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Introduction: The role of the immune and inflammatory pathways in diabetic patients with coronary artery disease (CAD) is important but not complete understood. The aim of this study was to evaluate concentrations of the interleukins 17 A and 22 in diabetic patients with stable CAD. Hypothesis: Interleukins 17 A and 22 are not increased in diabetic patients with stable CAD. Methods: This is a cross-sectional, prospective, analytical study, conducted from August to December 2012. We included 15 diabetic patients (P) with stable CAD, CCS III or IV, ischemic myocardial scintigraphy, who had not been subjected to any kind of myocardial revascularization and with coronary stenosis ≥ 50% according to current coronary angiography. There were 20 healthy volunteers (C), to take up comparison of concentrations of interleukins (IL). Interleukins were evaluated in serum of patients and after 48 hours of cells in culture with and without stimulus. IL concentrations were expressed in pg / ml. Statistical analysis was performed using the Mann-Whitney or Student t test. P ≤ 0,05 was considered statistically significant. Results: There were 6 men and 9 women in the group of the diabetic patients and 12 men and 8 women in the controls. The age was similar between the groups (61.6 ± 6.7 years vs 57.9 ± 9.4, p = ns). The main CAD risk factors: hypertension 73%, smoking 60%, dyslipidemia 40%, prior myocardial infarction 33%. The comparison between the groups showed: IL 17 A: Serum: P = 3.91 (3.91 -- 3.91 ) vs C = 3.91 (3.91 -- 3.91 ), p = 0.82; culture 48 hours without stimulus: P = 3.91 (3.91 -- 3.91) vs C = 3.91 (3.91 -- 3.91), p = 0.06; culture 48 hours with stimulus: P = 199 (3.91 -- 520) vs C = 154 (3.91 -- 574), p = 0.90. IL 22: Serum: P = 15.63 (15.63 -- 41.09) vs C = 15.63 (15.63 -- 41.09), p = 0.34; culture 48 hours without stimulus: P = 7.81 (7.81 -- 7.81) vs C = 7.81 (7.81 -- 7.81), p = 0.09; culture 48 hours with stimulus: P = 113.79 (7.81 - 248.63) vs C = 322.87 (7.81 - 628.49), p = 0.14. Conclusions: There were no differences in concentrations of IL 17 A and 22, does not matter in serum or cell in culture. In conclusion in diabetic patients with stable CAD the concentrations of interleukins 17 A and 22 were not increased.

Introduction: The effects of interleukins during development of coronary artery disease (CAD) have been studied by researchers and it may help to understand better this disease. The aim of this study was to evaluate if there are differences of concentrations of the IL 17 A between men and women with stable CAD. Hypothesis: There are no differences of concentrations of the IL 17 A according to gender of the patients. Methods: This is a cross-sectional, prospective, analytical study, conducted from August to December 2012. We included 40 patients (24 men (MP) and 16 women (WP) with stable CAD, CCS III or IV, ischemic myocardial scintigraphy, who had not been subjected to any kind of myocardial revascularization and with coronary stenosis ≥ 50% according to current coronary angiography. There were 20 healthy volunteers (12 men (MC) and 8 women (WC), to take up comparison of concentrations of interleukins (IL). Interleukins were evaluated in serum of patients and after 48 hours of cells in culture with and without stimulus. IL concentrations were expressed in pg / ml. Statistical analysis was performed using the Mann-Whitney or Student t test. P ≤ 0,05 was considered statistically significant. Results: The comparison between the groups showed: IL 17 A: Serum: MP = 3.91 (3.91 - 3.91) vs MC = 3.91 (3.91 - 9.28), p = 0.31; culture 48 hours without stimulus: MP = 3.91 (3.91 - 3.91) vs MC = 3.91 (3.91 - 3.91), p = 0.45; culture 48 hours with stimulus: MP = 451.67 (99.02 - 892.58) vs MC = 135 (3.91 -- 285), p = 0.04. IL 17 A: Serum: WP = 3.91 (3.91 - 3.91) vs WC = 3.91 (3.91 -- 6.25), p = 0.90; culture 48 hours without stimulus: WP = 3.91 (3.91 - 3.91) vs WC = 3.91 (3.91 -- 3.91), p = 0.20; culture 48 hours with stimulus: WP = 131.21 (3.91 - 231.97) vs WC = 173.78 (3.91 - 642), p = 0.24. IL 17 A: Serum: MP = 3.91 (3.91 - 3.91) vs WP = 3.91 (3.91 - 3.91), p = 0.17; culture 48 hours without stimulus: MP = 3.91 (3.91 - 3.91) vs WP = 3.91 (3.91 - 3.91), p = 0.47; culture 48 hours with stimulus: MP = 451.67 (99.02 -- 892.58) vs WP = 131.21 (3.91 - 231.97), p = 0.02. Conclusions: There were no differences of concentrations of the IL 17 A between WP and WC. However, MP had higher concentrations of the IL 17 A than MC and WP. Therefore, it is possible that the IL 17 A take part in a pathway which determines different patterns of CAD according to gender.