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Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. Here we show that signaling from the chemokine receptor CCR7 leads to activation of WNK1 and its downstream pathway at the leading edge of migrating CD4 + T cells, resulting in ion influx and water entry by osmosis. We propose that WNK1-induced water entry is required to swell the membrane at the leading edge, generating space into which actin filaments can polymerize, thereby facilitating forward movement of the cell. Given the broad expression of WNK1 pathway proteins, our study suggests that ion and water influx are likely to be essential for migration in many cell types, including leukocytes and metastatic tumor cells., (© 2023. The Author(s).)

Most of the previous work on hybrid transmit and receive beamforming focused on narrowband channels. Because the millimeter wave channels are expected to be wideband, it is crucial to propose efficient solutions for frequency-selective channels. In this regard, this paper proposes an iterative analog-digital multi-user equalizer scheme for the uplink of wideband millimeter-wave massive multiple-input-multiple-output (MIMO) systems. By iterative equalizer we mean that both analog and digital parts are updated using as input the estimates obtained at the previous iteration. The proposed iterative analog-digital multi-user equalizer is designed by minimizing the sum of the mean square error of the data estimates over the subcarriers. We assume that the analog part is fixed for all subcarriers while the digital part is computed on a per subcarrier basis. Due to the complexity of the resulting optimization problem, a sequential approach is proposed to compute the analog phase shifters values for each radio frequency (RF) chain. We also derive an accurate, semi-analytical approach for obtaining the bit error rate (BER) of the proposed hybrid system. The proposed solution is compared with other hybrid equalizer schemes, recently designed for wideband millimeter-wave (mmWave) massive MIMO systems. The simulation results show that the performance of the developed analog-digital multi-user equalizer is close to full-digital counterpart and outperforms the previous hybrid approach., Competing Interests: The authors declare no conflict of interest.