7 results on '"Magno, Jose Pedrito M."'
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2. Microbiota Associated With Cholesteatoma Tissue in Chronic Suppurative Otitis Media
- Author
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Frank, Daniel N., primary, Magno, Jose Pedrito M., additional, Velasco, Karen Joyce S., additional, Bootpetch, Tori C., additional, Salud, Jacob Ephraim D., additional, David, Kevin Jer V., additional, Miller, Aaron L., additional, Yee, Eljohn C., additional, Dulnuan, Heather P., additional, Pyles, Richard B., additional, Lacuata, Jan Alexeis C., additional, Arbizo, Jeric L., additional, Kofonow, Jennifer M., additional, Guce, Beatrice, additional, Mendoza, Kevin Michael D., additional, Robertson, Charles E., additional, Ilustre, Gabriel Martin S., additional, Chiong, Alessandra Nadine E., additional, Lu, Shi-Long, additional, Tongol, Erik A., additional, Sacayan, Nicole D., additional, Yarza, Talitha Karisse L., additional, Chiong, Charlotte M., additional, and Santos-Cortez, Regie Lyn P., additional
- Published
- 2022
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- View/download PDF
3. Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants
- Author
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Frank, Daniel N., primary, Giese, Arnaud P. J., additional, Hafren, Lena, additional, Bootpetch, Tori C., additional, Yarza, Talitha Karisse L., additional, Steritz, Matthew J., additional, Pedro, Melquiadesa, additional, Labra, Patrick John, additional, Daly, Kathleen A., additional, Tantoco, Ma. Leah C., additional, Szeremeta, Wasyl, additional, Reyes-Quintos, Maria Rina T., additional, Ahankoob, Niaz, additional, Llanes, Erasmo Gonzalo d.V., additional, Pine, Harold S., additional, Yousaf, Sairah, additional, Ir, Diana, additional, Einarsdottir, Elisabet, additional, de la Cruz, Rhodieleen Anne R., additional, Lee, Nanette R., additional, Nonato, Rachelle Marie A., additional, Robertson, Charles E., additional, Ong, Kimberly Mae C., additional, Magno, Jose Pedrito M., additional, Chiong, Alessandra Nadine E., additional, Espiritu-Chiong, Ma. Carmina, additional, San Agustin, Maria Luz, additional, Cruz, Teresa Luisa G., additional, Abes, Generoso T., additional, Bamshad, Michael J., additional, Cutiongco-de la Paz, Eva Maria, additional, Kere, Juha, additional, Nickerson, Deborah A., additional, Mohlke, Karen L., additional, Riazuddin, Saima, additional, Chan, Abner, additional, Mattila, Petri S., additional, Leal, Suzanne M., additional, Ryan, Allen F., additional, Ahmed, Zubair M., additional, Chonmaitree, Tasnee, additional, Sale, Michele M., additional, Chiong, Charlotte M., additional, and Santos-Cortez, Regie Lyn P., additional
- Published
- 2020
- Full Text
- View/download PDF
4. Follicular Dendritic Cell Sarcoma of the Tonsil: A Multimodality Approach
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King, Rich Ericson C., primary, Villaruel, Andrea R., additional, Magno, Jose Pedrito M., additional, de Guzman, Sean Patrick C., additional, Catedral, Lance Isidore G., additional, Mondragon, Karen Anjela M., additional, Ting, Frederic Ivan L., additional, Velasco, Rogelio N., additional, and Fernando, Gracieux Y., additional
- Published
- 2020
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5. A2ML1and otitis media: novel variants, differential expression, and relevant pathways
- Author
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Larson, Eric D., primary, Magno, Jose Pedrito M., additional, Steritz, Matthew J., additional, Llanes, Erasmo Gonzalo d.V., additional, Cardwell, Jonathan, additional, Pedro, Melquiadesa, additional, Roberts, Tori Bootpetch, additional, Einarsdottir, Elisabet, additional, Rosanes, Rose Anne Q., additional, Greenlee, Christopher, additional, Santos, Rachel Ann P., additional, Yousaf, Ayesha, additional, Streubel, Sven‐Olrik, additional, Santos, Aileen Trinidad R., additional, Ruiz, Amanda G., additional, Lagrana‐Villagracia, Sheryl Mae, additional, Ray, Dylan, additional, Yarza, Talitha Karisse L., additional, Scholes, Melissa A., additional, Anderson, Catherine B., additional, Acharya, Anushree, additional, , University of Washington Center for, additional, Gubbels, Samuel P., additional, Bamshad, Michael J., additional, Cass, Stephen P., additional, Lee, Nanette R., additional, Shaikh, Rehan S., additional, Nickerson, Deborah A., additional, Mohlke, Karen L., additional, Prager, Jeremy D., additional, Cruz, Teresa Luisa G., additional, Yoon, Patricia J., additional, Abes, Generoso T., additional, Schwartz, David A., additional, Chan, Abner L., additional, Wine, Todd M., additional, Cutiongco‐de la Paz, Eva Maria, additional, Friedman, Norman, additional, Kechris, Katerina, additional, Kere, Juha, additional, Leal, Suzanne M., additional, Yang, Ivana V., additional, Patel, Janak A., additional, Tantoco, Ma. Leah C., additional, Riazuddin, Saima, additional, Chan, Kenny H., additional, Mattila, Petri S., additional, Reyes‐Quintos, Maria Rina T., additional, Ahmed, Zubair M., additional, Jenkins, Herman A., additional, Chonmaitree, Tasnee, additional, Hafrén, Lena, additional, Chiong, Charlotte M., additional, and Santos‐Cortez, Regie Lyn P., additional
- Published
- 2019
- Full Text
- View/download PDF
6. Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5variants
- Author
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Frank, Daniel N., Giese, Arnaud P. J., Hafren, Lena, Bootpetch, Tori C., Yarza, Talitha Karisse L., Steritz, Matthew J., Pedro, Melquiadesa, Labra, Patrick John, Daly, Kathleen A., Tantoco, Ma. Leah C., Szeremeta, Wasyl, Reyes-Quintos, Maria Rina T., Ahankoob, Niaz, Llanes, Erasmo Gonzalo d.V., Pine, Harold S., Yousaf, Sairah, Ir, Diana, Einarsdottir, Elisabet, de la Cruz, Rhodieleen Anne R., Lee, Nanette R., Nonato, Rachelle Marie A., Robertson, Charles E., Ong, Kimberly Mae C., Magno, Jose Pedrito M., Chiong, Alessandra Nadine E., Espiritu-Chiong, Ma. Carmina, San Agustin, Maria Luz, Cruz, Teresa Luisa G., Abes, Generoso T., Bamshad, Michael J., Cutiongco-de la Paz, Eva Maria, Kere, Juha, Nickerson, Deborah A., Mohlke, Karen L., Riazuddin, Saima, Chan, Abner, Mattila, Petri S., Leal, Suzanne M., Ryan, Allen F., Ahmed, Zubair M., Chonmaitree, Tasnee, Sale, Michele M., Chiong, Charlotte M., and Santos-Cortez, Regie Lyn P.
- Abstract
BackgroundOtitis media (OM) susceptibility has significant heritability; however, the role of rare variants in OM is mostly unknown. Our goal is to identify novel rare variants that confer OM susceptibility.MethodsWe performed exome and Sanger sequencing of >1000 DNA samples from 551 multiethnic families with OM and unrelated individuals, RNA-sequencing and microbiome sequencing and analyses of swabs from the outer ear, middle ear, nasopharynx and oral cavity. We also examined protein localisation and gene expression in infected and healthy middle ear tissues.ResultsA large, intermarried pedigree that includes 81 OM-affected and 53 unaffected individuals cosegregates two known rare A2ML1variants, a common FUT2variant and a rare, novel pathogenic variant c.1682A>G (p.Glu561Gly) within SPINK5(LOD=4.09). Carriage of the SPINK5missense variant resulted in increased relative abundance of Microbacteriaceae in the middle ear, along with occurrence of Microbacteriaceae in the outer ear and oral cavity but not the nasopharynx. Eight additional novel SPINK5variants were identified in 12 families and individuals with OM. A role for SPINK5in OM susceptibility is further supported by lower RNA counts in variant carriers, strong SPINK5 localisation in outer ear skin, faint localisation to middle ear mucosa and eardrum and increased SPINK5expression in human cholesteatoma.ConclusionSPINK5variants confer susceptibility to non-syndromic OM. These variants potentially contribute to middle ear pathology through breakdown of mucosal and epithelial barriers, immunodeficiency such as poor vaccination response, alteration of head and neck microbiota and facilitation of entry of opportunistic pathogens into the middle ear.
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- 2021
- Full Text
- View/download PDF
7. A2ML1 and otitis media: novel variants, differential expression, and relevant pathways.
- Author
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Larson, Eric D., Magno, Jose Pedrito M., Steritz, Matthew J., Llanes, Erasmo Gonzalo d.V., Cardwell, Jonathan, Pedro, Melquiadesa, Roberts, Tori Bootpetch, Einarsdottir, Elisabet, Rosanes, Rose Anne Q., Greenlee, Christopher, Santos, Rachel Ann P., Yousaf, Ayesha, Streubel, Sven‐Olrik, Santos, Aileen Trinidad R., Ruiz, Amanda G., Lagrana‐Villagracia, Sheryl Mae, Ray, Dylan, Yarza, Talitha Karisse L., Scholes, Melissa A., and Anderson, Catherine B.
- Abstract
A genetic basis for otitis media is established, however, the role of rare variants in disease etiology is largely unknown. Previously a duplication variant within A2ML1 was identified as a significant risk factor for otitis media in an indigenous Filipino population and in US children. In this report exome and Sanger sequencing was performed using DNA samples from the indigenous Filipino population, Filipino cochlear implantees, US probands, Finnish, and Pakistani families with otitis media. Sixteen novel, damaging A2ML1 variants identified in otitis media patients were rare or low‐frequency in population‐matched controls. In the indigenous population, both gingivitis and A2ML1 variants including the known duplication variant and the novel splice variant c.4061 + 1 G>C were independently associated with otitis media. Sequencing of salivary RNA samples from indigenous Filipinos demonstrated lower A2ML1 expression according to the carriage of A2ML1 variants. Sequencing of additional salivary RNA samples from US patients with otitis media revealed differentially expressed genes that are highly correlated with A2ML1 expression levels. In particular, RND3 is upregulated in both A2ML1 variant carriers and high‐A2ML1 expressors. These findings support a role for A2ML1 in keratinocyte differentiation within the middle ear as part of otitis media pathology and the potential application of ROCK inhibition in otitis media. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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