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Bright print images help any product on the shelf stand out, attract the consumer, and add a unique value to the product. This research work is to empirically identify significant factors and optimize printing press parameters like press speed (x1: 5000, 7000, and 9000 sheets per hour), ink viscosity (x2: 15, 25, 35 Pa·s), and blanket rubber hardness (x3: 65, 70 and 75 shore A) to achieve prints with rich chroma yet with low dot gain in the lithography process, the most economical and widely used process today in the field of label and packaging industry. The parameters used during the printing process can affect the physical dot gain and the color of printed images. To study this, measurements were taken of the dot gain (y1) and color (measured in terms of lightness (y2) and chroma (y3)) at three different dot areas - highlight (25 %), middle tone (50 %), and shadow (75 %). Box-Behnken Design was used to test fifteen different print conditions. The second-order polynomial model's fit quality was good concerning the responses. The optimum printing machine conditions determined to minimize dot gain and lightness and maximize chroma were a press speed of 5000 sheets per hour, 30 Pa·s ink viscosity, and blanket rubber having 70 A shore hardness. The optimized values agreed with the predicted responses were acceptable, considering the right balance of minimum dot gain, higher chroma, and lower lightness to give the vibrant yet controlled halftone dot area in print production. [ABSTRACT FROM AUTHOR]

Genetic associations involving both rare and common alleles have been reported for schizophrenia but there have been no systematic scans for rare recessive genotypes using fully phased trio data. Here, we use exome sequencing in 604 schizophrenia proband-parent trios to investigate the role of recessive (homozygous or compound heterozygous) nonsynonymous genotypes in the disorder. The burden of recessive genotypes was not significantly increased in probands at either a genome-wide level or in any individual gene after adjustment for multiple testing. At a system level, probands had an excess of nonsynonymous compound heterozygous genotypes (minor allele frequency, MAF ⩽ 1%) in voltage-gated sodium channels (VGSCs; eight in probands and none in parents, P = 1.5 × 10(-)(4)). Previous findings of multiple de novo loss-of-function mutations in this gene family, particularly SCN2A, in autism and intellectual disability provide biological and genetic plausibility for this finding. Pointing further to the involvement of VGSCs in schizophrenia, we found that these genes were enriched for nonsynonymous mutations (MAF ⩽ 0.1%) in cases genotyped using an exome array, (5585 schizophrenia cases and 8103 controls), and that in the trios data, synaptic proteins interacting with VGSCs were also enriched for both compound heterozygosity (P = 0.018) and de novo mutations (P = 0.04). However, we were unable to replicate the specific association with compound heterozygosity at VGSCs in an independent sample of Taiwanese schizophrenia trios (N = 614). We conclude that recessive genotypes do not appear to make a substantial contribution to schizophrenia at a genome-wide level. Although multiple lines of evidence, including several from this study, suggest that rare mutations in VGSCs contribute to the disorder, in the absence of replication of the original findings regarding compound heterozygosity, this conclusion requires evaluation in a larger sample of trios.

A key component of genetic architecture is the allelic spectrum influencing trait variability. For autism spectrum disorder (herein termed autism), the nature of the allelic spectrum is uncertain. Individual risk-associated genes have been identified from

Hyaline fibromatosis syndrome (HFS) is rare autosomal recessive disease characterized by the deposition of amorphous hyaline material in skin and visceral organs. It represents a disease spectrum with infantile systemic hyalinosis (ISH) being the severe form and juvenile hyaline fibromatosis (JHF) being the mild form. Dermatologic manifestations include thickened skin, perianal nodules, and facial papules, gingival hyperplasia, large subcutaneous tumors on the scalp, hyperpigmented plaques over the metacarpophalangeal joints and malleoli, and joint contractures. ISH shows a severe visceral involvement, recurrent infections, and early death. We report a case of 2.5-year-old female patient who presented with HFS who had overlapping features of both ISH and JHF. To the best of our knowledge, very few cases of HFS have been reported in Indian literature till date.

In this paper, miniaturized tri-band Circularly Polarized (CP) staired Rectangular Dielectric Resonator Antenna (RDRA) using novel design feed network of trisection Wilkinson Power Divider (WPD) with wideband 900 phase shifter is developed for navigation satellite applications at L5-band (1.164 to 1.188 GHz), L1- band (1.565 to 1.585 GHz) and S-band (2.48 to 2.5 GHz). For tri-band RDRA, the ground plane size is reduced to 40 mm x 40 mm at lower resonance frequency of 1.176 GHz using high dielectric constant (er = 51.92) of dielectric resonator material and dielectric substrate (es = 10.2) (Rogers RO3210). Ground plane area and volume of RDRA are achieved small compared to published research works. Circular polarization of tri-band RDRA produces in L5-, L1- and Sband using novel design feed network trisection WPD with wideband 900 phase shifter. Far field radiation patterns of tri-band RDRA are obtained from electric field distribution of TEy111, TEy113 and TEy112 modes at center frequencies of 1.176 GHz, 1.575 GHz and 2.49 GHz, respectively. Simulated Return Loss (RL) of triband RDRA is achieved to be more than 10 dB over L5-, L1- and S-bands. The simulated peak Right Hand Circular Polarization (RHCP) gain is varying between 0.92 to 2.3 dB over all bands. Simulated Axial Ratio (AR) is obtained to be lower than 3 dB overall band. Tri-band RDRA is analyzed, fabricated and tested. Various parameters such as RL, RHCP-LHCP (Left Hand Circular Polarization) far field radiation patterns, RHCP gain and AR of tri-band DRA are obtained simultaneously over L5, L1 and Sbands as per design technical specifications that's novel contribution. [ABSTRACT FROM AUTHOR]