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2. Postural Orthostatic Tachycardia Syndrome (POTS) as a Cause of Dizziness - Expanding the Etiological Spectrum

Author

Baskar, Dipti, Mailankody, Pooja, Sathyaprabha, Talakad Narasappa, Mathuranath, P S, Mahale, Rohan R, and Padmanabha, Hansashree

Subjects
Dizziness -- Diagnosis -- Causes of
Abstract

Background and Objectives: Dizziness is a frequent complaint encountered in neurology clinics. Dizziness can be spontaneous or triggered, which includes orthostatic dizziness. Orthostatic dizziness can be acute (reflex/vasovagal syncope), chronic (orthostatic hypotension (OH), or postural orthostatic tachycardia syndrome (POTS). Since dizziness has numerous causes, these patients undergo extensive investigations before a diagnosis is made. Here, we describe five patients who presented with dizziness and were diagnosed to have POTS on evaluation. Materials and Methods: We conducted a retrospective study of patients who presented to the Department of Neurology from August 2020 to November 2021 with the complaint of dizziness and were diagnosed with POTS. The clinical history, neurological examination, treatment response, routine blood investigations, magnetic resonance imaging (MRI) brain, and autonomic function tests (AFTs) of the patients were reviewed from patients' clinical records. Patients with dizziness and with diagnosis other than POTS were excluded from the study. Results: Among the five patients, males were predominant with a male to female ratio of 3:2. All the patients were in their early fourth decade with a mean age of 35.4 years. The presenting symptom was dizziness, and the key associated symptoms were anxiety and headache. Due to the orthostatic nature of symptoms and absence of orthostatic fall in blood pressure (BP), a detailed AFT was carried out, leading to the diagnosis of POTS. Patients were assessed at 3-6 months after treatment and there was a moderate response in one and no response in the remaining four patients. Conclusion: POTS should be considered a possible etiology when patients present with orthostatic dizziness in the absence of orthostatic fall in BP. Anxiety and headache may be associated with this type of dizziness. Keywords: Anxiety, dizziness, headache, postural orthostatic tachycardia syndrome, Author(s): Dipti Baskar [1]; Pooja Mailankody (corresponding author) [1]; Talakad Narasappa Sathyaprabha [2]; P S Mathuranath [1]; Rohan R Mahale [1]; Hansashree Padmanabha [1] Key Message: POTS should be considered [...]

Published
2024
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5. Role of Optical Coherence Tomography in Predicting Visual Outcome after Surgery for Sellar and Supra-Sellar Tumors

Author

Singha, Souvik, Beniwal, Manish, Mailankody, Pooja, Battu, Rajani, Saini, Jitender, Tyagi, Gaurav, and Srinivas, Dwarakanath

Subjects
Tumors -- Prognosis -- Research, Tomography -- Research, Health
Abstract

Byline: Souvik. Singha, Manish. Beniwal, Pooja. Mailankody, Rajani. Battu, Jitender. Saini, Gaurav. Tyagi, Dwarakanath. Srinivas Background: Almost one-fifth of patients undergoing surgery for sellar/supra-sellar tumors do not gain a significant [...]

Published
2024

8. Spastic ataxia with sensory neuropathy sans cerebral leukodystrophy in probable adult polyglucosan body disease

Author

Mahale, Rohan, Shashi, Sridhar, Mahadevan, Anitha, Singh, Raviprakash, Potluri, Vivek, Padmanabha, Hansashree, Mailankody, Pooja, and Pavagada, Mathuranath

Subjects
Ataxia, Adults, Health
Abstract

Byline: Rohan. Mahale, Sridhar. Shashi, Anitha. Mahadevan, Raviprakash. Singh, Vivek. Potluri, Hansashree. Padmanabha, Pooja. Mailankody, Mathuranath. Pavagada Dear Sir, Adult polyglucosan body disease (APBD) is a neurogenetic disorder characterized by [...]

Published
2023

9. Rare Encephalitis-Like Presentation of a Pediatric Patient with Dual Positive Aquaporin-4 and Myelin Oligodendrocyte Antibodies: A Case Report with Review of Literature

Author

Dhar, Debjyoti, Mahadevan, Anita, Nagaraj, A., Mahale, Rohan, Prasad, Chandrajit, Shreedevi, Athyadi, Mailankody, Pooja, Mathuranath, P., and Padmanabha, Hansashree

Subjects
Pediatrics, Encephalitis, Aquaporins, Viral antibodies, B cells, Children -- Health aspects, Myelin proteins, Antibodies, Health
Abstract

Byline: Debjyoti. Dhar, Anita. Mahadevan, A. Nagaraj, Rohan. Mahale, Chandrajit. Prasad, Athyadi. Shreedevi, Pooja. Mailankody, P. Mathuranath, Hansashree. Padmanabha Dear Sir, Neuromyelitis optica spectrum disorder (NMOSD) and Myelin oligodendrocyte glycoprotein [...]

Published
2023

10. Collagen XII-Related Myopathy: An Emerging Spectrum of Extracellular Matrix-Related Myopathy

Author

Padmanabha, Hansashree, Arunachal, Gautham, Kishore, Pratik, Sharma, P., Mailankody, Pooja, Mahale, Rohan, Nashi, Saraswati, Mathuranath, P., and Chandra, Sadanandavalli

Subjects
Collagen, Amino acids, Health
Abstract

Byline: Hansashree. Padmanabha, Gautham. Arunachal, Pratik. Kishore, P. Sharma, Pooja. Mailankody, Rohan. Mahale, Saraswati. Nashi, P. Mathuranath, Sadanandavalli. Chandra Collagen XII, a member of a protein family called fibril associated [...]

Published
2023

11. Smartphone-based telestroke Vs'Stroke Physician' led acute stroke management (SMART INDIA): A protocol for a cluster-randomized trial

Author

Vishnu, Venugopalan, Bhatia, Rohit, Khurana, Dheeraj, Ray, Sucharita, Sharma, Sudhir, Kulkarni, Girish, Rao, Girish, Mailankody, Pooja, Garuda, Butchi, Bharadwaj, Amit, Angra, Monika, Ferriera, Teresa, Sharma, Ashish, Wilson, Vinny, Kuthiala, Neha, Sharma, Sakshi, Bhasin, Ashu, Mukherjee, Aprajita, Agarwal, Ayush, Murali, Suhas, Nilima, Nilima, and Srivastava, M. Padma

Subjects
Stroke (Disease) -- Care and treatment, Telemedicine -- Testing, Smart phones -- Usage -- Health aspects, Smart phone, Health
Abstract

Byline: Venugopalan. Vishnu, Rohit. Bhatia, Dheeraj. Khurana, Sucharita. Ray, Sudhir. Sharma, Girish. Kulkarni, Girish. Rao, Pooja. Mailankody, Butchi. Garuda, Amit. Bharadwaj, Monika. Angra, Teresa. Ferriera, Ashish. Sharma, Vinny. Wilson, Neha. [...]

Published
2022

12. Adult-Onset Ischemic Moyamoya Disease: Reasoning and Decision-Making

Author

Mailankody, Pooja, Pruthi, Nupur, Kulanthaivelu, Karthik, Mahale, Rohan, Padmanabha, Hansashree, Mathuranath, P., and Dubbal, Rohin

Subjects
Decision-making, Adults, Health
Abstract

Byline: Pooja. Mailankody, Nupur. Pruthi, Karthik. Kulanthaivelu, Rohan. Mahale, Hansashree. Padmanabha, P. Mathuranath, Rohin. Dubbal Sir, We present the case of a 27-year-old woman with adult-onset ischemic moyamoya disease (MMD) [...]

Published
2023

13. Hereditary spastic paraplegia due to LYST gene mutation: A novel causative gene

Author

Mahale, Rohan, Arunachal, Gautam, Singh, Raviprakash, Padmanabha, Hansashree, and Mailankody, Pooja

Subjects
Gene mutations -- Genetic aspects, Genes -- Genetic aspects, Nervous system diseases -- Genetic aspects, Paralysis, Spastic -- Genetic aspects, Darifenacin, Health
Abstract

Byline: Rohan. Mahale, Gautam. Arunachal, Raviprakash. Singh, Hansashree. Padmanabha, Pooja. Mailankody Dear Sir, Hereditary spastic paraplegias (HSP) are a diverse group of inherited neurodegenerative disorders characterized by insidiously progressive spasticity [...]

Published
2023

14. Autoimmune antibodies positivity in probable sporadic Creutzfeldt-Jakob disease: A mini-review of literature

Author

Anudeep, Davuluri Srinivas, Padmanabha, Hansashree, Mailankody, Pooja, Mathuranath, P., and Mahale, Rohan

Subjects
Encephalitis, Nervous system diseases, Viral antibodies, Prions, Antibodies, Creutzfeldt-Jakob disease, Health
Abstract

Byline: Davuluri. Srinivas Anudeep, Hansashree. Padmanabha, Pooja. Mailankody, P. Mathuranath, Rohan. Mahale Dear Editor, Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive neurodegenerative disease caused by the deposition of a [...]

Published
2023

15. Longitudinally extensive transverse myelitis with optic neuritis related to profound biotinidase deficiency: NMOSD mimic!

Author

Ravikumar, Nagaraj, Dhar, Debjyoti, Mahale, Rohan, Reddy, Ambati, Shreedevi, Athyadi, Prabhu, Sameetha, Saini, Jitender, Christopher, Rita, Mailankody, Pooja, Mathuranath, P., and Padmanabha, Hansashree

Subjects
Biotin -- Physiological aspects, Health
Abstract

Byline: Nagaraj. Ravikumar, Debjyoti. Dhar, Rohan. Mahale, Ambati. Reddy, Athyadi. Shreedevi, Sameetha. Prabhu, Jitender. Saini, Rita. Christopher, Pooja. Mailankody, P. Mathuranath, Hansashree. Padmanabha Dear Sir, Biotinidase deficiency is an autosomal [...]

Published
2023

16. Childhood-onset generalized dystonia due to NDUFA9 gene mutation: An expansion of mutations causing leigh's syndrome

Author

Singh, Raviprakash, Padmanabha, Hansashree, Arunachal, Gautam, Mailankody, Pooja, and Mahale, Rohan

Subjects
Gene mutations -- Genetic aspects, Enzymes -- Genetic aspects, Dystonia -- Genetic aspects, Health
Abstract

Byline: Raviprakash. Singh, Hansashree. Padmanabha, Gautam. Arunachal, Pooja. Mailankody, Rohan. Mahale Dear Sir, Leigh syndrome (LS) causes focal, necrotizing lesions of the basal ganglia, diencephalon, cerebellum, or brainstem and clinical [...]

Published
2023

20. DYT30 due to VPS16 mutation: An etiology of childhood-onset generalized dystonia

Author

Shashi, Sridhar, Nashi, Saraswati, Arunachal, Gautham, Venkatachalam, N., Padmanabha, Hansashree, Mailankody, Pooja, Menon, Deepak, Arshad, Faheem, Alladi, Suvarna, Mathuranath, Pavagada, and Mahale, Rohan

Subjects
Gene mutations -- Case studies, Children -- Diseases, Dystonia -- Case studies -- Genetic aspects -- Causes of, Health
Abstract

Byline: Sridhar. Shashi, Saraswati. Nashi, Gautham. Arunachal, N. Venkatachalam, Hansashree. Padmanabha, Pooja. Mailankody, Deepak. Menon, Faheem. Arshad, Suvarna. Alladi, Pavagada. Mathuranath, Rohan. Mahale Sir, The mutation in the VPS16 gene [...]

Published
2023

22. Spastic paraplegia type 8: A first report from India

Author

Mahale, Rohan, Arunachal, Gautam, Davuluri, Anudeep, Padmanabha, Hansashree, and Mailankody, Pooja

Subjects
Health
Abstract

Byline: Rohan. Mahale, Gautam. Arunachal, Anudeep. Davuluri, Hansashree. Padmanabha, Pooja. Mailankody Dear Sir, Spastic paraplegia type 8 (SPG8) is a rare autosomal-dominant hereditary spastic paraplegia (AD-HSP) caused by the mutation [...]

Published
2023

23. ANCA-associated vasculitic neuropathy following Anti-SARS-CoV-2 vaccination: An epiphenomenon or causal association?

Author

Jha, Shreyashi, Hema, A., Padmanabha, Hansashree, Mahadevan, Anitha, Mailankody, Pooja, Mathuranath, P., and Mahale, Rohan

Subjects
Health
Abstract

Byline: Shreyashi. Jha, A. Hema, Hansashree. Padmanabha, Anitha. Mahadevan, Pooja. Mailankody, P. Mathuranath, Rohan. Mahale Dear Sir, Anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines were introduced to enhance host [...]

Published
2023

24. Effectiveness of a training program in improving knowledge and skills about selected common neurological disorders among primary healthcare doctors: The Karnataka Brain Health Initiative (KaBHI) in India.

Author

Mailankody, Pooja, Parthasarathy, Rajani, Randeep, D, Rao, Girish N., Paplikar, Avanthi, Johnson, Annie Nithiya Vathani, Varghese, Feba, Govindaraj, Sarath, Shahed, Rehan, Vasudev, Aparna, Boopalan, Deenadayalan, Kulkarni, Girish B., Kalkonde, Yogeshwar, Sinha, Sanjib, and Alladi, Suvarna

Abstract

ABSTRACT: Introduction: Neurological disorders are the leading causes of death and disability globally. In low-middle-income countries such as India, there is a wide treatment gap for neurological disorders. To address this gap, an initiative known as the Karnataka Brain Health Initiative (KaBHI) was developed in collaboration with the public health system of the state of Karnataka in India. Method: A structured hybrid training program was conducted for 120 medical doctors working in the Primary Health Centers (PHCs) in the public health system in three districts of Karnataka. Pre- and post-training evaluation was conducted to assess physicians' knowledge and skills for evaluating patients with common neurological conditions. Results: Of 120 PHC doctors, 111 (92%) scored below the passing score of 50 points out of 100 before the training program. After the training, all trainees scored above this cut-off. The study found a significant improvement in knowledge and skills after the training (before training: 40.48 ± 7.92, after training: 66.28 ± 8.98 (P < 0.001) mean difference = 25.81), and was comparable among the PHC doctors in all three districts. Conclusions: Our study shows the feasibility of training primary care doctors in the public health system to manage selected common neurological disorders. The training program can potentially help to reduce the treatment gap for neurological disorders in India. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Leucine-rich Glioma Inactivated 1 (LGI-1) Limbic Encephalitis Presenting with Psychotic Symptoms without Seizures: A Case Report with Five-year Follow-up and Review of Literature.

Author

Mamtani, Harkishan, Mailankody, Pooja, Thippeswamy, Harish, Mathuranath, Pavagada S., Mahadevan, Anita, Chandra, Sadanandavalli R., and Thirthalli, Jagadisha

Subjects
*LITERATURE reviews, *APATHY, *SYMPTOMS, *ENCEPHALITIS, *SEIZURES (Medicine), *SELF-mutilation, *GLIOMAS
Abstract

This letter published in the Indian Journal of Psychological Medicine discusses a case of Leucine-rich Glioma Inactivated 1 (LGI-1) Limbic Encephalitis presenting with psychotic symptoms without seizures. The patient, a 48-year-old male, initially received a misdiagnosis of schizoaffective disorder due to his atypical presentation. However, further investigations revealed LGI-1 antibodies in his serum and cerebrospinal fluid. The patient was treated with intravenous methylprednisolone and plasmapheresis, resulting in significant improvement. Subsequent relapses were managed with rituximab. The case highlights the importance of considering a neurological etiology for patients presenting with psychotic symptoms, especially when accompanied by cognitive deficits and focal neurological deficits. [Extracted from the article]

Published
2024
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27. Pontine Tegmental Cap Dysplasia: A Rare Brainstem Malformation Mimicking Hereditary Sensory Autonomic Neuropathy

Author

Nagaraj, AR, primary, Shravanthi, Guduru, additional, Kumar, Tumulu Seetam, additional, Kenchiah, Raghavendra, additional, Mahale, Rohan, additional, Sandhya, M, additional, Udupi, Gautham Arunachal, additional, Mailankody, Pooja, additional, Mathuranath, PS, additional, Padmanabha, Hansashree, additional, Shaik, Reshma Sultana, additional, Yareeda, Sireesha, additional, Barathidasan, Gowri Shankar, additional, and Anand, Varun, additional

Published
2024
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32. Cervical dystonia with cerebellar ataxia in KCNA1 mutation: A phenotypic expansion

Author

Mahale, Rohan, Jayanth, S., Dutta, Debayan, Manu, S., Padmanabha, Hansashree, and Mailankody, Pooja

Subjects
Gene mutations -- Health aspects, DNA testing, Dystonia -- Diagnosis -- Genetic aspects, Cerebellar ataxia -- Diagnosis -- Genetic aspects, Health
Abstract

Byline: Rohan. Mahale, S. Jayanth, Debayan. Dutta, S. Manu, Hansashree. Padmanabha, Pooja. Mailankody Dear Sir, The KCNA1 gene encodes the voltage-gated potassium (K+) channel Kv1.1 a-sub-units, and the mutation has [...]

Published
2022

36. CSF1R related leukoencephalopathy - Rare childhood presentation of an autosomal dominant microgliopathy!

Author

Sriram, Neeharika, Padmanabha, Hansashree, Chandra, Sadanandavalli, Mahale, Rohan, Nandeesh, Bevinahalli, Bhat, Maya, Christopher, Rita, Gupta, Manisha, Udupi, Gautham, Mailankody, Pooja, and Mathuranath, Pavagada

Subjects
Gene mutations -- Case studies, Genetic disorders -- Case studies -- Diagnosis, Leukoencephalopathy -- Case studies -- Diagnosis, Pediatric research, Health
Abstract

Byline: Neeharika. Sriram, Hansashree. Padmanabha, Sadanandavalli. Chandra, Rohan. Mahale, Bevinahalli. Nandeesh, Maya. Bhat, Rita. Christopher, Manisha. Gupta, Gautham. Udupi, Pooja. Mailankody, Pavagada. Mathuranath Introduction Colony-stimulating factor 1 receptor (CSF1R) is [...]

Published
2022

37. Granulomatous panuveitis in multiple sclerosis: A rare occurrence

Author

Shah, Rutul, Mahale, Rohan, Babu, Kalpana, Shah, Dhwani, Vincent, Manu, Nanda, Satabdi, Sangeeth, T., Sriram, Neeharika, Tiwari, Ravindu, Padmanabha, Hansashree, Mailankody, Pooja, and Pavagada, Mathuranath

Subjects
Granuloma -- Case studies -- Diagnosis -- Risk factors, Multiple sclerosis -- Case studies -- Complications and side effects, Uveitis -- Case studies -- Diagnosis -- Risk factors, Health
Abstract

Byline: Rutul. Shah, Rohan. Mahale, Kalpana. Babu, Dhwani. Shah, Manu. Vincent, Satabdi. Nanda, T. Sangeeth, Neeharika. Sriram, Ravindu. Tiwari, Hansashree. Padmanabha, Pooja. Mailankody, Mathuranath. Pavagada Sir, Optic neuritis is the [...]

Published
2022

38. Pseudo-neonatal adrenoleukodystrophy: A rare peroxisomal disorder

Author

Arora, Cheshta, Padmanabha, Hansashree, Christopher, Rita, Mahale, Rohan, Bhat, Maya, Arunachal, Gautham, Shekhar, Ravi, Mailankody, Pooja, and Mathuranath, P.

Subjects
Rare diseases -- Case studies -- Diagnosis, Adrenoleukodystrophy -- Case studies -- Diagnosis, Infants (Newborn) -- Diseases, Peroxisomal disorders -- Case studies -- Diagnosis, Pediatric research, Health
Abstract

Byline: Cheshta. Arora, Hansashree. Padmanabha, Rita. Christopher, Rohan. Mahale, Maya. Bhat, Gautham. Arunachal, Ravi. Shekhar, Pooja. Mailankody, P. Mathuranath Dear Sir, Peroxisomes are essential subcellular structures that play an essential [...]

Published
2022

39. The spectrum of Neuro-COVID: A study of a comprehensively investigated large cohort from India

Author

Vengalil, Seena, Mahale, Rohan, Chakradhar, N., Alluri, Swathi, Navanith, P. Sagar, Ganaraja, V., Haripriya, K., Vikram, Holla, Asranna, Ajay, Mailankody, Pooja, Seshagiri, Doniparthi, Cheerla, H., Maturu, V., Vaddepally, C., Kenchaiah, Raghavendra, Srijithesh, P., Chaudhuri, Jaydip, Netravathi, M., and Alladi, Suvarna

Subjects
Nervous system diseases -- Statistics -- Risk factors, Neurologic manifestations of general diseases -- Statistics -- Risk factors, Health
Abstract

Byline: Seena. Vengalil, Rohan. Mahale, N. Chakradhar, Swathi. Alluri, P. Sagar Navanith, V. Ganaraja, K. Haripriya, Holla. Vikram, Ajay. Asranna, Pooja. Mailankody, Doniparthi. Seshagiri, H. Cheerla, V. Maturu, C. Vaddepally, [...]

Published
2022

40. Parkinsonism, olivary hypertrophy and cerebellar atrophy with TTC19 gene mutation

Author

Mahale, Rohan, Arunachal, Gautham, Gautam, Jyothi, Dutta, Debayan, Kovoor, Jennifer, Mailankody, Pooja, Padmanabha, Hansashree, and Mathuranath, P.

Subjects
Gene mutations -- Case studies, Atrophy -- Case studies -- Genetic aspects -- Diagnosis, Parkinsonism -- Case studies -- Genetic aspects -- Diagnosis, Mitochondrial diseases -- Case studies -- Genetic aspects -- Diagnosis, Health
Abstract

Byline: Rohan. Mahale, Gautham. Arunachal, Jyothi. Gautam, Debayan. Dutta, Jennifer. Kovoor, Pooja. Mailankody, Hansashree. Padmanabha, P. Mathuranath Dear Editor, Mitochondrial respiratory chain (MRC) complex III is responsible for the transfer [...]

Published
2021

41. Clinical, biochemical, radiological, and genetic profile of patients with homocysteine remethylation pathway defect and spastic paraplegia

Author

Padmanabha, Hansashree, Mahale, Rohan, Christopher, Rita, Arunachal, Gautham, Bhat, Maya, Mondal, Mahammad, Anjanappa, Ram, Mundlamuri, Ravindranadh, Yadav, Ravi, Vengalil, Seena, Mailankody, Pooja, Mathuranath, Pavagada, Chandra, Sadanandavalli, and Nalini, Atchayaram

Subjects
Homocysteine -- Health aspects -- Genetic aspects, Paralysis, Spastic -- Diagnosis -- Genetic aspects -- Complications and side effects, Health
Abstract

Byline: Hansashree. Padmanabha, Rohan. Mahale, Rita. Christopher, Gautham. Arunachal, Maya. Bhat, Mahammad. Mondal, Ram. Anjanappa, Ravindranadh. Mundlamuri, Ravi. Yadav, Seena. Vengalil, Pooja. Mailankody, Pavagada. Mathuranath, Sadanandavalli. Chandra, Atchayaram. Nalini Objectives: [...]

Published
2021

42. Pontine Tegmental Cap Dysplasia: A Rare Brainstem Malformation Mimicking Hereditary Sensory Autonomic Neuropathy.

Author

A. R., Nagaraj, Shravanthi, Guduru, Kumar, Tumulu Seetam, Kenchiah, Raghavendra, Mahale, Rohan, Sandhya M., Udupi, Gautham Arunachal, Mailankody, Pooja, P. S., Mathuranath, and Padmanabha, Hansashree

Subjects
BRAIN stem abnormalities, DIFFERENTIAL diagnosis, SENSORINEURAL hearing loss, RARE diseases, MAGNETIC resonance imaging, DEVELOPMENTAL disabilities, MASS spectrometry, AUTONOMIC nervous system diseases, MULTIPLE human abnormalities
Abstract

The article presents a case study of a young female with LGI1 antibody-positive syndrome, highlighting unique clinical and magnetic resonance imaging (MRI) findings. Topics include the clinical presentation of LGI1 encephalitis, the diagnostic challenges of autoimmune encephalitis, and the potential overlap of symptoms with other antibody-mediated conditions like CASPR2 encephalitis.

Published
2024
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43. ADCY5-related dyskinesia: A genetic cause of early-onset chorea-report of two cases and a novel mutation

Author

Padmanabha, Hansashree, Ray, Somdattaa, Mahale, Rohan, Arunachal, Gautham, Singhi, Pratibha, Mailankody, Pooja, and Pavagada, Mathuranath

Subjects
Gene mutations -- Health aspects, Movement disorders -- Genetic aspects -- Care and treatment -- Case studies, Chorea -- Genetic aspects -- Care and treatment -- Case studies, Health
Abstract

Byline: Hansashree. Padmanabha, Somdattaa. Ray, Rohan. Mahale, Gautham. Arunachal, Pratibha. Singhi, Pooja. Mailankody, Mathuranath. Pavagada Dear Sir, Chorea is a hyperkinetic movement disorder characterized by abnormal, involuntary, non-rhythmic, non-suppressible movements.[1] [...]

Published
2021

44. Kennedy's disease: A second genetically confirmed report from India

Author

Shah, Rutul, Mahale, Rohan, Padmanabha, Hansashree, and Mailankody, Pooja

Subjects
Kennedy disease -- Diagnosis -- Care and treatment -- Genetic aspects, Health
Abstract

Byline: Rutul. Shah, Rohan. Mahale, Hansashree. Padmanabha, Pooja. Mailankody Dear Sir, Kennedy's disease or spinal and bulbar muscular atrophy (SBMA) is a rare, X-linked trinucleotide repeat expansion-related hereditary degenerative condition [...]

Published
2021

45. The Rationale of Yoga in Parkinson's Disease: A Critical Review

Author

Mailankody, Pooja, Varambally, Shivarama, Thennarasu, K., and Pal, Pramod

Subjects
Parkinson's disease -- Care and treatment, Yoga -- Health aspects -- Physiological aspects, Health
Abstract

Byline: Pooja. Mailankody, Shivarama. Varambally, K. Thennarasu, Pramod. Pal Background: Patients with Parkinson's disease (PD) commonly use complementary and alternative medications. Yoga is a mind-body intervention that is being increasingly [...]

Published
2021

47. A systematic review and meta-analysis of Optical coherence tomography studies in Schizophrenia, Bipolar disorder and Major depressive disorder

Author

Prasannakumar, Akash, Kumar, Vijay, Mailankody, Pooja, Appaji, Abhishek, Battu, Rajani, Berendschot, Tos Tjm, Rao, Naren P, Prasannakumar, Akash, Kumar, Vijay, Mailankody, Pooja, Appaji, Abhishek, Battu, Rajani, Berendschot, Tos Tjm, and Rao, Naren P

Abstract

Objectives: Due to the common neurodevelopmental origin and easy accessibility, the retina serves as a surrogate marker for changes in the brain. Hence, Optical Coherence Tomography (OCT), a tool to examine the neuronal layers of retina has gained importance in investigating psychiatric disorders. Several studies in the last decade have reported retinal structural alterations in schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). However, the findings are inconsistent. Hence, we conducted a meta-analysis to investigate alterations in OCT parameters in patients with SCZ, BD and MDD. Methods: We searched electronic databases for studies that examined OCT parameters in patients with SCZ, BD and MDD published up to January 2023. The primary outcome measures were thickness and volumes of the retinal Nerve Fibre Layer (RNFL). We conducted meta-analysis using a random effects model. Results: The searches yielded 2638 publications of which 43 studies were included in the final analysis across all disorders. Compared to controls, the RNFL was thinner in SCZ patients (SMD = −0.37, p = <0.001) and BD patients (SMD = −0.67, p = < 0.001), but not in MDD patients (SMD = −0.08, p = 0.54). On quadrant wise analysis, temporal quadrant RNFL was thinner in SCZ but not in BD, while all other quadrants were thinner in both SCZ and BD. Conclusion: We found significant reductions in RNFL thickness in SCZ and BD, but not in MDD. The differential involvement in various quadrants and parameters across the disorders has potential implications for using retinal parameters as a diagnostic biomarker.

Published
2023

49. Upbeat nystagmus in late onset cerebellar ataxia: Think of anti-glutamate decarboxylase 65 antibody-associated cerebellar ataxia

Author

Mahale, Rohan, Dutta, Debayan, Kovoor, Jennifer, Mailankody, Pooja, Padmanabha, Hansashree, and Mathuranath, P.

Subjects
Nystagmus -- Case studies, Cerebellar ataxia -- Case studies, Glutamate decarboxylase -- Health aspects, Health
Abstract

Byline: Rohan. Mahale, Debayan. Dutta, Jennifer. Kovoor, Pooja. Mailankody, Hansashree. Padmanabha, P. Mathuranath The Editor, Glutamate decarboxylase (GAD) is an intracytoplasmic enzyme involved in the conversion of excitatory neurotransmitter glutamate [...]

Published
2021

50. Rapidly progressive spastic paraplegia due to hyperhomocysteinemia in child with MTHFR gene mutation and mitochondrial Complex I deficiency: A rare association

Author

Mahale, Rohan, Gautam, Jyothi, Arunachal, Gautam, Alappati, Sandhya, Varghese, Nibu, Kovoor, Jennifer, Mailankody, Pooja, Padmanabha, Hansashree, and Pavagada, Mathuranath

Subjects
Gene mutations -- Genetic aspects -- Physiological aspects, Seizures (Medicine) -- Genetic aspects, Enzymes -- Physiological aspects -- Genetic aspects, Homocysteine -- Physiological aspects, Paralysis, Spastic -- Genetic aspects, Health
Abstract

Byline: Rohan. Mahale, Jyothi. Gautam, Gautam. Arunachal, Sandhya. Alappati, Nibu. Varghese, Jennifer. Kovoor, Pooja. Mailankody, Hansashree. Padmanabha, Mathuranath. Pavagada MTHFR enzyme deficiency is an autosomal-recessive inborn error of folate metabolism. [...]

Published
2021

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