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47 results on '"Mai, Stefania"'

1. Post-COVID-19 Condition

Author

Piterà, Paolo, Verme, Federica, Fontana, Jacopo Maria, Cattaldo, Stefania, Mai, Stefania, Capodaglio, Paolo, and Capodaglio, Paolo, editor

Published
2024
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2. Obesity

Author

Fontana, Jacopo Maria, Piterà, Paolo, Verme, Federica, Cremascoli, Riccardo, Brunani, Amelia, Cattaldo, Stefania, Mai, Stefania, Milesi, Alessandra, Bianchi, Laura, Galli, Federica, La Pilusa, Federica, Tiburzi, Francesca, Cancello, Raffaella, Capodaglio, Paolo, and Capodaglio, Paolo, editor

Published
2024
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3. Fibromyalgia

Author

Verme, Federica, Piterà, Paolo, Fontana, Jacopo Maria, Varallo, Giorgia, Scarpa, Alessandra, Cattaldo, Stefania, Mai, Stefania, Capodaglio, Paolo, and Capodaglio, Paolo, editor

Published
2024
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5. Effects of Melatonin on Exercise-Induced Oxidative Stress in Adults with Obesity Undergoing a Multidisciplinary Body Weight Reduction Program.

Author

Rigamonti, Antonello E., Rubino, Federico M., Caroli, Diana, Bondesan, Adele, Mai, Stefania, Cella, Silvano G., Centofanti, Lucia, Paroni, Rita, and Sartorio, Alessandro

Subjects
WEIGHT loss, NEUTROPHIL lymphocyte ratio, BODY mass index, GLYCOSYLATED hemoglobin, BLOOD sugar
Abstract

Background: Obesity is characterized by increased oxidative stress, which, in a vicious circle, promotes chronic low-grade inflammation. Melatonin, a well-documented antioxidant, might be useful as a supplement to enhance the cardiometabolic benefits of any body weight reduction program (BWRP). Objectives/Methods: The present study aimed to evaluate the post-exercise oxidative stress and inflammation in a group of subjects with obesity treated with melatonin (2 mg/die) or placebo, undergoing a 2-week BWRP, with the administration of a single bout of acute exercise at the start and the end of the protocol (G1–G15). Results: Eighteen adults with obesity were enrolled and distributed to the two arms of the study: the melatonin group (F/M: 7/2; age: 27.8 ± 5.6 years; body mass index [BMI]: 43.0 ± 4.9 kg/m2) and the placebo group (F/M: 6/3; age: 28.8 ± 5.0 years; BMI: 42.8 ± 4.0 kg/m2). BWRP induced a decrease in BMI and waist circumference (WC) in both groups; plasma glucose, blood glycated hemoglobin (HbA1c), and neutrophil to lymphocyte ratio (NLR) were reduced only in the placebo group. Importantly, plasma biological antioxidant potential (BAP) increased throughout BWRP. Paradoxically, melatonin enhanced post-exercise production of plasma derivatives of reactive oxygen metabolites (d-ROMs) and erythrocytic glutathionyl-Hb (HbSSG) (at G1 and G15). Finally, differently from the placebo group, melatonin-treated subjects did not exhibit the BWRP-induced decrease in plasma levels of interleukin-6 (IL-6), before and after exercise, at the end of two weeks (G15). Conclusions: Melatonin is presumably an antioxidant with "conditional" prooxidant actions. The use of melatonin as a supplement in subjects with obesity might be deleterious due to the abolishment of BWRP-induced cardiometabolic benefits. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Gut Microbiota and Fear Processing in Women Affected by Obesity: An Exploratory Pilot Study

Author

Scarpina, Federica, primary, Turroni, Silvia, additional, Mambrini, Sara, additional, Barone, Monica, additional, Cattaldo, Stefania, additional, Mai, Stefania, additional, Prina, Elisa, additional, Bastoni, Ilaria, additional, Cappelli, Simone, additional, Castelnuovo, Gianluca, additional, Brigidi, Patrizia, additional, Scacchi, Massimo, additional, and Mauro, Alessandro, additional

Published
2022
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23. Exploring extra dimensions to capture saliva metabolite fingerprints from metabolically healthy and unhealthy obese patients by comprehensive two-dimensional gas chromatography featuring Tandem Ionization mass spectrometry

Author

Cialiè Rosso, Marta, primary, Stilo, Federico, additional, Squara, Simone, additional, Liberto, Erica, additional, Mai, Stefania, additional, Mele, Chiara, additional, Marzullo, Paolo, additional, Aimaretti, Gianluca, additional, Reichenbach, Stephen E., additional, Collino, Massimo, additional, Bicchi, Carlo, additional, and Cordero, Chiara, additional

Published
2020
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24. Evaluation of an Amino Acid Mix on the Secretion of Gastrointestinal Peptides, Glucometabolic Homeostasis, and Appetite in Obese Adolescents Administered with a Fixed-Dose or ad Libitum Meal

Author

Rigamonti, Antonello E., primary, Tamini, Sofia, additional, Cicolini, Sabrina, additional, De Col, Alessandra, additional, Caroli, Diana, additional, Mai, Stefania, additional, Rondinelli, Eugenia, additional, Saezza, Antonella, additional, Cella, Silvano G., additional, and Sartorio, Alessandro, additional

Published
2020
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27. Effect of Short-Term Dietary Intervention and Probiotic Mix Supplementation on the Gut Microbiota of Elderly Obese Women

Author

Cancello, Raffaella, primary, Turroni, Silvia, additional, Rampelli, Simone, additional, Cattaldo, Stefania, additional, Candela, Marco, additional, Cattani, Laila, additional, Mai, Stefania, additional, Vietti, Roberta, additional, Scacchi, Massimo, additional, Brigidi, Patrizia, additional, and Invitti, Cecilia, additional

Published
2019
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30. Circulating adipokines and metabolic setting in differentiated thyroid cancer

Author

Mele, Chiara, primary, Samà, Maria Teresa, additional, Bisoffi, Alessandro Angelo, additional, Caputo, Marina, additional, Bullara, Valentina, additional, Mai, Stefania, additional, Walker, Gillian Elisabeth, additional, Prodam, Flavia, additional, Marzullo, Paolo, additional, Aimaretti, Gianluca, additional, and Pagano, Loredana, additional

Published
2019
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31. Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity

Author

Pucci, Mariangela, primary, Micioni Di Bonaventura, Maria Vittoria, additional, Vezzoli, Valeria, additional, Zaplatic, Elizabeta, additional, Massimini, Marcella, additional, Mai, Stefania, additional, Sartorio, Alessandro, additional, Scacchi, Massimo, additional, Persani, Luca, additional, Maccarrone, Mauro, additional, Cifani, Carlo, additional, and D’Addario, Claudio, additional

Published
2019
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32. Analysis of predictive equations for estimating resting energy expenditure in a large cohort of morbidly obese patients

Author

Cancello, R, Soranna, D, Brunani, A, Scacchi, M, Tagliaferri, A, Mai, S, Marzullo, P, Zambon, A, Invitti, C, Cancello, Raffaella, Soranna, Davide, Brunani, Amelia, Scacchi, Massimo, Tagliaferri, Antonella, Mai, Stefania, Marzullo, Paolo, Zambon, Antonella, Invitti, Cecilia, Cancello, R, Soranna, D, Brunani, A, Scacchi, M, Tagliaferri, A, Mai, S, Marzullo, P, Zambon, A, Invitti, C, Cancello, Raffaella, Soranna, Davide, Brunani, Amelia, Scacchi, Massimo, Tagliaferri, Antonella, Mai, Stefania, Marzullo, Paolo, Zambon, Antonella, and Invitti, Cecilia

Abstract

The treatment of obesity requires creating an energy deficit through caloric restriction and physical activity. Energy needs are estimated assessing the resting energy expenditure (REE) that in the clinical practice is estimated using predictive equations. In the present cross sectional study, we compared, in a large cohort of morbidly obese patients, the accuracy of REE predictive equations recommended by current obesity guidelines [Harris-Benedict, WHO/FAO/ONU and Mifflin-St Jeor (MJ)] and/or developed for obese patients (Muller, Muller BC, Lazzer, Lazzer BC), focusing on the effect of comorbidities on the accuracy of the equations. Data on REE measured by indirect calorimetry and body composition were collected in 4,247 obese patients (69% women, mean age 48 ± 19 years, mean BMI 44 ± 7 Kg/m2) admitted to the Istituto Auxologico Italiano from 1999 to 2014. The performance of the equations was assessed in the whole cohort, in 4 groups with 0, 1, 2, or =≥3 comorbidities and in a subgroup of 1,598 patients with 1 comorbidity (47.1% hypertension, 16.7% psychiatric disorders, 13.3% binge eating disorders, 6.1% endocrine disorders, 6.4% type 2 diabetes, 3.5% sleep apnoea, 3.1% dyslipidemia, 2.5% coronary disease). In the whole cohort of obese patients, as well as in each stratum of comorbidity number, the MJ equation had the highest performance for agreement measures and bias. The MJ equation had the best performance in obese patients with ≥3 comorbidities (accuracy of 61.1%, bias of -89.87) and in patients with type 2 diabetes and sleep apnoea (accuracy/bias 69%/-19.17 and 66%/-21.67 respectively), who also have the highest levels of measured REE. In conclusion, MJ equation should be preferred to other equations to estimate the energy needs of Caucasian morbidly obese patients when measurement of the REE cannot be performed. As even MJ equation does not precisely predict REE, it should be better to plan the diet intervention by measuring rather than estimating REE. Fut

Published
2018

38. The impact of the metabolic phenotype on thyroid function in obesity

Author

Marzullo, Paolo, primary, Mele, Chiara, additional, Mai, Stefania, additional, Guzzaloni, Gabriele, additional, Soranna, Davide, additional, Tagliaferri, Maria Antonella, additional, Berselli, Maria Elisa, additional, Prodam, Flavia, additional, Surico, Daniela, additional, Aimaretti, Gianluca, additional, and Scacchi, Massimo, additional

Published
2016
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45. Molecular mechanisms of the antimetastatic activity of nuclear clusterin in prostate cancer cells.

Author

Moretti RM, Mai S, Montagnani Marelli M, Rizzi F, Bettuzzi S, and Limonta P

Subjects
Actin Depolymerizing Factors metabolism, Cadherins metabolism, Cell Line, Tumor, Cell Movement, Clusterin genetics, Cytoskeleton pathology, Gene Expression Regulation, Neoplastic, Humans, Lim Kinases metabolism, Male, Matrix Metalloproteinase 2 metabolism, Microtubules metabolism, Neoplasm Invasiveness pathology, Protein Binding, Protein Transport, Transfection, Vimentin metabolism, Cell Nucleus metabolism, Clusterin metabolism, Prostatic Neoplasms physiopathology
Abstract

The proapoptotic activity of nuclear clusterin (nCLU) in cancer cells is now well established. We previously showed that nCLU decreases the motility of prostate cancer cells by triggering a dramatic dismantling of the actin cytoskeleton. Here, we sought to unravel the molecular mechanisms of the antimetastatic activity of nCLU. We found that nCLU: i) decreases LIMK1 expression, thus increasing the levels of the active (unphosphorylated) form of cofilin, the well known actin depolymerizing factor; ii) binds to vimentin, sequestering the protein from its adhesion sites at the cell periphery, thus interfering with its role in cell motility and adhesion; iii) affects the intracellular distribution of E-cadherin (the major component of epithelial adherens junctions) which appears to be diffusely distributed in the cells. Through these mechanisms nCLU reduces the migratory/invasive behavior of PC3 cells; this effect is further demonstrated by a decreased secretion of active MMP-2 from the cells. Thus, in addition to its proapoptotic function, nCLU also exerts a strong anti-migratory/anti-invasive activity in prostate cancer cells, by interfering with the cytoskeletal components and by decreasing MMP-2 activity.

Published
2011
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46. Novel insights into GnRH receptor activity: role in the control of human glioblastoma cell proliferation.

Author

Montagnani Marelli M, Moretti RM, Mai S, Müller O, Van Groeninghen JC, and Limonta P

Subjects
Antineoplastic Agents, Hormonal pharmacology, Cell Growth Processes drug effects, Cell Line, Tumor, Cyclic AMP metabolism, Glioblastoma genetics, Glioblastoma pathology, Gonadotropin-Releasing Hormone agonists, Gonadotropin-Releasing Hormone genetics, Goserelin pharmacology, Humans, RNA, Messenger biosynthesis, RNA, Messenger genetics, Receptors, LHRH genetics, Reverse Transcriptase Polymerase Chain Reaction, Glioblastoma metabolism, Gonadotropin-Releasing Hormone biosynthesis, Receptors, LHRH biosynthesis
Abstract

Malignant glioblastoma is one of the highest proliferative and invasive tumors within the central nervous system (CNS); the therapeutical options for this disease are still very poor. Receptors for gonadotropin-releasing hormone (GnRH) have been reported to be present in glioblastoma tissues. This study aimed to determine the role of these receptors in the control of glioma growth. In two human glioblastoma cell lines, U87MG and U373, we demonstrated the expression of GnRH receptors, both at mRNA and protein levels. We also found that GnRH receptor is expressed in glioblastoma tissues from tumor patients as shown by Western blotting. In U87MG and U373 cell lines, we found the expression of mRNA for GnRH, indicating the presence of an autocrine GnRH-based system in these cell lines. Treatment of the two cell lines with a GnRH agonist resulted in a significant decrease of cell proliferation. Moreover, the GnRH agonist significantly counteracted the forskolin-induced increase of intracellular cAMP levels in these cells. These findings suggest that the GnRH receptor might represent a molecular target for an endocrine therapeutical approach against gliomas.

Published
2009
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47. Gonadotropin-releasing hormone agonists suppress melanoma cell motility and invasiveness through the inhibition of alpha3 integrin and MMP-2 expression and activity.

Author

Moretti RM, Montagnani Marelli M, Mai S, and Limonta P

Subjects
Antineoplastic Agents, Hormonal pharmacology, Blotting, Western, Cell Line, Tumor, Cell Movement drug effects, Fluorescent Antibody Technique, Humans, Integrin alpha Chains metabolism, Matrix Metalloproteinase 2 metabolism, Melanoma metabolism, Neoplasm Invasiveness pathology, Reverse Transcriptase Polymerase Chain Reaction, Gonadotropin-Releasing Hormone agonists, Goserelin pharmacology, Integrin alpha Chains drug effects, Matrix Metalloproteinase 2 drug effects, Melanoma pathology
Abstract

Cutaneous melanoma represents the leading cause of skin cancer deaths. The prognosis of highly aggressive, metastatic melanoma is still very poor, due to the resistance of the disseminated tumor to existing therapies. The clarification of the molecular mechanisms regulating melanoma growth and progression might help identify novel molecular targets for the development of new therapeutic interventions. We previously showed that gonadotropin-releasing hormone (GnRH) receptors are expressed in melanoma cells; activation of these receptors by means of GnRH agonists significantly reduces cell proliferation. In the current study, we first showed that GnRH agonists significantly reduced the metastatic behavior of melanoma cells in terms of both cell motility (haptotactic assay using laminin as the chemoattractant) and invasiveness (cell invasion assay evaluating the capacity of the cells to invade a reconstituted extracellular matrix barrier). On the basis of this observation, we then investigated the molecular mechanisms underlying the antimetastatic activity of GnRH agonists. We found that, in melanoma cells, a) the activity of the alpha3 integrin subunit is crucial for the migratory behavior of the cells; b) GnRH agonists significantly reduced alpha3 integrin expression (Western blotting and immunofluorescence studies); c) GnRH agonists significantly reduced MMP-2 expression (comparative RT-PCR) and activity (zymographic analysis performed on cell culture media). These data indicate that GnRH agonists, in addition to the previously reported antiproliferative effect, elicit a strong inhibitory activity on the migratory/invasive behavior of melanoma cells expressing GnRH receptors. These compounds reduce the metastatic potential of melanoma cells by interfering with the expression/activity of cell adhesion molecules (alpha3 integrin) and matrix metalloproteinase (MMP-2).

Published
2008

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