEFPCM). Linear correlations have been found between the theoretical and experimental chemical shifts of 4-[4-(2-aminoethoxy)benzyl]aniline in methanol-d4 and DMSO-d6. [ABSTRACT FROM AUTHOR]

Tropomyosin kinase receptor B (TrkB) has been explored as a therapeutic target for neurological and psychiatric disorders. However, the development of TrkB agonists was hindered by our poor understanding of the TrkB agonist binding location and affinity (both affect the regulation of disorder types). This motivated us to develop a combined computational and experimental approach to study TrkB binders. First, we developed a docking method to simulate the binding affinity of TrkB and binders identified by our magnetic drug screening platform from Gotu kola extracts. The Fred Docking scores from the docking computation showed strong agreement with the experimental results. Subsequently, using this screening platform, we identified a list of compounds from the NIH clinical collection library and applied the same docking studies. From the Fred Docking scores, we selected two compounds for TrkB activation tests. Interestingly, the ability of the compounds to increase dendritic arborization in hippocampal neurons matched well with the computational results. Finally, we performed a detailed binding analysis of the top candidates and compared them with the best-characterized TrkB agonist, 7,8-dyhydroxyflavon. The screening platform directly identifies TrkB binders, and the computational approach allows for the quick selection of top candidates with potential biological activities based on the docking scores. [ABSTRACT FROM AUTHOR]

Thanks to their lightweight, composite materials have become widely used in the automotive and aerospace industries. The design of components made from these materials is carried out by numerical modeling which can sometimes be tedious because of the need to take into account the internal structure of these materials. Obtaining the effective properties of an equivalent homogeneous material to replace the composite in our numerical models makes modeling easier. Classical homogenization approaches are not always suitable to obtain these effective properties. This article deals with an inverse problem that consists in computing the electromagnetic properties from the knowledge of the magnetic shielding effectiveness values. For different composite samples, an artificial neural network method is used to predict the effective conductivities from the magnetic shielding effectiveness measurements. The magnetic shielding effectiveness values computed from the predicted conductivities are close to those obtained from the measurements. [ABSTRACT FROM AUTHOR]

In this article, a magnetic shield for automotive Wireless Power Transfer (WPT) systems is proposed. Its innovative feature consists in the positioning of the shield, that is part of the Ground Assembly (GA) of the WPT system. Passive coils, assembled in an array-like structure to build the shields properly located near the transmitting coils are investigated. Currently, there are a variety of shielding methods, each of them with its peculiar feature. The proposed method is simple and does not increase the transmitting and the receiving coil sizes, a constraint that is often critical from a practical and an economical point of view. The main characteristic of the proposed shielding method is the location of the shielding coils on the same level as the GA. The results here presented are validated by Finite Element (FE) based simulations and are referred to an experimental prototype of wireless charging systems for electric vehicles operating at 85 kHz with a transmitted nominal power of 3.3 kW. The results show that the proposed shield reduces the leakage magnetic flux density in the system up to 37% with a marginal impact on the transmission efficiency, complying the SAE J2954 international standard. [ABSTRACT FROM AUTHOR]

We developed and implemented a method-independent, fully numerical, finite difference approach to calculating nuclear magnetic resonance shieldings, using gauge-including atomic orbitals. The resulting capability can be used to explore non-standard methods, given only the energy as a function of finite-applied magnetic fields and nuclear spins. For example, standard second-order Møller-Plesset theory (MP2) has well-known efficacy for 1H and 13C shieldings and known limitations for other nuclei such as 15N and 17O. It is, therefore, interesting to seek methods that offer good accuracy for 15N and 17O shieldings without greatly increased compute costs, as well as exploring whether such methods can further improve 1H and 13C shieldings. Using a small molecule test set of 28 species, we assessed two alternatives: κ regularized MP2 (κ-MP2), which provides energy-dependent damping of large amplitudes, and MP2.X, which includes a variable fraction, X, of third-order correlation (MP3). The aug-cc-pVTZ basis was used, and coupled cluster with singles and doubles and perturbative triples [CCSD(T)] results were taken as reference values. Our κ-MP2 results reveal significant improvements over MP2 for 13C and 15N, with the optimal κ value being element-specific. κ-MP2 with κ = 2 offers a 30% rms error reduction over MP2. For 15N, κ-MP2 with κ = 1.1 provides a 90% error reduction vs MP2 and a 60% error reduction vs CCSD. On the other hand, MP2.X with a scaling factor of 0.6 outperformed CCSD for all heavy nuclei. These results can be understood as providing renormalization of doubles amplitudes to partially account for neglected triple and higher substitutions and offer promising opportunities for future applications. [ABSTRACT FROM AUTHOR]

Decades of research have shown that magnetocardiography (MCG) has the potential to improve cardiac care decisions. However, sensor and system limitations have prevented its widespread adoption in clinical practice. We report an MCG system built around an array of scalar, optically pumped magnetometers (OPMs) that effectively rejects ambient magnetic interference without magnetic shielding. We successfully used this system, in conjunction with custom hardware and noise rejection algorithms, to record magneto-cardiograms and functional magnetic field maps from 30 volunteers in a regular downtown office environment. This demonstrates the technical feasibility of deploying our device architecture at the point-of-care, a key step in making MCG usable in real-world settings. [ABSTRACT FROM AUTHOR]

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal-dominant disorder caused by a heterozygous germline mutation in the fumarate hydratase (FH) gene. HLRCC is clinically characterized by the development of three tumors: uterine leiomyomata, cutaneous leiomyomata, and renal cell carcinoma (RCC). HLRCC-associated RCC is aggressive and diagnosed at a much earlier age than sporadic RCC. It is essential for carriers of HLRCC to undergo annual renal screening by magnetic resonance imaging to detect early stage RCCs. Metastatic HLRCC-associated RCC must be treated by systemic therapy; however, it is unclear which medicines are most effective in treating this cancer owing to its low incidence rate. Immune checkpoint inhibitor (ICI) combinations or ICIs plus tyrosine kinase inhibitors are administered as systemic therapy for clear cell RCC. Here, we report a patient with HLRCC-associated RCC treated with sequential therapy, including ipilimumab plus nivolumab combination and cabozantinib, after diagnosis of HLRCC-associated RCC using FoundationOne Liquid CDx and single-site analysis. We also investigated familial FH mutations and describe a new family pedigree for HLRCC. [ABSTRACT FROM AUTHOR]