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Background: Carbon dioxide (CO2), traditionally viewed as a mere byproduct of cellular respiration, plays a multifaceted role in human physiology beyond simple elimination through respiration. CO2 may regulate the tumor microenvironment by significantly affecting the release of oxygen (O2) to tissues through the Bohr effect and by modulating blood pH and vasodilation. Previous studies suggest hypercapnia (elevated CO2 levels) might trigger optimized cellular mechanisms with potential therapeutic benefits. The role of CO2 in cellular stress conditions within tumor environments and its impact on O2 utilization offers a new investigative area in oncology. Objectives: This study aims to explore CO2's role in the tumor environment, particularly how its physiological properties and adaptive responses can influence therapeutic strategies. Methods: By applying a structured translational approach using the Work Breakdown Structure method, the study divided the analysis into six interconnected work packages to comprehensively analyze the interactions between carbon dioxide and the tumor microenvironment. Methods included systematic literature reviews, data analyses, data integration for identifying critical success factors and exploring extracellular environment modulation. The research used SMART criteria for assessing innovation and the applicability of results. Results: The research revealed that the human body's adaptability to hypercapnic conditions could potentially inform innovative strategies for manipulating the tumor microenvironment. This could enhance O2 utilization efficiency and manage adaptive responses to cellular stress. The study proposed that carbon dioxide's hormetic potential could induce beneficial responses in the tumor microenvironment, prompting clinical protocols for experimental validation. The research underscored the importance of pH regulation, emphasizing CO2 and carbonic acid's role in modulating metabolic and signaling pathways related to cancer. Conclusion: The study underscores CO2 as vital to our physiology and suggests potential therapeutic uses within the tumor microenvironment. pH modulation and cellular oxygenation optimization via CO2 manipulation could offer innovative strategies to enhance existing cancer therapies. These findings encourage further exploration of CO2's therapeutic potential. Future research should focus on experimental validation and exploration of clinical applications, emphasizing the need for interdisciplinary and collaborative approaches to tackle current challenges in cancer treatment. [ABSTRACT FROM AUTHOR]

This paper identified the intangible aspects (IA) that generate impacts in companies of the agricultural sector in the different stages of the companies life cycle. This paper is based on a systematic review methodology to identify intangibles in the agricultural sector. Studies on the life cycle of companies were analyzed to classify the impact of intangible aspects according to the reality of companies. Identify the intangible aspects that impact the agricultural sector through a review of the scientific literature. How intangible aspects affect each stage of the life cycle of companies in the sector shows that they have a different impact depending on the period in which the company is located. Although, much of the previous literature has suggested that intangible aspects have positive effects on a variety of performance variables, there are no scientific studies that specifically address the importance of these intangible aspects in the life cycle of companies in the agricultural sector. [ABSTRACT FROM AUTHOR]

Agriculture is crucial for economic and social development, with rural producers playing a vital role in sustaining life. Various types of rural organizations exist, fostering diverse objectives among producers. Over the past fifty years, significant transformations have occurred in Brazil's agriculture, with farmers facing the challenge of producing more and better with less. This study aims to identify factors influencing the decision-making of rural producers. It employed a Systematic Literature Review to extract factors divided into four dimensions: technology, learning, market, and governance. These dimensions interfere with the decision-making process and are considered decisive for the success or failure of any rural producer. The primary outcome underscores the significance of understanding how to produce and all aspects encompassing the administrative and financial management of rural properties. Enhancing managerial capabilities is essential for rural producers. Faced with the implications of technological advances, rural producers must behave appropriately to manage their activities and property to remain and grow stronger in an increasingly competitive market, where efficiency and effectiveness are essential for survival. [ABSTRACT FROM AUTHOR]

Due to economic, social, and environmental factors that influence businesses related to renewable energy sources, such as photovoltaic energy (PV), several players are acting on these business models, forming a complex network of interrelations. In this sense, this paper aims to identify the players involved in PV businesses considering a global perspective, mapping the main relations between the players, contextualizing and discussing how these interactions develop in the context of PV businesses and help to the development and diffusion of the PV market. A systematic review (SR) based on the Preferred Reporting Items for Systematic Reviews and a Meta-Analyses (Prisma) statement was used to identify who the players were and to group them into clusters. The Apriori algorithm was used to build a players' network and a clusters' network, enabling a detailed discussion, based on a Political, Economic, Social, Technological, Legal, and Environmental (PESTLE) factors analysis, of these relationships. 35 players were identified, being grouped into 7 clusters, which can be related to the PV's businesses. 20 players achieved relevance through Apriori rules, appearing in the players' network. With the players' network related to the PV businesses, business models can be defined or improved, exploring the conditioning, and limiting factors to improve business processes. [ABSTRACT FROM AUTHOR]

Paper aims: This article aims to diagnose the penetration level of Industry 4.0 technologies in cloud-based energy management systems, the Energy Cloud. Originality: The energy sector is undergoing a technological evolution driven by the integration of Industry 4.0 technologies with energy management systems, making relevant the study of the permeability of these technologies with energy companies. Research method: The research used two articles on Energy Cloud as a theoretical basis and a data collection carried out with managers of renewable energy companies, with the data being analyzed using the MONNA software. Main findings: The results show that there is a greater understanding and use of the Internet of Things and Sensors technologies to the detriment of Cloud Computing and Big Data. Implications for theory and practice: The article shows that there is a need for managers to seek greater familiarization, especially with Cloud Computing and Big Data. [ABSTRACT FROM AUTHOR]

Copyright of Revista Producao Online is the property of Associacao Brasileira de Engenharia de Producao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Ágora is the property of Universidade do Contestado and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Iberoamerican Journal of Industrial Engineering is the property of Iberoamerican Journal of Industrial Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tecno-Lógica is the property of Tecno-Logica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Este artigo analisa o panorama das incubadoras de empresas de base tecnológica (IBTs) na região sul do Brasil sob um viés socioeconômico e intelectual, através de correlações com instituições de ensino superior com programas de pós-graduação stricto sensu, direitos de propriedade intelectual concedidos, investimento em ciência e tecnologia, Produto Interno Bruto (PIB) e Índice de Desenvolvimento Humano (IDH). O estudo focou na região sul-brasileira, visto que esta apresenta alguns dos melhores indicadores sociais do país. Através da análise de correlações, pode-se elucidar um cenário de destaque nas nações desenvolvidas, que envolve o empreendedorismo de base tecnológica. Os resultados demonstraram que: (1) a presença de IBTs está fortemente relacionada à existência de instituições de ensino superior com programas de pós-graduação stricto sensu; (2) a existência de IBTs está altamente relacionada a níveis elevados de produção intelectual; (3) estados que recebem mais investimentos em ciência e tecnologia estão positivamente relacionados com IBTs; (4) a existência de IBTs apresenta correlação desprezível com o PIB; (5) a existência de IBTs apresenta correlação fraca com o IDH. Assim, o estudo permitiu verificar o cenário sul-brasileiro com relação à implantação e ao funcionamento de IBTs. [ABSTRACT FROM AUTHOR]

Copyright of Iberoamerican Journal of Industrial Engineering is the property of Iberoamerican Journal of Industrial Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Brazilian Journal of Management / Revista de Administração da UFSM is the property of Brazilian Journal of Management / Revista de Administracao da UFSM and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study aimed to conduct an assessment of the technical efficiency of Business Administration courses in Brazil, by means of Data Envelopment Analysis (DEA), a nonparametric technique introduced by Charnes, Cooper and Rhodes (1978). Were used as variables in the model the eight component indicators of the Preliminary Concept of Course (CPC) to evaluate 1229 courses of Business Administration based on the results of the National Examination of Performance Evaluation of Students (ENADE) of 2009, obtaining as result that only 1.2% of these can be considered efficient. After this measurement, a step of recommendations was made to propose goals for the inefficient courses, thus bringing to light that better results can achieved given the inputs already available for Business Administration courses. [ABSTRACT FROM AUTHOR]

Copyright of Production / Produção is the property of Associacao Brasileira de Engenharia de Producao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article presents the quantitative study on the general course index of public and private universities in five regions in Brazil. It discusses how the study was conducted which involved 221 universities and examined the mapping patterns of regional identities. The results reportedly revealed that private universities were outperfomed by public universities.

Copyright of Revista Eletrônica de Estratégia & Negócios is the property of Revista Eletronica de Estrategia & Negocios and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The present proposal is aimed at investigating the importance of UFSM in the management plans of the solidary economy for the municipality of Santa Maria and meet the precept of the indissociability of teaching, research and extension, involving the students of graduate and post-graduate degree in Production Engineering. The survey data was performed on Friday Solidary Economy of MERCOSUR, on days 9, 10 and July 11, 2010, in Santa Maria, RS. The structured questionnaire with 16 open questions and question mainly, support and benefits that they receive from teaching centers, city halls, religious groups among others. In the result it was evidenced that the MERCOSUR countries and Brazilian states with support of political bodies, religious education or are undertaking that develop more quickly, due to the contribution in the light of the practice of self-management and increases the possibilities of sustainability in relation to association of persons where each seizing with the other. [ABSTRACT FROM AUTHOR]

The diffusion of photovoltaic distributed generation is relevant for addressing the political, economic, and environmental issues in the electricity sector. However, the proliferation of distributed generation brings new administrative and operational challenges for the sustainability of electric power utilities. Electricity distributors operate in economies of scale, and the high photovoltaic penetration means that these companies have economic and financial impacts, in addition to influencing the migration of other consumers. Thus, this paper aims to systematically identify and evaluate critical factors and indicators that may influence electricity distributors in predicting their consumers' adoption of photovoltaic technology, which were subjected to the analysis of 20 industry experts. Results show that the cost of electricity, generation capacity, and cost of the photovoltaic systems are the most relevant indicators, and it is possible to measure a considerable part of them using the internal data of the electricity distributors. The study contributes to the understanding of the critical factors for the forecast of the adoption of consumers to distributed photovoltaic generation, to assist the distribution network operators in the decision making, and the distribution sustainability. Also, it establishes the theoretical, political, and practical implications for the Brazilian scenario and developing countries. [ABSTRACT FROM AUTHOR]