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7 results on '"Majorova, Dominika"'

1. Corrigendum

Author

Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O'Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A., Stucki, Manuel, Le, Quynh-Thu, Leedham, Simon J., Giaccia, Amato J., and Olcina, Monica M.

Abstract

Original citation: J Clin Invest. 2023;133(23):e168277. https://doi.org/10.n72/JCI168277. During the preparation of this manuscript, the dose for PMX205 used for in vitro experiments was stated incorrectly in the legend for Figure [...]

Published
2024
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2. Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

Author

Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O'Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A., Stucki, Manuel, Le, Quynh-Thu, Leedham, Simon J., Giaccia, Amato J., and Olcina, Monica M.

Subjects
Thermo Fisher Scientific Inc., Scientific equipment and supplies industry, Gene expression, T cells, Tumors, Genes, Cancer -- Diagnosis, Colorectal cancer, Ethylenediaminetetraacetic acid, B cells, Radiotherapy, Health care industry, Wellcome Trust
Abstract

An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still a challenge. Using an integrated screening approach to identify cancer-specific vulnerabilities, we identified complement receptor C5aR1 as a druggable target, which when inhibited improved radiotherapy, even in tumors displaying immunosuppressive features and poor [CD8.sup.+] T cell infiltration. While C5aR1 is well-known for its role in the immune compartment, we found that C5aR1 is also robustly expressed on malignant epithelial cells, highlighting potential tumor cell-specific functions. C5aR1 targeting resulted in increased NF-[kappa]B-dependent apoptosis specifically in tumors and not normal tissues, indicating that, in malignant cells, C5aR1 primarily regulated cell fate. Collectively, these data revealed that increased complement gene expression is part of the stress response mounted by irradiated tumors and that targeting C5aR1 could improve radiotherapy, even in tumors displaying immunosuppressive features., Introduction The composition of the tumor microenvironment (TME) affects treatment responses in cancer (1-3). Immunosuppressive TME features, which act as a barrier to extensive [CD8.sup.+] T cell infiltration typically characterize [...]

Published
2023
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3. Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

Author

Beach, Callum, primary, MacLean, David, additional, Majorova, Dominika, additional, Melemenidis, Stavros, additional, Nambiar, Dhanya K., additional, Kim, Ryan K., additional, Valbuena, Gabriel N, additional, Guglietta, Silvia, additional, Krieg, Carsten, additional, Darvish, Damavandi Mahnaz, additional, Suwa, Tatsuya, additional, Easton, Alistair, additional, Domingo, Enric, additional, Moon, Eui Jung, additional, Jiang, Dadi, additional, Jiang, Yanyan, additional, Koong, Albert C, additional, Woodruff, Trent M., additional, Graves, Edward E., additional, Maughan, Tim, additional, Buczacki, Simon J. A., additional, Stucki, Manuel, additional, Le, Quynh-Thu, additional, Leedham, Simon J., additional, Giaccia, Amato J., additional, and Olcina, Monica M, additional

Published
2023
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5. 665: Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironments

Author

Beach, Callum, MacLean, David, Majorova, Dominika, Valbuena, Gabriel N., Damavandi, Mahnaz Darvish, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Moon, Eui Jung, Guglietta, Silvia, Krieg, Carsten, Woodruff, Trent M., Maughan, Tim, Buczacki, Simon J.A., Leedham, Simon J., Giaccia, Amato J., Clark, Heather, and Olcina, Monica M.

Published
2024
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7. Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.

Author

Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar DK, Kim RK, Valbuena GN, Guglietta S, Krieg C, Darvish-Damavandi M, Suwa T, Easton A, Hillson LV, McCulloch AK, McMahon RK, Pennel K, Edwards J, O'Cathail SM, Roxburgh CS, Domingo E, Moon EJ, Jiang D, Jiang Y, Zhang Q, Koong AC, Woodruff TM, Graves EE, Maughan T, Buczacki SJ, Stucki M, Le QT, Leedham SJ, Giaccia AJ, and Olcina MM

Subjects
Humans, Animals, Mice, Tumor Microenvironment immunology, Neoplasms radiotherapy, Neoplasms immunology, Neoplasms metabolism, Receptor, Anaphylatoxin C5a metabolism, Receptor, Anaphylatoxin C5a immunology, Receptor, Anaphylatoxin C5a genetics
Published
2024
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