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1. Probe-based confocal laser endomicroscopy (pCLE) is a suitable method for extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) evaluation

Author

Cannizzaro R, Maiero S, Fornasarig M, Canzonieri V, Magris R, Guarnieri G, Urbani M, Buonadonna A, Baresic T, and Spessotto P

Subjects
Probe-based confocal endomicroscopy, neoangiogenesis, extrapulmonary high grade neuroendocrine carcinoma, poorly differentiated adenocarcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Renato Cannizzaro,1 Stefania Maiero,1 Mara Fornasarig,1 Vincenzo Canzonieri,2 Raffaella Magris,1 Giovanni Guarnieri,1 Martina Urbani,3 Angela Buonadonna,4 Tanja Baresic,5 Paola Spessotto61Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy; 2Pathology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy; 3Oncologic Radiation Therapy and Diagnostic Imaging, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy; 4Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy; 5Nuclear Medicine, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy; 6Molecular Oncology, Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, ItalyAbstract: The potential role of the probe-based confocal laser endomicroscopy (pCLE) has been analyzed in different pathologic conditions of the gastrointestinal tract. Here, we analyzed a case of extrapulmonary high grade neuroendocrine rectal carcinoma (HGNEC) using, for the first time, the pCLE system. A 72-year old man was diagnosed with an 8 cm diameter rectal HGNEC by standard colonoscopy integrated with the pCLE system. The diagnosis of neuroendocrine carcinoma was confirmed by immunohistochemical analyses. By using the pCLE system, we well defined and resolved vascular structures and mucosal architecture. An altered mucosal pattern and vascular defects, peculiar for HGNEC, were observed at high magnification, allowing the identification of a pattern which was quite different from that observed in poorly differentiated adenocarcinomas (PDA) where tissues appear darker, very irregular, even if glandular structures can still be recognized. This underlines the usefulness of pCLE in discriminating HGNECs from PDAs. In conclusion, pCLE could represent a valid and helpful method for in vivo HGNEC diagnosis, allowing prompt and careful management of the patient.Keywords: probe-based confocal endomicroscopy, neoangiogenesis, extrapulmonary high grade neuroendocrine carcinoma, poorly differentiated adenocarcinoma

Published
2019

2. OC.18.6: MULTIMERIN-2 LOSS FAVORS COLORECTAL CANCER CELLS DISSEMINATION

Author

Poletto, E., primary, Andreuzzi, E., additional, Camicia, L., additional, Carobolante, G., additional, Schinello, G., additional, Di Siena, E., additional, Maiero, S., additional, Realdon, S., additional, Nadin, M.G., additional, Pelizzo, P., additional, Granziera, M., additional, Orbosuè, F., additional, Cannizzaro, R., additional, and Mongiat, M., additional

Published
2024
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6. H. PYLORI INFECTION AFFECTS THE HER2-CDH1 INTERACTION

Author

De Re, V., primary, Casarotto, M.T., additional, Brisotto, G., additional, Orbosuè, F., additional, Realdon, S., additional, Maiero, S., additional, Baldo, P., additional, Zanussi, S., additional, Steffan, A., additional, and Cannizzaro, R., additional

Published
2024
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7. Purastat Multicentric Registry: Preliminary results on the Italian Experience

Author

Maselli, R., additional, Da Rio, L., additional, Manno, M., additional, Soriani, P., additional, Fabbri, C., additional, Sbrancia, M., additional, Binda, C., additional, De Nucci, G., additional, Manes, G., additional, Cannizzaro, R., additional, Maiero, S., additional, Panarese, A., additional, D'abramo, F., additional, Staiano, T., additional, Rizza, S., additional, Hassan, C., additional, and Repici, A., additional

Published
2023
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8. Factors influencing the presence of potentially explosive gases during colonoscopy: Results of the SATISFACTION study

Author

Carnovali, M., Spada, Cristiano, Uebel, P., Bocus, P., Cannizzaro, Rino, Cavallaro, Fabio, Cesana, Bruno Mario, Cesaro, Paola, Costamagna, Guido, Dipaolo, D., Ferrari, A. P., Hinkel, C., Kashin, S., Massella, A., Melnikova, E., Orsatti, A., Ponchon, T., Prada, A., Radaelli, F., Sferrazza, Silvia, Soru, P., Testoni, P. A., Tontini, G. E., Vecchi, M., Fiori, G., Adyshirin, Z. S., Amato, Arianna, Anesi, A., Arpurt, J. P., Attardo, S., Balzarini, M., Bellon, S., Benini, M., Blanc, P., Bonato, G., Bordin, D., Bravi, I., Bulanova, N., Bunkova, E., Cadoni, S., Carparelli, S., Chashkova, E. Y., Ciprandi, Guido, Ciuffini, Cristina, Codazzi, M., Elli, L., Fedorishina, O., Hartmann, D., Jakobs, R., Janke, D., Kamalova, O., Karpova, I., Khitaryan, A., Lombardo, V., Lovera, Mauro, Maiero, S., Manes, G., Martino, G., Merkulova, E., Mura, D., Mutignani, Massimiliano, Occhipinti, P., Pescarolo, M., Petruzziello, Lucio, Pioche, M., Pisani, Anna, Poltorykhina, E., Pretti, C., Puzzono, M., Realdon, S., Reiche, P., Roberto, P., Roman, K., Rondonotti, E., Schettino, M., Segato, S., Shishin, K., Spina, L., Stefania, M., Trovato, C., Valats, J. C., Vena, N., Veselov, V., Viale, E., Vollmar, J., Zavyalov, D., Zimmermann, Thomas Alexander, Spada C. (ORCID:0000-0002-5692-0960), Cannizzaro R., Cavallaro F., Cesana B. M., Cesaro P., Costamagna G. (ORCID:0000-0002-8100-2731), Sferrazza S., Amato A., Ciprandi G., Ciuffini C., Lovera M., Mutignani M. (ORCID:0000-0002-1272-4888), Petruzziello L., Pisani A., Zimmermann T., Carnovali, M., Spada, Cristiano, Uebel, P., Bocus, P., Cannizzaro, Rino, Cavallaro, Fabio, Cesana, Bruno Mario, Cesaro, Paola, Costamagna, Guido, Dipaolo, D., Ferrari, A. P., Hinkel, C., Kashin, S., Massella, A., Melnikova, E., Orsatti, A., Ponchon, T., Prada, A., Radaelli, F., Sferrazza, Silvia, Soru, P., Testoni, P. A., Tontini, G. E., Vecchi, M., Fiori, G., Adyshirin, Z. S., Amato, Arianna, Anesi, A., Arpurt, J. P., Attardo, S., Balzarini, M., Bellon, S., Benini, M., Blanc, P., Bonato, G., Bordin, D., Bravi, I., Bulanova, N., Bunkova, E., Cadoni, S., Carparelli, S., Chashkova, E. Y., Ciprandi, Guido, Ciuffini, Cristina, Codazzi, M., Elli, L., Fedorishina, O., Hartmann, D., Jakobs, R., Janke, D., Kamalova, O., Karpova, I., Khitaryan, A., Lombardo, V., Lovera, Mauro, Maiero, S., Manes, G., Martino, G., Merkulova, E., Mura, D., Mutignani, Massimiliano, Occhipinti, P., Pescarolo, M., Petruzziello, Lucio, Pioche, M., Pisani, Anna, Poltorykhina, E., Pretti, C., Puzzono, M., Realdon, S., Reiche, P., Roberto, P., Roman, K., Rondonotti, E., Schettino, M., Segato, S., Shishin, K., Spina, L., Stefania, M., Trovato, C., Valats, J. C., Vena, N., Veselov, V., Viale, E., Vollmar, J., Zavyalov, D., Zimmermann, Thomas Alexander, Spada C. (ORCID:0000-0002-5692-0960), Cannizzaro R., Cavallaro F., Cesana B. M., Cesaro P., Costamagna G. (ORCID:0000-0002-8100-2731), Sferrazza S., Amato A., Ciprandi G., Ciuffini C., Lovera M., Mutignani M. (ORCID:0000-0002-1272-4888), Petruzziello L., Pisani A., and Zimmermann T.

Abstract

This study tested the hypothesis that bowel preparation with mannitol should not affect the colonic concentration of H2 and CH4. Therefore, the SATISFACTION study, an international, multicenter, randomized, parallel-group phase II–III study investigated this issue. The phase II dose-finding part of the study evaluated H2, CH4, and O2 concentrations in 179 patients randomized to treatment with 50 g, 100 g, or 150 g mannitol. Phase III of the study compared the presence of intestinal gases in 680 patients randomized (1:1) to receive mannitol 100 g in single dose or a standard split-dose 2 L polyethylene glycol (PEG)-Asc preparation (2 L PEG-Asc). Phase II results showed that mannitol did not influence the concentration of intestinal gases. During phase III, no patient in either group had H2 or CH4 concentrations above the critical thresholds. In patients with H2 and/or CH4 levels above detectable concentrations, the mean values were below the risk thresholds by at least one order of magnitude. The results also highlighted the effectiveness of standard washing and insufflation maneuvers in removing residual intestinal gases. In conclusion, bowel cleansing with mannitol was safe as the concentrations of H2 and CH4 were the same as those found in patients prepared with 2 L PEG-Asc. In both groups, the concentrations of gases were influenced more by the degree of cleansing achieved and the insufflation and washing maneuvers performed than by the preparation used for bowel cleansing. The trial protocol was registered with ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04759885) and with EudraCT (eudract_number: 2019-002856-18).

Published
2023

9. OC.13.4 THE ECM MOLECULE EMILIN-2 AFFECTS THE INFLAMMATORY RESPONSE VIA THE TLR-4/MYD88 PATHWAY IMPACTING ON COLORECTAL CANCER PATIENTS’ PROGNOSIS

Author

Andreuzzi, E., primary, Fejza, A., additional, Poletto, E., additional, Camicia, L., additional, Carobolante, G., additional, Polano, M., additional, Di Carlo, E., additional, Scarpa, M., additional, Maiero, S., additional, Fornasarig, M., additional, Cannizzaro, R., additional, and Mongiat, M., additional

Published
2022
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13. Novel 1-L polyethylene glycol + ascorbate versus high-volume polyethylene glycol regimen for colonoscopy cleansing: a multicenter, randomized, phase IV study

Author

Repici, A., Spada, Cristiano, Cannizzaro, Rino, Traina, M., Maselli, R., Maiero, S., Galtieri, A., Guarnieri, Giorgia, Di Leo, Mauro, Lorenzetti, R., Capogreco, A., Spadaccini, M., Antonelli, G., Zullo, A., Amata, M., Ferrara, Paola Emilia, Correale, L., Granata, A., Cesaro, Paola, Radaelli, F., Minelli Grazioli, L., Anderloni, A., Fugazza, A., Finati, E., Pellegatta, G., Carrara, S., Occhipinti, P., Buda, Alessandro, Fuccio, L., Manno, M., Hassan, Cesare, Spada C. (ORCID:0000-0002-5692-0960), Cannizzaro R., Guarnieri G., Di Leo M., Ferrara E., Cesaro P., Buda A., Hassan C., Repici, A., Spada, Cristiano, Cannizzaro, Rino, Traina, M., Maselli, R., Maiero, S., Galtieri, A., Guarnieri, Giorgia, Di Leo, Mauro, Lorenzetti, R., Capogreco, A., Spadaccini, M., Antonelli, G., Zullo, A., Amata, M., Ferrara, Paola Emilia, Correale, L., Granata, A., Cesaro, Paola, Radaelli, F., Minelli Grazioli, L., Anderloni, A., Fugazza, A., Finati, E., Pellegatta, G., Carrara, S., Occhipinti, P., Buda, Alessandro, Fuccio, L., Manno, M., Hassan, Cesare, Spada C. (ORCID:0000-0002-5692-0960), Cannizzaro R., Guarnieri G., Di Leo M., Ferrara E., Cesaro P., Buda A., and Hassan C.

Abstract

Background and Aims: Adequate bowel cleansing is critical to ensure quality and safety of a colonoscopy. A novel 1-L polyethylene glycol plus ascorbate (1L-PEG+ASC) regimen was previously validated against low-volume regimens but was never compared with high-volume regimens. Methods: In a phase IV study, patients undergoing colonoscopy were randomized 1:1 to receive split-dose 1L PEG+ASC or a split-dose 4-L PEG-based regimen (4L-PEG) in 5 Italian centers. Preparation was assessed with the Boston Bowel Preparation Scale (BBPS) by local endoscopists and centralized reading, both blinded to the randomization arm. The primary endpoint was noninferiority of 1L-PEG+ASC in colon cleansing. Secondary endpoints were superiority of 1L-PEG+ASC, patient compliance, segmental colon cleansing, adenoma detection rate, tolerability, and safety. Results: Three hundred eighty-eight patients (median age, 59.8 years) were randomized between January 2019 and October 2019: 195 to 1L-PEG+ASC and 193 to 4L-PEG. Noninferiority of 1L-PEG+ASC was demonstrated for cleansing in both the entire colon (BBPS ≥ 6: 97.9% vs 93%; relative risk [RR], 1.03; 95% confidence interval [CI], 1.001-1.04; P superiority = .027) and in the right-sided colon segment (98.4% vs 96.0%; RR, 1.02; 95% CI, .99-1.02; P noninferiority = .013). Compliance was higher with 1L-PEG+ASC than with 4L-PEG (178/192 [92.7%] vs 154/190 patients [81.1%]; RR, 1.10; 95% CI, 1.05-1.12), whereas no difference was found regarding safety (moderate/severe side effects: 20.8% vs 25.8%; P = .253). No difference in adenoma detection rate (38.8% vs 43.0%) was found. Conclusions: One-liter PEG+ASC showed noninferiority compared with 4L-PEG in achieving adequate colon cleansing and provided a higher patient compliance. No differences in tolerability and safety were detected. (Clinical trial registration number: NCT03742232.)

Published
2021

17. RANDOMIZED CONTROLLED TRIAL COMPARING THE BOWEL CLEANSING EFFICACY OF NOVEL 1 LITRE POLYETHYLENE GLYCOL+ASCORBATE NER1006 VERSUS HIGH-VOLUME POLYETHYLENE GLYCOL USING A SPLIT DOSING REGIMEN

Author

Repici, A, additional, Spada, C, additional, Cannizzaro, R, additional, Leo, MD, additional, Traina, M, additional, Buda, A, additional, Occhipinti, P, additional, Manno, M, additional, Fuccio, L, additional, Maselli, R, additional, Galtieri, PA, additional, Cesaro, P, additional, Spadaccini, M, additional, Lamonaca, L, additional, Minelli, L, additional, Granata, A, additional, Antonelli, G, additional, Maiero, S, additional, Guarnieri, G, additional, Amata, M, additional, Badalamenti, M, additional, Capogreco, A, additional, Lorenzetti, R, additional, Zullo, A, additional, Pellegatta, G, additional, Fugazza, A, additional, Carrara, S, additional, and Hassan, C, additional

Published
2020
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20. Evaluation of neoangiogenesis in locally advanced gastric cancer before and after neoadjuvant radiochemotherapy by probe confocal laser endomicroscopy (PCLE)

Author

Cannizzaro, R., primary, Magris, R., additional, Fornasarig, M., additional, Pivetta, E., additional, Maiero, S., additional, Mongiat, M., additional, De Re, V., additional, Canzonieri, V., additional, De Paoli, A., additional, Turriziani, V., additional, Guarnieri, G., additional, Buonadonna, A., additional, Belluco, C., additional, Serraino, D., additional, and Spessotto, P., additional

Published
2019
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21. PROBE-BASED CONFOCAL LASER ENDOMICROSCOPY IS A MANDATORY TOOL IN EVALUATION OF NEOANGIOGENESIS IN LOCALLY ADVANCED GASTRIC CANCER AND IN RECTAL CANCER PATIENTS

Author

Maiero, S, additional, Magris, R, additional, Guarnieri, G, additional, Fornasarig, M, additional, Pivetta, E, additional, Mongiat, M, additional, De Re, V, additional, Canton, E, additional, Canzonieri, V, additional, De Paoli, A, additional, Buonadonna, A, additional, Serraino, D, additional, Belluco, C, additional, Spessotto, P, additional, and Cannizzaro, R, additional

Published
2019
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22. P.05.34 EVALUATION OF NEOANGIOGENESIS IN LOCALLY ADVANCED GASTRIC CANCER BEFORE AND AFTER NEOADJUVANT RADIOCHEMOTHERAPY BY PROBE CONFOCAL LASER ENDOMICROSCOPY (PCLE)

Author

Cannizzaro, R., primary, Magris, R., additional, Fornasarig, M., additional, Pivetta, E., additional, Maiero, S., additional, Mongiat, M., additional, De Re, V., additional, Canzonieri, V., additional, De Paoli, A., additional, Guarnieri, G., additional, Buonadonna, A., additional, Belluco, C., additional, Serraino, D., additional, and Spessotto, P., additional

Published
2019
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24. OC.04.4 EMILIN1 DEFICIENCY AFFECTS EXPERIMENTAL COLITIS AND COLON CARCINOGENESIS ENHANCING LYMPHATIC DYSFUNCTION

Author

Capuano, A., primary, Bosisio, G., additional, Pivetta, E., additional, Scanziani, E., additional, Minoli, L., additional, Maiero, S., additional, Magris, R., additional, Bortoluzzi, S., additional, Gaffo, E., additional, Cannizzaro, R., additional, Doliana, R., additional, Colombatti, A., additional, and Spessotto, P., additional

Published
2019
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33. Evidence for the presence of non-celiac gluten sensitivity in patients with functional gastrointestinal symptoms: Results from a multicenter randomized double-blind placebo-controlled gluten challenge

Author

Elli, L, Tomba, C, Branchi, F, Roncoroni, L, Lombardo, V, Bardella, M, Ferretti, F, Conte, D, Valiante, F, Fini, L, Forti, E, Cannizzaro, R, Maiero, S, Londoni, C, Lauri, A, Fornaciari, G, Lenoci, N, Spagnuolo, R, Basilisco, G, Somalvico, F, Borgatta, B, Leandro, G, Segato, S, Barisani, D, Morreale, G, Buscarini, E, BARISANI, DONATELLA, Buscarini, E., Elli, L, Tomba, C, Branchi, F, Roncoroni, L, Lombardo, V, Bardella, M, Ferretti, F, Conte, D, Valiante, F, Fini, L, Forti, E, Cannizzaro, R, Maiero, S, Londoni, C, Lauri, A, Fornaciari, G, Lenoci, N, Spagnuolo, R, Basilisco, G, Somalvico, F, Borgatta, B, Leandro, G, Segato, S, Barisani, D, Morreale, G, Buscarini, E, BARISANI, DONATELLA, and Buscarini, E.

Abstract

Non-celiac gluten sensitivity (NCGS) is characterized by the onset of symptoms after eating gluten-containing food. We aimed to single out NCGS subjects among subjects with functional gastrointestinal symptoms. Patients were enrolled in a multicenter double-blind placebo-controlled trial with crossover. Symptoms and quality of life were evaluated by means of 10-cm VAS and SF36. Iron parameters, transaminases and C reactive protein (CRP) were evaluated. After a three-week-long gluten-free diet (GFD), responsive patients were randomly assigned to gluten intake (5.6 g/day) or placebo for seven days, followed by crossover. The primary endpoint was the worsening of symptoms (VAS increase ≥3 cm) during gluten ingestion compared to placebo. One hundred and forty patients were enrolled and 134 (17 males, mean age 39.1 ± 11.7 years, BMI 22.4 ± 3.8) completed the first period. A total of 101 subjects (10 males, mean age 39.3 ± 11.0 years, BMI 22.3 ± 4.0) reported a symptomatic improvement (VAS score 2.3 ± 1.2 vs. 6.5 ± 2.2 before and after GFD, p = 0.001). 98 patients underwent the gluten challenge and 28 (all females, mean age 38.9 ± 12.7 years, BMI 22.0 ± 2.9) reported a symptomatic relapse and deterioration of quality of life. No parameters were found to be statistically associated with positivity to the challenge. However, 14 patients responded to the placebo ingestion. Taking into account this finding, about 14% of patients responding to gluten withdrawal showed a symptomatic relapse during the gluten challenge. This group is suspected to have NCGS.

Published
2016

43. P.09.7 PROGNOSTIC SIGNIFICANCE OF CLINICALLY METASTATIC MESORECTAL LYMPH NODES IN LOCALLY ADVANCED RECTAL CANCER TREATED BY NEOADJUVANT CHEMORADIATION: IMPLICATIONS FOR SURGICAL STRATEGIES IN RELATION TO PATHOLOGICAL RESPONSE

Author

Belluco, C., primary, De Paoli, A., additional, Forlin, M., additional, Buonadonna, A., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Fornasarig, M., additional, Maiero, S., additional, Olivieri, M., additional, and Bertola, G., additional

Published
2016
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44. Effect of GnRH administration on progesterone blood levels in buffalo

Author

NEGLIA, GIANLUCA, BOCCIA, LUCIA, MAIERO S., DE ROSA A., PRANDI A., Neglia, Gianluca, Boccia, Lucia, Maiero, S., DE ROSA, A., and Prandi, A.

Subjects
Pituitary, GnRH, Buffalo, LH
Abstract

GnRH administration in buffalo species caused an increase of progesterone 96 hours after treatment. This aspect may result useful in order to increase progesterone blood levels and reduce the phenomenon of embryo mortality in buffalo. The aim of this study was to verify the pituitary response to a GnRH administration on day 6 post-insemination in buffalo. The trial was carried out in January on 21 pluriparous Italian Mediterranean Buffaloes (DIM=118±50 days). The animals were synchronized by using the Ovsynch-TAI Program and inseminated twice, 16 and 40 hours after the last administration of GnRH, with frozen semen. On day 6 post-insemination, buffaloes were treated with 12 μg of Buserelin acetate. Blood samples were collected just before GnRH administration (time 0 – T0) and 30 minutes (time 1 – T1), 3 hours (time 3 – T3) and 24 hours (time 24 – T24) after administration, in order to determine LH, FSH and E2 levels by using a double antibody radioimmuno assay (RIA) on plasma. Pregnancy diagnosis was performed 40 days post-insemination by ultrasound. The differences between the mean levels of LH, FSH and E2 after Buserelin acetate administration were analysed by t Student test. The administration of 12 mcg of Buserelin acetate significantly (P

Published
2005

50. Prevalence of nonpolypoid colorectal neoplasia: an italian multicenter observational study

Author

Bianco, Ma, Cipolletta, L, Rotondano, G, Buffoli, F, Gizzi, G, Tessari, F, Crotta, S, Strini, G, Orsello, M, Ballare, M, Gallo, M, Salacone, P, Asnaghi, G, Manca, A, Rizzi, R, Predebon, S, Quattrone, P, Vanni, R, Di Placido, R, Bastardini, R, Cristoni, Mv, Praiano, F, Meroni, E, Fasoli, A, Coccia, G, Allegretti, A, Manes, G, Cesari, P, Rolfi, F, Zambelli, A, Manfredi, G, Lisi, S, Cestari, R, Lancini, Gp, Crosta, C, Fiori, G, De Roberto, G, Dal Fante, M, Fazzini, L, Dinelli, M, Frego, R, Parente, F, Bargiggia, S, Paggi, S, Viale, E, Testoni, Pa, Iiritano, E, Andrian, G, Dinca, M, Germana, B, Lecis, P, Cappiello, R, Sablich, R, Tonello, C, Buri, L, Cannizzaro, R, Maiero, S, Fasoli, R, Ceroni, L, Eusebi, Lh, Iori, V, Tioli, C, Villani, V, Cortini, C, Maltoni, S, Forti, E, Solmi, L, Giovanardi, M, Calella, F, Tarantino, O, Widmayer, C, Silvestrelli, M, Bou Serhal, T, Feliciangeli, G, Tombesi, G, Anti, M, Pastorelli, A, Costamagna, G, Petruzziello, L, Cesaro, P, De Masi, E, Errico, A, Di Giulio, E, Carnuccio, A, Gabbrielli, Armando, Pandolfi, M, Lamazza, A, Femia, S, Morini, S, Lorenzetti, R, Del Vecchio Blanco, G, Grasso, E, Ferrara, M, Apuzzo, M, Iacopini, F, Milano, A, Balatsinou, C, Spadaccini, A, Silla, M, Ingrosso, M, Pirozzi, Ga, De Luca, L, De Bellis, M, Tempesta, A, De Palma GD, Siciliano, S, Di Giorgio, P, Giannattasio, F, Galloro, G, Grimaldi, E, Ciarleglio, A, Sarrantonio, G, Delle Cave, M, Lamanda, R, De Stefano, S, Labianca, O, Maisto, T, Montanaro, F, Pasquale, L, Di Girolamo, E, Piscopo, R, De Seta, M, Romano, M, Borgheresi, P, Gravina, Ag, Sarracco, P, Scaglione, G, Marmo, R, Salerno, R, Gentile, M, Annese, V, Della Valle, N, Muscatiello, N, Di Matteo, G, Giorgio, P, Fregola, G, Quatraro, F, Pisani, A, Tonti, P, Stoppino, G, Corazza, L, D'Ascoli, B, Ciuffi, M, Ignomirelli, O, Giglio, A, Rodino, S, Scanu, Am, Loriga, P, Murgia, R, Giacobbe, G, Grande, D, Montalbano, L, Linea, C., Bianco, Ma, Cipolletta, L, Rotondano, G, Buffoli, F, Gizzi, G, Tessari, F, Testoni, PIER ALBERTO, Flat Lesions Italian, Network, DE PALMA, GIOVANNI DOMENICO, Ma, Bianco, L., Cipolletta, G., Rotondano, F., Buffoli, G., Gizzi, F., Tessari, Romano, Marco, Gravina, A. G., Maria Antonia, Bianco, Livio, Cipolletta, Gianluca, Rotondano, Federico, Buffoli, Giuseppe, Gizzi, Francesco, Tessari, and Galloro, Giuseppe

Subjects
Male, medicine.medical_specialty, Colorectal cancer, Prevalence, Colonic Polyps, Colonoscopy, Colorectal Neoplasm, colonoscopy, flat lesions, colorectal neoplasia, Gastroenterology, Internal medicine, Epidemiology, medicine, Humans, Prospective Studies, Aged, Intraepithelial neoplasia, medicine.diagnostic_test, business.industry, Cancer, Histology, Middle Aged, medicine.disease, Colonic Polyp, Prospective Studie, Italy, Observational study, Female, Colorectal Neoplasms, business, Human
Abstract

BACKGROUND AND STUDY AIM: The aim of this study was to assess the prevalence of nonpolypoid lesions (NPLs) in Italy and their risk of containing neoplasia or advanced histology. PATIENTS AND METHODS: This was a multicenter cross-sectional observational study on consecutive patients undergoing total colonoscopy over a 3-month period in 80 Italian centers. RESULTS: In all, 27,400 total colonoscopies were analyzed. Cancer was diagnosed in 801 patients (2.9 %). A total of 6553 precancerous lesions were detected in 5609 patients. Of these, 4154 patients (74.1 %) had polypoid lesions and 1455 patients (25.9 %) had NPLs. Therefore, the prevalence of NPLs was 5.3 % (95 %CI 5.0 - 5.6). NPLs larger than 10 mm were detected in 254 patients (17.5 %). NPLs were more predominant in the proximal colon (OR 2.92, 95 %CI 2.56 - 3.43; P < 0.0001 vs. polypoid lesions). Neoplastic tissue was diagnosed in 79.0 % and advanced histology (high-grade intraepithelial neoplasia or more) in 20.9 % of resected lesions. The risk of advanced histology was similar for polypoid and nonpolypoid lesions when adjusted for size. Depressed lesions had the highest risk of advanced histology (OR 10.56, 95 %CI 6.02 - 18.55; P < 0.0000 vs. flat-elevated). Age was an independent predictor of both neoplasia and advanced histology ( P = 0.0001). CONCLUSIONS: NPLs are relatively common in the Italian population, with a prevalence similar to that in other Western series. NPLs are not more aggressive than polypoid lesions, except for those with depressed morphology. Georg Thieme Verlag KG Stuttgart. New York.

Published
2010

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