1. Acromegaly is associated with increased cancer risk: a survey in Italy
- Author
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Terzolo, Massimo, Reimondo, Giuseppe, Berchialla, Paola, FERRANTE, EMANUELE, Malchiodi, Elena, De Marinis, Laura, Pivonello, Rosario, Grottoli, Silvia, Losa, Marco, Cannavo, Salvatore, Ferone, Diego, Montini, Marcella, Bondanelli, Marta, De Menis, Ernesto, Martini, Chiara, Puxeddu, Efisio, Velardo, Antonino, Peri, Alessandro, Faustini-Fustini, Marco, Tita, Patrizia, Pigliaru, Francesca, Peraga, Giulia, Borretta, Giorgio, Scaroni, Carla, Bazzoni, Nicoletta, Bianchi, Antonio, Berton, Alessandro, Serban, Andreea Liliana, Baldelli, Roberto, Fatti, Letizia Maria, Colao, Annamaria, Arosio, Maura, Lombardi, G., TRIMARCHI, LORENZO, Degli Uberti, E. C., Ambrosio, M. R., Pagani, G., Attanasio, R., Kara, E., Mantero, F., Ceccato, F., Mortini, P., Razzore, P., Angeletti, G., Della Torre, D., Mariotti, S., Ghigo, E., Mainini, A. L., Appetecchia, M., Vigneri, R., Minuto, F., Nazzari, E., Cavagnini, F., Persani, L., Terzolo, Massimo, Reimondo, Giuseppe, Berchialla, Paola, Ferrante, Emanuele, Malchiodi, Elena, De Marinis, Laura, Pivonello, Rosario, Grottoli, Silvia, Losa, Marco, Cannavo, Salvatore, Ferone, Diego, Montini, Marcella, Bondanelli, Marta, De Menis, Ernesto, Martini, Chiara, Puxeddu, Efisio, Velardo, Antonino, Peri, Alessandro, Faustini-Fustini, Marco, Tita, Patrizia, Pigliaru, Francesca, Peraga, Giulia, Borretta, Giorgio, Scaroni, Carla, Bazzoni, Nicoletta, Bianchi, Antonio, Berton, Alessandro, Serban, Andreea Liliana, Baldelli, Roberto, Fatti, Letizia Maria, Colao, Annamaria, Arosio, Maura for the Italian Study Group of Acromegaly, Arosio, Maura, Lombardi, G., Trimarchi, Lorenzo, Degli Uberti, E. C., Ambrosio, M. R., Pagani, G., Attanasio, R., Kara, E., Mantero, F., Ceccato, F., Mortini, P., Razzore, P., Angeletti, G., Della Torre, D., Mariotti, S., Ghigo, E., Mainini, A. L., Appetecchia, M., Vigneri, R., Minuto, F., Nazzari, E., Cavagnini, F., and Persani, L.
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,NO ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Neoplasms ,Internal medicine ,Gh IGF1 ,Acromegaly ,Humans ,Medicine ,cancer ,Family history ,Thyroid cancer ,Acromegaly cancer ,Oncology ,business.industry ,GH ,IGF1 ,acromegaly ,Incidence ,Risk Factor ,Incidence (epidemiology) ,Cancer ,Middle Aged ,medicine.disease ,Diabetes and Metabolism ,Acromegaly, cancer, GH, IGF1 ,Italy ,030220 oncology & carcinogenesis ,Neoplasm ,Female ,Cohort Studie ,business ,Kidney cancer ,Human ,Cohort study - Abstract
It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18–1.68, P P = 0.022), kidney cancer (SIR 2.87; 95% CI, 1.55–5.34, P P
- Published
- 2017