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8. Validity and Repeatability of Single-Sensor Loadsol Insoles during Landing

Author

Peebles, Alexander T., Maguire, Lindsay A., Renner, Kristen E., Queen, Robin M., Peebles, Alexander T., Maguire, Lindsay A., Renner, Kristen E., and Queen, Robin M.

Abstract

Clinically feasible methods for quantifying landing kinetics could help identify patients at risk for secondary anterior cruciate ligament injuries. The purpose of this study was to evaluate the validity and between-day repeatability of the loadsol insole during a single-hop and bilateral stop-jump. Thirty healthy recreational athletes completed seven single-hops and seven stop-jumps while simultaneous loadsol (100 Hz) and force plate (1920 Hz) measurements were recorded. Peak impact force, loading rate, and impulse were computed for the dominant limb, and limb symmetry was calculated between limbs for each measure. All outcomes were compared between the loadsol and force plate using intraclass correlation coefficients (ICC) and Bland–Altman plots. Fifteen participants completed a second day of testing to assess between-day repeatability of the loadsol. Finally, an additional 14 participants completed the first day of testing only to assess the validity of the newest generation loadsol, which sampled at 200 Hz. At 100 Hz, validity ICC results were moderate to excellent (0.686–0.982), and repeatability ICC results were moderate to excellent (0.616–0.928). The 200 Hz loadsol demonstrated improved validity ICC (0.765–0.987). Bland–Altman plots revealed that the loadsol underestimated load measures. However, this bias was not observed for symmetry outcomes. The loadsol device is a valid and repeatable tool for evaluating kinetics during landing.

Published
2018
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9. Validity and Repeatability of Single-Sensor Loadsol Insoles during Landing

Author

Biomedical Engineering and Mechanics, Fralin Biomedical Research Institute, Peebles, Alexander T., Maguire, Lindsay A., Renner, Kristen E., Queen, Robin M., Biomedical Engineering and Mechanics, Fralin Biomedical Research Institute, Peebles, Alexander T., Maguire, Lindsay A., Renner, Kristen E., and Queen, Robin M.

Abstract

Clinically feasible methods for quantifying landing kinetics could help identify patients at risk for secondary anterior cruciate ligament injuries. The purpose of this study was to evaluate the validity and between-day repeatability of the loadsol insole during a single-hop and bilateral stop-jump. Thirty healthy recreational athletes completed seven single-hops and seven stop-jumps while simultaneous loadsol (100 Hz) and force plate (1920 Hz) measurements were recorded. Peak impact force, loading rate, and impulse were computed for the dominant limb, and limb symmetry was calculated between limbs for each measure. All outcomes were compared between the loadsol and force plate using intraclass correlation coefficients (ICC) and Bland–Altman plots. Fifteen participants completed a second day of testing to assess between-day repeatability of the loadsol. Finally, an additional 14 participants completed the first day of testing only to assess the validity of the newest generation loadsol, which sampled at 200 Hz. At 100 Hz, validity ICC results were moderate to excellent (0.686–0.982), and repeatability ICC results were moderate to excellent (0.616–0.928). The 200 Hz loadsol demonstrated improved validity ICC (0.765–0.987). Bland–Altman plots revealed that the loadsol underestimated load measures. However, this bias was not observed for symmetry outcomes. The loadsol device is a valid and repeatable tool for evaluating kinetics during landing.

Published
2018

11. Comparison of the cytotoxic effects of ??-sitosterol oxides and a cholesterol oxide, 7??-hydroxycholesterol, in cultured mammalian cells.

Author

Maguire, Lindsay, Konoplyannikov, Mikhail, Ford, Alan, Maguire, Anita R., and O'Brien, Nora M.

Abstract

Phytosterols are plant sterols found in foods such as oils, nuts and vegetables. Phytosterols, in the same way as cholesterol, contain a double bond and are susceptible to oxidation. The objective of the present study was to assess the potential toxic effects of ??-sitosterol oxides on U937 cells. The effects of increasing concentrations (0-120 ??M) of ??-sitosterol oxides on cellular cytotoxicity, apoptosis, anti-oxidant status and genotoxicity was assessed over 12, 24 and 48h exposure periods. Following 12h, the viability of cells treated with 120 ??M-??-sitosterol oxides was reduced to 51??7% relative to control. At 24 and 48 h, both 60 and 120 ??M-??-sitosterol oxides caused a significant decrease in cell viability. For comparison, a decrease in viability of cells treated with a cholesterol oxide, 7??-hydroxycholesterol (7??-OH, 30 ??M), was evident at 24 h. An increase in apoptotic cells, assessed using Hoechst 33342, indicates that the mode of cell death in U937 cells following exposure to 7??-OH (30 ??M) and ??-sitosterol oxides (60 and 120 ??M) was by apoptosis. The increase in apoptotic cells after 12h following treatment with 120 ??M-??-sitosterol oxides was accompanied by a decrease in cellular glutathione. Similarly, 7??-OH (30 ??M) treatment resulted in decreased glutathione at 12 h. Catalase activity was not affected by any of the treatments. ??-Sitosterol oxides had no genotoxic effects on U937 and V79 cells as assessed by the comet and sister chromatid exchange assays respectively. In general, the results indicate that thermally oxidised derivatives of ??-sitosterol demonstrate similar biological effects as 7??-OH in U937 cells, but at higher concentrations. [ABSTRACT FROM PUBLISHER]

Published
2003
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12. Downstairs on the Dot.

Author

Maguire, Cheryl, Maguire, Lindsay, and Naumburg, Carla

Subjects
PUNCTUALITY, BREAKFASTS, CHILD psychology, ELECTRONIC equipment, CHILD behavior
Published
2019

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