93 results on '"Mahesh Kumar Goenka"'
Search Results
2. Endoscopic Ultrasound-Guided Celiac Plexus Block Can Be a Useful Procedure for Pain Relief in Chronic Pancreatitis When Used Selectively
- Author
-
Nikhil Sonthalia, Vikram Patil, Awanish Tewari, Akash Roy, and Mahesh Kumar Goenka
- Subjects
endoscopic ultrasound-guided celiac plexus block/neurolysis ,management of pain in chronic pancreatitis ,celiac ganglion ,celiac plexus neurolysis ,endotherapy in chronic pancreatitis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and Objectives: Endoscopic ultrasound (EUS)-guided celiac plexus block (CPB) for pain relief in chronic pancreatitis (CP) has wide variation in results as reported in the literature. The objective was to find out the efficacy of EUS-CPB in painful CP from our region where phenotype of CP is different from West and to find out factors favoring response to EUS-CPB.
- Published
- 2023
- Full Text
- View/download PDF
3. A prospective study of fully covered self-expandable metal stents for refractory benign pancreatic duct strictures
- Author
-
Bhavik Bharat Shah, Gajanan Ashokrao Rodge, Usha Goenka, Shivaraj Afzalpurkar, and Mahesh Kumar Goenka
- Subjects
efficacy ,feasibility ,fully covered self-expanding metal stents ,refractory pancreatic duct strictures ,safety ,Internal medicine ,RC31-1245 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aims Fully covered self-expanding metal stents (FCSEMSs) are a relatively novel option for treating painful main pancreatic duct refractory strictures in patients with chronic pancreatitis. Herein, we aimed to assess the efficacy, feasibility, and safety of FCSEMSs in this patient group. Methods This prospective single-center study included patients who underwent endoscopic retrograde pancreatography with FCSEMS placement. The primary endpoints were the technical and clinical success rates. A reduction in visual analog scale pain score of >50% compared with that before stent placement was defined as clinical success. Secondary endpoints were resolution of pancreatic strictures on fluoroscopy during endoscopic retrograde pancreatography and the development of stent-related adverse events. Results Thirty-six patients were included in the analysis. The technical success rate was 100% (n=36) and the clinical success rate was 86.1% (n=31). There was a significant increase in stricture diameter from 1.7 mm to 3.5 mm (p
- Published
- 2022
- Full Text
- View/download PDF
4. Endovascular management of massive hemoptysis due to covid-19 related pulmonary artery pseudoaneurysm: A rare entity
- Author
-
Surabhi Jajodia, MD, Usha Goenka, MD, FACG, Debraj Jash, MD, DM, Indrajeet Tiwary, DA, MD, and Mahesh Kumar Goenka, MD, DM
- Subjects
Pulmonary artery pseudoaneurysms ,COVID-19 pneumonia ,Cavitating pneumonia ,Hemoptysis ,Embolization ,Coils ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Pulmonary artery pseudoaneurysms are rare causes of massive hemoptysis, even less common in setting of COVID-19 pneumonia. We describe and discuss an index case of cavitating COVID-19 pneumonia complicated by a pulmonary artery pseudoaneurysm without concomitant pulmonary thromboembolism. The patient presented with severe hemoptysis and was managed by endovascular coil embolization. Good technical and clinical success was achieved with complete resolution of hemoptysis.
- Published
- 2021
- Full Text
- View/download PDF
5. COVID‐19 vaccine‐associated myositis – a case report
- Author
-
Ponnu Bose, Usha Goenka, Saibal Moitra, Sanjib Majumdar, Mahesh Kumar Goenka, and Srijita Ghosh Sen
- Subjects
adverse effect ,case report ,COVID‐19 vaccine ,vaccine‐associated myositis ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Myositis is one of the uncommon adverse events following COVID‐19 vaccination, and its mechanism is still unclear. A strong clinical suspicion and further evaluation are important not only for early diagnosis and management but also for better understanding of the unprecedented effects of this novel vaccine. We present a case of myositis following the first dose of the ChAdOx1 nCoV‐19 Corona Virus Vaccine, evidenced by serology and MRI.
- Published
- 2022
- Full Text
- View/download PDF
6. Endoscopic ultrasonography-guided rendezvous technique for removal of a long biliary ascariasis: a challenging case
- Author
-
Nikhil Sonthalia, MD, DM, Gajanan Ashokrao Rodge, MD, Bhavik Bharat Shah, MD, DNB, Vikram Patil, MD, and Mahesh Kumar Goenka, MD, DM, FACG, FASGE
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2021
- Full Text
- View/download PDF
7. Obscure gastrointestinal bleeding
- Author
-
Shivaraj Afzalpurkar and Mahesh Kumar Goenka
- Subjects
capsule endoscopy ,enteroscopy ,obscure ,overt ,small bowel bleeding ,Medicine - Abstract
The term “obscure gastrointestinal (GI) bleeding” is often replaced by “small bowel bleeding” by some authors. It accounts to 5%–10% of overall GI bleeding. We need to suspect obscure or small bowel bleeding when no source of bleeding is identified during routine standard endoscopy and colonoscopy. Video capsule endoscopy (VCE), balloon enteroscopy, spiral enteroscopy, etc., are some of the advances in small bowel evaluation that have improved the ability to detect the source of bleeding. The common causes in patients with 40 or more years of age are Angioectasia, Dieulafoy's lesions, Nonsteroidal anti-inflammatory drug-induced ulcers, and neoplasm. Black tarry stools with characteristic smell (melena) and/or passing of red blood from rectum (hematochezia) is the most common presentation. Routine performance of second look endoscopy is not always a cost-effective approach. The current available evidence is sufficient to suggest VCE as the first endoscopic investigation in diagnosis of obscure GI bleeding. In routine clinical practice the double balloon enteroscopy, single balloon enteroscopy, and spiral enteroscopy are the three different armamentariums available for evaluating small bowel. Motorized spiral enteroscopy (power spiral) is the new addition to it. Patients in whom the source of bleeding is not identified after appropriate small bowel evaluation should be initially managed conservatively with oral or intravenous iron therapy (strong recommendation). Medical management with iron supplements, somatostatin analogs, or antiangiogenic treatment should be administered to the patients with persistent and recurrent bleeding. The evaluation of small bowel in patients with obscure GI bleeding is a challenging task. There is a huge data on each of the modality involved in investigating small bowel. Systematic review of the topic is need of the hour to help understand the concept of diagnosis and management of obscure GI bleeding.
- Published
- 2021
- Full Text
- View/download PDF
8. Noninvasive assessment of nonalcoholic fatty liver disease
- Author
-
Gajanan A Rodge and Mahesh Kumar Goenka
- Subjects
nafld ,hepatic steatosis ,liver fibrosis ,noninvasive assessment ,Medicine - Abstract
Nonalcoholic fatty liver disease (NAFLD) is ongoing pandemic of the 21st century. The noninvasive assessment includes serum biomarkers, predictive models, and imaging modalities. The “Steato test,” “NAFLD liver fat score,” and “Fatty liver index” are models developed for noninvasive assessment of hepatic steatosis. Out of the imaging modalities, magnetic resonance imaging proton density fat fraction is the most sensitive test to detect hepatic steatosis. Out of the various serum biomarkers to detect nonalcoholic steatohepatitis (NASH), cytokeratin-18 has been the most widely investigated. Recent approach for the diagnosis of NASH has targeted research toward genetic biomarkers such as PNPLA3 and microRNAs. However, none of the presently available biomarkers or imaging modalities are able to differentiate simple hepatic steatosis from NASH with a high sensitivity and specificity. Different models have been developed to predict fibrosis which are aspartate transaminase (AST)/platelet ratio index (APRI), fibrosis-4 (Fib-4) index, nonalcoholic fatty liver disease fibrosis (NFS) score and body mass index, AST: Alanine transaminase Ratio, diabetes (BARD) score. The accuracy of BARD, APRI, FIB-4, and NFS to detect advanced liver fibrosis was found to be of 0.76, 0.77, 0.84, and 0.84, respectively, in a large meta-analysis. Transient elastography, acoustic radiation force impulse, and magnetic resonance elastography (MRE) are imaging techniques available to detect liver fibrosis. MRE has shown to have a pooled accuracy 0.96 to detect advanced fibrosis in NAFLD patients. Noninvasive tests may not completely replace liver biopsy, but it may help to avoid it where probability of fibrosis is low.
- Published
- 2021
- Full Text
- View/download PDF
9. Endoscopic Management with a Novel Over-The-Scope Padlock Clip System
- Author
-
Mahesh Kumar Goenka, Gajanan Ashokrao Rodge, and Indrajeet Kumar Tiwary
- Subjects
endoscopic management ,gastrointestinal hemorrhages ,novel over-the-scope clip ,over-the-scope clip ,padlock ,Internal medicine ,RC31-1245 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aims: The Padlock clip is a recently introduced over-the-scope clip (OTSC) that requires the use of an alternate technique and has a different design from previous OTSCs. However, data regarding its clinical use are limited. The aim of this study is to present our clinical experience using this novel Padlock clip system. Methods: Between September 2018 and June 2019, 7 consecutive patients underwent Padlock clip application at our center by an experienced endoscopist. A Padlock clip was used for achieving hemostasis in 4 patients presenting with gastrointestinal (GI) bleeding, as well as for endoscopic full-thickness resection in the remaining 3 patients. Results: All 7 patients achieved technical as well as clinical success, with absence of complications or rebleeding, during a follow-up of a minimum of 3 weeks. All patients were hospitalized post procedure for a minimum of 48 hours, and an absence of adverse events was noted in our patient population throughout the procedure and post-procedure period. Antiplatelet therapy was reinstated shortly after the application of the Padlock clip, with no GI bleeding observed. Conclusions: The Padlock clip is a novel OTSC, with benefits that include safe, simple, and rapid deployment. Antiplatelet therapy may be reinstated for patients, when necessary, shortly after applying the Padlock clip due to full-thickness closure of the tissue.
- Published
- 2019
- Full Text
- View/download PDF
10. Difficult Biliary Cannulation for Intradiverticular Papilla: Forceps Technique Revisited
- Author
-
Mahesh Kumar Goenka, Gajanan Ashokrao Rodge, Bhavik Bharat Shah, and Shivaraj Afzalpurkar
- Subjects
periampullary diverticula ,ercp ,two-devices in one-channel method ,difficult biliary cannulation ,Surgery ,RD1-811 - Abstract
Periampullary diverticula (PAD) have been encountered in 5.9 to 18.5% of patients during all the endoscopic retrograde cholangiopancreatography (ERCP). Cannulation in the presence of PAD can sometimes be difficult, time consuming, and often requires a higher level of endoscopic skills. Several techniques have been reported to facilitate and increase the chances of successful bile duct cannulation in the presence of PAD. The two-devices in one-channel method has been sparingly used. It involves the simultaneous use of a biopsy forceps and another instrument, either a cannula or sphincterotome through the same working channel. We successfully performed ERCP in three cases, where bile duct cannulation was performed in the setting of intradiverticular papilla using two-devices in one-channel method. We feel that the two-devices in one-channel method can be very useful and positioned higher up in the algorithm for successful cannulation in patients with PAD.
- Published
- 2021
- Full Text
- View/download PDF
11. Oral Sulfate Solution versus Polyethylene Glycol as a Single-Day Preparation for Colonoscopy: A Randomized Control Trial
- Author
-
Bhavik Bharat Shah, Bubun Patel, and Mahesh Kumar Goenka
- Subjects
colonoscopy preparation ,oral sulfate solution ,polyethylene glycol ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background Colonoscopy is a principal diagnostic tool for most colonic disorders. Adequate bowel preparation is essential for proper visualization of the mucosa. The aim of this study was to compare the tolerability, efficacy, and safety profile of 1 L of oral sulfate solution (OSS) in comparison to 2 L of polyethylene glycol (PEG) solution. Methods In this single-center prospective study conducted at our institute, patients were randomly assigned to receive either OSS or PEG solutions for colonoscopy preparation. Patients enrolled in either group completed a questionnaire assessing the taste of the solution used, adverse effects, and number of stools passed. Grading of the bowel cleansing quality was done as per Boston Bowel Preparation (BBP) score. Results Total of 400 patients, with 222 patients in the PEG group and 178 patients in the OSS group, were assessed. In the PEG group, 148 (66.75%) patients were males and in the OSS group 112 (62.9%) patients were males. There was no statistical significance on comparison of the taste as “good” or “bad” in both groups. All the adverse events were mild to moderate in intensity and their frequencies were comparable for both the groups. The OSS group had better bowel preparation as per the BBP score (p = 0.021) and lesser cecal intubation time (p = 0.028). Conclusion The present study demonstrated that 1 L of OSS is better than the well-established 2 L PEG solution, in terms of bowel preparation and shorter time to cecal intubation.
- Published
- 2019
- Full Text
- View/download PDF
12. Mucosal Changes in the Small Intestines in Portal Hypertension: First Study Using the Pillcam SB3 Capsule Endoscopy System
- Author
-
Mahesh Kumar Goenka, Bhavik Bharat Shah, Vijay Kumar Rai, Surabhi Jajodia, and Usha Goenka
- Subjects
Capsule endoscopy ,Intestine, small ,Hypertension, portal ,Cirrhosis ,PillCam SB3 ,Internal medicine ,RC31-1245 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aims To evaluate patients with portal hypertension (PH) of varied etiologies for portal hypertensive enteropathy (PHE) using the PillCam SB3 capsule endoscopy (CE) system. Methods Consecutive patients with PH presenting with unexplained anemia and/or occult gastrointestinal bleeding were evaluated using the PillCam SB3 CE system. Abnormal findings were categorized as vascular or non-vascular. The patients with ongoing bleeding caused by PHE were treated. The correlation of the CE scores of PHE with the clinical, laboratory, and endoscopic features was determined. Results Of the 43 patients included in the study, 41 (95.3%) showed PHE findings. These included varices (67.4%), red spots (60.5%), erythema (44.2%), villous edema (46.5%), telangiectasia (16.3%), and polyps (16.3%). The CE scores varied from 0 to 8 (mean±standard deviation, 4.09±1.8). Five patients (11.6%) showed evidence of ongoing or recent bleeding due to PHE. Three of these five patients underwent endotherapy, and one patient underwent radiological coil placement. Conclusions The PillCam SB3 CE system revealed a high prevalence of PHE in the patients with PH. Using this system, evidence of bleeding due to PHE was found in a small but definite proportion of the patients.
- Published
- 2018
- Full Text
- View/download PDF
13. Routine Screening before Endoscopic Procedures: A Systematic Review
- Author
-
Gajanan Ashokrao Rodge and Mahesh Kumar Goenka
- Subjects
coagulation screening ,endoscopic retrograde cholangiopancreatography endoscopic procedure ,routine laboratory testing ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Routine screening prior to endoscopic procedures includes ordering a panel of tests on all patients undergoing endoscopic procedures without seeking any history and physical examination of the patients. These laboratory testing increases the cost burden on the patient but can have a strong impact on complications after endoscopic procedures. Selective preoperative tests (i.e., tests ordered after consideration of careful history taking and physical examination) may assist in making decisions about the process of perioperative assessment and management. We believe that the Society of Gastrointestinal Endoscopy of India should take initiative to draw its own position paper / guideline in view of the strong impact on cost and medico-legal issue in an Indian setting.
- Published
- 2018
- Full Text
- View/download PDF
14. Pancreatic Necrosectomy through Sinus Tract Endoscopy
- Author
-
Mahesh Kumar Goenka, Usha Goenka, Md.Yasin Mujoo, Indrajit Kumar Tiwary, Sanjay Mahawar, and Vijay Kumar Rai
- Subjects
Walled-off necrosis ,Pancreatitis, acute necrotizing ,Sinus tract endoscopy ,Necrosectomy ,Internal medicine ,RC31-1245 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aims Direct endoscopic pancreatic necrosectomy is increasingly being utilized to treat infected or symptomatic walled-off necrosis (WON) located close to the stomach or duodenum. Laterally-placed WON has traditionally been treated surgically. We evaluated a less utilized technique of sinus tract endoscopy (STE) for symptomatic laterally-placed WON. Methods Two hundred seventy-six patients with acute pancreatitis admitted in our hospital, 32 had symptomatic or infected WON requiring intervention. Of the 12 patients with laterally placed WON, 10 were treated by STE. STE was performed with a standard adult gastroscope passed through a percutaneous tract created by the placement of a 32-Fr drain. Results Ten patients (7 males; mean age, 43.8 years) underwent STE. Mean number of sessions was 2.3 (range, 1–4), with mean time of 70 minutes for each session (range, 15–70 minutes). While 9 patients had complete success, 1 patient had fever and chose to undergo surgery. Two patients developed pneumoperitoneum, which was treated conservatively. There was no mortality, cutaneous fistula, or recurrence during follow-up. Conclusions Laterally placed WON can be successfully managed by STE performed through a percutaneously placed drain. Details of the technique and end-points of STE require further evaluation.
- Published
- 2018
- Full Text
- View/download PDF
15. Best of the Best Articles of 2020
- Author
-
Mahesh Kumar Goenka and Shivaraj Afzalpurkar
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2021
- Full Text
- View/download PDF
16. Guest Editorial
- Author
-
Mahesh Kumar Goenka
- Subjects
Medicine - Published
- 2021
- Full Text
- View/download PDF
17. Endoscopic Management of Gastrointestinal Leaks and Bleeding with the Over-the-Scope Clip: A Prospective Study
- Author
-
Mahesh Kumar Goenka, Vijay Kumar Rai, Usha Goenka, and Indrajit Kumar Tiwary
- Subjects
Ovesco ,Over-the-scope clip ,Fistula closure ,Gastrointestinal hemorrhage ,Internal medicine ,RC31-1245 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aims The over-the-scope clip (OTSC) is a device used for endoscopic closure of perforations, leaks and fistulas, and for endoscopic hemostasis. To evaluate the clinical effectiveness and safety of OTSC. Methods Between October 2013 and November 2015, 12 patients underwent OTSC placement by an experienced endoscopist. OTSC was used for the closure of gastrointestinal (GI) leaks and fistula in six patients, three of which were iatrogenic (esophageal, gastric, and duodenal) and three of which were inflammatory. In six patients, OTSC was used for hemostasis of non-variceal upper GI bleeding. Endoscopic tattooing using India ink was used to assist the accurate placement of the clip. Results All subjects except one with a colonic defect experienced immediate technical success as well as long-term clinical success, during a mean follow-up of 6 weeks. Only one clip was required to close each of the GI defects and to achieve hemostasis in all patients. There were no misfirings or complications of clips. The procedure was well tolerated, and patients were hospitalized for an average of 8 days (range, 3 to 10). Antiplatelet therapy was continued in patients with GI bleeding. Conclusions In our experience, OTSC was safe and effective for the closure of GI defect and to achieve hemostasis of non-variceal GI bleeding.
- Published
- 2017
- Full Text
- View/download PDF
18. From Editor-In-Chief’s Desk
- Author
-
Mahesh Kumar Goenka
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2020
- Full Text
- View/download PDF
19. Migration of Pigtail Biliary Stent through Surface of the Left Lobe of Liver
- Author
-
Bhavik Bharat Shah, Usha Goenka, Debashish Banerjee, Vijay Rai, and Mahesh Kumar Goenka
- Subjects
hepatotomy ,left lobe of liver ,migration ,pigtail biliary stent ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
We report a rare case of a patient of choledocholithiasis who underwent CBD stone removal with pigtail biliary stenting four year back, presenting with proximal migration of stent piercing the left lobe of liver. The stent was removed at laparotomy, by doing hepatotomy. We discuss this unreported case of proximal migration of pigtail biliary stent through surface of left lobe of liver.
- Published
- 2018
- Full Text
- View/download PDF
20. Spectrum of upper gastrointestinal bleed: An experience from Eastern India
- Author
-
Md Nadeem Parvez, Mahesh Kumar Goenka, Indrajeet Kumar Tiwari, and Usha Goenka
- Subjects
clinical presentation ,etiology ,outcome ,upper gastrointestinal bleed ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aims: The etiology of upper gastrointestinal bleed (UGIB) is variable in different geographical regions. Epidemiological data are helpful in knowing the burden of the problem. This study was conducted to know the etiological spectrum, mortality, morbidity, and predictors of outcome in patients with acute UGIB. Materials and Methods: We retrospectively analyzed the data of patients admitted to our hospital between January 2013 and May 2015, with UGIB and noted the clinical presentation, etiology of bleed, and outcome. Results: A total of 337 patients [272 (80.7%) male, 65 (19.3%) female (male:female ratio: 4:1)] of UGIB were included in the study. The mean age of the patients was 55.11 ± 14.8 years (Range - 14–85 years). The most common etiology of UGIB was peptic ulcer (40.05%) followed by varices (33%). Majority of patients were managed medically. Endotherapy was required only in 33% patients. The mean duration of hospital stay was 6.6 ± 5.79 days. Rebleed was seen in 11 (3.2) patients and surgery was required in 6 (1.7%). In hospital, mortality was 2.6%. Age ≥65 years (odds ratio [OR]: 9.5, 95% confidence interval [CI]: 3.108–29.266), serum albumin 2 mg/dl (OR: 4.1, 95% CI: 1.068–8.591) were associated with increased mortality. Conclusions: Peptic ulcer disease is still the most common cause of UGIB. Majority of patients can be managed medically. Rebleed rate, need for surgery, and mortality due to UGIB are declining. Elderly age (>65), hypoalbuminemia serum albumin2) are important factors associated with increased mortality.
- Published
- 2016
- Full Text
- View/download PDF
21. Endoscopic Band Ligation for the Hemostasis of Active Esophageal Variceal Hemorrhage: Technique, Tips, and Tricks
- Author
-
Ashish Kumar Jha and Mahesh Kumar Goenka
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2019
- Full Text
- View/download PDF
22. Esophageal lichen planus: A rare and under-recognized disorder
- Author
-
Md Nadeem Parvez, Vijay Rai, Enam Mursheed Khan, and Mahesh Kumar Goenka
- Subjects
dysphagia ,esophageal lichen planus ,esophageal ulceration ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Lichen planus (LP) is a chronic idiopathic disorder involving the skin and mucosal surfaces. Although oral mucosal involvement is common, esophageal LP (ELP) is uncommon and also under-reported. Here, we present a case of ELP who was symptomatic with dysphagia for a year, but was untreated. Increasing awareness of this condition can help identify more cases and increase our understanding of this uncommon but interesting condition.
- Published
- 2016
- Full Text
- View/download PDF
23. Nanotechnology in gastrointestinal endoscopy: A primer
- Author
-
Ashish Kumar Jha, Mahesh Kumar Goenka, Sandeep Nijhawan, Ramesh Roop Rai, Usha Goenka, and Arya Suchismita
- Subjects
nanotechnology ,nanoparticles ,nanomaterials ,nanopowder ,hemospray ,nano-based capsule-endoscopy ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Nanotechnology is the understanding, control of matter and development of engineered devices in nanometer range (1-100 nm). Nanoparticles have different physicochemical properties (small size, large surface area to volume ratio, and high reactivity) in comparison to bulk materials of the same composition. The nanotechnology has proved its usefulness in early diagnosis, proteonomics, imaging diagnostics and multifunctional therapeutics. Recent studies have shown its role in early diagnosis and targeted therapy of various gastrointestinal disorders such as hepatitis B virus and hepatitis C virus related liver disease, inflammatory bowel disease, gastric ulcer, and malignancy. Application of this technology appears promising in diagnostic and therapeutic endoscopy such as the endoscopic hemostasis of peptic ulcer bleeding, prevention of clogging of plastic stent and advance capsule endoscopy. This article will highlight the basic concepts of nanotechnology and its potential application in gastrointestinal endoscopy.
- Published
- 2012
- Full Text
- View/download PDF
24. Endoscopic ultrasound coil placement of gastric varices: Emerging modality for recurrent bleeding gastric varices
- Author
-
Yogesh Harwani, Mahesh Kumar Goenka, Vijay Rai, and Usha Goenka
- Subjects
endoscopic ultrasound guided coil placement ,gastric varices ,variceal bleeding ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Gastric varices are the probable source of bleeding in 10-36% of patients, with acute variceal bleeding and carry high mortality and rebleeding rates. Till date, cyanoacrylate glue injection is considered as the standard of care but has high complication rate. Endoscopic ultrasound (EUS) guided coil placement is a new emerging technique of management of gastric varices. In this case report, we detail the EUS guided coil placement for management of gastric varices after failed glue injections.
- Published
- 2014
- Full Text
- View/download PDF
25. Transgastric migration of gossypiboma: A preventable complication
- Author
-
Mahesh Kumar Goenka, Ashish Kumar Jha, and Usha Goenka
- Subjects
endoscopy ,gossypiboma ,transgastric migration ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Gossypiboma is term given for retained piece of cotton/sponge during surgery. The incidence of gossypiboma has described as 1 in 1000-3000 surgeries. Incidence is underestimated because of underreporting due to fear of medico-legal litigation and extreme criticism by media. Intraluminal migration is a rare complication of gossypiboma. Small intestine is most common intraluminal site followed by duodenum. Here, we report sixth case of transgastric migration of gossypiboma.
- Published
- 2015
- Full Text
- View/download PDF
26. Focal intestinal lymphangiectasia: An unusual cause of acute overt obscure gastrointestinal bleeding
- Author
-
Ashish Kumar Jha, Ragesh Babu Thandassery, and Mahesh Kumar Goenka
- Subjects
acute overt obscure gastrointestinal bleeding ,capsule endoscopy ,focal lymphangiectasia ,intestinal lymphangiectasia ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Detection of bleeding lesion in a patient of acute overt obscure gastrointestinal bleeding is a real challenge. Recently, authors have showed superiority of urgent capsule endoscopy (CE) over angiography in patients with acute overt obscure gastrointestinal bleeding. Focal type of intestinal lymphangiectasia is a rare cause of acute gastrointestinal bleeding. Here, we describe a case of focal lymphangiectasia who presented to us with acute overt obscure gastrointestinal bleeding and diagnosed by urgent CE.
- Published
- 2014
- Full Text
- View/download PDF
27. Endoscopy in 2012
- Author
-
Ashish Kumar Jha, T. S. Chandrasekar, and Mahesh Kumar Goenka
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2012
- Full Text
- View/download PDF
28. Ileocolonic Intussusception: An uncommon Finding on Colonoscopy
- Author
-
Pranav Kumar Mandal, Usha Goenka, Pranav Kumar Mondal, Enam Murshed Khan, Madhuchanda Kar, and Mahesh Kumar Goenka
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2011
- Full Text
- View/download PDF
29. Kinetics of Covid-19 antibodies in terms of titre and duration among healthcare workers: A longitudinal study
- Author
-
MAHESH KUMAR GOENKA, USHA GOENKA, VIKRAM UTTAM PATIL, SUDIPTA SEKHAR DAS, SHIVARAJ AFZALPURKAR, SURABHI JAJODIA, MUHUYA MUKHERJEE, BHAVIK BHARAT SHAH, and SAIBAL MOITRA
- Subjects
General Medicine - Abstract
Background Most individuals with Covid-19 infection develop antibodies specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the dynamics of these antibodies is variable and not well-studied. We aimed to determine the titres of naturally acquired antibodies over a 12-week follow-up. Methods We recruited healthcare workers who had tested positive on a specific quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for SARS-CoV-2, and then tested for the presence of immunoglobulin G (IgG) antibody against the same virus at baseline and again at 6 and 12 weeks. The antibody titre was determined by a semi-quantitative assay based on signal/cut-off ratio. Healthcare workers with antibody positivity were divided into those with high titre (ratio ≥12) and low titre ( Results Of the 286 healthcare workers, 10.48% had high antibody titres. Healthcare workers who had tested positive by qRT-PCR and those who had received the Bacille Calmette–Guérin (BCG) vaccination or other immune-boosters had a higher frequency of high antibody titres. While there was a significant decline in antibody titres at 6 and 12 weeks, 87.46% of individuals positive for IgG antibody persisted to have the antibody even at 12 weeks. Conclusion Healthcare workers who tested positive for SARS-CoV-2 on qRT-PCR had a high positivity for the specific antibody, which continued to express in them even at 12 weeks. Further follow-up is likely to enhance our understanding of antibody kinetics following SARS-CoV-2 infection.
- Published
- 2023
30. Six Months Follow-Up Study on Health Care Workers on Persistence of Antibodies to SARS-CoV-2 after Covishield Vaccination
- Author
-
null Shinjini Chaudhuri, null Shivaraj Afzalpurkar, null Vikram Uttam Patil, null Gajanan Ashok Rodge, null Mohuya Mukherjee, null Surabhi Jajodia, null Usha Goenka, and null Mahesh Kumar Goenka
- Abstract
BACKGROUND Efficacy of COVID vaccines has been evaluated in various studies. The interim analysis from four randomized controlled trials in UK, Brazil, and south Africa regarding efficacy of two doses of the vaccine was found to be 70.4% (95·8% CI 54·8–80·6). There is a limited data on follow-up Ab titer post vaccination. Hence, the current study is first of its kind with the objective to determine vaccine long term efficacy and its determinants. METHODS Health Care Workers (HCW) from Apollo Multispeciality Hospitals, Kolkata who underwent Covishield vaccination from January 2021 to April 2021 were included in the study. Serological testing was done prior to first and second dose of vaccinations, and additionally around six months post second dose. RESULTS Between January 2021 to April 2021, 2032 HCW, with predominant age of less than 30 years (44.83%) and male gender (61.96%) undergoing Covishield vaccination were enrolled. Antibodies were detected in 953 (46.9%) individuals prior to first dose, 1449 out of 1495 (96.9%) remained positive prior to second dose and 465 out of 504 (92.3%) HCW after 6 months and remaining 39 (7.7%) either had lost or never had antibodies in their blood. The mean ± SD value of first, second and third antibodies were 2.35 ± 3.10, 10.46 ± 4.84 and 8.75 ± 4.88 respectively. CONCLUSIONS This study provides long observation period, covering the complete progress of the pandemic which provides a “real-life” picture of the antibody level dynamics over time, and after vaccination.
- Published
- 2022
31. Role of artificial intelligence–guided esophagogastroduodenoscopy in assessing the procedural completeness and quality
- Author
-
Mahesh Kumar Goenka, Shivaraj Afzalpurkar, Saurabh Jejurikar, Gajanan Ashokrao Rodge, and Awanish Tiwari
- Subjects
Gastroenterology - Published
- 2023
32. <scp>COVID</scp> ‐19 vaccine‐associated myositis – a case report
- Author
-
Ponnu Bose, Usha Goenka, Saibal Moitra, Sanjib Majumdar, Mahesh Kumar Goenka, and Srijita Ghosh Sen
- Subjects
General Medicine - Published
- 2022
33. COVID‐19 prevalence among health‐care workers of Gastroenterology department: An audit from a tertiary‐care hospital in India
- Author
-
Sudipto S Das, Syamasis Bandopadhyay, Vikram Patil, Ujjaini Khan, Mohuya Mukherjee, Shivaraj Afzalpurkar, Usha Goenka, Gajanan Ashokrao Rodge, Mahesh Kumar Goenka, Surabhi Jajodia, and Bhavik Bharat Shah
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,education ,gastroenterology ,Audit ,Disease ,RC799-869 ,03 medical and health sciences ,0302 clinical medicine ,COVID‐19 ,Health care ,medicine ,Medical history ,health‐care workers ,Hepatology ,business.industry ,seroassay ,Incidence (epidemiology) ,Original Articles ,Tertiary care hospital ,Diseases of the digestive system. Gastroenterology ,Gastroenterology department ,030220 oncology & carcinogenesis ,Emergency medicine ,Original Article ,030211 gastroenterology & hepatology ,business - Abstract
Background and Aim In the present coronavirus disease‐19 (COVID‐19) era, health‐care workers (HCWs) warrant special attention because of their higher risk and potential to transmit the disease. Gastroenterology services include emergency and critical care along with the endoscopy procedures, which have aerosol‐generating potential. This study was aimed at auditing the COVID‐19 impact on HCWs working in the Gastroenterology department of our hospital. Methods The COVID‐19 status of 117 HCWs was collected using either polymerase chain reaction (PCR) or Immunoglobulin G (IgG) seroassay. COVID‐19 positivity was correlated with demographic characteristics, job profile, area of work, and medical history. Results Thirty‐eight HCWs (32.48%) showed evidence of COVID‐19 using PCR (23.93%) or only IgG assay (8.55%). Endoscopy technicians (68.75%) exhibited significantly higher (P = 0.003) COVID‐19 incidence compared to doctors (20.69%). Those working in the critical care units exhibited a trend toward higher COVID‐19 incidence (42.86%). None of the six HCWs who received adequate hydroxychloroquine prophylaxis developed evidence of COVID‐19. All the HCWs with COVID‐19 disease recovered. However, there was a considerable loss of “man‐days.” Conclusions In our setting, we observed a high COVID‐19 risk for HCWs working in the Gastroenterology department, with the highest risk among the endoscopy technicians. A more stringent triaging and pretesting of patients, as well as HCWs, might decrease the risk of COVID‐19. Further multicenter studies are needed to evaluate the risk and related parameters., We observed high COVID‐19 risk in health‐care workers (HCWs) working in the gastroenterology department, with the highest risk among endoscopy technicians. A more stringent triaging and pretesting of patients, as well as HCWs, might decrease the risk of COVID‐19.
- Published
- 2021
34. Single-balloon enteroscopy in management of small-bowel disorders
- Author
-
Shivaraj Afzalpurkar, Gajanan Ashokrao Rodge, Vijay Kumar Rai, Rachit Agarwal, Bhavik Bharat Shah, Mahesh Kumar Goenka, Usha Goenka, and Bhageerath Raj
- Subjects
Adult ,Male ,Enteroscopy ,medicine.medical_specialty ,Adolescent ,Jejunal perforation ,law.invention ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Capsule endoscopy ,law ,Internal medicine ,Intestine, Small ,medicine ,Humans ,Aged ,Aged, 80 and over ,business.industry ,Gastroenterology ,Single-Balloon Enteroscopy ,Middle Aged ,Hepatology ,medicine.disease ,Surgery ,Intestinal Diseases ,Treatment Outcome ,Iron-deficiency anemia ,030220 oncology & carcinogenesis ,Unexplained abdominal pain ,Acute pancreatitis ,Female ,030211 gastroenterology & hepatology ,Safety ,business - Abstract
Device-assisted enteroscopy including single-balloon enteroscopy (SBE) allows direct visualization of the small bowel and has good safety and efficacy in experienced hands. Our study is aimed to share our single-centre experience of SBE in diagnosing and treating small-bowel disorders. We reviewed the prospectively collected data (from December 2016 to December 2019) of 180 consecutive anterograde and/or retrograde procedures. Analysis of baseline characteristics, endoscopic findings, and diagnostic and therapeutic rates was done. SBE was done in 158 patients with a median age of 55 years (range, 13–94 years) for suspected small-bowel lesions. Dual enteroscopy (anterograde plus retrograde) was done in 22 patients (13.92%). The indication for the procedure was obscure gastrointestinal bleeding in 129 (71.66%), chronic unexplained abdominal pain in 20 (11.11%), suspected small-bowel abnormality in the form of narrowing and/or mass on imaging in 10 (5.5%), chronic diarrhea in 9 (5%), unexplained iron deficiency anemia in 9 (5%), and retained capsule in 2 (1.11%). The most common finding was ulcer, which was noted in 45 (25%) patients followed by stricture in 8 (4.44%) and both ulcers and strictures in 6 (3.33%) patients. SBE was normal in 61 (33.88%) patients. SBE gave a diagnosis in 66.11% while in 28.43% cases, therapeutic intervention was done. Minor complications like bleeding were noted in 3 patients and mild acute pancreatitis in 2 patients. Jejunal perforation requiring surgical intervention was noted in 1 patient. SBE is a safe and effective procedure in diagnosing and treating small-bowel diseases.
- Published
- 2020
35. Correction: Flat-based over-the-scope clip-assisted endoscopic full-thickness resection of a duodenal neuroendocrine tumour: a safe alternative to endoscopic submucosal dissection
- Author
-
Nikhil Sonthalia, Bhavik Bharat Shah, and Mahesh Kumar Goenka
- Subjects
Gastroenterology - Published
- 2022
36. A rare peritoneal egg: Case report with literature review
- Author
-
Enam Murshed Khan, Mahesh Kumar Goenka, Shivaraj Afzalpurkar, Arpita Sutradhar, Usha Goenka, Vinay Mahendra, and Nilu Malpani Dhoot
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Abdominal pain ,medicine.medical_specialty ,Gastrointestinal ,lcsh:R895-920 ,Free floating ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,food ,medicine ,Radiology, Nuclear Medicine and imaging ,Fat necrosis ,Laparoscopy ,Pathological ,Pelvis ,Boiled egg ,medicine.diagnostic_test ,business.industry ,Emergency department ,medicine.disease ,food.food ,Surgery ,medicine.anatomical_structure ,Fibro collagenous tissue ,Abdomen ,Peritoneal body ,medicine.symptom ,Giant ,business ,030217 neurology & neurosurgery - Abstract
The occurrence of peritoneal loose bodies has been known for hundreds of years. Although rarely, they attain a diameter of more than 5 cm and are then named “giant” peritoneal bodies (gPLBs). Even these huge peritoneal bodies are generally symptom free, but may be linked with chronic symptoms like abdominal pain or discomfort. Many a times, these gPLBs are misinterpreted as intraabdominal tumors or foreign bodies and unnecessary surgical interventions are carried out. We report a rare case of a 75-year-old male, who presented to our tertiary care center emergency department with history of chronic intermittent abdominal discomfort with acute diarrhea and peri-anal pain. Contrast enhanced computed tomography of the abdomen and pelvis revealed round to oval mass in the pelvis measuring 6.2 cm × 5.8 cm. On laparoscopy, a hard, free floating object with the appearance of a boiled egg could just be scooped out from the pelvis. The postoperative pathological examination revealed laminated strands of hyalinized fibro collagenous tissue with central fat necrosis confirming the diagnosis of gPLB. Postoperative period was uneventful. Peritoneal bodies are rare intraabdominal bodies which are either detected incidentally or present with vague symptoms and require interdisciplinary management.
- Published
- 2020
37. A comprehensive review of vaccination in patients with inflammatory bowel diseases: An Indian perspective
- Author
-
Mahesh Kumar Goenka and Bhavik Bharat Shah
- Subjects
Male ,medicine.medical_treatment ,Vaccine recommendations ,Review Article ,Vaccine types ,Global Burden of Disease ,0302 clinical medicine ,Infection prevention ,Infection control ,Child ,Aged, 80 and over ,Vaccines ,Vaccination ,Gastroenterology ,Crohn disease ,Immunosuppression ,Biosimilar ,Middle Aged ,Ulcerative colitis ,030220 oncology & carcinogenesis ,Child, Preschool ,030211 gastroenterology & hepatology ,Female ,Immunosuppressive Agents ,Adult ,Risk ,medicine.medical_specialty ,Adolescent ,India ,Biologicals ,03 medical and health sciences ,Immunocompromised Host ,Young Adult ,Internal medicine ,Vaccine-Preventable Diseases ,medicine ,Humans ,Intensive care medicine ,Disease burden ,Aged ,Biosimilars ,business.industry ,Hepatology ,medicine.disease ,Inflammatory Bowel Diseases ,digestive system diseases ,Vaccination policy ,business - Abstract
The disease burden of inflammatory bowel diseases (IBD) in India is estimated to be one of the highest in the world in the near future. Patients with IBD, particularly those on immunosuppressive therapy, are at increased risk for developing vaccine-preventable illnesses. Adult vaccination policy and vaccination in patients with IBD are presently being at a very low level in India. This review discusses in detail the need for vaccination, levels of immunosuppression, a brief account of live and inactivated vaccines, available vaccines, and their utility in patients with IBD, with a special focus on recent recommendations.
- Published
- 2020
38. The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study
- Author
-
Haq Nawaz, Silvia C. Gutierrez, Luis F. Lara, Narcis O. Zarnescu, Bechien U. Wu, Pedram Paragomi, Rakesh Kochhar, Jose A Gonzalez, Shyam Thakkar, Somashekar G. Krishna, Samuel Han, Livia Archibugi, Carlos Ocampo, Gregory A. Cote, Georgios I. Papachristou, Enrique de-Madaria, Sorin T. Barbu, Jeffrey J. Easler, Alice Hinton, Vikesh K. Singh, Aiste Gulla, Ioannis Pothoulakis, Mario Pelaez-Luna, Tyler Stevens, Peter Lee, Mahesh Kumar Goenka, Konstantinos Triantafyllou, Rupjyoti Talukdar, and Miguel Ferreira Bogado
- Subjects
Male ,medicine.medical_specialty ,Severity of Illness Index ,Article ,Gee ,Severity ,Cohort Studies ,Acute Pancreatitis ,Interquartile range ,Internal medicine ,medicine ,Humans ,Disease Activity ,Generalized estimating equation ,Hepatology ,business.industry ,Gastroenterology ,Middle Aged ,medicine.disease ,PASS ,Confidence interval ,Systemic inflammatory response syndrome ,Pancreatitis ,ROC Curve ,Acute Disease ,Cohort ,Acute pancreatitis ,Female ,business - Abstract
BACKGROUND & AIMS: The aims of this study were to: (1) assess the performance of the Pancreatitis Activity Scoring System (PASS) in a large intercontinental cohort of patients with acute pancreatitis (AP); and (2) investigate whether a modified PASS (mPASS) yields a similar predictive accuracy and produces distinct early trajectories between severity subgroups. METHODS: Data was prospectively collected through the Acute Pancreatitis Patient Registry to Examine Novel Therapies In Clinical Experience (APPRENTICE) consortium (2015-2018) involving 22 centers from 4 continents. AP severity was categorized per the revised Atlanta classification. PASS trajectories were compared between the three severity groups using the generalized estimating equations model. Four mPASS models were generated by modifying the morphine equivalent dose (MED), and their trajectories were compared. RESULTS: A total of 1393 subjects were enrolled (median age, 49 years; 51% males). The study cohort included 950 mild (68.2%), 315 (22.6%) moderately severe, and 128 (9.2%) severe AP. Mild cases had the lowest PASS at each study time point (all P < .001). A subset of patients with outlier admission PASS values was identified. In the outlier group, 70% of the PASS variation was attributed to the MED, and 66% of these patients were from the United States centers. Among the 4 modified models, the mPASS-1 (excluding MED from PASS) demonstrated high performance in predicting severe AP with an area under the receiver operating characteristic curve of 0.88 (vs area under the receiver operating characteristic of 0.83 in conventional PASS) and produced distinct trajectories with distinct slopes between severity subgroups (all P < .001). CONCLUSION: We propose a modified model by removing the MED component, which is easier to calculate, predicts accurately severe AP, and maintains significantly distinct early trajectories.
- Published
- 2022
39. The Relationship Between Pre-existing Diabetes Mellitus and the Severity of Acute Pancreatitis: Report From a Large International Registry
- Author
-
Sorin T. Barbu, Peter Lee, Miguel Ferreira Bogado, Mahesh Kumar Goenka, Pedram Paragomi, Shyam Thakkar, Konstantinos Triantafyllou, Phil A. Hart, Carlos Ocampo, Georgios I. Papachristou, Dhiraj Yadav, Kwonho Jeong, Haq Nawaz, Rakesh Kochhar, Vikesh K. Singh, Rupjyoti Talukdar, Livia Archibugi, Ioannis Pothoulakis, Bechien U. Wu, Gregory A. Cote, Aiste Gulla, Tyler Stevens, Darwin L. Conwell, Mario Pelaez-Luna, Frederico G.S. Toledo, Alice Hinton, Enrique de-Madaria, Jose A Gonzalez, Narcis O. Zarnescu, Silvia C. Gutierrez, and Jeffrey J. Easler
- Subjects
Adult ,Male ,medicine.medical_specialty ,Etiology ,Endocrinology, Diabetes and Metabolism ,Severity of Illness Index ,Article ,law.invention ,law ,Diabetes mellitus ,Internal medicine ,medicine ,Prevalence ,Humans ,Registries ,Risk factor ,Mortality ,Aged ,Retrospective Studies ,Hepatology ,business.industry ,Confounding ,Diabetes ,Gastroenterology ,Middle Aged ,medicine.disease ,Intensive care unit ,Systemic Inflammatory Response Syndrome ,Systemic inflammatory response syndrome ,Hospitalization ,Diabetes Mellitus, Type 2 ,Pancreatitis ,Acute Disease ,Acute pancreatitis ,Female ,business - Abstract
BACKGROUND/OBJECTIVES: The relationship between pre-existing diabetes mellitus (DM) and acute pancreatitis (AP) severity has not been established. We assessed the impact of pre-existing DM on AP severity in an international, prospectively ascertained registry. METHODS: APPRENTICE registry prospectively enrolled 1543 AP patients from 22 centers across 4 continents (8 US, 6 Europe, 5 Latin America, 3 India) between 2015 and 2018, and collected detailed clinical information. Pre-existing DM was defined a diagnosis of DM prior to AP admission. The primary outcome was AP severity defined by the Revised Atlanta Classification (RAC). Secondary outcomes were development of systemic inflammatory response syndrome (SIRS) or intensive care unit (ICU) admission. RESULTS: Pre-existing DM was present in 270 (17.5%) AP patients, of whom 252 (93.3%) had type 2 DM. Patients with pre-existing DM were significantly (p
- Published
- 2021
40. Successful extraction of hepatic duct calculus using retrieval basket under cholangioscopic guidance
- Author
-
Mahesh Kumar, Goenka, Shivaraj, Afzalpurkar, Gajanan Ashokrao, Rodge, and Usha, Goenka
- Subjects
Biliary Tract Surgical Procedures ,Gastroenterology ,Humans ,Hepatic Duct, Common ,Gallstones ,Catheterization - Published
- 2022
41. A prospective study of fully covered self-expandable metal stents for refractory benign pancreatic duct strictures
- Author
-
Bhavik Bharat Shah, Gajanan Ashokrao Rodge, Usha Goenka, Shivaraj Afzalpurkar, and Mahesh Kumar Goenka
- Subjects
Gastroenterology ,Medicine (miscellaneous) ,Radiology, Nuclear Medicine and imaging - Abstract
Background/Aims: Fully covered self-expanding metal stents (FCSEMSs) are a relatively novel option for treating painful main pancreatic duct refractory strictures in patients with chronic pancreatitis. Herein, we aimed to assess the efficacy, feasibility, and safety of FCSEMSs in this patient group.Methods: This prospective single-center study included patients who underwent endoscopic retrograde pancreatography with FCSEMS placement. The primary endpoints were the technical and clinical success rates. A reduction in visual analog scale pain score of >50% compared with that before stent placement was defined as clinical success. Secondary endpoints were resolution of pancreatic strictures on fluoroscopy during endoscopic retrograde pancreatography and the development of stent-related adverse events.Results: Thirty-six patients were included in the analysis. The technical success rate was 100% (n=36) and the clinical success rate was 86.1% (n=31). There was a significant increase in stricture diameter from 1.7 mm to 3.5 mm (p
- Published
- 2021
42. Improvement of hepatic steatosis by Saroglitazar and Vitamin E in patients of Non Alcoholic Fatty Liver Disease (NAFLD) with metabolic risk factors: A prospective, comparative, observational study
- Author
-
Swayambhu Banerjee, Gajanan Rodge, Akash Roy, Usha Goenka, and Mahesh Kumar Goenka
- Subjects
Hepatology - Published
- 2022
43. Indian consensus on gastroesophageal reflux disease in adults: A position statement of the Indian Society of Gastroenterology
- Author
-
Randhir Sud, Jayanthi Venkataraman, SK Issar, Lorance Peter, Krishnadas Devadas, A V Siva Prasad, Rakesh Kochhar, Saurabh Kedia, Venkatakrishnan Leelakrishnan, Jose Filipe Alvares, Govind K. Makharia, SP Singh, Devinder Singh, Amarender Singh Puri, Ajay Kumar, Uday C Ghoshal, Naresh Bhat, Ajit Sood, Vandana Midha, Rohit Dama, L. Shimpi, Rajkumar T Wadhwa, Mahesh Kumar Goenka, Vineet Ahuja, Mohandas K. Mallath, Ajay Jain, Subhashchandra Nandwani, Philip Mathew, Amol Bapaye, Shobna Bhatia, Philip Abraham, Abhinav Jain, Praveen Mathew, Amit Kumar Dutta, Sunil Dadhich, D. Nageshwar Reddy, Cannanore Ganesh Pai, Binita Goswami, Jaswinder Singh Sodhi, Rakesh Kalapala, Usha Dutta, G Venkat Rao, and Vinod Kumar Dixit
- Subjects
Adult ,Male ,medicine.medical_specialty ,Consensus ,Population ,India ,Gastroenterology ,Helicobacter Infections ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Epidemiology ,Prevalence ,Esophagitis ,Humans ,Medicine ,education ,Societies, Medical ,education.field_of_study ,Helicobacter pylori ,medicine.diagnostic_test ,business.industry ,Proton Pump Inhibitors ,Guideline ,Hepatology ,medicine.disease ,humanities ,digestive system diseases ,Diet ,Histamine H2 Antagonists ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Gastroesophageal Reflux ,GERD ,Female ,030211 gastroenterology & hepatology ,Antacids ,business ,Esophageal pH monitoring ,Cohort study - Abstract
The Indian Society of Gastroenterology developed this evidence-based practice guideline for management of gastroesophageal reflux disease (GERD) in adults. A modified Delphi process was used to develop this consensus containing 58 statements, which were generated by electronic voting iteration as well as face-to-face meeting and review of the supporting literature primarily from India. These statements include 10 on epidemiology, 8 on clinical presentation, 10 on investigations, 23 on treatment (including medical, endoscopic, and surgical modalities), and 7 on complications of GERD. When the proportion of those who voted either to accept completely or with minor reservation was 80% or higher, the statement was regarded as accepted. The prevalence of GERD in India ranges from 7.6% to 30%, being
- Published
- 2019
44. A study on confocal endomicroscopy in comparison with histopathology for polypoidal lesions of the gastrointestinal tract: A prospective single-centre experience
- Author
-
Mahesh Kumar Goenka, Enam Murshed Khan, Parvez Ahmed Shah, Vijay Kumar Rai, and Bhavik Bharat Shah
- Subjects
Adult ,Male ,medicine.medical_specialty ,Gastrointestinal Diseases ,medicine.medical_treatment ,Concordance ,Sensitivity and Specificity ,Endoscopy, Gastrointestinal ,03 medical and health sciences ,Polyps ,0302 clinical medicine ,Predictive Value of Tests ,otorhinolaryngologic diseases ,Endomicroscopy ,Humans ,Medicine ,Prospective Studies ,Gastrointestinal Polyp ,Aged ,Microscopy, Confocal ,business.industry ,Stomach ,fungi ,Gastroenterology ,Histology ,Middle Aged ,Lipoma ,medicine.disease ,Polypectomy ,Gastrointestinal Tract ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Histopathology ,Radiology ,business - Abstract
Confocal laser endomicroscopy (CLE) has a potential to make optical diagnosis of neoplastic polypoidal lesions and may replace traditional histology in the proposed “diagnose and discard approach”. The present study was planned to assess the accuracy of probe-based CLE in predicting histology of polypoidal lesions of gastrointestinal (GI) tract in vivo before their removal. In this prospective single-centre study, patients with upper and/or lower GI polypoidal lesions were enrolled. After detection of polypoidal lesions with white light endoscopy, probe-based CLE examination was performed. Real-time and offline presumptive CLE diagnosis of polypoidal lesions was made as per Miami classification and was compared with histopathology as the gold standard. A total of 50 GI polyps from 50 patients (28 males) were assessed. The mean (±SD) size of polyps was 13.7 (± 8.5) mm. Most polyps were located at the cecum (24.0%) or stomach (24.0%). On histological examination, hyperplastic and adenomatous polyps, adenocarcinoma, and lipoma were seen in 54%, 26%, 18% and 2% patients, respectively. On comparison of real-time CLE examination with histopathology, 40 (83.3%) and 8 patients (16.7%) had concordant and discordant results, respectively. Two polyps were inconclusively diagnosed on CLE. On offline examination, concordance with histopathology was observed in 85.4% (n = 41) of polyps, which was marginally better than online examination, though the difference was not statistically significant (p = 0.45). On comparing the real-time and offline findings of CLE, concordance was found in 91.7% of the cases. Accuracy, sensitivity, specificity, positive and negative predictive values on real-time evaluation were 83.3%, 87.5%, 79.1%, 80.7%, and 86.3%, respectively. CLE is a useful tool for prediction of histology to assess the polypoidal lesions of the GI tract, and it may avoid polypectomy at least in some patients.
- Published
- 2019
45. Oral Sulfate Solution versus Polyethylene Glycol as a Single-Day Preparation for Colonoscopy: A Randomized Control Trial
- Author
-
Bubun Patel, Bhavik Bharat Shah, and Mahesh Kumar Goenka
- Subjects
medicine.medical_specialty ,Colonoscopy ,Polyethylene glycol ,Gastroenterology ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,colonoscopy preparation ,0302 clinical medicine ,Randomized controlled trial ,law ,Statistical significance ,Internal medicine ,oral sulfate solution ,PEG ratio ,Medicine ,lcsh:RC799-869 ,Prospective cohort study ,Adverse effect ,General Environmental Science ,medicine.diagnostic_test ,business.industry ,chemistry ,Tolerability ,030220 oncology & carcinogenesis ,polyethylene glycol ,030211 gastroenterology & hepatology ,lcsh:Diseases of the digestive system. Gastroenterology ,business - Abstract
Background Colonoscopy is a principal diagnostic tool for most colonic disorders. Adequate bowel preparation is essential for proper visualization of the mucosa. The aim of this study was to compare the tolerability, efficacy, and safety profile of 1 L of oral sulfate solution (OSS) in comparison to 2 L of polyethylene glycol (PEG) solution. Methods In this single-center prospective study conducted at our institute, patients were randomly assigned to receive either OSS or PEG solutions for colonoscopy preparation. Patients enrolled in either group completed a questionnaire assessing the taste of the solution used, adverse effects, and number of stools passed. Grading of the bowel cleansing quality was done as per Boston Bowel Preparation (BBP) score. Results Total of 400 patients, with 222 patients in the PEG group and 178 patients in the OSS group, were assessed. In the PEG group, 148 (66.75%) patients were males and in the OSS group 112 (62.9%) patients were males. There was no statistical significance on comparison of the taste as “good” or “bad” in both groups. All the adverse events were mild to moderate in intensity and their frequencies were comparable for both the groups. The OSS group had better bowel preparation as per the BBP score (p = 0.021) and lesser cecal intubation time (p = 0.028). Conclusion The present study demonstrated that 1 L of OSS is better than the well-established 2 L PEG solution, in terms of bowel preparation and shorter time to cecal intubation.
- Published
- 2019
46. Mucosal Changes in the Small Intestines in Portal Hypertension: First Study Using the Pillcam SB3 Capsule Endoscopy System
- Author
-
Vijay Kumar Rai, Usha Goenka, Bhavik Bharat Shah, Mahesh Kumar Goenka, and Surabhi Jajodia
- Subjects
medicine.medical_specialty ,Gastrointestinal bleeding ,lcsh:Internal medicine ,Cirrhosis ,Anemia ,Medicine (miscellaneous) ,Gastroenterology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Capsule endoscopy ,law ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Enteropathy ,Hypertension, portal ,lcsh:RC799-869 ,Telangiectasia ,lcsh:RC31-1245 ,business.industry ,medicine.disease ,PillCam SB3 ,Intestine, small ,030220 oncology & carcinogenesis ,Portal hypertension ,Original Article ,030211 gastroenterology & hepatology ,lcsh:Diseases of the digestive system. Gastroenterology ,medicine.symptom ,Varices ,business - Abstract
Background/Aims To evaluate patients with portal hypertension (PH) of varied etiologies for portal hypertensive enteropathy (PHE) using the PillCam SB3 capsule endoscopy (CE) system. Methods Consecutive patients with PH presenting with unexplained anemia and/or occult gastrointestinal bleeding were evaluated using the PillCam SB3 CE system. Abnormal findings were categorized as vascular or non-vascular. The patients with ongoing bleeding caused by PHE were treated. The correlation of the CE scores of PHE with the clinical, laboratory, and endoscopic features was determined. Results Of the 43 patients included in the study, 41 (95.3%) showed PHE findings. These included varices (67.4%), red spots (60.5%), erythema (44.2%), villous edema (46.5%), telangiectasia (16.3%), and polyps (16.3%). The CE scores varied from 0 to 8 (mean±standard deviation, 4.09±1.8). Five patients (11.6%) showed evidence of ongoing or recent bleeding due to PHE. Three of these five patients underwent endotherapy, and one patient underwent radiological coil placement. Conclusions The PillCam SB3 CE system revealed a high prevalence of PHE in the patients with PH. Using this system, evidence of bleeding due to PHE was found in a small but definite proportion of the patients.
- Published
- 2018
47. Indian consensus on chronic constipation in adults: A joint position statement of the Indian Motility and Functional Diseases Association and the Indian Society of Gastroenterology
- Author
-
Abhai Verma, Balakrishnan S. Ramakrishna, Omesh Goyal, Abhijit Chandra, Shivaram Prasad Singh, Naresh Bhat, V G Mohan Prasad, Sujit Chaudhuri, N. K. Anupama, Duvvuru Nageshwar Reddy, Jayanthi Venkataraman, Akash Shukla, Rajesh Sainani, T. Chandrasekar, Arun Karyampudi, Rajesh Upadhyay, Govind K. Makharia, Gautam Ray, Nitesh Pratap, Asha Misra, Ashok Gupta, Sanjeev Sachdeva, Shobna Bhatia, Maneesh Paliwal, Mahesh Kumar Goenka, Karmabir Chakravartty, S. Sadasivan, Philip Abraham, and Uday C Ghoshal
- Subjects
Adult ,Male ,medicine.medical_specialty ,Consensus ,Statement (logic) ,Functional gastrointestinal disorders ,media_common.quotation_subject ,education ,India ,Gastroenterology ,03 medical and health sciences ,Face-to-face ,Presentation ,0302 clinical medicine ,Internal medicine ,Epidemiology ,medicine ,Humans ,Association (psychology) ,Societies, Medical ,Irritable bowel syndrome ,Colon transit ,media_common ,Fecal evacuation disorder ,Chronic constipation ,Evidence-Based Medicine ,business.industry ,Bristol stool form ,Guideline ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,Chronic Disease ,Practice Guidelines as Topic ,Original Article ,Female ,030211 gastroenterology & hepatology ,business ,Constipation - Abstract
The Indian Motility and Functional Diseases Association and the Indian Society of Gastroenterology developed this evidence-based practice guideline for management of chronic constipation. A modified Delphi process was used to develop this consensus containing 29 statements, which were generated by electronic voting iteration as well as face to face meeting and review of the supporting literature primarily from India. These statements include 9 on epidemiology, clinical presentation, and diagnostic criteria; 8 on pathophysiology; and the remaining 12 on investigations and treatment. When the proportion of those who voted either to accept completely or with minor reservation was 80% or higher, the statement was regarded as accepted. The members of the consensus team believe that this would be useful for teaching, clinical practice, and research on chronic constipation in India and in other countries with similar spectrum of the disorders.
- Published
- 2018
48. Endoscopy in Small Bowel Diseases
- Author
-
Gajanan Ashokrao Rodge, Mahesh Kumar Goenka, and Usha Goenka
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine ,Radiology ,business ,Endoscopy - Published
- 2021
49. Introductory Chapter: Endoscopy in Small Bowel Diseases
- Author
-
Usha Goenka, Mahesh Kumar Goenka, and Gajanan Ashokrao Rodge
- Subjects
03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,medicine.diagnostic_test ,business.industry ,030220 oncology & carcinogenesis ,General surgery ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,medicine ,030211 gastroenterology & hepatology ,business ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Endoscopy - Published
- 2021
50. Author’s reply to comment on article: A single-centre experience on single balloon enteroscopy in management of small bowel disorders
- Author
-
Bhavik Bharat Shah, Shivaraj Afzalpurkar, Gajanan Ashokrao Rodge, Usha Goenka, and Mahesh Kumar Goenka
- Subjects
medicine.medical_specialty ,business.industry ,General surgery ,Gastroenterology ,MEDLINE ,Single-Balloon Enteroscopy ,Hepatology ,Intestinal Diseases ,Single centre ,Internal medicine ,Intestine, Small ,medicine ,Humans ,business - Published
- 2021
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.