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44 results on '"Majno, Pietro E"'

6. Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells

Author

Mele, Valentina; https://orcid.org/0000-0002-7648-0835, Basso, Camilla, Governa, Valeria; https://orcid.org/0000-0001-9999-0590, Glaus Garzon, Jesus F, Muraro, Manuele G; https://orcid.org/0000-0002-4590-1916, Däster, Silvio; https://orcid.org/0000-0001-5188-4908, Nebiker, Christian A, Mechera, Robert; https://orcid.org/0000-0002-4533-9265, Bolli, Martin, Schmidt, Alexander, Geiger, Roger; https://orcid.org/0000-0002-8016-1669, Spagnoli, Giulio C, Christoforidis, Dimitri, Majno, Pietro E, Borsig, Lubor; https://orcid.org/0000-0003-2263-9545, Iezzi, Giandomenica, Mele, Valentina; https://orcid.org/0000-0002-7648-0835, Basso, Camilla, Governa, Valeria; https://orcid.org/0000-0001-9999-0590, Glaus Garzon, Jesus F, Muraro, Manuele G; https://orcid.org/0000-0002-4590-1916, Däster, Silvio; https://orcid.org/0000-0001-5188-4908, Nebiker, Christian A, Mechera, Robert; https://orcid.org/0000-0002-4533-9265, Bolli, Martin, Schmidt, Alexander, Geiger, Roger; https://orcid.org/0000-0002-8016-1669, Spagnoli, Giulio C, Christoforidis, Dimitri, Majno, Pietro E, Borsig, Lubor; https://orcid.org/0000-0003-2263-9545, and Iezzi, Giandomenica

Abstract

Stromal infiltration is associated with poor prognosis in human colon cancers. However, the high heterogeneity of human tumor-associated stromal cells (TASCs) hampers a clear identification of specific markers of prognostic relevance. To address these issues, we established short-term cultures of TASCs and matched healthy mucosa-associated stromal cells (MASCs) from human primary colon cancers and, upon characterization of their phenotypic and functional profiles in vitro and in vivo, we identified differentially expressed markers by proteomic analysis and evaluated their prognostic significance. TASCs were characterized by higher proliferation and differentiation potential, and enhanced expression of mesenchymal stem cell markers, as compared to MASCs. TASC triggered epithelial-mesenchymal transition (EMT) in tumor cells in vitro and promoted their metastatic spread in vivo, as assessed in an orthotopic mouse model. Proteomic analysis of matched TASCs and MASCs identified a panel of markers preferentially expressed in TASCs. The expression of genes encoding two of them, calponin 1 (CNN1) and tropomyosin beta chain isoform 2 (TPM2), was significantly associated with poor outcome in independent databases and outperformed the prognostic significance of currently proposed TASC markers. The newly identified markers may improve prognostication of primary colon cancers and identification of patients at risk.

Published
2022

7. Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells

Author

Mele, Valentina, primary, Basso, Camilla, additional, Governa, Valeria, additional, Glaus Garzon, Jesus F., additional, Muraro, Manuele G., additional, Däster, Silvio, additional, Nebiker, Christian A., additional, Mechera, Robert, additional, Bolli, Martin, additional, Schmidt, Alexander, additional, Geiger, Roger, additional, Spagnoli, Giulio C., additional, Christoforidis, Dimitri, additional, Majno, Pietro E., additional, Borsig, Lubor, additional, and Iezzi, Giandomenica, additional

Published
2022
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25. Liver Transplantation for Hepatic Trauma: A Study From the European Liver Transplant Registry

Author

Krawczyk, Marek, Grat, Michal, Adam, Rene, Polak, Wojciech G, Klempnauer, Jurgen, Pinna, Antonio, Di Benedetto, Fabrizio, Filipponi, Franco, Senninger, Norbert, Foss, Aksel, Rufián-Peña, Sebastian, Bennet, William, Pratschke, Johann, Paul, Andreas, Settmacher, Utz, Rossi, Giorgio, Salizzoni, Mauro, Fernandez-Selles, Carlos, Martínez de Rituerto, Santiago T, Gómez-Bravo, Miguel A, Pirenne, Jacques, Detry, Olivier, Majno, Pietro E, Nemec, Petr, Bechstein, Wolf O, Bartels, Michael, Nadalin, Silvio, Pruvot, Francois R, Mirza, Darius F, Lupo, Luigi, Colledan, Michele, Tisone, Giuseppe, Ringers, Jan, Daniel, Jorge, Charco Torra, Ramón, Moreno González, Enrique, Bañares Cañizares, Rafael, Cuervas-Mons Martinez, Valentin, San Juan Rodríguez, Fernando, Yilmaz, Sezai, Remiszewski, Piotr, Remiszweski, Piotr, Deschans, Bruno, Hans, Marie France, Meyer, Stephanie Hauss, Rutarova, Jana, Siems, Martina, Knochel, Cornelia Swillus, Wilhelm, Dietmar, Hecker, Sandy, Harms, Simone, Sakirow, Larissa, Eissing, Elvira, Schenk, Martin, Poli, Elisabetta, Guizzetti, Michela, Grazi, Gian Luca, Maggi, Umberto, Montalti, Roberto, Arenga, Giuseppe, Sforza, Daniele, Cibelli, Alessandra, Foss, Stein, Caetano, Rosario, Ispir, Mukadder, Krawczyk, M, Grat, M, Adam, R, Polak, W, Klempnauer, J, Pinna, A, Di Benedetto, F, Filipponi, F, Senninger, N, Foss, A, Rufian-Pena, S, Bennet, W, Pratschke, J, Paul, A, Settmacher, U, Rossi, G, Salizzoni, M, Fernandez-Selles, C, de Rituerto, S, Gomez-Bravo, M, Pirenne, J, Detry, O, Majno, P, Nemec, P, Bechstein, W, Bartels, M, Nadalin, S, Pruvot, F, Mirza, D, Lupo, L, Colledan, M, Tisone, G, Ringers, J, Daniel, J, Torra, R, Gonzalez, E, Canizares, R, Martinez, V, Rodriguez, F, Yilmaz, S, Remiszewski, P, and Surgery

Subjects
Registrie, Graft Rejection, Male, medicine.medical_specialty, medicine.medical_treatment, Medizin, 030230 surgery, Liver transplantation, Extracorporeal, Female, Humans, Injury Severity Score, Liver, Registries, Retrospective Studies, Liver Transplantation, 03 medical and health sciences, 0302 clinical medicine, Statistical significance, Risk of mortality, Medicine, Risk factor, Transplantation, ddc:617, business.industry, 030208 emergency & critical care medicine, Retrospective cohort study, Surgery, Settore MED/18, business, Human
Abstract

Background Liver transplantation is the most extreme form of surgical management of patients with hepatic trauma, with very limited literature data supporting its use. The aim of this study was to assess the results of liver transplantation for hepatic trauma. Methods This retrospective analysis based on European Liver Transplant Registry comprised data of 73 recipients of liver transplantation for hepatic trauma performed in 37 centers in the period between 1987 and 2013. Mortality and graft loss rates at 90 days were set as primary and secondary outcome measures, respectively. Results Mortality and graft loss rates at 90 days were 42.5% and 46.6%, respectively. Regarding general variables, cross-clamping without extracorporeal veno-venous bypass was the only independent risk factor for both mortality (P = 0.031) and graft loss (P = 0.034). Regarding more detailed factors, grade of liver trauma exceeding IV increased the risk of mortality (P = 0.005) and graft loss (P = 0.018). Moreover, a tendency above the level of significance was observed for the negative impact of injury severity score (ISS) on mortality (P = 0.071). The optimal cut-off for ISS was 33, with sensitivity of 60.0%, specificity of 80.0%, positive predictive value of 75.0%, and negative predictive value of 66.7%. Conclusions Liver transplantation seems to be justified in selected patients with otherwise fatal severe liver injuries, particularly in whom cross-clamping without extracorporeal bypass can be omitted. The ISS cutoff less than 33 may be useful in the selection process.

Published
2016

29. A survival analysis of the liver-first reversed management of advanced simultaneous colorectal liver metastases: a LiverMetSurvey-based study.

Author

UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, Andres, Axel, Toso, Christian, Adam, Rene, Barroso, Eduardo, Hubert , Catherine, Capussotti, Lorenzo, Gerstel, Eric, Roth, Arnaud, Majno, Pietro E, Mentha, Gilles, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, Andres, Axel, Toso, Christian, Adam, Rene, Barroso, Eduardo, Hubert , Catherine, Capussotti, Lorenzo, Gerstel, Eric, Roth, Arnaud, Majno, Pietro E, and Mentha, Gilles

Abstract

Classical and reversed managements of metastatic liver disease in colorectal cancer are associated with similar survival when successfully completed.

Published
2012

34. Improved Long-Term Outcome of Surgery for Advanced Colorectal Liver Metastases: Reasons and Implications for Management on the Basis of a Severity Score

Author

Andres, Axel, primary, Majno, Pietro E., additional, Morel, Philippe, additional, Rubbia-Brandt, Laura, additional, Giostra, Emiliano, additional, Gervaz, Pascal, additional, Terraz, Sylvain, additional, Allal, Abdelkarim S., additional, Roth, Arnaud D., additional, and Mentha, Gilles, additional

Published
2007
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44. Acute portal hemodynamics and cytokine changesfollowing selective transarterial chemoembolization in patients with cirrhosis and hepatocellular carcinoma.

Author

Spahr L, Becker C, Pugin J, Majno PE, and Hadengue A

Subjects
Aged, Aged, 80 and over, Alanine Transaminase blood, Aspartate Aminotransferases blood, Blood Flow Velocity, Body Temperature physiology, Carcinoma, Hepatocellular blood, Carcinoma, Hepatocellular diagnostic imaging, Carcinoma, Hepatocellular therapy, Female, Humans, Liver Cirrhosis blood, Liver Cirrhosis therapy, Liver Neoplasms blood, Liver Neoplasms diagnostic imaging, Liver Neoplasms therapy, Male, Middle Aged, Portal Pressure physiology, Portal Vein diagnostic imaging, Portal Vein physiology, Ultrasonography, Doppler, Duplex, Carcinoma, Hepatocellular blood supply, Chemoembolization, Therapeutic, E-Selectin blood, Liver Cirrhosis physiopathology, Liver Neoplasms blood supply, Tumor Necrosis Factor-alpha metabolism, Vascular Cell Adhesion Molecule-1 blood
Abstract

Background: Altered portal hemodynamics and inflammation may occur following transcatheter arterial chemoembolization (TACE), but early biological and portal perfusion changes are not well characterized when this procedure is performed selectively., Material/methods: We studied variations in portal flow velocity (PFV) using Doppler ultrasonography, as well as serum TNFa, vCAM-1, and E-Selectin at 2 and 24 hours after supraselective TACE in 15 consecutive patients with cirrhosis and hepatocellular carcinoma., Results: Variations in PFV occurred both in the embolized and non-embolized liver lobe. PFV increased significantly at 2 hours in the right and left portal vein. At 24 hours, right PFV remained elevated. Serum TNFa increased significantly at 2 hours, but VCAM-1 and E-Selectin levels remained unchanged. Changes in right and left PFV showed a positive correlation (r=0.9, p<0.001). No correlation could be observed between biological and Doppler changes in portal veins., Conclusions: In patients with cirrhosis and hepatocellular carcinoma, PFV increased in both liver lobes 2 hours after supraselective TACE, in association with high serum TNFa. Diffuse changes in PFV after TACE suggests that mechanisms involved in the regulation of portal and hepatic arterial hemodynamics are present in patients with cirrhosis. A major role for TNFa in acute portal flow velocity variations is unlikely in this situation.

Published
2003

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