37 results on '"Maiolo M"'
Search Results
2. A Novel Geo-Based Ranking Method for Selection of the Most Suitable NBSs.
- Author
-
Pirouz, B, Palermo, S A, Turco, M, Frega, F, Ferrante, A P, Falco, S, and Maiolo, M
- Published
- 2023
- Full Text
- View/download PDF
3. Thyroid hormones inhibit cell migration and proliferation activated by IGF-1 and MCP-1 in THP-1 monocytes through integrin αvβ3 by different mechanisms
- Author
-
Candelotti, E, De Luca, R, Megna, R, Maiolo, M, De Vito, P, Percario, Z, Borgatti, M, Gambari, R, Davis, Pj, Lin, Hy, Polticelli, F, Persichini, T, Colasanti, M, Affabris, E, Pedersen, Jz, and Incerpi, S
- Subjects
MCP-1 induced proliferation ,Thyroid hormones and IGF-1 Cross-talk ,Thyroid hormones ,Nongenomic effects ,Integrin αvβ3 ,Settore BIO/10 - Published
- 2021
4. Sustainable Water Management Index, SWaM_Index
- Author
-
Maiolo, M., primary and Pantusa, D., additional
- Published
- 2019
- Full Text
- View/download PDF
5. Environmental Aspects in the Use of Sea Outfalls: a Sensitivity Analysis
- Author
-
Veltri, P., primary and Maiolo, M., additional
- Published
- 1992
- Full Text
- View/download PDF
6. Water-Energy Related Aspect of Extensive Green Roofs: The Role of Evapotranspiration
- Author
-
Bevilacqua, P., primary, Principato, F., additional, Maiolo, M., additional, Piro, P., additional, and Arcuri, N., additional
- Published
- 2018
- Full Text
- View/download PDF
7. Life Cycle Assessment of a Bitumen Anti-root Barrier on a Green Roof in the Mediterranean Area
- Author
-
Maiolo, M., primary, Carini, M., additional, Capano, G., additional, Nigro, G., additional, and Piro, P., additional
- Published
- 2018
- Full Text
- View/download PDF
8. Infrastructure Vulnerability Index of drinking water systems to terrorist attacks
- Author
-
Maiolo, M., primary and Pantusa, D., additional
- Published
- 2018
- Full Text
- View/download PDF
9. Synthetic sustainability index (SSI) based on life cycle assessment approach of low impact development in the Mediterranean area
- Author
-
Maiolo, M., primary, Carini, M., additional, Capano, G., additional, and Piro, P., additional
- Published
- 2017
- Full Text
- View/download PDF
10. The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases
- Author
-
Bultet, LA, Aguilar-Rodriguez, J, Ahrens, CH, Ahrne, EL, Ai, N, Aimo, L, Akalin, A, Aleksiev, T, Alocci, D, Altenhoff, A, Alves, I, Ambrosini, G, Pedone, PA, Angelina, P, Anisimova, M, Appel, R, Argoud-Puy, G, Arnold, K, Arpat, B, Artimo, P, Ascencao, K, Auchincloss, A, Axelsen, K, Gerritsen, VB, Bairoch, A, Barisal, P, Baratin, D, Barbato, A, Barbie, V, Barras, D, Barreiro, M, Barret, S, Bastian, F, Batista Neto, TM, Baudis, M, Beaudoing, E, Beckmann, JS, Bekkar, AK, Cammoun, LBH, Benmohammed, S, Bernard, M, Bertelli, C, Bertoni, M, Bienert, S, Bignucolo, O, Bilbao, A, Bilican, A, Blank, D, Blatter, M-C, Blum, L, Bocquet, J, Boeckmann, B, Bolleman, JT, Bordoli, L, Bosshard, L, Boucher, G, Bougueleret, L, Boutet, E, Bovigny, C, Bratulic, S, Breuza, L, Bridge, AJ, Britan, A, Brito, F, Frazao, JB, Bruggmann, R, Bucher, P, Burdet, F, Burger, L, Cabello, EM, Gomez, RMC, Calderon, S, Cannarozzi, G, Carl, S, Casas, CC, Catherinet, S, Perier, RC, Charpilloz, C, Chaskar, PD, Chen, W, Pepe, AC, Chopard, B, Chu, HY, Civic, N, Claassen, M, Clottu, S, Colombo, M, Cosandier, I, Coudert, E, Crespo, I, Creus, M, Cuche, B, Cuendet, MA, Cusin, I, Daga, N, Daina, A, Dauvillier, J, David, F, Davydov, I, Ferreira, MDSRM, de Beer, T, de Castro, E, de Santana, C, Delafontaine, J, Delorenzi, M, Delucinge-Vivier, C, Demirel, O, Derham, R, Dermitzakis, EM, Dib, L, Diene, S, Dilek, N, Dilmi, J, Domagalski, MJ, Dorier, J, Dornevil, D, Dousse, A, Dreos, R, Duchen, P, Roggli, PD, Duperret, ID, Durinx, C, Duvaud, S, Engler, R, Frkek, S, Lopez, PE, Fstreicher, A, Excoffier, L, Fabbretti, R, Falcone, J-L, Falquet, L, Famiglietti, ML, Ferreira, A-M, Feuermann, M, Filliettaz, M, Hegel, V, Foucal, A, Franceschini, A, Fucile, G, Gaidatzis, D, Garcia, V, Gasteiger, E, Gateau, A, Gatti, L, Gaudet, P, Gaudinat, A, Gehant, S, Gfeller, D, Gharib, WH, Ghraichy, M, Gidoin, C, Gil, M, Gleizes, A, Gobeill, J, Gonnet, G, Gos, A, Gotz, L, Gouy, A, Grbic, D, Groux, R, Gruaz-Gumowski, N, Grun, D, Gschwind, A, Guex, N, Gupta, S, Getaz, M, Haake, D, Haas, J, Hatzimanikatis, V, Heckel, G, Gardiol, DFH, Hinard, V, Hinz, U, Homicsko, K, Horlacher, O, Hosseini, S-R, Hotz, H-R, Hulo, C, Hundsrucker, C, Ibberson, M, Ilmjarv, S, Ioannidis, V, Ioannidis, P, Iseli, C, Ivanek, R, Iwaszkiewicz, J, Jacquet, P, Jacquot, M, Jagannathan, V, Jan, M, Jensen, J, Johansson, MU, Johner, N, Jungo, F, Junier, T, Kahraman, A, Katsantoni, M, Keller, G, Kerhornou, A, Khalid, F, Klingbiel, D, Kimljenovic, A, Kriventseva, E, Kryuchkova, N, Kumar, S, Kutalik, Z, Kuznetsov, D, Kuzyakiv, R, Lane, L, Lara, V, Ledesma, L, Leleu, M, Lemercier, P, Lew, D, Lieberherr, D, Liechti, R, Lisacek, F, Fischer, H, Litsios, G, Liu, J, Lombardot, T, Mace, A, Maffioletti, S, Mahi, M-A, Maiolo, M, Majjigapu, SR, Malmstrom, L, Mangold, V, Marek, D, Mariethoz, J, Marin, R, Martin, O, Martin, X, Martin-Campos, T, Mary, C, Masclaux, F, Masson, P, Meier, C, Messina, A, Lenoir, MM, Meyer, X, Michel, P-A, Michielin, O, Milanese, A, Missiaglia, E, Perez, JM, Caria, VM, Moret, P, Moretti, S, Morgat, A, Mottaz, A, Mottin, L, Mouscaz, Y, Mueller, M, Murri, R, Mylonas, R, Neuenschwander, S, Nikitin, F, Niknejad, A, Nouspikel, N, Nso, LN, Okoniewski, M, Omasits, U, Paccaud, B, Pachkov, M, Paesano, SG, Pagni, M, Palagi, PM, Pasche, E, Payne, JL, Pedruzzi, I, Peischl, S, Peitsch, M, Perlini, S, Pilbout, S, Podvinec, M, Pohlmann, R, Polizzi, D, Potter, D, Poux, S, Pozzato, M, Pradervand, S, Praz, V, Pruess, M, Pujadas, E, Racle, J, Raschi, M, Ratib, O, Rausell, A, de Laval, VR, Redaschi, N, Rempfer, C, Ren, G, Vandati, RAR, Rib, L, Grognuz, OR, Altimiras, ER, Rivoire, C, Robin, T, Robinson-Rechavi, M, Rodrigues, J, Roechert, B, Roelli, P, Romano, V, Rossier, G, Roth, A, Rougemont, J, Roux, J, Royo, H, Ruch, P, Ruinelli, M, Rustom, M, Sates, A, Roehrig, UF, Rueeger, S, Salamin, N, Sankar, M, Sarkar, N, Saxenhofer, M, Schaeffer, M, Schaerli, Y, Schaper, E, Schmid, A, Schmid, E, Schmid, C, Schmid, M, Schmidt, S, Schmocker, D, Schneider, M, Schuepbach, T, Schwede, T, Schuetz, F, Sengstag, T, Serrano, M, Sethi, A, Shahmirzadi, O, Sigrist, C, Silvestro, D, Simao Neto, FA, Simillion, C, Simonovic, M, Skunca, N, Sluzek, K, Soneson, C, Sprouffske, K, Stadler, M, Staehli, S, Stevenson, B, Stockinger, H, Straszewski, J, Stricker, T, Studer, G, Stutz, A, Suffiotti, M, Sundaram, S, Szklarczyk, D, Szovenyi, P, Tegenfeldt, F, Teixeira, D, Tellenbach, S, Smith, AAT, Tognolli, M, Topolsky, I, Thuong, VDT, Tsantoulis, P, Tzika, AC, Agote, AU, van Nimwegen, E, von Mering, C, Varadarajan, A, Veranneman, M, Verbregue, L, Veuthey, A-L, Vishnyakova, D, Vyas, R, Wagner, A, Walther, D, Wan, HW, Wang, M, Waterhouse, R, Waterhouse, A, Wicki, A, Wigger, L, Wirapati, P, Witschi, U, Wyder, S, Wyler, K, Wuethrich, D, Xenarios, I, Yamada, K, Yan, Z, Yasrebi, H, Zahn, M, Zangger, N, Zdobnov, E, Zerzion, D, Zoete, V, Zoller, S, Bultet, LA, Aguilar-Rodriguez, J, Ahrens, CH, Ahrne, EL, Ai, N, Aimo, L, Akalin, A, Aleksiev, T, Alocci, D, Altenhoff, A, Alves, I, Ambrosini, G, Pedone, PA, Angelina, P, Anisimova, M, Appel, R, Argoud-Puy, G, Arnold, K, Arpat, B, Artimo, P, Ascencao, K, Auchincloss, A, Axelsen, K, Gerritsen, VB, Bairoch, A, Barisal, P, Baratin, D, Barbato, A, Barbie, V, Barras, D, Barreiro, M, Barret, S, Bastian, F, Batista Neto, TM, Baudis, M, Beaudoing, E, Beckmann, JS, Bekkar, AK, Cammoun, LBH, Benmohammed, S, Bernard, M, Bertelli, C, Bertoni, M, Bienert, S, Bignucolo, O, Bilbao, A, Bilican, A, Blank, D, Blatter, M-C, Blum, L, Bocquet, J, Boeckmann, B, Bolleman, JT, Bordoli, L, Bosshard, L, Boucher, G, Bougueleret, L, Boutet, E, Bovigny, C, Bratulic, S, Breuza, L, Bridge, AJ, Britan, A, Brito, F, Frazao, JB, Bruggmann, R, Bucher, P, Burdet, F, Burger, L, Cabello, EM, Gomez, RMC, Calderon, S, Cannarozzi, G, Carl, S, Casas, CC, Catherinet, S, Perier, RC, Charpilloz, C, Chaskar, PD, Chen, W, Pepe, AC, Chopard, B, Chu, HY, Civic, N, Claassen, M, Clottu, S, Colombo, M, Cosandier, I, Coudert, E, Crespo, I, Creus, M, Cuche, B, Cuendet, MA, Cusin, I, Daga, N, Daina, A, Dauvillier, J, David, F, Davydov, I, Ferreira, MDSRM, de Beer, T, de Castro, E, de Santana, C, Delafontaine, J, Delorenzi, M, Delucinge-Vivier, C, Demirel, O, Derham, R, Dermitzakis, EM, Dib, L, Diene, S, Dilek, N, Dilmi, J, Domagalski, MJ, Dorier, J, Dornevil, D, Dousse, A, Dreos, R, Duchen, P, Roggli, PD, Duperret, ID, Durinx, C, Duvaud, S, Engler, R, Frkek, S, Lopez, PE, Fstreicher, A, Excoffier, L, Fabbretti, R, Falcone, J-L, Falquet, L, Famiglietti, ML, Ferreira, A-M, Feuermann, M, Filliettaz, M, Hegel, V, Foucal, A, Franceschini, A, Fucile, G, Gaidatzis, D, Garcia, V, Gasteiger, E, Gateau, A, Gatti, L, Gaudet, P, Gaudinat, A, Gehant, S, Gfeller, D, Gharib, WH, Ghraichy, M, Gidoin, C, Gil, M, Gleizes, A, Gobeill, J, Gonnet, G, Gos, A, Gotz, L, Gouy, A, Grbic, D, Groux, R, Gruaz-Gumowski, N, Grun, D, Gschwind, A, Guex, N, Gupta, S, Getaz, M, Haake, D, Haas, J, Hatzimanikatis, V, Heckel, G, Gardiol, DFH, Hinard, V, Hinz, U, Homicsko, K, Horlacher, O, Hosseini, S-R, Hotz, H-R, Hulo, C, Hundsrucker, C, Ibberson, M, Ilmjarv, S, Ioannidis, V, Ioannidis, P, Iseli, C, Ivanek, R, Iwaszkiewicz, J, Jacquet, P, Jacquot, M, Jagannathan, V, Jan, M, Jensen, J, Johansson, MU, Johner, N, Jungo, F, Junier, T, Kahraman, A, Katsantoni, M, Keller, G, Kerhornou, A, Khalid, F, Klingbiel, D, Kimljenovic, A, Kriventseva, E, Kryuchkova, N, Kumar, S, Kutalik, Z, Kuznetsov, D, Kuzyakiv, R, Lane, L, Lara, V, Ledesma, L, Leleu, M, Lemercier, P, Lew, D, Lieberherr, D, Liechti, R, Lisacek, F, Fischer, H, Litsios, G, Liu, J, Lombardot, T, Mace, A, Maffioletti, S, Mahi, M-A, Maiolo, M, Majjigapu, SR, Malmstrom, L, Mangold, V, Marek, D, Mariethoz, J, Marin, R, Martin, O, Martin, X, Martin-Campos, T, Mary, C, Masclaux, F, Masson, P, Meier, C, Messina, A, Lenoir, MM, Meyer, X, Michel, P-A, Michielin, O, Milanese, A, Missiaglia, E, Perez, JM, Caria, VM, Moret, P, Moretti, S, Morgat, A, Mottaz, A, Mottin, L, Mouscaz, Y, Mueller, M, Murri, R, Mylonas, R, Neuenschwander, S, Nikitin, F, Niknejad, A, Nouspikel, N, Nso, LN, Okoniewski, M, Omasits, U, Paccaud, B, Pachkov, M, Paesano, SG, Pagni, M, Palagi, PM, Pasche, E, Payne, JL, Pedruzzi, I, Peischl, S, Peitsch, M, Perlini, S, Pilbout, S, Podvinec, M, Pohlmann, R, Polizzi, D, Potter, D, Poux, S, Pozzato, M, Pradervand, S, Praz, V, Pruess, M, Pujadas, E, Racle, J, Raschi, M, Ratib, O, Rausell, A, de Laval, VR, Redaschi, N, Rempfer, C, Ren, G, Vandati, RAR, Rib, L, Grognuz, OR, Altimiras, ER, Rivoire, C, Robin, T, Robinson-Rechavi, M, Rodrigues, J, Roechert, B, Roelli, P, Romano, V, Rossier, G, Roth, A, Rougemont, J, Roux, J, Royo, H, Ruch, P, Ruinelli, M, Rustom, M, Sates, A, Roehrig, UF, Rueeger, S, Salamin, N, Sankar, M, Sarkar, N, Saxenhofer, M, Schaeffer, M, Schaerli, Y, Schaper, E, Schmid, A, Schmid, E, Schmid, C, Schmid, M, Schmidt, S, Schmocker, D, Schneider, M, Schuepbach, T, Schwede, T, Schuetz, F, Sengstag, T, Serrano, M, Sethi, A, Shahmirzadi, O, Sigrist, C, Silvestro, D, Simao Neto, FA, Simillion, C, Simonovic, M, Skunca, N, Sluzek, K, Soneson, C, Sprouffske, K, Stadler, M, Staehli, S, Stevenson, B, Stockinger, H, Straszewski, J, Stricker, T, Studer, G, Stutz, A, Suffiotti, M, Sundaram, S, Szklarczyk, D, Szovenyi, P, Tegenfeldt, F, Teixeira, D, Tellenbach, S, Smith, AAT, Tognolli, M, Topolsky, I, Thuong, VDT, Tsantoulis, P, Tzika, AC, Agote, AU, van Nimwegen, E, von Mering, C, Varadarajan, A, Veranneman, M, Verbregue, L, Veuthey, A-L, Vishnyakova, D, Vyas, R, Wagner, A, Walther, D, Wan, HW, Wang, M, Waterhouse, R, Waterhouse, A, Wicki, A, Wigger, L, Wirapati, P, Witschi, U, Wyder, S, Wyler, K, Wuethrich, D, Xenarios, I, Yamada, K, Yan, Z, Yasrebi, H, Zahn, M, Zangger, N, Zdobnov, E, Zerzion, D, Zoete, V, and Zoller, S
- Abstract
The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article.
- Published
- 2016
11. Renal structure incaucasian noninsulindependent diabetic patients
- Author
-
Nosadini, R., Mauer, M., Brocco, E., Carraro, A., Saller, A., Sambataro, M., Chiesura, M., Bianchi, L., Baggio, Bruno, Maiolo, M., Velussi, M., and PAOLA FIORETTO
- Published
- 1997
12. Un codice di calcolo automatico per la determinazione della dispersività applicato a misure sperimentali con tracciante
- Author
-
Fallico C., Coscarelli R., and Maiolo M.
- Abstract
Dopo un breve richiamo alle tecniche più comunemente utilizzate per la determinazione della dispersività, vengono esposte le caratteristiche del codice di calcolo IRPADIAS, valido nell'ambito deterministico e che utilizza esclusivamente i dati forniti da prove sperimentali con l'uso di traccianti. Inoltre, per una particolare esperienza effettuata presso il campo prove di Montalto Uffugo (CS), si effettua un confronto tra i risultati ottenuti tramite tale codice di calcolo e quelli ricavati mediante un calcolo manuale secondo le procedure tradizionali
- Published
- 1995
13. A RANDOMIZED, DOUBLE-BLIND, CROSS-OVER STUDY COMPARING A LEVOSULPIRIDE-BASED AND A METOCLOPRAMIDE-BASED COMBINATION IN THE PREVENTION OF PROMECE-CYTABOM-INDUCED EMESIS
- Author
-
Roberto Sabbatini, Federico, M., Baldini, L., Barbieri, F., Maiolo, M. T., and Silingardi, V.
- Subjects
Adult ,LEVOSULPIRIDE ,PROMECE-CYTABOM ,Metoclopramide ,Vomiting ,Promethazine ,Drug Administration Schedule ,Prochlorperazine ,Bleomycin ,EMESIS ,METOCLOPRAMIDE ,NON-HODGKINS LYMPHOMA ,Basal Ganglia Diseases ,Double-Blind Method ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Cyclophosphamide ,Epirubicin ,Etoposide ,Cross-Over Studies ,Diazepam ,Lymphoma, Non-Hodgkin ,Cytarabine ,Nausea ,Middle Aged ,Methotrexate ,Treatment Outcome ,Vincristine ,Antiemetics ,Prednisone ,Drug Therapy, Combination ,Sulpiride - Abstract
To test two different antiemetic regimens for preventing nausea and vomiting in patient with non-Hodgkin's lymphoma (NHL) undergoing systemic chemotherapy (CT) with ProMECE-CytaBOM (P-C).Twenty consecutive untreated adult outpatients with histologically confirmed NHL and scheduled to receive P-C chemotherapy were registered in a randomized, double-blind, cross-over study to compare the antiemetic efficacy of a levosulpiride (LS)-based and metoclopramide (MTC)-based regimen.Complete protection from vomiting was recorded in 93% (62/67) of courses with the LS-regimen and in 89% (62/70) with the MTC-regimen (p = 0.428). No nausea was observed in 84% (56/67) of courses with the LS-regimen and in 74% (52/70) with the MTC-regimen (p = 0.183). No differences in prevention of emesis were recorded when patients crossed to the other regimen. Both regimens were well tolerated; however, on day 8 of chemotherapy, when both antiemetic regimens were administered at a higher dose, the LS-based combination showed significantly lower toxicity (p = 0.035).ProMECE-CytaBOM-induced emesis can be prevented in most cases with appropriate, specifically designed antiemetic therapy. Both the LS- and MTC-based combinations resulted in a high percentage of complete protection from emesis, but the higher incidence of side effects observed with MTC makes the LS-based regimen preferable for patients receiving P-C chemotherapy.
- Published
- 1995
14. La caratterizzazione dell'acquifero interessato da un campo prove per lo studio sperimentale di fenomeni idrodispersivi in mezzi porosi
- Author
-
Troisi S., Fallico C., Maiolo M., and Coscarelli R.
- Subjects
parametri idrodispersivi ,sismica a riflessione ,prospezioni elettriche - Abstract
Nei pressi del Dipartimento di Difesa del Suolo dell'Università della Calabria è stato realizzato un campo prove per lo studio sperimentale dei fenomeni di trasporto di inquinanti in un acquifero poroso. Il sito interessato dal campo prove è stato caratterizzato da un punto di vista idrogeologico al fine di pervenire ad una corretta modellizzazione delle caratteristiche strutturali e di flusso. Dopo un inquadramento geologico, per il quale si è fatto riferimento alla cartografia ufficiale, per la individuazione dell'acquifero, si sono integrate le informazioni puntuali, ricavate da una stratigrafia ricostruita durante la perforazione dei pozzi, con quelle spaziali ottenute mediante prospezioni geoelettriche, con il metodo dei sondaggi elettrici verticali, e geofisiche, con il metodo microsismico a riflessione ad alta risoluzione. La taratura dei dati sismici ed elettrici per la determinazione dei parametri idrogeologici, oltre che con le procedure caratteristiche dei relativi metodi, è stata effettuata anche sulla base di informazioni stratigrafiche dirette. Dopo aver descritto le tecnologie adoperate per l'acquisizione delle suddette informazioni e i risultati ottenuti viene schematizzata la caratterizzazione dell'acquifero.
- Published
- 1995
15. EVALUATING SURVIVAL AFTER ALLOGENEIC BONE-MARROW TRANSPLANT FOR CHRONIC MYELOID-LEUKEMIA IN CHRONIC PHASE - A COMPARISON OF TRANSPLANT VERSUS NO-TRANSPLANT IN A COHORT OF 258 PATIENTS 1ST SEEN IN ITALY BETWEEN 1984 AND 1986
- Author
-
Tura, S, Fanin, R, Russo, D, Zuffa, F, Fiacchini, M, Baccarani, M, Testoni, N, Zamagni, D, Zaccaria, A, Damiani, D, Michieli, M, Alimena, G, Montefusco, E, Mandelli, F, Morra, E, Bernasconi, C, Guglielmi, P, Cacciola, E, Battista, R, Dini, E, Specchia, G, Liso, V, Majolino, I, Caronia, F, Leoni, P, Danieli, G, Nosari, A, Decataldo, F, Paolino, F, Resegotti, L, Comotti, B, Barbui, T, Scapoli, G, Castoldi, G, Prossomariti, L, Montuori, R, Riccardi, A, Ascari, E, Landolfi, R, Bizzi, B, Lombardo, M, Torlontano, G, Leoni, F, Ferrini, P, Sparaventi, G, Delfini, C, Papineschi, F, Spremolla, G, Broccia, G, Nardelli, S, Ciccone, F, Deriu, L, Miraglia, E, Debiase, R, Bodenizza, C, Carotenuto, M, Rotondo, S, Gentilini, I, Coser, P, Capucci, A, Izzi, T, Luciano, L, Rotoli, B, Iacopino, P, Nobile, F, Cantonetti, M, Papa, G, Pinotti, G, Sala, G, Foa, P, Maiolo, M, Avanzini, P, Gobbi, F, Dore, F, Pardini, S, Ambrosetti, A, Perona, G, Dini, D, Liberati, A, Martelli, M, Grignani, F, Montuoro, A, Delaurenzi, A, Gallo, E, Pileri, A, Gallamini, A, Buffa, F, Abbadessa, A, Bruzzese, L, Derosa, C, Cimino, R, Mangoni, L, Rizzoli, V, Pizzuti, M, Ricciuti, F, Galieni, P, Dispensa, E, Zagonel, V, Pinto, A, Musolino, C, Squadrito, G, Perricone, R, Cajozzo, A, Morandi, S, Bianchini, E, Miliani, A, Monaco, M, Difrancesco, A, Quaglino, D, Rosti, G, Marangolo, M, Pasini, F, Diperri, T, Aglietta, M, and Gavosto, F
- Subjects
RISK ,Settore MED/06 - Oncologia Medica ,CHRONIC MYELOGENOUS LEUKEMIA ,CHRONIC GRANULOCYTIC-LEUKEMIA ,CHEMOTHERAPY ,IRRADIATION ,RELAPSE ,Settore MED/15 - Malattie del Sangue - Published
- 1993
16. Profilassi del vomito nei pazienti affetti da linfoma non-Hodgkin trattati con il protocollo ProMECE-CytaBOM. Risultati preliminari di uno studio clinico controllato
- Author
-
Sabbatini, R., Federico, Massimo, Baldini, L., Maiolo, M. T., and Silingardi, Vittorio
- Subjects
Promece-Cytabom ,Profilassi vomito ,linfoma non-Hodgkin - Published
- 1993
17. An experimental site for measurements of hydrodispersive parameters in porous media
- Author
-
Troisi S., Fallico C., Maiolo M., and Coscarelli R.
- Published
- 1993
18. CONFIRMATION AND IMPROVEMENT OF SOKAL PROGNOSTIC CLASSIFICATION OF PH+ CHRONIC MYELOID-LEUKEMIA - THE VALUE OF EARLY EVALUATION OF THE COURSE OF THE DISEASE
- Author
-
Tura, S, Russo, D, Zuffa, E, Fiacchini, M, Baccarani, M, Testoni, N, Zamagni, D, Zaccaria, A, Fanin, R, Damiani, D, Michieli, M, Alimena, G, Montefusco, E, Mandelli, F, Morra, E, Bernasconi, C, Guglielmi, P, Cacciola, E, Battista, R, Dini, E, Specchia, G, Liso, V, Majolino, I, Caronia, F, Leoni, P, Danieli, G, Nosari, A, Decataldo, F, Paolino, F, Resegotti, L, Comotti, B, Barbui, T, Scapoli, G, Castoldi, G, Prossomariti, L, Montuori, R, Riccardi, A, Ascari, E, Landolfi, R, Bizzi, B, Lombardo, M, Torlontano, G, Leoni, F, Ferrini, P, Sparaventi, G, Lucarelli, G, Papineschi, F, Spremolla, G, Broccia, G, Nardelli, S, Ciccone, F, Deriu, L, Miraglia, E, Debiase, R, Bodenizza, C, Carotenuto, M, Rotondo, S, Gentilini, I, Coser, P, Capucci, A, Izzi, T, Luciano, L, Rotoli, B, Iacopino, P, Nobile, F, Cantonetti, M, Papa, G, Pinotti, G, Sala, G, Foa, P, Maiolo, M, Avanzini, P, Gobbi, F, Dore, F, Longinotti, M, Ambrosetti, A, Perona, G, Dini, D, Diprisco, U, Liberati, A, Martelli, M, Grignani, F, Montuoro, A, Delaurenzi, A, Gallo, E, Pileri, A, Gallamini, A, Buffa, F, Abbadessa, A, Bruzzese, L, Derosa, C, Cimino, R, Mangoni, L, Rizzoli, V, Pizzuti, M, Ricciuti, F, Galieni, P, Dispensa, E, Zagonel, V, Pinto, A, Musolino, C, Squadrito, G, Perricone, R, Cajozzo, A, Morandi, S, Bianchini, E, Miliani, A, Monaco, M, Difrancesco, A, Quaglino, D, Rosti, G, Marangolo, M, Pasini, F, Diperri, T, Aglietta, M, and Gavosto, F
- Subjects
MARROW TRANSPLANTATION ,CHRONIC MYELOCYTIC-LEUKEMIA ,Settore MED/06 - Oncologia Medica ,CHRONIC MYELOGENOUS LEUKEMIA ,DURATION ,SURVIVAL ,CHRONIC PHASE ,CHRONIC GRANULOCYTIC-LEUKEMIA ,MULTIVARIATE-ANALYSIS ,BCR BREAKPOINT ,DIAGNOSIS ,Settore MED/15 - Malattie del Sangue - Published
- 1991
19. Assessment criteria for a sustainable management of the water resources
- Author
-
Maiolo, M., primary
- Published
- 2006
- Full Text
- View/download PDF
20. Soft carrier phase recovery for continuous phase modulations.
- Author
-
Maiolo, M., Boccolini, G., and Luise, M.
- Published
- 2010
- Full Text
- View/download PDF
21. On the fractal description of natural channel networks
- Author
-
Veltri, M., primary, Veltri, P., additional, and Maiolo, M., additional
- Published
- 1996
- Full Text
- View/download PDF
22. Modelling and optimization of least-cost water distribution networks with multiple supply sources and users
- Author
-
Gilda Capano, Francesco Chiaravalloti, Daniela Pantusa, Mario Maiolo, Manuela Carini, Carini, M., Maiolo, M., Pantusa, D., Chiaravalloti, F., and Capano, G.
- Subjects
Flexibility (engineering) ,Mathematical optimization ,Optimization problem ,010504 meteorology & atmospheric sciences ,Computer science ,Applied Mathematics ,General Mathematics ,0208 environmental biotechnology ,02 engineering and technology ,01 natural sciences ,Field (computer science) ,020801 environmental engineering ,Water resources ,Pipeline transport ,Network planning and design ,Null (SQL) ,Work (electrical) ,0105 earth and related environmental sciences - Abstract
The proper allocation of water resources is a very important practical problem in the field of water network planning. Optimization models that are expeditious and easy to use for all stakeholders of the sector play an important role for water resource management. The present work resumes and reviews a least-cost optimization model proposed by our group (Maiolo and Pantusa in Water Sci Tech-W Sup. https://doi.org/10.2166/ws.2015.114 , 2016), able to design a water distribution network with multiple supply sources and multiple users. This approach requires of solving an optimization problem based on a nonlinear objective function which is proportional to the cost of the water distribution network. The cost of pre-existing pipelines is considered null. A more realistic scenario, able to consider the maximum flow rate allowed for existing sources-users connections, is considered here. In order to illustrate the usefulness and flexibility of the proposed approach, an application of the model to the real case of the province of Croton, Southern Italy, is presented.
- Published
- 2017
23. Infrastructure Vulnerability Index of drinking water systems to terrorist attacks
- Author
-
Mario Maiolo, Daniela Pantusa, Maiolo, M., and Pantusa, D.
- Subjects
vulnerability assessment ,General Computer Science ,Vulnerability index ,business.industry ,General Chemical Engineering ,0208 environmental biotechnology ,General Engineering ,Water supply ,social sciences ,02 engineering and technology ,intentional water contamination ,020801 environmental engineering ,drinking water systems ,terrorist attacks ,Vulnerability assessment ,lcsh:TA1-2040 ,physical damage ,Terrorism ,Business ,lcsh:Engineering (General). Civil engineering (General) ,Environmental planning ,infrastructure vulnerability index - Abstract
Drinking water supply systems are vulnerable targets for which counter-terrorism measures have been raised worldwide. The threat of terrorist attacks to these systems has led to the need for the international scientific community to deal with the vulnerability assessment related to such events. In this context, this paper proposes an Infrastructure Vulnerability Index for drinking water distribution system with the aim of providing managers with a tool to assess system vulnerability to possible terrorist acts and to support the investments choice aimed at increasing security. This index is obtained using a set of indicators with reference to the structural parts of the system and considers both intentional contamination and physical damage. The index uses a hierarchic structure and decomposes the system into components and uses the Analytic Hierarchy Process to compute the weights. An application of the index was carried out for three water schemes of the Province of Crotone (Southern Italy) and the results obtained allowed to highlight the characteristics of the index and its usefulness.
- Published
- 2018
24. A New Vulnerability Measure for Water Distribution Network
- Author
-
Francesco Chiaravalloti, Manuela Carini, Antonio Procopio, Mario Maiolo, Daniela Pantusa, Gilda Capano, Maiolo, M., Pantusa, D., Carini, M., Capano, G., Chiaravalloti, F., and Procopio, A.
- Subjects
Service (systems architecture) ,lcsh:Hydraulic engineering ,Relation (database) ,Computer science ,media_common.quotation_subject ,0208 environmental biotechnology ,Geography, Planning and Development ,Complex system ,02 engineering and technology ,water supply system, network vulnerability, network performance analysis models ,Aquatic Science ,Biochemistry ,lcsh:Water supply for domestic and industrial purposes ,lcsh:TC1-978 ,Quality (business) ,Resilience (network) ,Robustness (economics) ,Water Science and Technology ,media_common ,Vulnerability (computing) ,lcsh:TD201-500 ,Measure (data warehouse) ,network performance analysis models ,020801 environmental engineering ,Risk analysis (engineering) ,water supply system ,network vulnerability - Abstract
The main objective of a water distribution network is to provide water to users in compliance with quality and service standards under different conditions. The ability to meet the water demand at the nodes, under the required pressures head, depends on many characteristic factors of the water network, such as various infrastructural components. A water distribution network is a complex system consisting of numerous structural elements and dependent by several factors. Resilience, robustness and vulnerability are of great interest, for these systems, in relation to the possible failure conditions which may compromise the network&rsquo, s ability to fulfill the project conditions. Vulnerability measures how much the network is fragile: a higher value of vulnerability means that the network is prone to fail in achieving the project conditions. In the present work, a new vulnerability measure based on a topological approach is proposed. A first application of the proposed vulnerability measure on two water networks known in the literature is described, and the obtained results are compared with other performance indices showing a significant correlation.
- Published
- 2018
25. A methodological proposal for the evaluation of potable water use risk
- Author
-
Daniela Pantusa, Mario Maiolo, Maiolo, M., and Pantusa, D.
- Subjects
Estimation ,Emergency management ,business.industry ,Climate change ,Economic shortage ,Potable water use risk, Sustainable management of water resources, Water distribution systems ,Water resources ,Potable water ,Key factors ,Environmental science ,Water resource management ,business ,Environmental planning ,Water Science and Technology - Abstract
Water shortages are due to a number of factors such as pollution of sources, decrease of water availability, climate change, wrong use of water resources and the inaccurate management of water systems, including the physiological dysfunctions of waterwork facilities. In order to improve the planning of emergency management, forecasting and prevention of this type of risk, it is helpful to address the study of the risk of potable water use. Through the analysis of water systems in all its components, key factors have been identified that influence the incorrect operation of systems and it was possible to define the risk for potable water use in order to formulate an initial proposal for an estimation method.
- Published
- 2015
26. Non-Hotspot PIK3CA Variants Have Higher Variant Allele Frequency and are More Common in Syndromic Vascular Malformations.
- Author
-
Andreoti TA, Maiolo M, Tuleja A, Döring Y, Schaller A, Vassella E, Boon LM, Baumgartner I, Bernhard SM, Zweier C, Vikkula M, and Rössler J
- Abstract
PIK3CA variants are known to cause vascular malformations. We were interested in studying the phenotypic spectrum, the location within the PIK3CA gene, and the variant allele frequency (VAF) of somatic PI3KCA variants in vascular malformations. Clinical data of consecutive patients with extracranial/extraspinal vascular malformations were collected in the context of the VASCOM cohort (2008-2022, n = 558). Starting October 2020, biopsy samples were tested with the TSO500 gene panel (Illumina). All consenting patients with PIK3CA variants were included in this study. Eighty-nine patients had available genetic results by June 2022. PIK3CA variants (n = 25) were found in 16 simple/combined (nonsyndromic) vascular malformations and in nine vascular malformations associated with other anomalies (syndromic). Four hotspot variants in exons 9 and 20 (c.1624G>A, c.1633G>A, c.3140A>G, c.3140A>T) were identified in 16/25 patients (VAF 0.9%-9.7%). Six non-hotspot variants (c.328_330del, c.323_337del, c.353G>A, c.1258T>C, c.3132T>A, c.3195_3203delinsT) were detected in nine patients (VAF 3.6%-31.7%). Non-hotspot variants were more frequent in syndromic than nonsyndromic vascular malformations (p = 0.0034) and exhibited a higher VAF than hotspot variants (p = 0.0253). Our study contributes to the growing body of knowledge of the genetic background in vascular malformations. Further studies will enrich the ever-growing list of pathogenic PIK3CA variants associated with vascular malformations., (© 2024 The Author(s). American Journal of Medical Genetics Part A published by Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
27. ARPIP: Ancestral Sequence Reconstruction with Insertions and Deletions under the Poisson Indel Process.
- Author
-
Jowkar G, Pečerska J, Maiolo M, Gil M, and Anisimova M
- Subjects
- Phylogeny, Likelihood Functions, Sequence Alignment, Evolution, Molecular, INDEL Mutation genetics, Algorithms
- Abstract
Modern phylogenetic methods allow inference of ancestral molecular sequences given an alignment and phylogeny relating present-day sequences. This provides insight into the evolutionary history of molecules, helping to understand gene function and to study biological processes such as adaptation and convergent evolution across a variety of applications. Here, we propose a dynamic programming algorithm for fast joint likelihood-based reconstruction of ancestral sequences under the Poisson Indel Process (PIP). Unlike previous approaches, our method, named ARPIP, enables the reconstruction with insertions and deletions based on an explicit indel model. Consequently, inferred indel events have an explicit biological interpretation. Likelihood computation is achieved in linear time with respect to the number of sequences. Our method consists of two steps, namely finding the most probable indel points and reconstructing ancestral sequences. First, we find the most likely indel points and prune the phylogeny to reflect the insertion and deletion events per site. Second, we infer the ancestral states on the pruned subtree in a manner similar to FastML. We applied ARPIP (Ancestral Reconstruction under PIP) on simulated data sets and on real data from the Betacoronavirus genus. ARPIP reconstructs both the indel events and substitutions with a high degree of accuracy. Our method fares well when compared to established state-of-the-art methods such as FastML and PAML. Moreover, the method can be extended to explore both optimal and suboptimal reconstructions, include rate heterogeneity through time and more. We believe it will expand the range of novel applications of ancestral sequence reconstruction. [Ancestral sequences; dynamic programming; evolutionary stochastic process; indel; joint ancestral sequence reconstruction; maximum likelihood; Poisson Indel Process; phylogeny; SARS-CoV.]., (© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Systematic Biologists.)
- Published
- 2023
- Full Text
- View/download PDF
28. A model for the adsorption process of water dissolved elements flowing into reactive porous media: Characterization and sizing of water mining/filtering systems.
- Author
-
Chidichimo F, De Biase M, Tursi A, Maiolo M, Straface S, Baratta M, Olivito F, and De Filpo G
- Abstract
This study presents a mathematical model describing the adsorption-desorption process of water dissolved elements onto reactive porous materials during filtering operations performed under dynamic flow conditions. The developed model is based on a reversible second order adsorption kinetic featuring the progressive reduction of the purifying capacity of the filtering material due to the gradual exhaustion of the active sites available for solute retention. It enables the simulation of the performances of water filtering systems through the use of parameters having a clear chemical-physical significance or it can be used for the estimation of these parameters to characterize the adsorption properties of the reactive material. Starting from the same adsorptive conceptual model used for the filtering system marked by ongoing flowing conditions, an adaptation for static systems was performed on the mathematical framework in order to process the same chemical physical parameters in both schemes. Adsorption laboratory tests were carried out to validate the developed model. Results show that the kinetic constants and adsorption capacities (a maximum of about 45 mg g
-1 was obtained for the tested material) are highly comparable, both within the same experimental system, and between different experimental setup. This confirms the validity of the developed model which is able to perfectly fit the observed concentration data in all tested configurations., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Michele De Biase reports financial support was provided by European Commission., (Copyright © 2022 Elsevier B.V. All rights reserved.)- Published
- 2023
- Full Text
- View/download PDF
29. High-density EEG power topography and connectivity during confusional arousal.
- Author
-
Castelnovo A, Amacker J, Maiolo M, Amato N, Pereno M, Riccardi S, Danani A, Ulzega S, and Manconi M
- Subjects
- Child, Electroencephalography methods, Humans, Polysomnography methods, Sleep, Sleep Arousal Disorders, Somnambulism
- Abstract
Confusional arousal is the milder expression of a family of disorders known as Disorders of Arousal (DOA) from non-REM sleep. These disorders are characterized by recurrent abnormal behaviors that occur in a state of reduced awareness for the external environment. Despite frequent amnesia for the nocturnal events, when actively probed, patients are able to report vivid hallucinatory/dream-like mental imagery. Traditional (low-density) scalp and stereo-electroencephalographic (EEG) recordings previously showed a pathological admixture of slow oscillations typical of NREM sleep and wake-like fast-mixed frequencies during these phenomena. However, our knowledge about the specific neural EEG dynamics over the entire brain is limited. We collected 2 consecutive in-laboratory sleep recordings using high-density (hd)-EEG (256 vertex-referenced geodesic system) coupled with standard video-polysomnography (v-PSG) from a 12-year-old drug-naïve and otherwise healthy child with a long-lasting history of sleepwalking. Source power topography and functional connectivity were computed during 20 selected confusional arousal episodes (from -6 to +18 sec after motor onset), and during baseline slow wave sleep preceding each episode (from - 3 to -2 min before onset). We found a widespread increase in slow wave activity (SWA) theta, alpha, beta, gamma power, associated with a parallel decrease in the sigma range during behavioral episodes compared to baseline sleep. Bilateral Broadman area 7 and right Broadman areas 39 and 40 were relatively spared by the massive increase in SWA power. Functional SWA connectivity analysis revealed a drastic increase in the number and complexity of connections from baseline sleep to full-blown episodes, that mainly involved an increased out-flow from bilateral fronto-medial prefrontal cortex and left temporal lobe to other cortical regions. These effects could be appreciated in the 6 sec window preceding behavioral onset. Overall, our results support the idea that DOA are the expression of peculiar brain states, compatible with a partial re-emergence of consciousness., Competing Interests: Declaration of competing interest None to declare., (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
30. Smart Technologies for Water Resource Management: An Overview.
- Author
-
Palermo SA, Maiolo M, Brusco AC, Turco M, Pirouz B, Greco E, Spezzano G, and Piro P
- Subjects
- Cities, Climate Change, Water, Technology, Water Resources
- Abstract
The latest progress in information and communication technology (ICT) and the Internet of Things (IoT) have opened up new opportunities for real-time monitoring and controlling of cities' structures, infrastructures, and services. In this context, smart water management technology provides the data and tools to help users more effectively manage water usage. Data collected with smart water devices are being integrated with building management systems to show how much water is used by occupants as well as to identify the consumption areas to use water more efficiently. By this approach, smart buildings represent an innovative solution that enhances a city's sustainability and contributes to overcoming environmental challenges due to increasing population and climate change. One of the main challenges is resource-saving and recovery. Water is an all-important need of all living beings, and the concerns of its scarcity impose a transition to innovative and sustainable management starting from the building scale. Thus, this manuscript aims to provide an updated and valuable overview for researchers, consumers, and stakeholders regarding implementing smart and sustainable technologies for water resource management, primarily for building-scale uses.
- Published
- 2022
- Full Text
- View/download PDF
31. Flu vaccination in multiple sclerosis patients: a monocentric prospective vaccine-vigilance study.
- Author
-
Maniscalco GT, Scavone C, Moreggia O, Di Giulio Cesare D, Aiezza ML, Guglielmi G, Longo G, Maiolo M, Raiola E, Russo G, and Capuano A
- Subjects
- COVID-19 Vaccines, Humans, Recurrence, Vaccination adverse effects, Vaccination methods, COVID-19 prevention & control, Influenza Vaccines adverse effects, Multiple Sclerosis chemically induced
- Abstract
Background: In 2020, the Italian Medicines Agency recommended to bring forward the flu vaccination campaign, whose importance was also emphasized for patients with Multiple Sclerosis (MS). We aimed to assess the safety profile of flu vaccines in terms of occurrence of short-term and long-term Adverse Events Following Immunization (AEFIs)., Methods: This is an observational study that enrolled MS patients who were eligible for any of the flu vaccines recommended by the Italian medicines Agency., Results: 194 patients were enrolled. Out of 133 patients who accepted to be vaccinated, 45 experienced not serious short-term AEFIs (pain at the injection site, headache, flu-like symptoms, fatigue). Long-term AEs were detected in 12 vaccinated patients (flu-like symptoms, COVID-19 and MS relapse). No statistically significant differences in terms of infections or MS relapse were found between vaccinated and unvaccinated groups. Using Kaplan-Meier analysis we observed no differences in the cumulative survival rate in both groups., Conclusion: Flu vaccines were well tolerated in MS patients, who mainly experienced not serious short term AEFIs. Considering that COVID-19 vaccines campaign is still ongoing among MS patients, our results might bring new knowledge concerning the safety profile of vaccines in this frail population.
- Published
- 2022
- Full Text
- View/download PDF
32. ProPIP: a tool for progressive multiple sequence alignment with Poisson Indel Process.
- Author
-
Maiolo M, Gatti L, Frei D, Leidi T, Gil M, and Anisimova M
- Subjects
- Algorithms, Phylogeny, Sequence Alignment, Software, Evolution, Molecular, INDEL Mutation
- Abstract
Background: Current alignment tools typically lack an explicit model of indel evolution, leading to artificially short inferred alignments (i.e., over-alignment) due to inconsistencies between the indel history and the phylogeny relating the input sequences., Results: We present a new progressive multiple sequence alignment tool ProPIP. The process of insertions and deletions is described using an explicit evolutionary model-the Poisson Indel Process or PIP. The method is based on dynamic programming and is implemented in a frequentist framework. The source code can be compiled on Linux, macOS and Microsoft Windows platforms. The algorithm is implemented in C++ as standalone program. The source code is freely available on GitHub at https://github.com/acg-team/ProPIP and is distributed under the terms of the GNU GPL v3 license., Conclusions: The use of an explicit indel evolution model allows to avoid over-alignment, to infer gaps in a phylogenetically consistent way and to make inferences about the rates of insertions and deletions. Instead of the arbitrary gap penalties, the parameters used by ProPIP are the insertion and deletion rates, which have biological interpretation and are contextualized in a probabilistic environment. As a result, indel rate settings may be optimised in order to infer phylogenetically meaningful gap patterns., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
33. Inhibition by Thyroid Hormones of Cell Migration Activated by IGF-1 and MCP-1 in THP-1 Monocytes: Focus on Signal Transduction Events Proximal to Integrin αvβ3.
- Author
-
Candelotti E, De Luca R, Megna R, Maiolo M, De Vito P, Gionfra F, Percario ZA, Borgatti M, Gambari R, Davis PJ, Lin HY, Polticelli F, Persichini T, Colasanti M, Affabris E, Pedersen JZ, and Incerpi S
- Abstract
Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T
4 , but also T3 , act non-genomically through mechanisms that involve a plasma membrane receptor αvβ3 integrin, a co-receptor for insulin-like growth factor-1 (IGF-1). Previous data from our laboratory show a crosstalk between thyroid hormones and IGF-1 because thyroid hormones inhibit the IGF-1-stimulated glucose uptake and cell proliferation in L-6 myoblasts, and the effects are mediated by integrin αvβ3. IGF-1 also behaves as a chemokine, being an important factor for tissue regeneration after damage. In the present study, using THP-1 human leukemic monocytes, expressing αvβ3 integrin in their cell membrane, we focused on the crosstalk between thyroid hormones and either IGF-1 or monocyte chemoattractant protein-1 (MCP-1), studying cell migration and proliferation stimulated by the two chemokines, and the role of αvβ3 integrin, using inhibitors of αvβ3 integrin and downstream pathways. Our results show that IGF-1 is a potent chemoattractant in THP-1 monocytes, stimulating cell migration, and thyroid hormone inhibits the effect through αvβ3 integrin. Thyroid hormone also inhibits IGF-1-stimulated cell proliferation through αvβ3 integrin, an example of a crosstalk between genomic and non-genomic effects. We also studied the effects of thyroid hormone on cell migration and proliferation induced by MCP-1, together with the pathways involved, by a pharmacological approach and docking simulation. Our findings show a different downstream signaling for IGF-1 and MCP-1 in THP-1 monocytes mediated by the plasma membrane receptor of thyroid hormones, integrin αvβ3., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with one of the authors RDL., (Copyright © 2021 Candelotti, De Luca, Megna, Maiolo, De Vito, Gionfra, Percario, Borgatti, Gambari, Davis, Lin, Polticelli, Persichini, Colasanti, Affabris, Pedersen and Incerpi.)- Published
- 2021
- Full Text
- View/download PDF
34. Accelerating phylogeny-aware alignment with indel evolution using short time Fourier transform.
- Author
-
Maiolo M, Ulzega S, Gil M, and Anisimova M
- Abstract
Recently we presented a frequentist dynamic programming (DP) approach for multiple sequence alignment based on the explicit model of indel evolution Poisson Indel Process (PIP). This phylogeny-aware approach produces evolutionary meaningful gap patterns and is robust to the 'over-alignment' bias. Despite linear time complexity for the computation of marginal likelihoods, the overall method's complexity is cubic in sequence length. Inspired by the popular aligner MAFFT, we propose a new technique to accelerate the evolutionary indel based alignment. Amino acid sequences are converted to sequences representing their physicochemical properties, and homologous blocks are identified by multi-scale short-time Fourier transform. Three three-dimensional DP matrices are then created under PIP, with homologous blocks defining sparse structures where most cells are excluded from the calculations. The homologous blocks are connected through intermediate 'linking blocks'. The homologous and linking blocks are aligned under PIP as independent DP sub-matrices and their tracebacks merged to yield the final alignment. The new algorithm can largely profit from parallel computing, yielding a theoretical speed-up estimated to be proportional to the cubic power of the number of sub-blocks in the DP matrices. We compare the new method to the original PIP approach and demonstrate it on real data., (© The Author(s) 2019. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.)
- Published
- 2020
- Full Text
- View/download PDF
35. Progressive multiple sequence alignment with indel evolution.
- Author
-
Maiolo M, Zhang X, Gil M, and Anisimova M
- Subjects
- Humans, Probability, Sequence Alignment, Algorithms, Evolution, Molecular, INDEL Mutation, Phylogeny
- Abstract
Background: Sequence alignment is crucial in genomics studies. However, optimal multiple sequence alignment (MSA) is NP-hard. Thus, modern MSA methods employ progressive heuristics, breaking the problem into a series of pairwise alignments guided by a phylogeny. Changes between homologous characters are typically modelled by a Markov substitution model. In contrast, the dynamics of indels are not modelled explicitly, because the computation of the marginal likelihood under such models has exponential time complexity in the number of taxa. But the failure to model indel evolution may lead to artificially short alignments due to biased indel placement, inconsistent with phylogenetic relationship., Results: Recently, the classical indel model TKF91 was modified to describe indel evolution on a phylogeny via a Poisson process, termed PIP. PIP allows to compute the joint marginal probability of an MSA and a tree in linear time. We present a new dynamic programming algorithm to align two MSAs -represented by the underlying homology paths- by full maximum likelihood under PIP in polynomial time, and apply it progressively along a guide tree. We have corroborated the correctness of our method by simulation, and compared it with competitive methods on an illustrative real dataset., Conclusions: Our MSA method is the first polynomial time progressive aligner with a rigorous mathematical formulation of indel evolution. The new method infers phylogenetically meaningful gap patterns alternative to the popular PRANK, while producing alignments of similar length. Moreover, the inferred gap patterns agree with what was predicted qualitatively by previous studies. The algorithm is implemented in a standalone C++ program: https://github.com/acg-team/ProPIP . Supplementary data are available at BMC Bioinformatics online.
- Published
- 2018
- Full Text
- View/download PDF
36. Synthesis, structure and molecular modelling of anionic carbosilane dendrimers.
- Author
-
Rasines B, Sánchez-Nieves J, Maiolo M, Maly M, Chonco L, Jiménez JL, Muñoz-Fernández MÁ, de la Mata FJ, and Gómez R
- Subjects
- Carboxylic Acids chemistry, Magnetic Resonance Spectroscopy, Molecular Structure, Polyphenols chemistry, Silicon chemistry, Sulfonic Acids chemistry, Dendrimers chemistry, Models, Molecular, Silanes chemistry
- Abstract
Anionic carbosilane dendrimers of generations 1-3 have been synthesized containing carboxylate G(n)X(C(2)H(4)CO(2)Na)(m) and sulfonate G(n)X(C(2)H(4)SO(3)Na)(m) peripheral groups and derived from two different cores, 1,3,5-(HO)(3)C(6)H(3) (X = O(3)) and Si(C(3)H(5))(4) (X = Si). The peripheral anionic groups make these dendrimers water soluble, despite their highly hydrophobic framework. These dendrimers present a net negative charge in water, which was influenced by the pH of the medium. This characteristic was studied by pH titration. Also molecular modeling calculations have been performed to study differences in an aqueous medium between carboxylate and sulfonate dendrimers of different cores. The results obtained were also compared with those obtained from DOSY NMR experiments and zeta-potential measurements.
- Published
- 2012
- Full Text
- View/download PDF
37. A randomized, double-blind, cross-over study comparing a levosulpiride-based and a metoclopramide-based combination in the prevention of ProMECE-CytaBOM-induced emesis.
- Author
-
Sabbatini R, Federico M, Baldini L, Barbieri F, Maiolo MT, and Silingardi V
- Subjects
- Adult, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Basal Ganglia Diseases chemically induced, Bleomycin administration & dosage, Bleomycin adverse effects, Cross-Over Studies, Cyclophosphamide administration & dosage, Cyclophosphamide adverse effects, Cytarabine administration & dosage, Cytarabine adverse effects, Diazepam administration & dosage, Diazepam analogs & derivatives, Diazepam therapeutic use, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Epirubicin administration & dosage, Epirubicin adverse effects, Etoposide administration & dosage, Etoposide adverse effects, Humans, Lymphoma, Non-Hodgkin complications, Methotrexate administration & dosage, Methotrexate adverse effects, Metoclopramide administration & dosage, Metoclopramide adverse effects, Middle Aged, Nausea chemically induced, Nausea prevention & control, Prednisone administration & dosage, Prednisone adverse effects, Prochlorperazine administration & dosage, Prochlorperazine therapeutic use, Promethazine administration & dosage, Promethazine therapeutic use, Sulpiride administration & dosage, Sulpiride adverse effects, Sulpiride therapeutic use, Treatment Outcome, Vincristine administration & dosage, Vincristine adverse effects, Vomiting chemically induced, Antiemetics therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Lymphoma, Non-Hodgkin drug therapy, Metoclopramide therapeutic use, Sulpiride analogs & derivatives, Vomiting prevention & control
- Abstract
Background: To test two different antiemetic regimens for preventing nausea and vomiting in patient with non-Hodgkin's lymphoma (NHL) undergoing systemic chemotherapy (CT) with ProMECE-CytaBOM (P-C)., Patients and Methods: Twenty consecutive untreated adult outpatients with histologically confirmed NHL and scheduled to receive P-C chemotherapy were registered in a randomized, double-blind, cross-over study to compare the antiemetic efficacy of a levosulpiride (LS)-based and metoclopramide (MTC)-based regimen., Results: Complete protection from vomiting was recorded in 93% (62/67) of courses with the LS-regimen and in 89% (62/70) with the MTC-regimen (p = 0.428). No nausea was observed in 84% (56/67) of courses with the LS-regimen and in 74% (52/70) with the MTC-regimen (p = 0.183). No differences in prevention of emesis were recorded when patients crossed to the other regimen. Both regimens were well tolerated; however, on day 8 of chemotherapy, when both antiemetic regimens were administered at a higher dose, the LS-based combination showed significantly lower toxicity (p = 0.035)., Conclusions: ProMECE-CytaBOM-induced emesis can be prevented in most cases with appropriate, specifically designed antiemetic therapy. Both the LS- and MTC-based combinations resulted in a high percentage of complete protection from emesis, but the higher incidence of side effects observed with MTC makes the LS-based regimen preferable for patients receiving P-C chemotherapy.
- Published
- 1995
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.